Scaffold-based transplantation of vascular endothelial growth factor-overexpressing stem cells leads to neovascularization in ischemic myocardium but did not show a functional regenerative effect

ASAIO Journal

Volumn 58, Issue 3, 2012, Pages 268-274

  Von Wattenwyl, Robert ^a   Blumenthal, Britta ^a   Heilmann, Claudia ^a   Golsong, Peter ^a   Poppe, Annika ^a   Beyersdorf, Friedhelm ^a   Siepe, Matthias ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; CARDIAC FUNCTIONS; CELL TRANSFER; DIASTOLIC FUNCTION; GROWTH FACTOR; IN-VITRO; IN-VIVO; MYOBLASTS; MYOCARDIAL INFARCTION; MYOCARDIAL RECOVERY; NEOVASCULARIZATION; OVER-EXPRESSION; PARACRINE; REGENERATIVE EFFECTS; SHAM OPERATIONS; SKELETAL MYOBLASTS; STUDY GROUPS; VASCULAR ENDOTHELIAL GROWTH; VASCULAR ENDOTHELIAL GROWTH FACTOR;

RATS; STEM CELLS;

SCAFFOLDS (BIOLOGY);

VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL; ARTICLE; FEMALE; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HEART MUSCLE ISCHEMIA; LEWIS RAT; MALE; METABOLISM; MYOBLAST; NEWBORN; PATHOPHYSIOLOGY; RAT; REGENERATION; TRANSPLANTATION;

ANIMALS; ANIMALS, NEWBORN; FEMALE; GENE THERAPY; MALE; MYOBLASTS, SKELETAL; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, INBRED LEW; REGENERATION; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84860771412     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAT.0b013e3182523237     Document Type: Article

References (14)

1. Lekas M, Lekas P, Latter DA, Kutryk MB, Stewart DJ: Growth factor- induced therapeutic neovascularization for ischaemic vascular disease: Time for a re-evaluation? Curr Opin Cardiol 21: 376-384, 2006.
2. Ye L, Haider HKh, Tan R, et al: Transplantation of nanoparticle transfected skeletal myoblasts overexpressing vascular endothelial growth factor-165 for cardiac repair. Circulation 116(11 Suppl): I113-I120, 2007.
3. Leobon B, Garcin I, Menasche P, Vilquin JT, Audinat E, Charpak S: Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc Natl Acad Sci USA 100: 7808-7811, 2003.
4. Pouzet B, Vilquin JT, Hagege AA, et al: Intramyocardial transplantation of autologous myoblasts: Can tissue processing be optimized? Circulation 102(19 Suppl 3): III210-III215, 2000.
5. Gisselfalt K, Edberg B, Flodin P: Synthesis and properties of degradable poly(urethane urea)s to be used for ligament reconstructions. Biomacromolecules 3: 951-958, 2002.
6. Siepe M, Giraud MN, Pavlovic M, et al: Myoblast-seeded biodegradable scaffolds to prevent post-myocardial infarction evolution toward heart failure. J Thorac Cardiovasc Surg 132: 124-131, 2006.
7. Siepe M, Giraud MN, Liljensten E, et al: Construction of skeletal myoblast-based polyurethane scaffolds for myocardial repair. Artif Organs 31: 425-433, 2007.
8. Blumenthal B, Golsong P, Poppe A, et al: Polyurethane scaffolds seeded with genetically engineered skeletal myoblasts: A promising tool to regenerate myocardial function. Artif Organs 34: E46-E54, 2010.
9. Henry TD, Annex BH, McKendall GR, et al: VIVA Investigators: The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis. Circulation 107: 1359-1365, 2003.
10. Simons M, Annex BH, Laham RJ, et al: Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: Double-blind, randomized, controlled clinical trial. Circulation 105: 788-793, 2002.
11. Lederman RJ, Mendelsohn FO, Anderson RD, et al: TRAFFIC Investigators: Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): A randomised trial. Lancet 359: 2053-2058, 2002.
12. Stewart DJ, Kutryk MJ, Fitchett D, et al: NORTHERN Trial Investigators: VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: Results of the NORTHERN trial. Mol Ther 17: 1109-1115, 2009.
13. Goncalves GA, Vassallo PF, dos Santos L, et al: Intramyocardial transplantation of fibroblasts expressing vascular endothelial growth factor attenuates cardiac dysfunction. Gene Ther 17: 305-314, 2010.
14. Haider HKh, Ye L, Jiang S, et al: Angiomyogenesis for cardiac repair using human myoblasts as carriers of human vascular endothelial growth factor. J Mol Med 82: 539-549, 2004.