Differential efficacy of DOTAP enantiomers for siRNA delivery in vitro

International Journal of Pharmaceutics

Volumn 430, Issue 1-2, 2012, Pages 328-334

  Terp, Megan Cavanaugh ^a   Bauer, Finn ^c   Sugimoto, Yasuro ^b   Yu, Bo ^a   Brueggemeier, Robert W ^b   Lee, L James ^a   Lee, Robert J ^a,b,d  

^a The Ohio State University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c MERCK KGAA   (Germany)

^d College of Pharmacy ^*  (United States)

Author keywords

Aromatase; DOTAP; Enantiomer; Lipoplex; Modeling; siRNA

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; AROMATASE; CHOLESTEROL; CLATHRIN; LIPOPLEX; SMALL INTERFERING RNA;

ARTICLE; CAVEOLA; CELL STRAIN MCF 7; CELL VIABILITY; CHEMICAL STRUCTURE; CHIRALITY; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DOWN REGULATION; DRUG FORMULATION; ENANTIOMER; ENZYME ACTIVITY; IN VITRO STUDY; LIPID RAFT; LIPOSOMAL GENE DELIVERY SYSTEM; MEMBRANE MODEL; PINOCYTOSIS; PRIORITY JOURNAL; RACEMIC MIXTURE; SIMULATION; STEREOCHEMISTRY; TRANSMISSION ELECTRON MICROSCOPY;

AROMATASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHOLESTEROL; COMPUTER SIMULATION; CRYOELECTRON MICROSCOPY; DOWN-REGULATION; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HUMANS; ISOMERISM; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUATERNARY AMMONIUM COMPOUNDS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84860771690     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.017     Document Type: Article

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