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Volumn 8, Issue 4, 2012, Pages 520-527

An overview of sipuleucel-T: Autologous cellular immunotherapy for prostate cancer

Author keywords

Active cellular therapy; Autologous cellular therapy; Immunotherapy; Prostate cancer; Sipuleucel T

Indexed keywords

ABIRATERONE; ACID PHOSPHATASE PROSTATE ISOENZYME; ALPHA INTERFERON; BCG VACCINE; CABAZITAXEL; CYTOKINE; DOCETAXEL; GLYCOPROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; PA 2024; RECOMBINANT PROTEIN; SIPULEUCEL T; TUMOR ANTIGEN; UNCLASSIFIED DRUG; CANCER VACCINE; IMMUNOLOGIC FACTOR; TISSUE EXTRACT;

EID: 84860757857     PISSN: None     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.18769     Document Type: Review
Times cited : (24)

References (52)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • PMID:21685461
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61:212-36; PMID:21685461; http://dx.doi.org/10.3322/caac. 20121.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 38849123209 scopus 로고    scopus 로고
    • The immune system - Is it relevant to cancer development, progression and treatment?
    • PMID:18037277
    • Prestwich RJ, Errington F, Hatfield P, Merrick AE, Ilett EJ, Selby PJ, et al. The immune system - is it relevant to cancer development, progression and treatment? Clin Oncol (R Coll Radiol) 2008; 20:101-12; PMID:18037277; http://dx.doi.org/10.1016/j.clon.2007.10.011.
    • (2008) Clin Oncol (R Coll Radiol) , vol.20 , pp. 101-112
    • Prestwich, R.J.1    Errington, F.2    Hatfield, P.3    Merrick, A.E.4    Ilett, E.J.5    Selby, P.J.6
  • 3
    • 0001991479 scopus 로고
    • Spontaneous regression of human melanoma: Clinical and experimental studies
    • PMID:13835693
    • Sumner WC, Foraker AG. Spontaneous regression of human melanoma: clinical and experimental studies. Cancer 1960; 13:79-81; PMID:13835693; http://dx.doi.org/10.1002/1097-0142(196001/02)13:1〈79:: AIDCNCR2820130115〉3.0.CO;2-4.
    • (1960) Cancer , vol.13 , pp. 79-81
    • Sumner, W.C.1    Foraker, A.G.2
  • 4
    • 0017150560 scopus 로고
    • Relationship of causative factors in spontaneous regression of cancer to immunologic factors possibly effective in cancer
    • PMID:792571
    • Cole WH. Relationship of causative factors in spontaneous regression of cancer to immunologic factors possibly effective in cancer. J Surg Oncol 1976; 8:391-411; PMID:792571; http://dx.doi.org/10.1002/jso.2930080506.
    • (1976) J Surg Oncol , vol.8 , pp. 391-411
    • Cole, W.H.1
  • 5
    • 79952140079 scopus 로고    scopus 로고
    • Cancer immunotherapy
    • PMID:21355777
    • Dillman RO. Cancer immunotherapy. Cancer Biother Radiopharm 2011; 26:1-64; PMID:21355777; http://dx.doi.org/10.1089/cbr.2010.0902.
    • (2011) Cancer Biother Radiopharm , vol.26 , pp. 1-64
    • Dillman, R.O.1
  • 6
    • 70349438847 scopus 로고    scopus 로고
    • Engineering lymphocyte subsets: Tools, trials and tribulations
    • PMID:19859065
    • June CH, Blazar BR, Riley JL. Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol 2009; 9:704-16; PMID:19859065; http://dx.doi.org/10.1038/nri2635.
    • (2009) Nat Rev Immunol , vol.9 , pp. 704-716
    • June, C.H.1    Blazar, B.R.2    Riley, J.L.3
  • 7
    • 41149097574 scopus 로고    scopus 로고
    • Adoptive cell transfer: A clinical path to effective cancer immunotherapy
    • PMID:18354418
    • Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 2008; 8:299-308; PMID:18354418; http://dx.doi.org/10.1038/nrc2355.
    • (2008) Nat Rev Cancer , vol.8 , pp. 299-308
    • Rosenberg, S.A.1    Restifo, N.P.2    Yang, J.C.3    Morgan, R.A.4    Dudley, M.E.5
  • 8
    • 70449117415 scopus 로고    scopus 로고
    • T cell receptor gene therapy for cancer
    • PMID:19702439
    • Schmitt TM, Ragnarsson GB, Greenberg PD. T cell receptor gene therapy for cancer. Hum Gene Ther 2009; 20:1240-8; PMID:19702439; http://dx.doi.org/10. 1089/hum.2009.146.
    • (2009) Hum Gene Ther , vol.20 , pp. 1240-1248
