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Volumn 88, Issue 2-3, 2012, Pages 199-209

Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease

Author keywords

Behaviour; Gene expression; Huntington's disease; Neurodegeneration; Transgenic mouse models

Indexed keywords

MESSENGER RNA;

EID: 84860842187     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2011.10.001     Document Type: Article
Times cited : (16)

References (51)
  • 1
    • 84860836982 scopus 로고    scopus 로고
    • Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse
    • [Epub ahead of print]
    • Bayram-Weston Z., Torres E.M., Jones L., Dunnett S.B., Brooks S.P. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse. Brain Res. Bull. 2011, [Epub ahead of print].
    • (2011) Brain Res. Bull.
    • Bayram-Weston, Z.1    Torres, E.M.2    Jones, L.3    Dunnett, S.B.4    Brooks, S.P.5
  • 2
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 1995, 57:289-300.
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 3
    • 56549119132 scopus 로고    scopus 로고
    • Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease
    • Benn C.L., Fox H., Bates G.P. Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease. Mol. Neurodegener. 2008, 3:17.
    • (2008) Mol. Neurodegener. , vol.3 , pp. 17
    • Benn, C.L.1    Fox, H.2    Bates, G.P.3
  • 5
    • 84860836124 scopus 로고    scopus 로고
    • Gene expression and behaviour in mouse models of Huntington's disease
    • in press, [Epub ahead of print].
    • K.R. Bowles, S.P. Brooks, S.B. Dunnett, L. Jones, Gene expression and behaviour in mouse models of Huntington's disease, Brain Res. Bull., in press, [Epub ahead of print].
    • Brain Res. Bull.
    • Bowles, K.R.1    Brooks, S.P.2    Dunnett, S.B.3    Jones, L.4
  • 6
    • 79959806933 scopus 로고    scopus 로고
    • Longitudinal analysis of the behavioural phenotype in Hdh((CAG)150) Huntington's disease knock-in mice
    • [Epub ahead of print]
    • Brooks S., Higgs G., Jones L., Dunnett S.B. Longitudinal analysis of the behavioural phenotype in Hdh((CAG)150) Huntington's disease knock-in mice. Brain Res. Bull. 2010, [Epub ahead of print].
    • (2010) Brain Res. Bull.
    • Brooks, S.1    Higgs, G.2    Jones, L.3    Dunnett, S.B.4
  • 7
    • 33646038884 scopus 로고    scopus 로고
    • Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease
    • Brooks S.P., Betteridge H., Trueman R.C., Jones L., Dunnett S.B. Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease. Brain Res. Bull. 2006, 69:452-457.
    • (2006) Brain Res. Bull. , vol.69 , pp. 452-457
    • Brooks, S.P.1    Betteridge, H.2    Trueman, R.C.3    Jones, L.4    Dunnett, S.B.5
  • 9
    • 79551655290 scopus 로고    scopus 로고
    • Huntington's disease: can mice lead the way to treatment?
    • Crook Z.R., Housman D. Huntington's disease: can mice lead the way to treatment?. Neuron 2011, 69:423-435.
    • (2011) Neuron , vol.69 , pp. 423-435
    • Crook, Z.R.1    Housman, D.2
  • 10
    • 79953087575 scopus 로고    scopus 로고
    • Differential gene expression profiling in the mouse brain during motor skill learning: focus on the striatum structure
    • D'Amours G., Bureau G., Boily M.J., Cyr M. Differential gene expression profiling in the mouse brain during motor skill learning: focus on the striatum structure. Behav. Brain Res. 2010, 221:108-117.
    • (2010) Behav. Brain Res. , vol.221 , pp. 108-117
    • D'Amours, G.1    Bureau, G.2    Boily, M.J.3    Cyr, M.4
  • 11
    • 79956023002 scopus 로고    scopus 로고
    • Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference
    • de Mezer M., Wojciechowska M., Napierala M., Sobczak K., Krzyzosiak W.J. Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference. Nucleic Acids Res. 2011, 39:3852-3863.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 3852-3863
    • de Mezer, M.1    Wojciechowska, M.2    Napierala, M.3    Sobczak, K.4    Krzyzosiak, W.J.5
  • 12
    • 2942587013 scopus 로고    scopus 로고
    • Mouse Huntington's disease homolog mRNA levels: variation and allele effects
    • Dixon K.T., Cearley J.A., Hunter J.M., Detloff P.J. Mouse Huntington's disease homolog mRNA levels: variation and allele effects. Gene Expr. 2004, 11:221-231.
    • (2004) Gene Expr. , vol.11 , pp. 221-231
    • Dixon, K.T.1    Cearley, J.A.2    Hunter, J.M.3    Detloff, P.J.4
  • 14
    • 77953429462 scopus 로고    scopus 로고
    • Brain function and chromatin plasticity
    • Dulac C. Brain function and chromatin plasticity. Nature 2010, 465:728-735.
    • (2010) Nature , vol.465 , pp. 728-735
    • Dulac, C.1
  • 18
    • 1342288026 scopus 로고    scopus 로고
    • Affy-analysis of Affymetrix GeneChip data at the probe level
    • Gautier L., Cope L., Bolstad B.M., Irizarry R.A. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004, 20:307-315.
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 19
    • 60549103857 scopus 로고    scopus 로고
    • The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease
    • Gil J.M., Rego A.C. The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease. Brain Res. Rev. 2009, 59:410-431.
    • (2009) Brain Res. Rev. , vol.59 , pp. 410-431
    • Gil, J.M.1    Rego, A.C.2
  • 20
    • 0037111980 scopus 로고    scopus 로고
    • Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure
