-
1
-
-
28444490353
-
Induction therapy for adults with acute lymphoblastic leukemia: Results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
-
DOI 10.1182/blood-2005-04-1623
-
Rowe JM, Buck G, Burnett AK, et al. Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ ECOG E2993. Blood. 2005;106:3760-7. (Pubitemid 41739010)
-
(2005)
Blood
, vol.106
, Issue.12
, pp. 3760-3767
-
-
Rowe, J.M.1
Buck, G.2
Burnett, A.K.3
Chopra, R.4
Wiernik, P.H.5
Richards, S.M.6
Lazarus, H.M.7
Franklin, I.M.8
Litzow, M.R.9
Ciobanu, N.10
Prentice, H.G.11
Durrant, J.12
Tallman, M.S.13
Goldstone, A.H.14
-
2
-
-
33846869976
-
Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study
-
DOI 10.1182/blood-2006-05-018192
-
Fielding AK, Richards SM, Chopra R, et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood. 2007;109:944-50. (Pubitemid 46220637)
-
(2007)
Blood
, vol.109
, Issue.3
, pp. 944-950
-
-
Fielding, A.K.1
Richards, S.M.2
Chopra, R.3
Lazarus, H.M.4
Litzow, M.R.5
Buck, G.6
Durrant, I.J.7
Luger, S.M.8
Marks, D.I.9
Franklin, I.M.10
McMillan, A.K.11
Tallman, M.S.12
Rowe, J.M.13
Goldstone, A.H.14
-
3
-
-
77950391359
-
Implications for the use of monoclonal antibodies in future adult ALL trials: Analysis of antigen expression in 505 B-Lineage (B-Lin) all patients (pts) on the MRC UKALLXII/ECOG2993 intergroup trial [abstract]
-
Paietta E, Li X, Richards S, et al. Implications for the use of monoclonal antibodies in future adult ALL trials: analysis of antigen expression in 505 B-Lineage (B-Lin) all patients (pts) on the MRC UKALLXII/ECOG2993 intergroup trial [abstract]. Proc ASH. 2008;112:1907. http://bloodjournal. hematologylibrary.org.
-
(2008)
Proc ASH
, vol.112
, pp. 1907
-
-
Paietta, E.1
Li, X.2
Richards, S.3
-
4
-
-
79957450612
-
Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: Analysis of 552 cases
-
Lists clinical characteristics ofCD19, CD20, CD22, and CD33 expression in ALL
-
Raponi S, De Propris MS, Intoppa S, et al. Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases. Leuk Lymphoma. 2011;52:1098-107. Lists clinical characteristics ofCD19, CD20, CD22, and CD33 expression in ALL.
-
(2011)
Leuk Lymphoma
, vol.52
, pp. 1098-107
-
-
Raponi, S.1
De Propris, M.S.2
Intoppa, S.3
-
5
-
-
67650594764
-
Prognostic significance of CD20 expression in adults with de novo precursor Blineage acute lymphoblastic leukemia
-
CD20 expression denotes a poor prognosis in precursor B-ALL
-
Thomas DA, O'Brien S, Jorgensen JL, et al. Prognostic significance of CD20 expression in adults with de novo precursor Blineage acute lymphoblastic leukemia. Blood. 2009;113:6330-7. CD20 expression denotes a poor prognosis in precursor B-ALL.
-
(2009)
Blood
, vol.113
, pp. 6330-7
-
-
Thomas, D.A.1
O'brien, S.2
Jorgensen, J.L.3
-
6
-
-
0030995678
-
Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A Pediatric Oncology Group study
-
Borowitz MJ, Shuster J, Carroll AJ, et al. Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A pediatric oncology group study. Blood. 1997;89:3960-6. (Pubitemid 27220939)
-
(1997)
Blood
, vol.89
, Issue.11
, pp. 3960-3966
-
-
Borowitz, M.J.1
Shuster, J.2
Carroll, A.J.3
Nash, M.4
Look, A.T.5
Camitta, B.6
Mahoney, D.7
Lauer, S.J.8
Pullen, D.J.9
-
7
-
-
61849173968
-
CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: Setting the stage for anti-CD20 directed immunotherapy
-
Dworzak MN, Schumich A, Printz D, et al. CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy. Blood. 2008;112:3982-8.
