Prognostic significance of elevated baseline troponin in patients with acute coronary syndromes and chronic kidney disease treated with different antithrombotic regimens: A substudy from the ACUITY trial

Circulation: Cardiovascular Interventions

Volumn 5, Issue 2, 2012, Pages 157-165

  Acharji, Subasit ^a   Baber, Usman ^b   Mehran, Roxana ^a,b   Fahy, Martin ^a   Kirtane, Ajay J ^a,d   Lansky, Alexandra J ^c   Stone, Gregg W ^a,d  

^a CARDIOVASCULAR RESEARCH FOUNDATION   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Acute coronary syndromes; Chronic kidney disease; Outcomes; Troponin

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; HIRULOG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; THIENOPYRIDINE DERIVATIVE; TROPONIN;

ACUTE CORONARY SYNDROME; AGED; ANGIOCARDIOGRAPHY; ARTICLE; CHRONIC KIDNEY DISEASE; CORONARY ARTERY RECANALIZATION; CREATININE CLEARANCE; DEATH; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROGNOSIS;

ACUTE CORONARY SYNDROME; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; FEMALE; FIBRINOLYTIC AGENTS; FOLLOW-UP STUDIES; HEPARIN; HIRUDINS; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MYOCARDIAL INFARCTION; PEPTIDE FRAGMENTS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROGNOSIS; RECOMBINANT PROTEINS; REFERENCE STANDARDS; SURVIVAL ANALYSIS; TROPONIN T;

EID: 84860800384     PISSN: 19417640     EISSN: 19417632     Source Type: Journal    
DOI: 10.1161/CIRCINTERVENTIONS.111.963876     Document Type: Article

References (37)

1. Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, Cannon CP, Fischer GA, Fung AY, Thompson C, Wybenga D, Braunwald E. Cardiac-specific troponin-I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med. 1996; 335:1342-1349. (Pubitemid 26360452)
2. Ohman EM, Armstrong PW, Christenson RH, Granger CB, Katus HA, Hamm CW, O'Hanesian MA, Wagner GS, Kleiman NS, Harrell FE Jr, Califf RM, Topol EJ. Cardiac troponin-T levels for risk stratification in acute myocardial ischemia. N Engl J Med. 1996;335:1333-1341. (Pubitemid 26360451)
3. Hamm CW, Heeschen C, Goldmann B, Vahanian A, Adgey J, Miguel CM, Rutsch W, Berger J, Kootstra J, Simoons ML. Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. N Engl J Med. 1999;340:1623-1629. (Pubitemid 29249431)
4. Newby LK, Ohman EM, Christenson RH, Moliterno DJ, Harrington RA, White HD, Armstrong PW, Van De Werf F, Pfisterer M, Hasselblad V, Califf RM, Topol EJ. Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: the paragon-B troponin T substudy. Circulation. 2001;103:2891-2896. (Pubitemid 32578124)
5. Bhayana V, Gougoulias T, Cohoe S, Henderson AR. Discordance between results for serum troponin T and troponin I in renal disease. Clin Chem. 1995;41:312-317.
6. Croitoru M, Taegtmeyer H. Spurious rises in troponin T in end-stage renal disease. Lancet. 1995;346:1558.
7. Mehran R, Nikolsky E, Lansky AJ, Kirtane AJ, Kim YH, Feit F, Manoukian S, Moses JW, Ebrahimi R, Ohman EM, White HD, Pocock SJ, Dangas GD, Stone GW. Impact of chronic kidney disease on early (30-day) and late (1-year) outcomes of patients with acute coronary syndromes treated with alternative antithrombotic treatment strategies: an ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) substudy. J Am Coll Cardiol Cardiovasc Interv. 2009;2: 748-757.
8. Stone GW, Bertrand M, Colombo A, Dangas G, Farkouh ME, Feit F, Lansky AJ, Lincoff AM, Mehran R, Moses JW, Ohman M, White HD. Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial: study design and rationale. Am Heart J. 2004;148: 764-775.
9. Stone GW, McLaurin BT, Cox DA, Bertrand ME, Lincoff AM, Moses JW, White HD, Pocock SJ, Ware JH, Feit F, Colombo A, Aylward PE, Cequier AR, Darius H, Desmet W, Ebrahimi R, Hamon M, Rasmussen LH, Rupprecht HJ, Hoekstra J, Mehran R, Ohman EM; ACUITY Investigators. Bivalirudin for patients with acute coronary syndromes. N Eng J Med. 2006;355:2203-2216. (Pubitemid 44791162)
10. Stone GW, Ware JH, Bertrand ME, Lincoff AM, Moses JW, Ohman EM, White HD, Feit F, Colombo A, McLaurin BT, Cox DA, Manoukian SV, Fahy M, Clayton TC, Mehran R, Pocock SJ; ACUITY Investigators. Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management: one-year results from the ACUITY trial. JAMA. 2007;298:2497-2506. (Pubitemid 350223536)
11. Califf RM, Phillips HR III, Hindman MC, Mark DB, Lee KL, Behar VS, Johnson RA, Pryor DB, Rosati RA, Wagner GS. Prognostic value of a coronary artery jeopardy score. J Am Coll Cardiol. 1985;5:1055-1063. (Pubitemid 15050990)
12. The TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial: phase findings. N Engl J Med. 1985;312:932-936.
13. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39 Suppl 1:S1-266.
14. World Health Organization. Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5-37.
15. Aviles RJ, Askari AT, Lindahl B, Wallentin L, Jia G, Ohman EM, Mahaffey KW, Newby LK, Califf RM, Simoons ML, Topol EJ, Berger P, Lauer MS. Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. N Engl J Med. 2002;346:2047-2052. (Pubitemid 34680596)
16. Van Lente F, McErlean ES, DeLuca SA, Peacock WF, Rao JS, Nissen SE. Ability of troponins to predict adverse outcomes in patients with renal insufficiency and suspected acute coronary syndromes: a case-matched study. J Am Coll Cardiol. 1999;33:471-478. (Pubitemid 29234210)
17. Musso P, Cox I, Vidano E, Zambon D, Panteghini M. Cardiac troponin elevations in chronic renal failure: prevalence and clinical significance. Clin Biochem. 1999;32:125-130. (Pubitemid 29131932)
18. Apple FS, Sharkey SW, Hoeft P, Skeate R, Voss E, Dahlmeier BA, Preese LM. Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: a 1-year outcomes analysis. Am J Kidney Dis. 1997;29: 399-403. (Pubitemid 27106562)
19. James SK, Armstrong P, Barnathan E, Califf R, Lindahl B, Siegbahn A, Simoons ML, Topol EJ, Venge P, Wallentin L. Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a GUSTO-IV substudy. J Am Coll Cardiol. 2003;41:916.
20. Melloni C, Alexander KP, Milford-Beland S, Newby LK, Szczech LA, Pollack CV, Kirk JD, Christenson RH, Harrington RA, Gibler WB, Ohman EM, Peterson ED, Roe MT. Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease. Clin Cardiol. 2008;31:125-129. (Pubitemid 351442472)
