A new oral contraceptive regimen for endometriosis management: Preliminary experience with 24/4-day drospirenone/ethinilestradiol 3mg/20 mcg

Gynecological Endocrinology

Volumn 28, Issue 6, 2012, Pages 451-454

  Mabrouk, Mohamed ^a,b   Solfrini, Serena ^a   Frascà, Clarissa ^a   Del Forno, Simona ^a   Montanari, Giulia ^a   Ferrini, Giulia ^a   Paradisi, Roberto ^a   Seracchioli, Renato ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

24 4; Combined oral contraceptives; Continuous regimen; Drospirenone; Dysmenorrhoea; Endometriosis

Indexed keywords

DROSPIRENONE PLUS ETHINYLESTRADIOL;

ADULT; ARTICLE; BLOATING; BREAST TENDERNESS; CLINICAL ASSESSMENT; CLINICAL EXAMINATION; DRUG TOLERABILITY; DYSMENORRHEA; DYSPAREUNIA; ENDOMETRIOSIS; ENDOMETRIUM TUMOR; FEMALE; FOLLOW UP; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; NAUSEA; ORAL CONTRACEPTION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECURRENCE RISK; RETROSPECTIVE STUDY; SPOTTING; TRANSVAGINAL ECHOGRAPHY; TREATMENT DURATION; VAGINAL DRYNESS; VISUAL ANALOG SCALE;

ADULT; ANDROSTENES; COMBINED MODALITY THERAPY; CONTRACEPTIVES, ORAL, COMBINED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOMETRIOSIS; ETHINYL ESTRADIOL; FEMALE; FOLLOW-UP STUDIES; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; OVARIAN DISEASES; PILOT PROJECTS; POSTOPERATIVE PERIOD; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84861052688     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2011.634936     Document Type: Article

References (29)

