Prognostic factors and outcomes of patients with hepatocellular carcinoma in non-cirrhotic liver

Scandinavian Journal of Gastroenterology

Volumn 47, Issue 6, 2012, Pages 718-728

  Wörns, Marcus A ^a   Bosslet, Timon ^a   Victor, Anja ^a   Koch, Sandra ^a   Hoppe Lotichius, Maria ^a   Heise, Michael ^a   Hansen, Torsten ^a   Pitton, Michael B ^a   Niederle, Ina M ^a   Schuchmann, Marcus ^a   Weinmann, Arndt ^a   Düber, Christoph ^a   Galle, Peter R ^a   Otto, Gerd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

hepatocellular carcinoma; non cirrhotic liver; non surgical treatment approaches; overall survival; prognostic factors; resection

Indexed keywords

SORAFENIB;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHEMOEMBOLIZATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; LIVER; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; TREATMENT OUTCOME; TUMOR VOLUME; VIRUS HEPATITIS;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; FEMALE; FOLLOW-UP STUDIES; HEPATECTOMY; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84860871750     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2012.677952     Document Type: Article

References (42)

1. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-76.
2. Kew MC, Popper H. Relationship between hepatocellular carcinoma and cirrhosis. Semin Liver Dis 1984;4:136-46.
3. Trevisani F, Frigerio M, Santi V, Grignaschi A, Bernardi M. Hepatocellular carcinoma in non-cirrhotic liver: a reappraisal. Dig Liver Dis 2010;42:341-7.
4. Nagasue N, Ono T, Yamanoi A, Kohno H, El-Assal ON, Taniura H, et al. Prognostic factors and survival after hepatic resection for hepatocellular carcinoma without cirrhosis. Br J Surg 2001;88:515-22.
5. Chen MF, Tsai HP, Jeng LB, Lee WC, Yeh CN, Yu MC, et al. Prognostic factors after resection for hepatocellular carcinoma in noncirrhotic livers: univariate and multivariate analysis. World J Surg 2003;27:443-7.
6. Grazi GL, Cescon M, Ravaioli M, Ercolani G, Gardini A, Del Gaudio M, et al. Liver resection for hepatocellular carcinoma in cirrhotics and noncirrhotics. evaluation of clinicopathologic features and comparison of risk factors for long-term survival and tumour recurrence in a single centre.Aliment Pharmacol Ther 2003;17(Suppl 2):119-29.
7. Chang CH, Chau GY, Lui WY, Tsay SH, King KL, Wu CW. Long-term results of hepatic resection for hepatocellular carcinoma originating from the noncirrhotic liver. Arch Surg 2004;139:320-5.
8. Laurent C, Blanc JF,Nobili S, Sa Cunha A, le Bail B, Bioulac-Sage P, et al. Prognostic factors and long-term survival after hepatic resection for hepatocellular carcinoma originating from noncirrhotic liver. J Am Coll Surg 2005;201:656-62.
9. Lang H, Sotiropoulos GC, Domland M, Fruhauf NR, Paul A, Husing J, et al. Liver resection for hepatocellular carcinoma in non-cirrhotic liver without underlying viral hepatitis. Br J Surg 2005;92:198-202.
10. Dupont-Bierre E, Compagnon P, Raoul JL, Fayet G, de Lajarte-Thirouard AS, Boudjema K. Resection of hepatocellular carcinoma in noncirrhotic liver: analysis of risk factors for survival. J Am Coll Surg 2005;201:663-70.
11. Bege T, Le Treut YP, Hardwigsen J, Ananian P, Richa H, Campan P, et al. Prognostic factors after resection for hepatocellular carcinoma in nonfibrotic or moderately fibrotic liver. A 116-case European series. J Gastrointest Surg 2007;11:619-25.
12. Lang H, Sotiropoulos GC, Brokalaki EI, Schmitz KJ, Bertona C, Meyer G, et al. Survival and recurrence rates after resection for hepatocellular carcinoma in noncirrhotic livers. J Am Coll Surg 2007;205:27-36.
13. Lubrano J, Huet E, Tsilividis B, Francois A, Goria O, Riachi G, et al. Long-term outcome of liver resection for hepatocellular carcinoma in noncirrhotic nonfibrotic liver with no viral hepatitis or alcohol abuse. World J Surg 2008;32:104-9.
14. Xu L, Huang L, Li BK, Zhang YQ, Li JQ, Yuan YF. Clinicopathologic features and long-term outcomes of Chinese patients with hepatocellular carcinoma in non-cirrhotic liver. Dig Surg 2008;25:376-82.
15. Sotiropoulos GC, Bockhorn M, Sgourakis G, Brokalaki EI, Molmenti EP, Neuhauser M, et al. R0 liver resections for primary malignant liver tumors in the noncirrhotic liver: a diagnosis-related analysis. Dig Dis Sci 2009;54: 887-94.
