Inhibition of VEGF expression and corneal neovascularization by shRNA targeting HIF-1α in a mouse model of closed eye contact lens wear

Molecular Vision

Volumn 18, Issue , 2012, Pages 864-873

  Chen, Peng ^a,b   Yin, Hongmei ^b   Wang, Ye ^b   Wang, Yao ^b   Xie, Lixin ^b  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b SHANDONG EYE INSTITUTE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SHORT HAIRPIN RNA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTACT LENS; CORNEA EPITHELIUM; CORNEA NEOVASCULARIZATION; EYE INJURY; HOMOGENATE; HYPOXIA; IMMUNOFLUORESCENCE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SLIT LAMP; WESTERN BLOTTING;

ANIMALS; ANOXIA; CONTACT LENSES; CORNEA; CORNEAL NEOVASCULARIZATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INJECTIONS, INTRAOCULAR; MALE; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TIME FACTORS; TISSUE EXTRACTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84860879539     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Nomura K, Nakao M, Matsubara K. Subjective symptom of eye dryness and lifestyle factors with corneal neovascularization in contact lens wearers. Eye Contact Lens 2004; 30:95-8. [PMID: 15260357]
2. Polse KA. Factors controlling oxygen tension under a hydrogel contact lens. J Am Optom Assoc 1981; 52:203-8. [PMID: 7229237]
3. Conners MS, Stoltz RA, Davis KL, Dunn MW, Abraham NG, Levere RD, Laniado-Schwartzman M. A closed eye contact lens model of corneal inflammation. Part 2: Inhibition of cytochrome P450 arachidonic acid metabolism alleviates inflammatory sequelae. Invest Ophthalmol Vis Sci 1995; 36:841-50. [PMID: 7706032]
4. Bruce AS, Brennan NA. Corneal pathophysiology with contact lens wear. Surv Ophthalmol 1990; 35:25-58. [PMID: 2204128]
5. Semenza GL. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 2000; 59:47-53. [PMID: 10605934]
6. Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92:5510-4. [PMID: 7539918]
7. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003; 9:677-84. [PMID: 12778166]
8. Ozaki H, Yu AY, Della N, Ozaki K, Luna JD, Yamada H, Hackett SF, Okamoto N, Zack DJ, Semenza GL, Campochiaro PA. Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 1999; 40:182-9. [PMID: 9888442]
9. Lebherz C, Maguire AM, Auricchio A, Tang W, Aleman TS, Wei Z, Grant R, Cideciyan AV, Jacobson SG, Wilson JM, Bennett J. Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor. Diabetes 2005; 54:1141-9. [PMID: 15793254]
10. Cui JZ, Kimura H, Spee C, Thumann G, Hinton DR, Ryan SJ. Natural history of choroidal neovascularization induced by vascular endothelial growth factor in the primate. Graefes Arch Clin Exp Ophthalmol 2000; 238:326-33. [PMID: 10853932]
11. Tolentino MJ, Brucker AJ, Fosnot J, Ying GS, Wu IH, Malik G, Wan S, Reich SJ. Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization. Retina 2004; 24:660. [PMID: 15473063]
12. Ishibashi T, Hata Y, Yoshikawa H, Nakagawa K, Sueishi K, Inomata H. Expression of vascular endothelial growth factor in experimental choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol 1997; 235:159-67. [PMID: 9085111]
13. Otani A, Takagi H, Oh H, Koyama S, Ogura Y, Matumura M, Honda Y. Vascular endothelial growth factor family and receptor expression in human choroidal neovascular membranes. Microvasc Res 2002; 64:162-9. [PMID: 12074642]
14. Barouch FC, Miller JW. Anti-vascular endothelial growth factor strategies for the treatment of choroidal neovascularization from age-related macular degeneration. Int Ophthalmol Clin 2004; 44:23-32. [PMID: 15211174]
15. Kim SY, Lim JA, Choi JS, Choi EC, Joo CK. Comparison of antibiotic effect and corneal epithelial toxicity of levofloxacin and moxifloxacin in vitro. Cornea 2007; 26:720-5. [PMID: 17592324]
16. Totan Y, Aydin E, Cekic O, Cihan Dagloglu M, Borazan M, Daglioglu K, Gultek A. Effect of caffeic acid phenethyl ester on corneal neovascularization in rats. Curr Eye Res 2001; 23:291-7. [PMID: 11852431]