-
(2008)
Blood
, vol.112
, pp. 3982-8
-
-
Dworzak, M.N.1
Schumich, A.2
Printz, D.3
-
9
-
-
84870846936
-
Immunochemotherapy with rituximab improves molecular CR rate and outcome in CD20+ B-Lineage standard and high risk patients; Results of 263 CD20+ patients studied prospectively in GMALL study 07/ 2003. [abstract]
-
Hoelzer D, Huettmann A, Kaul F, et al. Immunochemotherapy with rituximab improves molecular CR rate and outcome in CD20+ B-Lineage standard and high risk patients; results of 263 CD20+ patients studied prospectively in GMALL study 07/2003. [abstract]. Proc ASH. 2010;116:170.http://bloodjournal. hematologylibrary.org.
-
Proc ASH
, vol.2010
, Issue.116
, pp. 170
-
-
Hoelzer, D.1
Huettmann, A.2
Kaul, F.3
-
10
-
-
31544467825
-
Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia
-
DOI 10.1182/blood-2005-07-2708
-
Brüggemann M, Raff T, Flohr T, et al. Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood. 2006;107:1116-23. (Pubitemid 43156313)
-
(2006)
Blood
, vol.107
, Issue.3
, pp. 1116-1123
-
-
Bruggemann, M.1
Raff, T.2
Flohr, T.3
Gokbuget, N.4
Nakao, M.5
Droese, J.6
Luschen, S.7
Pott, C.8
Ritgen, M.9
Scheuring, U.10
Horst, H.-A.11
Thiel, E.12
Hoelzer, D.13
Bartram, C.R.14
Kneba, M.15
-
11
-
-
5444234832
-
CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms
-
DOI 10.1038/ni1121
-
Poe JC, Fujimoto Y, Hasegawa M, et al. CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. Nat Immunol. 2004;5:1078-87. (Pubitemid 41057728)
-
(2004)
Nature Immunology
, vol.5
, Issue.10
, pp. 1078-1087
-
-
Poe, J.C.1
Fujimoto, Y.2
Hasegawa, M.3
Haas, K.M.4
Miller, A.S.5
Sanford, I.G.6
Bock, C.B.7
Fujimoto, M.8
Tedder, T.F.9
-
12
-
-
55849128896
-
Durable complete responses from therapy with combined epratuzumab and rituximab: Final results from an international multicenter, phase 2 study in recurrent, indolent, non-Hodgkin lymphoma
-
Leonard JP, Schuster SJ, Emmanouilides C, et al. Durable complete responses from therapy with combined epratuzumab and rituximab: final results from an international multicenter, phase 2 study in recurrent, indolent, non-Hodgkin lymphoma. Cancer. 2008;113:2714-23.
-
(2008)
Cancer
, vol.113
, pp. 2714-23
-
-
Leonard, J.P.1
Schuster, S.J.2
Emmanouilides, C.3
-
13
-
-
4143123338
-
Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lymphoma: Phase I/II clinical trial results
-
DOI 10.1158/1078-0432.CCR-04-0294
-
Leonard JP, Coleman M, Ketas JC, et al. Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lymphoma: phase I/II clinical trial results. Clin Cancer Res. 2004;10:5327-34. (Pubitemid 39100467)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.16
, pp. 5327-5334
-
-
Leonard, J.P.1
Coleman, M.2
Ketas, J.C.3
Chadburn, A.4
Furman, R.5
Schuster, M.W.6
Feldman, E.J.7
Ashe, M.8
Schuster, S.J.9
Wegener, W.A.10
Hansen, H.J.11
Ziccardi, H.12
Eschenberg, M.13
Gayko, U.14
Fields, S.Z.15
Cesano, A.16
Goldenberg, D.M.17
-
14
-
-
49249109608
-
Chemoimmunotherapy reinduction with epratuzumab in children with acute lymphoblastic leukemia in marrow relapse: A children's oncology group pilot study
-
Early study with epratuzumab in childhood ALL showing limited toxicity and early promise
-
Raetz EA, Cairo MS, Borowitz MJ, et al. Chemoimmunotherapy reinduction with epratuzumab in children with acute lymphoblastic leukemia in marrow relapse: a children's oncology group pilot study. J ClinOncol. 2008;26:3756-62. Early study with epratuzumab in childhood ALL showing limited toxicity and early promise.
-
(2008)
J ClinOncol
, vol.26
, pp. 3756-62
-
-
Raetz, E.A.1
Cairo, M.S.2
Borowitz, M.J.3
-
15
-
-
50549083190
-
Reinduction platform for children with first marrow relapse of acute lymphoblastic leukemia: A children's oncology group study[corrected]
-
Raetz EA, Borowitz MJ, Devidas M, et al. Reinduction platform for children with first marrow relapse of acute lymphoblastic leukemia: a children's oncology group study[corrected]. J Clin Oncol. 2008;26:3971-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3971-8
-
-
Raetz, E.A.1
Borowitz, M.J.2
Devidas, M.3
-
16
-
-
84859159818
-
Reinduction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL) in children, adolescents and young adults: Results from Children's Oncology Group (COG) study ADVL04P2 [abstract]
-
Raetz EA, Cairo MS, Borowitz MJ, et al. Reinduction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL) in children, adolescents and young adults: results from Children's Oncology Group (COG) study ADVL04P2 [abstract]. Proc ASH. 2011;118:573. http://bloodjournal. hematologylibrary.org.
