OxLDL downregulates the dendritic cell homing factors CCR7 and CCL21

Mediators of Inflammation

Volumn 2012, Issue , 2012, Pages

  Nickel, Thomas ^a   Pfeiler, Susanne ^a   Summo, Claudia ^a   Kopp, Reinhard ^a   Meimarakis, Georgios ^a   Sicic, Zeljka ^a   Lambert, Marius ^a   Lackermair, Korbinian ^a   David, Robert ^a   Beiras Fernandez, Andres ^b   Kaczmarek, Ingo ^a   Weis, Michael ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; OXIDIZED LOW DENSITY LIPOPROTEIN ANTIBODY; SECONDARY LYMPHOID TISSUE CHEMOKINE; CCL19 PROTEIN, HUMAN; CCL21 PROTEIN, HUMAN; CCR7 PROTEIN, HUMAN; LIGAND; LOW DENSITY LIPOPROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; OXIDIZED LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ARTICLE; CAROTID ATHEROSCLEROSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVASCULAR ENDOTHELIAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ATHEROSCLEROSIS; CAROTID ARTERY; CAROTID ARTERY OBSTRUCTION; CELL MOTION; CYTOLOGY; DISEASE COURSE; ENDOTHELIUM CELL; FLUORESCENCE MICROSCOPY; METABOLISM; METHODOLOGY; MICROCIRCULATION; MONOCYTE; PATHOLOGY;

ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID STENOSIS; CELL MOVEMENT; CHEMOKINE CCL19; CHEMOKINE CCL21; DENDRITIC CELLS; DISEASE PROGRESSION; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMANS; LIGANDS; LIPOPROTEINS, LDL; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; MONOCYTES; RECEPTORS, CCR7;

EID: 84861017467     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2012/320953     Document Type: Article

References (36)

