CD3+/Tregs Ratio in Donor Grafts Is Linked to Acute Graft-versus-Host Disease and Immunologic Recovery after Allogeneic Peripheral Blood Stem Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 18, Issue 6, 2012, Pages 887-893

  Pastore, Domenico ^a   Delia, Mario ^a   Mestice, Anna ^a   Carluccio, Paola ^a   Perrone, Tommasina ^a   Gaudio, Francesco ^a   Curci, Paola ^a   Rossi, Antonella Russo ^a   Ricco, Alessandra ^a   Specchia, Giorgina ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

AGVHD; Graft content; Immunereconstitution

Indexed keywords

BUSULFAN; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUCONAZOLE; LEVOFLOXACIN; METHOTREXATE; METHYLPREDNISOLONE; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOMEGALOVIRUS INFECTION; FEMALE; HUMAN; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; NONMYELOABLATIVE CONDITIONING; PNEUMOCYSTOSIS; REGULATORY T LYMPHOCYTE;

ACUTE DISEASE; ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANTIGENS, CD3; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; RISK FACTORS; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 84860838743     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.10.039     Document Type: Article

References (28)

1. Mielcarek M., Martin P.J., Leisenring W., et al. Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation. Blood 2003, 102:756-762.
2. Flowers M.E.D., Traina F., Storer B., et al. Serious graft-versus-host disease after hematopoietic cell transplantation following nonmyeloablative conditioning. Bone Marrow Transplant 2005, 35:277-282.
3. Couriel D.R., Saliba R.M., Giralt S., et al. Acute and chronic graft-versus-host disease after abative and nonmyeloablative condition for allogeneic hematopoietic transplantation. Biol Blood Marrow Transplant 2004, 10:178-185.
4. Horowitz M.M., Gale R.P., Sondel P.M., et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990, 75:555-562.
5. Carnevale-Schianca F., Leisenring W., Martin P.J., et al. Longitudinal assessment of morbidity and acute graft versus host disease after allogeneic hematopoietic cell transplantation: retrospective analysis of a multicenter phase III study. Biol Blood Marrow Transplant 2009, 15:749-756.
6. Snider D., Liang H. Early intestinal Th1 inflammation and mucosal T cell recruitment during acute graft-versus-host reaction. J Immunol 2001, 166:5991-5999.
7. Ferrara J.L., Levy R., Chao N.J. Pathophysiologic mechanisms of graft-versus-host-disease. Biol Blood Marrow Transplant 1999, 5:347-356.
8. Shlomchik W.D., Couzens M.S., Tang C.B., et al. Prevention of graft-versus-host disease by inactivation of host antigen-presenting cells. Science 1999, 285:412-415.
9. Martin P.J., Hansen C.D., Buckner C.D., et al. Effects on in vitro depletion of T cells in HLA-identical allogeneic marrow graft. Blood 1985, 66:664-672.
10. Mackall C.L., Gress R.E. Thymic aging and T-cell regeneration. Immunol Rev 1997, 160:91-102.
11. Sakaguchi S. Naturally arising CD41 regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004, 22:531-562.
12. Dulude G., Roy D.C., Perralut C. The effect of graft-versus-host disease on T cell production and homeostasis. J Exp Med 1999, 189:1329-1342.
13. Wall D.A., Hamberg S.D., Reynolds D.S., et al. Immunodeficiency in graft-versus-host disease: mechanism of immune suppression. J Immunol 1988, 140:2970-2976.
14. Nguyen V.H., Shashidhar S., Chang S.D., et al. The impact of regulatory T cells on T-cell immunity following hemtopoietic cell transplantation. Blood 2008, 11:945-953.
15. + T cells and Tregs after allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2011, 17:550-557.
16. + suppressor T cells. Immunol Rev 2001, 182:58-67.
17. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000, 30:1538-1543.
18. Glucksberg H., Storb R., Fefer A., et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow HLA-matched sibling donors. Transplantation 1974, 18:295-304.
19. Hanley J.A., McNeil B.J. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982, 143:29-36.
20. Wolf D., Wolf A.M., Fong D., et al. Regulatory T-cells in the graft and the risk of acute graft-versus-host disease after allogeneic stem cell transplantation. Transplantation 2007, 83:1107-1113.
21. + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003, 9:1144-1150.
22. Miura Y., Thoburn C.J., Bright E.C., et al. Association of Foxp3 regulatory gene expression with acute graft-versus-host disease. Blood 2004, 104:2187-2193.
23. Hess A.D. Modulation of graft-versus-host disease: role of regulatory T lymphocytes. Biol Blood Marrow Transplant 2006, 12:13-21.
24. + T cells is associated with an increate risk for graft-versus-host-disease after HLA-identical stem cell transplantation in humans. Blood 2004, 103:1140-1146.
25. Mineishi S., Schuening F.G. Graft-versus-host disease in mini-transplant. Leuk Lymphoma 2004, 45:1969-1980.
26. + regulatory T cells in vitro. Blood 2008, 111:3675-3683.
27. Hakki M., Riddell S.R., Storek J., et al. Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation. Blood 2003, 102:3060-3067.
28. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J Exp Med 2002, 196:247-253.