-
(2011)
Proc ASH
, vol.118
, pp. 573
-
-
Raetz, E.A.1
Cairo, M.S.2
Borowitz, M.J.3
-
17
-
-
84860839099
-
The novel calicheamicinconjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells
-
In press
-
de Vries JF, Zwaan CM, De Bie M, et al. The novel calicheamicinconjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells. Leukemia. 2011; In press.
-
(2011)
Leukemia
-
-
De Vries, J.F.1
Zwaan, C.M.2
De Bie, M.3
-
18
-
-
35548931579
-
Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia
-
DOI 10.1038/sj.leu.2404866, PII 2404866
-
Dijoseph JF, Dougher MM, Armellino DC, Evans DY, Damle NK. Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia. Leukemia. 2007;21:2240-5. (Pubitemid 350011695)
-
(2007)
Leukemia
, vol.21
, Issue.11
, pp. 2240-2245
-
-
DiJoseph, J.F.1
Dougher, M.M.2
Armellino, D.C.3
Evans, D.Y.4
Damle, N.K.5
-
19
-
-
77951648118
-
Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non- Hodgkin's lymphoma: Results of a phase i study
-
IO use in relapsed and refractory NHL had limited toxicity with 68 % ORR in follicular lymphoma. 20. Jabbour E, O'Brien S, Thomas D, et al. Inotuzumab ozogamicin (IO; CMC544), a CD22 monoclonal antibody attached to calicheamycin,produces complete response (CR) plus complete marrow response (mCR) of greater than 50 % in refractory relapse (R-R) acute lymphocytic leukemia (ALL) [abstract]. Proc ASCO. 2011;29
-
Advani A, Coiffier B, Czuczman MS, et al. Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non- Hodgkin's lymphoma: results of a phase I study. J Clin Oncol. 2010;28:2085-93. IO use in relapsed and refractory NHL had limited toxicity with 68 % ORR in follicular lymphoma. 20. Jabbour E, O'Brien S, Thomas D, et al. Inotuzumab ozogamicin (IO; CMC544), a CD22 monoclonal antibody attached to calicheamycin,produces complete response (CR) plus complete marrow response (mCR) of greater than 50 % in refractory relapse (R-R) acute lymphocytic leukemia (ALL) [abstract]. Proc ASCO. 2011;29:6507. http://www.asco.org
-
(2010)
J Clin Oncol
, vol.28
, pp. 2085-93
-
-
Advani, A.1
Coiffier, B.2
Czuczman, M.S.3
-
20
-
-
33746836125
-
+ regulatory T cells
-
DOI 10.1016/j.clim.2006.05.006, PII S1521661606007431
-
Watanabe T, Masuyama J-I, Sohma Y, et al. CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells. Clin Immunol. 2006;120:247-59. (Pubitemid 44175899)
-
(2006)
Clinical Immunology
, vol.120
, Issue.3
, pp. 247-259
-
-
Watanabe, T.1
Masuyama, J.-i.2
Sohma, Y.3
Inazawa, H.4
Horie, K.5
Kojima, K.6
Uemura, Y.7
Aoki, Y.8
Kaga, S.9
Minota, S.10
Tanaka, T.11
Yamaguchi, Y.12
Kobayashi, T.13
Serizawa, I.14
-
21
-
-
33745190097
-
Activity of alemtuzumab in patients with CD52-positive acute leukemia
-
Tibes R, Keating MJ, Ferrajoli A, et al. Activity of alemtuzumab in patients with CD52-positive acute leukemia. Cancer. 2006;106:2645-51.
-
(2006)
Cancer
, vol.106
, pp. 2645-51
-
-
Tibes, R.1
Keating, M.J.2
Ferrajoli, A.3
-
22
-
-
69949120991
-
Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model
-
Hu Y, Turner MJ, Shields J, et al. Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model. Immunology. 2009;128:260-70.
-
(2009)
Immunology
, vol.128
, pp. 260-70
-
-
Hu, Y.1
Turner, M.J.2
Shields, J.3
-
23
-
-
71049160105
-
A phase II study of campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: A children's oncology group report
-
Angiolillo AL, Yu AL, Reaman G, et al. A phase II study of campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: a children's oncology group report. Pediatr Blood Canc. 2009;53:978-83.