1. Ross R., Atherosclerosis: an inflammatory disease New England Journal of Medicine 1999 340 2 115 126
2. Damas J. K., Smith C., Oie E., Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 3 614 620
3. Wick G., Perschinka H., Xu Q., Autoimmunity and atherosclerosis American Heart Journal 1999 138 5 444 449
4. Wick G., Romen M., Amberger A., Metzler B., Mayr M., Falkensammer G., Atherosclerosis, autoimmunity, and vascular-associated lymphoid tissue The FASEB Journal 1997 11 13 1199 1207 (Pubitemid 27481444)
5. Bobryshev Y. V., Dendritic cells in atherosclerosis: current status of the problem and clinical relevance European Heart Journal 2005 26 17 1700 1704 (Pubitemid 41219842)
6. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y. J., Immunobiology of dendritic cells Annual Review of Immunology 2000 18 767 811 (Pubitemid 30365397)
7. Erbel C., Sato K., Meyer F. B., Kopecky S. L., Frye R. L., Goronzy J. J., Functional profile of activated dendritic cells in unstable atherosclerotic plaque Basic Research in Cardiology 2007 102 2 123 132 (Pubitemid 46189953)
8. Breloer M., Kretschmer B., Luthje K., Ehrlich S., Ritter U., Bickert T., CD83 is a regulator of murine B cell function in vivo European Journal of Immunology 2007 37 3 634 648 (Pubitemid 46916931)
9. Nickel T., Schmauss D., Hanssen H., Sicic Z., Krebs B., Jankl S., OxLDL uptake by dendritic cells induces upregulation of scavenger-receptors, maturation and differentiation Atherosclerosis 2009 205 2 442 450
10. Van Brussel I., Van Vre E. A., De Meyer G. R., Vrints C. J., Bosmans J. M., Bult H., Decreased numbers of peripheral blood dendritic cells in patients with coronary artery disease are associated with diminished plasma Flt3 ligand levels and impaired plasmacytoid dendritic cell function Clinical Science 2011 120 415 426
11. Forster R., Davalos-Misslitz A. C., Rot A., CCR7 and its ligands: balancing immunity and tolerance Nature Reviews Immunology 2008 8 5 362 371 (Pubitemid 351595218)
12. Bromley S. K., Thomas S. Y., Luster A. D., Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics Nature Immunology 2005 6 9 895 901 (Pubitemid 43090444)
13. Bobryshev Y. V., Dendritic cells and their role in atherogenesis Laboratory Investigation 2010 90 970 984
14. Greaves D. R., Schall T. J., Chemokines and myeloid cell recruitment Microbes and Infection 2000 2 3 331 336 (Pubitemid 30167668)
15. Boger R. H., Bode-Boger S. M., Kienke S., Stan A. C., Nafe R., Frolich J. C., Dietary l-arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterol-fed rabbits Atherosclerosis 1998 136 1 67 77 (Pubitemid 28341443)
16. Nickel T., Hanssen H., Emslander I., Drexel V., Hertel G., Schmidt-Trucksass A., Immunomodulatory effects of aerobic training in obesity Mediators of Inflammation 2011 2011 10
17. Nickel T., Hanssen H., Sisic Z., Pfeiler S., Summo C., Schmauss D., Immunoregulatory effects of the flavonol quercetin in vitro and in vivo European Journal of Nutrition 2010 50 3 163 172
18. Boyum A., Isolation of human blood monocytes with nycodenz, a new non-ionic iodinated gradient medium Scandinavian Journal of Immunology 1983 17 5 429 436 (Pubitemid 13134342)
19. Romani N., Ratzinger G., Pfaller K., Salvenmoser W., Stossel H., Koch F., Migration of dendritic cells into lymphatics-the langerhans cell example: routes, regulation, and relevance International Review of Cytology 2001 207 237 270 (Pubitemid 32429925)
20. Nickel T., Deutschmann A., Hanssen H., Summo C., Wilbert-Lampen U., Modification of endothelial biology by acute and chronic stress hormones Microvascular Research 2009 78 3 364 369
21. Gunn M. D., Tangemann K., Tam C., Cyster J. G., Rosen S. D., Williams L. T., A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive t lymphocytes National Academy of Sciences of the United States of America 1998 95 1 258 263 (Pubitemid 28103941)
22. McColl S. R., Chemokines and dendritic cells: a crucial alliance Immunology and Cell Biology 2002 80 5 489 496
23. Surdacki A., Nowicki M., Sandmann J., Tsikas D., Boeger R. H., Bode-Boeger S. M., Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension Journal of Cardiovascular Pharmacology 1999 33 4 652 658 (Pubitemid 29164831)
24. Meisel S. R., Xu X. P., Edgington T. S., Dose-dependent modulation of tissue factor protein and procoagulant activity in human monocyte-derived macrophages by oxidized low density lipoprotein Journal of Atherosclerosis and Thrombosis 2011 18 7 596 603
25. Zaguri R., Verbovetski I., Atallah M., Danger effect of low-density lipoprotein (LDL) and oxidized LDL on human immature dendritic cells Clinical and Experimental Immunology 2007 149 3 543 552 (Pubitemid 47256159)
26. Weis M., Schlichting C. L., Engleman E. G., Cooke J. P., Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 11 1817 1823 (Pubitemid 35315767)
27. Yilmaz A., Lipfert B., Cicha I., Schubert K., Klein M., Raithel D., Accumulation of immune cells and high expression of chemokines/chemokine receptors in the upstream shoulder of atherosclerotic carotid plaques Experimental and Molecular Pathology 2007 82 3 245 255 (Pubitemid 46686659)
28. Yilmaz A., Lochno M., Traeg F., Cicha I., Reiss C., Stumpf C., Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques Atherosclerosis 2004 176 1 101 110 (Pubitemid 39078651)
29. Llodra J., Angeli V., Liu J., Trogan E., Fisher E. A., Randolph G. J., Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques National Academy of Sciences of the United States of America 2004 101 32 11779 11784 (Pubitemid 39095371)
30. Randolph G. J., Angeli V., Swartz M. A., Dendritic-cell trafficking to lymph nodes through lymphatic vessels Nature Reviews Immunology 2005 5 8 617 628 (Pubitemid 41113193)
31. Nishi K., Itabe H., Uno M., Kitazato K. T., Horiguchi H., Shinno K., Oxidized LDL in carotid plaques and plasma associates with plaque instability Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 10 1649 1654
32. Trogan E., Feig J. E., Dogan S., Rothblat G. H., Angeli V., Tacke F., Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in apoe-deficient mice National Academy of Sciences of the United States of America 2006 103 10 3781 3786 (Pubitemid 43376632)
33. Hansson G. K., Inflammation, atherosclerosis, and coronary artery disease The New England Journal of Medicine 2005 352 16 1685 1695
34. Yoshida R., Nagira M., Kitaura M., Imagawa N., Imai T., Yoshie O., Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7 Journal of Biological Chemistry 1998 273 12 7118 7122 (Pubitemid 28160383)
35. Bobryshev Y. V., Lord R. S., Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions Cardiovascular Research 1998 37 3 799 810 (Pubitemid 28231176)
36. Wick G., Knoflach M., Xu Q., Autoimmune and inflammatory mechanisms in atherosclerosis Annual Review of Immunology 2004 22 361 403 (Pubitemid 38680427)