    • Schmitt, T.M.1    Ragnarsson, G.B.2    Greenberg, P.D.3
  • 9
    • 65249128775 scopus 로고    scopus 로고
    • Adoptive transfer of virus-specific and tumor-specific T cell immunity
    • PMID:19304470
    • Berger C, Turtle CJ, Jensen MC, Riddell SR. Adoptive transfer of virus-specific and tumor-specific T cell immunity. Curr Opin Immunol 2009; 21:224-32; PMID:19304470; http://dx.doi.org/10.1016/j.coi.2009.02.010.
    • (2009) Curr Opin Immunol , vol.21 , pp. 224-232
    • Berger, C.1    Turtle, C.J.2    Jensen, M.C.3    Riddell, S.R.4
  • 10
    • 62149129236 scopus 로고    scopus 로고
    • Therapeutic antibodies: Successes, limitations and hopes for the future
    • PMID:19459844
    • Chames P, Van Regenmortel M, Weiss E, Baty D. Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmacol 2009; 157:220-33; PMID:19459844; http://dx.doi.org/10.1111/j.1476-5381.2009.00190.x.
    • (2009) Br J Pharmacol , vol.157 , pp. 220-233
    • Chames, P.1    Van Regenmortel, M.2    Weiss, E.3    Baty, D.4
  • 11
    • 11844293364 scopus 로고    scopus 로고
    • Finding a place for tumor-specific T cells in targeted cancer therapy
    • PMID:15611285
    • Riddell SR. Finding a place for tumor-specific T cells in targeted cancer therapy. J Exp Med 2004; 200:1533-7; PMID:15611285; http://dx.doi.org/10.1084/ jem.20042004.
    • (2004) J Exp Med , vol.200 , pp. 1533-1537
    • Riddell, S.R.1
  • 12
    • 41149090985 scopus 로고    scopus 로고
    • Engineering antitumor immunity by T-cell adoptive immunotherapy
    • PMID:18024637
    • Riddell SR. Engineering antitumor immunity by T-cell adoptive immunotherapy. Hematology Am Soc Hematol Educ Program 2007; 250-6; PMID:18024637; http://dx.doi.org/10.1182/asheducation-2007.1.250.
    • (2007) Hematology Am Soc Hematol Educ Program , pp. 250-256
    • Riddell, S.R.1
  • 13
    • 77958006456 scopus 로고    scopus 로고
    • Cellular vaccine approaches
    • PMID:20693840
    • Le DT, Pardoll DM, Jaffee EM. Cellular vaccine approaches. Cancer J 2010; 16:304-10; PMID:20693840; http://dx.doi.org/10.1097/PPO.0b013e3181eb33d7.
    • (2010) Cancer J , vol.16 , pp. 304-310
    • Le, D.T.1    Pardoll, D.M.2    Jaffee, E.M.3
  • 14
    • 33745988889 scopus 로고    scopus 로고
    • Cancer vaccines: Preclinical studies and novel strategies
    • PMID:16860657
    • Palena C, Abrams SI, Schlom J, Hodge JW. Cancer vaccines: preclinical studies and novel strategies. Adv Cancer Res 2006; 95:115-45; PMID:16860657; http://dx.doi.org/10.1016/S0065-230X(06)95004-0.
    • (2006) Adv Cancer Res , vol.95 , pp. 115-145
    • Palena, C.1    Abrams, S.I.2    Schlom, J.3    Hodge, J.W.4
  • 15
    • 37349109250 scopus 로고    scopus 로고
    • Plasmid DNA- and messenger RNA-based anticancer vaccination
    • PMID:18006079
    • Weide B, Garbe C, Rammensee HG, Pascolo S. Plasmid DNA- and messenger RNA-based anticancer vaccination. Immunol Lett 2008; 115:33-42; PMID:18006079; http://dx.doi.org/10.1016/j.imlet.2007.09.012.
    • (2008) Immunol Lett , vol.115 , pp. 33-42
    • Weide, B.1    Garbe, C.2    Rammensee, H.G.3    Pascolo, S.4
  • 16
    • 79954675872 scopus 로고    scopus 로고
    • Clinical development directions in oncolytic viral therapy
    • PMID:21436867
    • Eager RM, Nemunaitis J. Clinical development directions in oncolytic viral therapy. Cancer Gene Ther 2011; 18:305-17; PMID:21436867; http://dx.doi.org/10.1038/cgt.2011.7.
    • (2011) Cancer Gene Ther , vol.18 , pp. 305-317
    • Eager, R.M.1    Nemunaitis, J.2
  • 17
    • 42649109659 scopus 로고    scopus 로고
    • Immuno-gene threapy approaches for cancer: From in vitro studies to clinical trials
    • Loisel-Meyer S, Foley R, Medin JA. Immuno-gene threapy approaches for cancer: from in vitro studies to clinical trials. Front Biosci 2008; 1:3202-14; http://dx.doi.org/10.2741/2921.
    • (2008) Front Biosci , vol.1 , pp. 3202-3214
    • Loisel-Meyer, S.1    Foley, R.2    Medin, J.A.3
  • 18
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • PMID:19536890