17. Chen P, Yin H, Wang Y, Mi J, He W, Xie L. Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularization. Mol Vis 2010; 16:310-9. [PMID: 20208988]
18. Polse KA, Brand R, Mandell R, Vastine D, Demartini D, Flom R. Age differences in corneal hydration control. Invest Ophthalmol Vis Sci 1989; 30:392-9. [PMID: 2925313]
19. Liesegang TJ. Physiologic changes of the cornea with contact lens wear. CLAO J 2002; 28:12-27. [PMID: 11838985]
20. Efron N. Re-thinking extended contact lens wear. Ophthalmic Physiol Opt 1998; 18:241-2. [PMID: 9829110]
21. Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha→ hypoxia response element→ VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res 2000; 60:6248-52. [PMID: 11103778]
22. Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 2000; 95:189-97. [PMID: 10607702]
23. Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, Risau W. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 2000; 156:965-76. [PMID: 10702412]
24. Conners MS, Stoltz RA, Webb SC, Rosenberg J, Dunn MW, Abraham NG, Laniado-Schwartzman M. A closed eye contact lens model of corneal inflammation. Part 1: Increased synthesis of cytochrome P450 arachidonic acid metabolites. Invest Ophthalmol Vis Sci 1995; 36:828-40. [PMID: 7706031]
25. Moses MA. The regulation of neovascularization of matrix metalloproteinases and their inhibitors. Stem Cells 1997; 15:180-9. [PMID: 9170209]
26. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87:2095-147. [PMID: 8630372]
27. Dana MR, Zhu SN, Yamada J. Topical modulation of interleukin-1 activity in corneal neovascularization. Cornea 1998; 17:403-9. [PMID: 9676913]
28. Fukuda M, Mishima H, Otori T. Detection of interleukin-1 beta in the tear fluid of patients with corneal disease with or without conjunctival involvement. Jpn J Ophthalmol 1997; 41:63-6. [PMID: 9152805]
29. Saika S, Miyamoto T, Yamanaka O, Kato T, Ohnishi Y, Flanders KC, Ikeda K, Nakajima Y, Kao WW, Sato M, Muragaki Y, Ooshima A. Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factorkappaB, in treatment of corneal alkali burns in mice. Am J Pathol 2005; 166:1393-403. [PMID: 15855640]
30. Lu Y, Fukuda K, Liu Y, Kumagai N, Nishida T. Dexamethasone inhibition of IL-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture. Invest Ophthalmol Vis Sci 2004; 45:2998-3004. [PMID: 15326113]
31. Kim H, Koh G. Lipopolysaccharide activates matrix metalloproteinase-2 in endothelial cells through an NF-kappaB-dependent pathway. Biochem Biophys Res Commun 2000; 269:401-5. [PMID: 10708565]
32. Joyce D, Albanese C, Steer J, Fu M, Bouzahzah B, Pestell RG. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev 2001; 12:73-90. [PMID: 11312120]
33. Han S, Yoon K, Lee K, Kim K, Jang H, Lee NK, Hwang K, Young Lee S. TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NFkappa B through TNF receptor-associated factors. Biochem Biophys Res Commun 2003; 305:789-96. [PMID: 12767899]
34. Ramanathan M, Pinhal-Enfield G, Hao I, Leibovich SJ. Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell 2007; 18:14-23. [PMID: 17065555]
35. Minami T, Miura M, Aird WC, Kodama T. Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium. J Biol Chem 2006; 281:20503-20. [PMID: 16627481]
36. Ko HM, Jung HH, Seo KH, Kang YR, Kim HA, Park SJ, Lee HK, Im SY. Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity. FEBS Lett 2006; 580:3006-12. [PMID: 16684540]
37. Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH. Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 2006; 66:2778-84. [PMID: 16510599]
38. Yoshida S, Ono M, Shono T, Izumi H, Ishibashi T, Suzuki H, Kuwano M. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol 1997; 17:4015-23. [PMID: 9199336]
39. Witmer AN, Vrensen GF, Van Noorden CJ, Schlingemann RO. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res 2003; 22:1-29. [PMID: 12597922]