Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin

Skin Pharmacology and Physiology

Volumn 25, Issue 4, 2012, Pages 192-199

  Schrader, A ^a   Siefken, W ^a   Kueper, T ^b   Breitenbach, U ^a   Gatermann, C ^a   Sperling, G ^a   Biernoth, T ^a   Scherner, C ^a   Stab F ^a   Wenck, H ^a   Wittern, K P ^a   Blatt, T ^a  

^a BEIERSDORF AG   (Germany)

^b InterMed Discovery GmbH   (Germany)

Author keywords

Aquaporin 3; Glyceryl glucoside; Transepidermal water loss measurement; Water transport

Indexed keywords

AQUAPORIN 3; GLYCEROL; GLYCEROL DERIVATIVE; GLYCERYL GLUCOSIDE; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLISTER; CELL LEVEL; CHEMICAL COMPOSITION; CLINICAL ARTICLE; CONTROLLED STUDY; DEHYDRATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG FORMULATION; DRUG MECHANISM; DRUG PENETRATION; DRY SKIN; EX VIVO STUDY; FEMALE; FLUID BALANCE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYDRATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KERATINOCYTE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; SKIN FUNCTION; SKIN WATER LOSS; TREATMENT OUTCOME; UPREGULATION; WATER TRANSPORT;

ADULT; AQUAPORIN 3; CELLS, CULTURED; DOUBLE-BLIND METHOD; FEMALE; GLUCOSIDES; HUMANS; KERATINOCYTES; MALE; MIDDLE AGED; RNA, MESSENGER; SKIN; WATER; YOUNG ADULT;

EID: 84860805840     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000338190     Document Type: Article

References (32)

