Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-kB pathway in human lung epithelial cells

Canadian Journal of Physiology and Pharmacology

Volumn 90, Issue 5, 2012, Pages 647-653

  Shao, Zhen Jun ^a,b   Zheng, Xiao Wei ^c   Feng, Ting ^a   Huan, Juan ^a   Chen, Jian ^c   Wu, Yi Ying ^c   Zhou, Li Ming ^c   Tu, Wen Wei ^a   Li, Hong ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b SICHUAN UNIVERSITY   (China)

^c ZHEJIANG CANCER HOSPITAL   (China)

Author keywords

defensin; Andrographolide; Antimicrobial; Defensin; HBD 2; Mapks; NF kB; P38 MAPK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANDROGRAPHOLIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA DEFENSIN 2; I KAPPA B; I KAPPA B KINASE INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; CELLS, CULTURED; DITERPENES; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; HUMANS; LUNG; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84860799843     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y2012-050     Document Type: Article

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