Differential efficacy of DOTAP enantiomers for siRNA delivery in vitro

International Journal of Pharmaceutics

Volumn 430, Issue 1-2, 2012, Pages 328-334

  Terp, Megan Cavanaugh ^a,b   Bauer, Finn ^c   Sugimoto, Yasuro ^b   Yu, Bo ^a,b   Brueggemeier, Robert W ^b   Lee, L James ^a,b   Lee, Robert J ^b,d  

^a The Ohio State University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c MERCK KGAA   (Germany)

^d College of Pharmacy ^*  (United States)

Author keywords

Aromatase; DOTAP; Enantiomer; Lipoplex; Modeling; siRNA

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; AROMATASE; CHOLESTEROL; CLATHRIN; LIPOPLEX; SMALL INTERFERING RNA;

ARTICLE; CAVEOLA; CELL STRAIN MCF 7; CELL VIABILITY; CHEMICAL STRUCTURE; CHIRALITY; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DOWN REGULATION; DRUG FORMULATION; ENANTIOMER; ENZYME ACTIVITY; IN VITRO STUDY; LIPID RAFT; LIPOSOMAL GENE DELIVERY SYSTEM; MEMBRANE MODEL; PINOCYTOSIS; PRIORITY JOURNAL; RACEMIC MIXTURE; SIMULATION; STEREOCHEMISTRY; TRANSMISSION ELECTRON MICROSCOPY;

AROMATASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHOLESTEROL; COMPUTER SIMULATION; CRYOELECTRON MICROSCOPY; DOWN-REGULATION; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HUMANS; ISOMERISM; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUATERNARY AMMONIUM COMPOUNDS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84860771690     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.017     Document Type: Article

References (22)

1. J. Adler, and I. Parmryd Quantifying colocalization by correlation: the Pearson correlation coefficient is superior to the Mander's overlap coefficient Cytometry A 77 2010 733 742
2. S. Batzri, and E.D. Korn Single bilayer liposomes prepared without sonication Biochim. Biophys. Acta 298 1973 1015 1019
3. J.R. Bellare, H.T. Davis, L.E. Scriven, and Y. Talmon Controlled environment vitrification system: an improved sample preparation technique J. Electron Microsc. Tech. 10 1988 87 111
4. R.W. Brueggemeier, L. Pui-Kai, C.E. Snider, M.V. Darby, and N.E. Katlic 7α alpha-substituted androstenediones as effective in vitro and in vivo inhibitors of aromatase Steroids 50 1987 163 178
5. D. Danino, A. Bernheim-Groswasser, and Y. Talmon Digital cryogenic transmission electron microscopy: an advanced tool for direct imaging of complex fluids Colloid Surf. A 183 2001 113 122 (Pubitemid 32396881)
6. B.J. Deroo, and K.S. Korach Estrogen receptors and human disease J. Clin. Invest. 3 2006 561 570 (Pubitemid 43326860)
7. L. Desigaux, M. Sainlos, O. Lambert, R. Chevre, E. Letrou-Bonneval, J.P. Vigneron, P. Lehn, J.M. Lehn, and B. Pitar Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference Proc. Natl. Acad. Sci. U.S.A. 42 2007 16534 16539 (Pubitemid 350211053)
8. P.L. Felgner, T.R. Gadek, M. Holm, R. Roman, H.W. Chan, M. Wenz, J.P. Northrop, G.M. Ringold, and M. Danielson Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure Proc. Natl. Acad. Sci. U.S.A. 84 1987 7413 7417
9. C.R. Hopkins, and I.S. Trowbridge Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells J. Cell Biol. 97 1983 508 521 (Pubitemid 13041016)
10. W. Janni, and P. Hepp Adjuvant aromatase inhibitor therapy: outcomes and safety Cancer Treat. Rev. 36 2010 249 261
11. C. Lonez, M.F. Lensink, E. Kleiren, J.M. Vanderwinden, J.M. Ruysschaert, and M. Vandenbranden Fusogenic activity of cationic lipids and lipid shape distribution Cell. Mol. Life Sci. 67 2010 483 494
12. J.L. Lu, R. Langer, and J. Chen A novel mechanism is involved in cationic lipid-mediated functional siRNA delivery Mol. Pharm. 6 2009 763 771
13. B.J. Nichols, A.K. Kenworthy, R.S. Polishchuk, R. Lodge, T.H. Roberts, K. Hirschberg, R.D. Phair, and J. Lipincott-Schwartz Rapid cycling of lipid raft markers between the cell surface and Golgi complex J. Cell Biol. 153 2001 529 541 (Pubitemid 34280140)
14. J.M. Oliver, R.D. Berlin, and B.H. Davis Use of horseradish peroxidase and fluorescent dextrans to study fluid pinocytosis in leukocytes Methods Enzymol. 108 1984 336 347 (Pubitemid 15215639)
15. P.A. Orlandi, and P.H. Fishman Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains J. Cell Biol. 141 1998 905 915 (Pubitemid 28243959)
16. Platscher, M.; Hedinger, A. (inventors), 2008, January 17. Stable crystal modifications of DOTAP chloride. U.S. Patent Application Publication 2008/0014254.
17. D. Simberg, S. Weisman, Y. Talmon, and Y. Barenholz DOTAP (and other cationic lipids): chemistry, biophysics, and transfection Crit. Rev. Ther. Drug 4 2004 257 317 (Pubitemid 41647579)
18. B. Sommer, T. Dingersen, C. Gamroth, S.E. Schneider, S. Rubert, J. Krüger, and K.J. Dietz CELLmicrocosmos 2.2 MembraneEditor: a modular interactive shape-based software approach to solve heterogeneous membrane packing problems J. Chem. Inf. Model. 51 2011 1165 1182
19. L. Stamatatos, R. Leventis, M.J. Zuckermann, and J.R. Silvius Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes Biochemistry 27 1988 3917 3925
20. E.A. Vasievich, W. Chen, and L. Huang Enantiospecific adjuvant activity of cationic lipid DOTAP in cancer vaccine Cancer Immunol. Immunother. 5 2011 629 638
21. L. Wang, H.L. McLeod, and R.M. Weinshilboum Genomics and drug response N. Engl. J. Med. 364 2011 1144 1153
22. Y. Zheng, B. Yu, W. Weecharangsan, L. Piao, M. Darby, Y. Mao, R. Koynova, X. Yang, H. Li, S. Xu, L.J. Lee, Y. Sugimoto, R.W. Brueggemeier, and R.J. Lee Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7αAPTADD to breast cancer cells Int. J. Pharm. 390 2010 234 241