    • Guan Z., Giustetto M., Lomvardas S., Kim J.H., Miniaci M.C., Schwartz J.H., Thanos D., Kandel E.R. Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Cell 2002, 111:483-493.
    • (2002) Cell , vol.111 , pp. 483-493
    • Guan, Z.1    Giustetto, M.2    Lomvardas, S.3    Kim, J.H.4    Miniaci, M.C.5    Schwartz, J.H.6    Thanos, D.7    Kandel, E.R.8
  • 21
    • 24044442568 scopus 로고    scopus 로고
    • Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing
    • Hickey M.A., Gallant K., Gross G.G., Levine M.S., Chesselet M.F. Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing. Neurobiol. Dis. 2005, 20:1-11.
    • (2005) Neurobiol. Dis. , vol.20 , pp. 1-11
    • Hickey, M.A.1    Gallant, K.2    Gross, G.G.3    Levine, M.S.4    Chesselet, M.F.5
  • 23
    • 41749121925 scopus 로고    scopus 로고
    • Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease
    • Hodges A., Hughes G., Brooks S., Elliston L., Holmans P., Dunnett S.B., Jones L. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes Brain Behav. 2008, 7:288-299.
    • (2008) Genes Brain Behav. , vol.7 , pp. 288-299
    • Hodges, A.1    Hughes, G.2    Brooks, S.3    Elliston, L.4    Holmans, P.5    Dunnett, S.B.6    Jones, L.7
  • 26
    • 43049168861 scopus 로고    scopus 로고
    • Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation
    • Kim M.O., Chawla P., Overland R.P., Xia E., Sadri-Vakili G., Cha J.H. Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation. J. Neurosci. 2008, 28:3947-3957.
    • (2008) J. Neurosci. , vol.28 , pp. 3947-3957
    • Kim, M.O.1    Chawla, P.2    Overland, R.P.3    Xia, E.4    Sadri-Vakili, G.5    Cha, J.H.6
  • 28
    • 33744466559 scopus 로고    scopus 로고
    • Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation
    • Levenson J.M., Sweatt J.D. Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation. Cell. Mol. Life Sci. 2006, 63:1009-1016.
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 1009-1016
    • Levenson, J.M.1    Sweatt, J.D.2
  • 29
    • 26844498655 scopus 로고    scopus 로고
    • The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies
    • Li J.Y., Popovic N., Brundin P. The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx 2005, 2:447-464.
    • (2005) NeuroRx , vol.2 , pp. 447-464
    • Li, J.Y.1    Popovic, N.2    Brundin, P.3
  • 31
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 33
    • 77958109197 scopus 로고    scopus 로고
    • Mechanisms of trinucleotide repeat instability during human development
    • McMurray C.T. Mechanisms of trinucleotide repeat instability during human development. Nat. Rev. Genet. 2010, 11:786-799.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 786-799
    • McMurray, C.T.1
  • 34
  • 35
    • 16244384501 scopus 로고    scopus 로고
    • A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease
    • Morton A.J., Hunt M.J., Hodges A.K., Lewis P.D., Redfern A.J., Dunnett S.B., Jones L. A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease. Eur. J. Neurosci. 2005, 21:855-870.
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 855-870
    • Morton, A.J.1    Hunt, M.J.2    Hodges, A.K.3    Lewis, P.D.4    Redfern, A.J.5    Dunnett, S.B.6    Jones, L.7
  • 36
    • 84873376098 scopus 로고    scopus 로고
    • Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model
    • Quinti L., Chopra V., Rotili D., Valente S., Amore A., Franci G., Meade S., Valenza M., Altucci L., Maxwell M.M., Cattaneo E., Hersch S., Mai A., Kazantsev A. Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model. PLoS Curr. 2010, 2.
    • (2010) PLoS Curr. , vol.2
    • Quinti, L.1    Chopra, V.2    Rotili, D.3    Valente, S.4    Amore, A.5    Franci, G.6    Meade, S.7    Valenza, M.8    Altucci, L.9    Maxwell, M.M.10    Cattaneo, E.11    Hersch, S.12    Mai, A.13    Kazantsev, A.14
  • 44
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983. The Huntington's Disease Collaborative Research Group.
    • (1993) Cell , vol.72 , pp. 971-983
  • 46
    • 33847053686 scopus 로고    scopus 로고
    • The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease
    • Trueman R.C., Brooks S.P., Jones L., Dunnett S.B. The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease. Eur. J. Neurosci. 2007, 25:551-558.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 551-558
    • Trueman, R.C.1    Brooks, S.P.2    Jones, L.3    Dunnett, S.B.4
  • 48
    • 0042666901 scopus 로고    scopus 로고
    • Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation
    • Wood N.I., Morton A.J. Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation. Brain Res. Bull. 2003, 61:375-383.
    • (2003) Brain Res. Bull. , vol.61 , pp. 375-383
    • Wood, N.I.1    Morton, A.J.2
  • 51
    • 12744279625 scopus 로고    scopus 로고
    • Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1
    • Zucker B., Luthi-Carter R., Kama J.A., Dunah A.W., Stern E.A., Fox J.H., Standaert D.G., Young A.B., Augood S.J. Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1. Hum. Mol. Genet. 2005, 14:179-189.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 179-189
    • Zucker, B.1    Luthi-Carter, R.2    Kama, J.A.3    Dunah, A.W.4    Stern, E.A.5    Fox, J.H.6    Standaert, D.G.7    Young, A.B.8    Augood, S.J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.