21. Lindahl B, Diderholm E, Lagerqvist B, Venge P, Wallentin L; FRISC II(Fast Revascularization during InStability in CAD) Investigators. Mechanisms behind the prognostic value of troponin T in unstable coronary artery disease: a FRISC II substudy. J Am Coll Cardiol. 2001;38: 979-986. (Pubitemid 32912698)
22. Hyde TA, French JK, Wong C-K, Straznicky IT, Whitlock RM, White HD. Four-year survival of patients with acute coronary syndromes without ST-segment elevation and prognostic significance of 0.5 mm ST-segment depression. Am J Cardiol. 1999;84:379-385. (Pubitemid 29398654)
23. Cannon CP, McCabe CH, Stone PH, Rogers WJ, Schactman M, Thompson BW, Pearce DJ, Diver DJ, Kells C, Feldman T, Williams M, Gibson RS, Kronenberg MW, Ganz LI, Anderson HV, Braunwald E. The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q-wave myocardial infarction: results of the TIMI III registry ECG ancillary study. J Am Coll Cardiol. 1997;30:133-140. (Pubitemid 27357138)
24. Diderholm E, Andren B, Frostfeldt G, Genberg M, Jernberg T, Lagerqvist B, Lindahl B, Wallentin LII. For the Fast Revascularization during Instability in Coronary artery disease (FRISC II) Investigators. ST depression in ECG at entry indicates severe coronary lesions and large benefits of an early invasive treatment strategy in unstable coronary artery disease. Eur Heart J. 2002;23:41-49. (Pubitemid 35215118)
25. Kaul P, Fu Y, Chang W-C, Harrington RA, Wagner GS, Goodman SG, Granger CB, Moliterno DJ, Van De Werf F, Califf RM, Topol EJ, Armstrong PW; PARAGON-A and GUSTO IIb Investigators. Prognostic value of ST-segment depression in acute coronary syndromes: insights from PARAGON-A applied to GUSTO-IIb. J Am Coll Cardiol. 2001;38: 64-71. (Pubitemid 32613829)
26. Kaul P, Newby LK, Fu Y, Hasselblad V, Mahaffey KW, Christenson RH, Harrington RA, Ohman EM, Topol EJ, Califf RM, Van De Werf F, Armstrong PW; PARAGON-B Investigators. Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients. J Am Coll Cardiol. 2003;41:371-380. (Pubitemid 36164489)
27. Freda BJ, Tang WH, Van Lente F, Peacock WF, Francis GS. Cardiac troponins in renal insufficiency: review and clinical implications. J Am Coll Cardiol. 2002;40:2065-2071. (Pubitemid 36005889)
28. Barbash GI, Reiner J, White HD, Wilcox RG, Armstrong PW, Sadowski Z, Morris D, Aylward P, Woodlief LH, Topol EJ. Evaluation of paradoxic beneficial effects of smoking in patients receiving thrombolytic therapy for acute myocardial infarction: mechanism of the "smoker's paradox" from the GUSTO-I trial, with angiographic insights. Global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries. J Am Coll Cardiol. 1995;26:1222-1229.
29. Okamatsu K, Takano M, Sakai S, Ishibashi F, Uemura R, Takano T, Mizuno K. Elevated troponin T levels and lesion characteristics in non- ST-elevation acute coronary syndromes. Circulation. 2004;109:465-470. (Pubitemid 38168507)
30. Heeschen C, van Den Brand MJ, Hamm CW, Simoons ML. Angiographic findings in patients with refractory unstable angina according to troponin T status. Circulation. 1999;104:1509-1514. (Pubitemid 29461462)
31. Jurlander B, Farhi ER, Banas JJ Jr, Keany CM, Balu D, Grande P, Ellis AK. Coronary angiographic findings and troponin T in patients with unstable angina pectoris. Am J Cardiol. 2000;85:810-814. (Pubitemid 30157844)
32. Lansky AJ, Goto K, Cristea E, Fahy M, Parise H, Feit F, Ohman EM, White HD, Alexander KP, Bertrand ME, Desmet W, Hamon M, Mehran R, Moses J, Leon M, Stone GW. Clinical and angiographic predictors of short- and long-term ischemic events in acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial. Circ Cardiovasc Interv. 2010;3:308-316.
33. Charytan DM, Wallentin L, Lagerqvist B, Spacek R, De Winter RJ, Stern NM, Braunwald E, Cannon CP, Choudhry NK. Early angiography in patients with chronic kidney disease: a collaborative systematic review. Clin J Am Soc Nephrol. 2009;4:1032-1043.
34. Kimmelstiel C, Zhang P, Kapur NK, Weintraub A, Krishnamurthy B, Castaneda V, Covic L, Kuliopulos A. Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention. Circ Cardiovasc Interv. 2011;4:171-179.
35. Alexander KP, Chen AY, Roe MT, Newby LK, Gibson CM, Allen- LaPointe NM, Pollack C, Gibler WB, Ohman EM, Peterson ED. Excess dosing of antiplatelet and antithrombin agents in the treatment of non- ST-segment elevation acute coronary syndromes. JAMA. 2005;294: 3108-3116. (Pubitemid 43016802)
36. Melloni C, Alexander KP, Chen AY, Newby LK, Roe MT, Allen LaPointe NM, Pollack CV Jr, Gibler WB, Ohman EM, Peterson ED. Unfractionated heparin dosing and risk of major bleeding in non-STsegment elevation acute coronary syndromes. Am Heart J. 2008;156: 209-215.
37. Abbas NA, John RI, Webb MC, Kempson ME, Potter AN, Price CP, Vickery S, Lamb EJ. Cardiac troponins and renal function in nondialysis patients with chronic kidney disease. Clin Chem. 2005;51:2059-2066. (Pubitemid 41532621)