1. Verdier-Sévrain S, Bonté F: Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol 2007; 6: 75-82.
2. Rojek A, Praetorius J, Frøkiaer J, Nielsen S, Fenton RA: A current view of the mammalian aquaglyceroporins. Annu Rev Physiol 2008; 70: 301-327. (Pubitemid 351738182)
3. Yang B, Verkman AS: Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope- tagged constructs in Xenopus oocytes. J Biol Chem 1997; 272: 16140-16146. (Pubitemid 27276428)
4. Boury-Jamot M, Daraspe J, Bonté F, Perrier E, Schnebert S, Dumas M, Verbavatz JM: Skin aquaporins: function in hydration, wound healing, and skin epidermis homeostasis. Handb Exp Pharmacol 2009; 190: 205-217.
5. Hara M, Ma T, Verkman AS: Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery. J Biol Chem 2002; 277: 46616-46621.
6. Verkman AS: Knock-out models reveal new aquaporin function. Handb Exp Pharmacol 2009; 190: 359-381.
7. Hara-Chikuma M, Verkman AS: Roles of aquaporin-3 in the epidermis. J Invest Dermatol 2008; 128: 2145-2151.
8. Sougrat R, Morand M, Gondran C, Barré P, Gobin R, Bonté F, Dumas M, Verbavatz JM: Functional expression of AQP3 in human skin epidermis and reconstructed epidermis. J Invest Dermatol 2002; 118: 678-685. (Pubitemid 34309989)
9. Boury-Jamot M, Sougrat R, Tailhardat M, Le Varlet B, Bonté F, Dumas M, Verbavatz JM: Expression and function of aquaporins in human skin: is aquaporin-3 just a glycerol transporter? Biochim Biophys Acta 2006; 1758: 1034-1042.
10. Cao C, Wan S, Jiang Q, Amaral A, Lu S, Hu G, Bi Z, Kouttab N, Chu W, Wan Y: All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes. J Cell Physiol 2008; 215: 506-516. (Pubitemid 351468963)
11. Sugiyama Y, Ota Y, Hara M, Inoue S: Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes. Biochim Biophys Acta 2001; 1522: 82-88. (Pubitemid 34028208)
12. Palleroni NJ, Doudoroff M, Stanier RY, Solánes RE, Mandel M: Taxonomy of the aerobic pseudomonads: the properties of the Pseudomonas stutzeri group. J Gen Microbiol 1970; 60: 215-231.
13. Marin K, Zuther E, Kerstan T, Kunert A, Hagemann M: The ggpS gene from Synechocystis sp. strain PCC 6803 encoding glucosylglycerol- phosphate synthase is involved in osmolyte synthesis. J Bacteriol 1998; 180: 4843-4849. (Pubitemid 28429371)
14. Pocard JA, Smith LT, Smith GM, Le Rudulier D: A prominent role for glucosylglycerol in the adaptation of Pseudomonas mendocina SKB70 to osmotic stress. J Bacteriol 1994; 176: 6877-6884. (Pubitemid 24349425)
15. Mikkat S, Hagemann M, Schoor A: Active transport of glucoglycerol is involved in salt adaptation of the cyanobacterium Synechocystis sp. strain PCC 6803. Microbiology 1996; 142: 1725-1732. (Pubitemid 26248430)
16. Kueper T, Grune T, Prahl S, Lenz H, Welge V, Biernoth T, Vogt Y, Muhr GM, Gaemlich A, Jung T, Boemke G, Elsässer HP, Wittern KP, Wenck H, Stäb F, Blatt T: Vimentin is the specific target in skin glycation: structural prerequisites, functional consequences, and role in skin aging. J Biol Chem 2007; 282: 23427- 23436.
17. Kiistala U, Mustakallio KK: In-vivo separation of epidermis by production of suction blisters. Lancet 1964;i:1444-1445.
18. Kiistala U: Suction blister device for separation of viable epidermis from dermis. J Invest Dermatol 1968; 50: 129-137.
19. Rogiers V; EEMCO group: EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol 2001; 14: 117-128.
20. Zheng X, Bollinger Bollag W: Aquaporin 3 colocates with phospholipase d2 in caveolinrich membrane microdomains and is downregulated upon keratinocyte differentiation. J Invest Dermatol 2003; 121: 1487-1495. (Pubitemid 38005503)
21. Dumas M, Gondran C, Barré P, Sougrat R, Verbavatz JM, Heusele C, Schnébert S, Bonté F: Effect of an Ajuga turkestanica extract on aquaporin 3 expression, water flux, differentiation and barrier parameters of the human epidermis. Eur J Dermatol 2002; 12: 25-26.
22. Brandner JM: Pores in the epidermis: aquaporins and tight junctions. Int J Cosmet Sci 2007; 29: 413-422.
23. Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, Miyachi Y: The expression of differentiation markers in aquaporin-3 deficient epidermis. Arch Dermatol Res 2009; 301: 245-252.
24. Papadopoulos MC, Saadoun S, Verkman AS: Aquaporins and cell migration. Pflugers Arch 2008; 456: 693-700. (Pubitemid 351692135)
25. Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS: Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci USA 2000; 97: 4386-4391. (Pubitemid 30226142)
26. Ma T, Hara M, Sougrat R, Verbavatz JM, Verkman AS: Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. J Biol Chem 2002; 277: 17147-17153. (Pubitemid 34967747)
27. Itoh K, Kawasaki S, Kawamoto S, Seishima M, Chiba H, Michibata H, Wakimoto K, Imai Y, Minesaki Y, Otsuji M, Okubo K: Identification of differentially expressed genes in psoriasis using expression profiling approaches. Exp Dermatol 2005; 14: 667-674. (Pubitemid 41150362)
28. Nejsum LN, Kwon TH, Marples D, Flyvbjerg A, Knepper MA, Frøkiaer J, Nielsen S: Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Am J Physiol Renal Physiol 2001; 280:F715-F726.
29. Dumas M, Sadick NS, Noblesse E, Juan M, Lachmann-Weber N, Boury-Jamot M, Sougrat R, Verbavatz JM, Schnebert S, Bonté F: Hydrating skin by stimulating biosynthesis of aquaporins. J Drugs Dermatol 2007; 6: 20-24.
30. Rawlings AV, Canestrari DA, Dobkowski B: Moisturizer technology versus clinical performance. Dermatol Ther 2004; 17(suppl 1): 49-56.
31. Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol 2008; 159: 23-34. (Pubitemid 351874509)
32. Hara M, Verkman AS: Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice. Proc Natl Acad Sci USA 2003; 100: 7360-7365. (Pubitemid 36706442)