Intestinally targeted diacylglycerol acyltransferase 1 (DGAT1) inhibitors robustly suppress postprandial triglycerides

ACS Medicinal Chemistry Letters

Volumn 3, Issue 5, 2012, Pages 411-415

  Serrano Wu, Michael H ^a   Coppola, Gary M ^a   Gong, Yongjin ^a   Neubert, Alan D ^a   Chatelain, Ricardo ^a   Clairmont, Kevin B ^a   Commerford, Renee ^a   Cosker, Theresa ^a   Daniels, Thomas ^a   Hou, Ying ^a   Jain, Monish ^a   Juedes, Marlene ^a   Li, Lisha ^a   Mullarkey, Tara ^a   Rocheford, Erik ^a   Sung, Moo Je ^a   Tyler, Andrew ^a   Yang, Qing ^a   Yoon, Taeyoung ^a   Hubbard, Brian K ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL ACYLTRANSFERASE 1 INHIBITOR; GLYCOPROTEIN P; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERTRIGLYCERIDEMIA; INTESTINE CELL; MALE; NONHUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL;

CANIS FAMILIARIS; RATTUS;

EID: 84861026742     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml3000512     Document Type: Article

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