1. Vercellini P, Somigliana E, Viganò P, Abbiati A, Daguati R, Crosignani PG. Endometriosis: Current and future medical therapies. Best Pract Res Clin Obstet Gynaecol 2008;22:275-306. (Pubitemid 351305700)
2. Seracchioli R, Mabrouk M, Manuzzi L, Vicenzi C, Frascà C, Elmakky A, Venturoli S. Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis. Hum Reprod 2009;24:2729-2735.
3. Davis LJ, Kennedy SS, Moore J, Prentice A. Modern combined oral contraceptives for pain with endometriosis. Cochrane Database Syst Rev 2007;18:CD001019.
4. Seracchioli R, Mabrouk M, Frascà C, Manuzzi L, Montanari G, Keramyda A, Venturoli S. Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: A randomized controlled trial. Fertil Steril 2010;93:52-56.
5. Vercellini P, Crosignani P, Somigliana E, Viganò P, Frattaruolo MP, Fedele L. 'Waiting for Godot': A commonsense approach to the medical treatment of endometriosis. Hum Reprod 2011;26:3-13.
6. Vercellini P, Frontino G, De Giorgi O, Pietropaolo G, Pasin R, Crosignani PG. Continuous use of an oral contraceptive for endometriosisassociated recurrent dysmenorrhea that does not respond to a cyclic pill regimen. Fertil Steril 2003;80:560-563. (Pubitemid 37102866)
7. Sulak PJ. Continuous oral contraception: changing times. Best Pract Res Clin Obstet Gynaecol 2008;22:355-374. (Pubitemid 351305699)
8. Bachmann G, Sulak PJ, Sampson-Landers C, Benda N, Marr J. Efficacy and safety of a low-dose 24-day combined oral contraceptive containing 20 micrograms ethinylestradiol and 3 mg drospirenone. Contraception 2004;70:191-198. (Pubitemid 39119980)
9. Hernádi L, Marr J, Trummer D, De Leo V, Petraglia F. Efficacy and safety of a low-dose combined oral contraceptive containing drospirenone 3 mg and ethinylestradiol 20 mcg in a 24/4-day regimen. Contraception 2009;80:18-24.
10. Anttila L, Kunz M, Marr J. Bleeding pattern with drospirenone 3 mg + ethinyl estradiol 20 mcg 24/4 combined oral contraceptive compared with desogestrel 150 mcg + ethinyl estradiol 20 mcg 21/7 combined oral contraceptive. Contraception 2009;80:445-451.
11. Coffee AL, Sulak PJ, Kuehl TJ. Long-term assessment of symptomatology and satisfaction of an extended oral contraceptive regimen. Contraception 2007;75:444-449. (Pubitemid 46764300)
12. Yonkers KA, Brown C, Pearlstein TB, Foegh M, Sampson-Landers C, Rapkin A. Efficacy of a new low-dose oral contraceptive with drospirenone in premenstrual dysphoric disorder. Obstet Gynecol 2005;106:492-501. (Pubitemid 41208780)
13. Fenton C, Wellington K, Moen MD, Robinson DM. Drospirenone/ ethinylestradiol 3 mg/20 mcg (24/4 day regimen): A review of its use in contraception, premenstrual dysphoric disorder and moderate acne vulgaris. Drugs 2007;67:1748-1765.
14. Klipping C, Duijkers I, Trummer D, Marr J. Suppression of ovarian activity with a drospirenone-containing oral contraceptive in a 24/4 regimen. Contraception 2008;78:16-25.
15. Huskisson EE. Visual analogue scales. Pain measurement and assessement. New York: Raven Press; 1983. pp. 33-37.
16. Seracchioli R, Mabrouk M, Frascà C, Manuzzi L, Savelli L, Venturoli S. Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: A randomized controlled trial. Fertil Steril 2010;94:464-471.
17. Van Holsbeke C, Van Calster B, Guerriero S, Savelli L, Paladini D, Lissoni AA, Czekierdowski A, et al. Endometriomas: Their ultrasound characteristics. Ultrasound Obstet Gynecol 2010;35:730-740.
18. Exacoustos C, Zupi E, Carusotti C, Rinaldo D, Marconi D, Lanzi G, Arduini D. Staging of pelvic endometriosis: Role of sonographic appearance in determining extension of disease and modulating surgical approach. J Am Assoc Gynecol Laparosc 2003;10:378-382. (Pubitemid 37082503)
19. Savelli L. Transvaginal sonography for the assessment of ovarian and pelvic endometriosis: How deep is our understanding? Ultrasound Obstet Gynecol 2009;33:497-501.
20. Kamencic H, Thiel JA. Pentoxifylline after conservative surgery for endometriosis: A randomized, controlled trial. J Minim Invasive Gynecol 2008;15:62-66. (Pubitemid 351199832)
21. Harada T, Momoeda M, Taketani Y, Hoshiai H, Terakawa N. Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: A placebo-controlled, double-blind, randomized trial. Fertil Steril 2008;90:1583-1588.
22. Vercellini P, De Giorgi O, Mosconi P, Stellato G, Vicentini S, Crosignani PG. Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis. Fertil Steril 2002;77:52-61. (Pubitemid 34093893)
23. Vercellini P, Pietropaolo G, De Giorgi O, Pasin R, Chiodini A, Crosignani PG. Treatment of symptomatic rectovaginal endometriosis with an estrogen-progestogen combination versus low-dose norethindrone acetate. Fertil Steril 2005;84:1375-1387. (Pubitemid 41571884)
24. Rodgers AK, Falcone T. Treatment strategies for endometriosis. Expert Opin Pharmacother 2008;9:243-255. (Pubitemid 351233732)
25. Crosignani P, Olive D, Bergqvist A, Luciano A. Advances in the management of endometriosis: An update for clinicians. Hum Reprod Update 2006;12:179-189. (Pubitemid 43231450)
26. Fauconnier A, Chapron C. Endometriosis and pelvic pain: Epidemiological evidence of the relationship and implications. Hum Reprod Update 2005;11:595-606. (Pubitemid 41631309)
27. Meresman GF, Augé L, Barañao RI, Lombardi E, Tesone M, Sueldo C. Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis. Fertil Steril 2002;77:1141-1147. (Pubitemid 34626320)
28. Howard FM. Endometriosis and mechanisms of pelvic pain. J Minim Invasive Gynecol 2009;16:540-550.
29. Muzii L, Marana R, Caruana P, Catalano GF, Margutti F, Panici PB. Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: A prospective, randomized trial. Am J Obstet Gynecol 2000;183:588-592.