16. Smoot RL, Nagorney DM, Chandan VS, Que FG, Schleck CD, Harmsen WS, et al. Resection of hepatocellular carcinoma in patients without cirrhosis. Br J Surg 2011;98: 697-703.
17. Trevisani F, D'Intino PE, Caraceni P, Pizzo M, Stefanini GF, Mazziotti A, et al. Etiologic factors and clinical presentation of hepatocellular carcinoma. Differences between cirrhotic and noncirrhotic Italian patients. Cancer 1995;75:2220-32.
18. Grando-Lemaire V, Guettier C, Chevret S, Beaugrand M, Trinchet JC. Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver. groupe d'Etude et de traitement du carcinome hepatocellulaire. J Hepatol 1999;31: 508-13.
19. Bralet MP, Regimbeau JM, Pineau P, Dubois S, Loas G, Degos F, et al. Hepatocellular carcinoma occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 French cases. Hepatology 2000;32:200-4.
20. Nzeako UC, Goodman ZD, Ishak KG. Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. a clinicohistopathologic study of 804 North American patients. Am J Clin Pathol 1996;105:65-75.
21. Smalley SR, Moertel CG, Hilton JF, Weiland LH, Weiand HS, et al. Hepatoma in the noncirrhotic liver. Cancer 1988;62:1414-24.
22. Edeline J, Raoul JL, Vauleon E, Guillygomac'h A, Boudjema K, Boucher E. Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver: a retrospective study. World J Gastroenterol 2009;15:713-16.
23. Verhoef C, de Man RA, Zondervan PE, Eijkemans MJ, Tilanus HW, Ijzermans JN. Good outcomes after resection of large hepatocellular carcinoma in the non-cirrhotic liver. Dig Surg 2004;21:380-6.
24. Gibson J, Sobin H. Histological typing of tumors of the liver, biliary tract and pancreas (International histological classification of tumors, No20). Geneva: World Health Organization; 1978.
25. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7:462-503.
26. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG. Liver including intrahepatic bile ducts American Joint Committee on Cancer Staging Manuel. 6th ed. Chicago: Springer; 2002.
27. Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. study of 850 patients. Cancer 1985;56:918-28.
28. Llovet JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999;19:329-38.
29. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology 1998;28: 751-5.
30. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994;19:1513-20.
31. Neuberger J, Forman D, Doll R, Williams R. Oral contraceptives and hepatocellular carcinoma. Br Med J (Clin Res Ed) 1986;292:1355-7.
32. Forman D, Vincent TJ, Doll R. Cancer of the liver and the use of oral contraceptives. Br Med J (Clin Res Ed) 1986;292: 1357-61.
33. Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6: 674-87.
34. Trichopoulos D, Day NE, Kaklamani E, Tzonou A, Munoz N, Zavitsanos X, et al. Hepatitis B virus, tobacco smoking and ethanol consumption in the etiology of hepatocellular carcinoma. Int J Cancer 1987;39:45-9.
35. Chen CJ, Liang KY, Chang AS, Chang YC, Lu SN, Liaw YF, et al. Effects of hepatitis B virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma. Hepatology 1991;13:398-406.
36. Okuda K, Nakashima T, Kojiro M, Kondo Y, Wada K. Hepatocellular carcinoma without cirrhosis in Japanese patients. Gastroenterology 1989;97:140-6.
37. Ko S, Kanehiro H, Hisanaga M, Nagao M, Ikeda N, Nakajima Y. Liver fibrosis increases the risk of intrahepatic recurrence after hepatectomy for hepatocellular carcinoma. Br J Surg 2002;89:57-62.
38. Paradis V, Zalinski S, Chelbi E, Guedj N, Degos F, Vilgrain V, et al. Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis. Hepatology 2009;49:851-9.
39. Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010;51:1972-8.
40. Caldwell SH, Crespo DM, Kang HS, Al-Osaimi AM. Obesity and hepatocellular carcinoma. Gastroenterology 2004; 127(5 Suppl 1):S97-103.
41. El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004;126:460-8.
42. Shimada M, Rikimaru T, Sugimachi K, Hamatsu T, Yamashita Y, Aishima S, et al. The importance of hepatic resection for hepatocellular carcinoma originating from nonfibrotic liver. J Am Coll Surg 2000;191:531-7.