-
(2009)
Pediatr Blood Canc
, vol.53
, pp. 978-83
-
-
Angiolillo, A.L.1
Yu, A.L.2
Reaman, G.3
-
24
-
-
79951816232
-
Alemtuzumab can be incorporated into front-line therapy of adult Acute Lymphoblastic Leukemia (ALL): Final phase i results of a Cancer and Leukemia Group B study (CALGB 10102) [abstract]
-
Stock W, Sanford B, Lozanski G, et al. Alemtuzumab can be incorporated into front-line therapy of adult Acute Lymphoblastic Leukemia (ALL): final phase I results of a Cancer and Leukemia Group B study (CALGB 10102) [abstract]. Proc ASH. 2009;114:838.
-
(2009)
Proc ASH
, vol.114
, pp. 838
-
-
Stock, W.1
Sanford, B.2
Lozanski, G.3
-
25
-
-
0029116251
-
CD19 antigen in leukemia and lymphoma diagnosis and immunotherapy
-
Scheuermann RH, Racila E. CD19 antigen in leukemia and lymphoma diagnosis and immunotherapy. Leuk Lymphoma. 1995;18:385-97.
-
(1995)
Leuk Lymphoma
, vol.18
, pp. 385-97
-
-
Scheuermann, R.H.1
Racila, E.2
-
26
-
-
79955662260
-
Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab
-
Nagorsen D, Baeuerle PA. Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab. Exp Cell Res. 2011;317:1255-60.
-
(2011)
Exp Cell Res
, vol.317
, pp. 1255-60
-
-
Nagorsen, D.1
Baeuerle, P.A.2
-
27
-
-
68449086890
-
Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab
-
Nagorsen D, Bargou R, Ruttinger D, et al. Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab. Leuk Lymphoma. 2009;50:886-91.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 886-91
-
-
Nagorsen, D.1
Bargou, R.2
Ruttinger, D.3
-
28
-
-
37349123501
-
Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class
-
DOI 10.1097/CJI.0b013e318156750c, PII 0000237120071100000002
-
Brischwein K, Parr L, Pflanz S, et al. Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class. J Immunother. 2007;30:798-807. (Pubitemid 350295358)
-
(2007)
Journal of Immunotherapy
, vol.30
, Issue.8
, pp. 798-807
-
-
Brischwein, K.1
Parr, L.2
Pflanz, S.3
Volkland, J.4
Lumsden, J.5
Klinger, M.6
Locher, M.7
Hammond, S.A.8
Kiener, P.9
Kufer, P.10
Schlereth, B.11
Baeuerle, P.A.12
-
29
-
-
49649120397
-
Tumor regression in cancer patients by very Low doses of a T cell-engaging antibody
-
Bargou R, Leo E, Zugmaier G, et al. Tumor regression in cancer patients by very Low doses of a T cell-engaging antibody. Science. 2008;321:974-7.
-
(2008)
Science
, vol.321
, pp. 974-7
-
-
Bargou, R.1
Leo, E.2
Zugmaier, G.3
-
30
-
-
79959312575
-
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapyrefractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
-
Blinatumomab is well tolerated and efficacious in MRD-positive B-ALL.
-
Topp M.S.,Kufer P.,Gökbuget N.,et al.,Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapyrefractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival,J Clin Oncol, 20111 29,2493-8
-
(2011)
J Clin Oncol
, vol.29
, pp. 2493-8
-
-
Topp, M.S.1
Kufer, P.2
Gökbuget, N.3
-
31
-
-
78651290248
-
Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia
-
Topp MS, Kufer P, Gökbuget N, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapyrefractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol. 2011;29:2493-8. Blinatumomab is well tolerated and efficacious in MRD-positive B-ALL. 32. Handgretinger R, Zugmaier G, Henze G, et al. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia. Leukemia. 2011;25:181-4.
-
(2011)
Leukemia
, vol.25
, pp. 181-4
-
-
Handgretinger, R.1
Zugmaier, G.2
Henze, G.3
-
32
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
First description of CAR therapy in CLL
-
Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. NEngl J Med. 2011;365:725-33. First description of CAR therapy in CLL.
-
(2011)
NEngl J Med
, vol.365
, pp. 725-33
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
Bagg, A.4
June, C.H.5
-
33
-
-
80051775476
-
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
-
Kalos M, Levine BL, Porter DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med. 2011;3:95ra73.
-
(2011)
Sci Transl Med
, vol.3
-
-
Kalos, M.1
Levine, B.L.2
Porter, D.L.3
|