Micro magnetic gyromixer for speeding up reactions in droplets

Microfluidics and Nanofluidics

Volumn 12, Issue 5, 2012, Pages 787-794

  Zhang, Yi ^a   Wang, Tza Huei ^a,b  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Droplet; Gyromixer; Magnetic; MEMS; Microfluidics; Quantum dot

Indexed keywords

BIOCHEMICAL REACTIONS; BIOTIN-STREPTAVIDIN; DROPLET SURFACES; FLUORESCENCE RESONANT ENERGY TRANSFERS; GYROMIXER; GYROSCOPIC EFFECTS; HIGH FLEXIBILITY; INTERNAL FLUID; MAGNETIC; MINIATURIZED TOTAL ANALYSIS SYSTEM; SENSING SYSTEMS; SOFT LITHOGRAPHY;

ENERGY TRANSFER; MEMS; MICROFLUIDICS; MIXING; PROTEINS; SEMICONDUCTOR QUANTUM DOTS; SENSORS; TURNAROUND TIME;

DROPS;

EID: 84860841983     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-011-0922-2     Document Type: Article

References (40)

1. Bailey VJ, Easwaran H et al (2009) MS-qFRET: a quantum dot-based method for analysis of DNA methylation. Genome Res 19(8):1455-1461
2. Bailey VJ, Keeley BP et al (2010) Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection. Chembiochem 11(1):71-74
3. Baroud CN, Gallaire F et al (2010) Dynamics of microfluidic droplets. Lab Chip 10(16):2032-2045
4. Beer NR, Hindson BJ et al (2007) On-chip, real-time, single-copy polymerase chain reaction in picoliter droplets. Anal Chem 79(22):8471-8475 (Pubitemid 350171354)
5. Broder GR, Ranasinghe RT et al (2011) Kinetics and thermodynamics of biotinylated oligonucleotide probe binding to particle-immobilized avidin and implications for multiplexing applications. Anal Chem 83(6):2005-2011
6. Butikov E (2006) Precession and nutation of a gyroscope. Eur J Phys 27(5):1071-1081
7. Clausell-Tormos J, Lieber D (2008) Droplet-based microfluidic platforms for the encapsulation, screening of mammalian cells, multicellular organisms (vol 15, pg 427). Chem Biol 15(8):875
8. Edd JF, Di Carlo D et al (2008) Controlled encapsulation of single-cells into monodisperse picolitre drops. Lab Chip 8(8):1262-1264
9. Erickson D, Li DQ (2002) Influence of surface heterogeneity on electrokinetically driven microfluidic mixing. Langmuir 18(5):1883-1892 (Pubitemid 35384001)
10. Fair RB (2007) Digital microfluidics: is a true lab-on-a-chip possible? Microfluid Nanofluid 3(3):245-281
11. Fan SK, Hsieh TH et al (2009) General digital microfluidic platform manipulating dielectric and conductive droplets by dielectrophoresis and electrowetting. Lab Chip 9(9):1236-1242
12. Fowles G R (1986) Analytical mechanics. Holt, Rinehart and Winston, Inc., Philadelphia
13. Guttenberg Z, Muller H et al (2005) Planar chip device for PCR and hybridization with surface acoustic wave pump. Lab Chip 5(3):308-317 (Pubitemid 40460448)
14. Hessel V, Lowe H et al (2005) Micromixers-a review on passive and active mixing principles. Chem Eng Sci 60(8-9):2479-2501 (Pubitemid 40306800)
15. Ho CM (2001) Fluidics-the link between micro and nano sciences and technologies. In: Proceedings of the 14th IEEE international conference on micro electro mechanical systems, 2001
16. Jones SW, Young WR (1994) Shear dispersion and anomalous diffusion by chaotic advection. J Fluid Mech 280:149-172 (Pubitemid 290910)
17. Korczyk PM, Cybulski O et al (2011) Effects of unsteadiness of the rates of flow on the dynamics of formation of droplets in microfluidic systems. Lab Chip 11(1):173-175
18. Kumaresan P, Yang CJ et al (2008) High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets. Anal Chem 80(10):3529
19. Liang-Hsuan L, Kee Suk R et al (2002) A magnetic microstirrer and array for microfluidic mixing. J Microelectromech Syst 11(5): 462-469
20. Nguyen NT, Wu ZG (2005) Micromixers-a review. J Micromech Microeng 15(2):R1-R16
21. Niu XZ, Lee YK (2003) Efficient spatial-temporal chaotic mixing in microchannels. J Micromech Microeng 13(3):454-462
22. Ottino JM, Wiggins S (2004) Introduction: mixing in microfluidics. Philos Trans Royal Soc Lond Ser Math Phys Eng Sci 362(1818): 923-935 (Pubitemid 38652640)
23. Paik P, Pamula VK et al (2003) Rapid droplet mixers for digital microfluidic systems. Lab Chip 3(4):253-259 (Pubitemid 41646532)
24. Pipper J, Inoue M et al (2007) Catching bird flu in a droplet. Nat Med 13:1259-1263 (Pubitemid 47530628)
25. Pipper J, Zhang Y et al (2008) Clockwork PCR including sample preparation. Angewandte Chem Int Ed 47(21):3900-3904
26. Roy T, Sinha A, et al (2009) Magnetic microsphere-based mixers for microdroplets. Phy Fluids 21(2)
27. Ryu KS, Shaikh K et al (2004) Micro magnetic stir-bar mixer integrated with parylene microfluidic channels. Lab Chip 4(6):608-613 (Pubitemid 39657914)
28. Srisa-Art M, Dyson EC et al (2008) Monitoring of real-time streptavidin/biotin binding kinetics using droplet microfluidics. Anal Chem 80(18):7063-7067
29. Stone HA, Stroock AD et al (2004) Engineering flows in small devices: microfluidics toward a lab-on-a-chip. Annu Rev Fluid Mech 36:381-411 (Pubitemid 38381916)
30. Stroock AD, Dertinger SKW et al (2002) Chaotic mixer for microchannels. Science 295(5555):647-651 (Pubitemid 34111816)
31. Teh SY, Lin R et al (2008) Droplet microfluidics. Lab Chip 8(2):198-220 (Pubitemid 351191417)
32. Therriault D, White SR et al (2003) Chaotic mixing in threedimensional microvascular networks fabricated by direct-write assembly. Nat Mater 2(4):265-271
33. Tian Y, Zhang Y-L et al (2010) High performance magnetically controllable microturbines. Lab Chip 10(21):2902-2905
34. Wayment JR, Harris JM (2009) Biotin-avidin binding kinetics measured by single-molecule imaging. Anal Chem 81(1):336-342
35. Wheeler AR (2008) Chemistry-Putting electrowetting to work. Science 322(5901):539-540
36. Whitesides GM (2006) The origins and the future of microfluidics. Nature 442(7101):368-373 (Pubitemid 44264779)
37. Yamanishi Y, Yu-Ching L, et al (2007) Magnetically modified PDMS microtools for micro particle manipulation. In: Proceedings of IEEE/RSJ International Conference on Intelligent Robots and Systems, 2007
38. Zhang CY, Yeh HC et al (2005) Single-quantum-dot-based DNA nanosensor. Nat Mater 4(11):826-831
39. Zhang Y, Bailey V et al (2009) DNA methylation analysis on a droplet-in-oil PCR array. Lab Chip 9(8):1059-1064
40. Zhang Y, Park S et al (2011) A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification. Lab Chip 11(3):398-406