    • Higano CS, Schellhammer PF, Small EJ, Burch PA, Nemunaitis J, Yuh L, et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer 2009; 115:3670-9; PMID:19536890; http://dx.doi.org/10.1002/cncr. 24429.
    • (2009) Cancer , vol.115 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3    Burch, P.A.4    Nemunaitis, J.5    Yuh, L.6
  • 19
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • IMPACT Study Investigators. PMID:20818862
    • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al.; IMPACT Study Investigators. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363:411-22; PMID:20818862; http://dx.doi.org/10.1056/NEJMoa1001294.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3    Berger, E.R.4    Small, E.J.5    Penson, D.F.6
  • 23
    • 0022574146 scopus 로고
    • Induction by IL 1 and interferon-gamma: Tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1)
    • PMID:3086451
    • Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1). J Immunol 1986; 137:245-54; PMID:3086451.
    • (1986) J Immunol , vol.137 , pp. 245-254
    • Dustin, M.L.1    Rothlein, R.2    Bhan, A.K.3    Dinarello, C.A.4    Springer, T.A.5
  • 24
    • 45849146906 scopus 로고    scopus 로고
    • CD54 is a surrogate marker of antigen presenting cell activation
    • PMID:18297282
    • Sheikh NA, Jones LA. CD54 is a surrogate marker of antigen presenting cell activation. Cancer Immunol Immunother 2008; 57:1381-90; PMID:18297282; http://dx.doi.org/10.1007/s00262-008-0474-9.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1381-1390
    • Sheikh, N.A.1    Jones, L.A.2
  • 26
    • 84860773399 scopus 로고    scopus 로고
    • Sipuleucel-T treatment results in sequential ex vivo activation of APCs and T cells during the culture step - Evidence for in vivo immunological priming
    • abstract
    • Sheikh NA, Dela Rosa C, Frohlich MW, Urdal DL, Provost NM. Sipuleucel-T treatment results in sequential ex vivo activation of APCs and T cells during the culture step - evidence for in vivo immunological priming [abstract]. AACR. Washington DC 2010.
    • AACR. Washington DC 2010
    • Sheikh, N.A.1    Dela Rosa, C.2    Frohlich, M.W.3    Urdal, D.L.4    Provost, N.M.5
  • 27
    • 84860733643 scopus 로고    scopus 로고
    • Characterization of antigen specific T cell activation and cytokine expression induced by sipuleucel-T
    • Wesley JD, Chadwick E, Kuan LY, Dela Rosa C, Frohlich M, Urdal D, et al. Characterization of antigen specific T cell activation and cytokine expression induced by sipuleucel-T. J Immunother 2010; 33:912-3.
    • (2010) J Immunother , vol.33 , pp. 912-913
    • Wesley, J.D.1    Chadwick, E.2    Kuan, L.Y.3    Dela Rosa, C.4    Frohlich, M.5    Urdal, D.6
  • 28
    • 80052458892 scopus 로고    scopus 로고
    • Characterization of antigen specifric T-cell activation and cytokine expression induced by sipuleucel-T
    • Sheikh NA, Wesley JD, Chadwick E, Perdue N, Dela Rosa C, Frohlich MW, et al. Characterization of antigen specifric T-cell activation and cytokine expression induced by sipuleucel-T. J Clin Oncol 2011; 29.
    • (2011) J Clin Oncol , vol.29
    • Sheikh, N.A.1    Wesley, J.D.2    Chadwick, E.3    Perdue, N.4    Dela Rosa, C.5    Frohlich, M.W.6
  • 29
    • 0034043167 scopus 로고    scopus 로고
    • Priming tissue-specific cellular immunity in a phase I trial of autologous dendritic cells for prostate cancer
    • PMID:10873066
    • Burch PA, Breen JK, Buckner JC, Gastineau DA, Kaur JA, Laus RL, et al. Priming tissue-specific cellular immunity in a phase I trial of autologous dendritic cells for prostate cancer. Clin Cancer Res 2000; 6:2175-82; PMID:10873066.
    • (2000) Clin Cancer Res , vol.6 , pp. 2175-2182
    • Burch, P.A.1    Breen, J.K.2    Buckner, J.C.3    Gastineau, D.A.4    Kaur, J.A.5    Laus, R.L.6
  • 30
    • 0034554863 scopus 로고    scopus 로고
    • Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells
    • PMID:11099318
    • Small EJ, Fratesi P, Reese DM, Strang G, Laus R, Peshwa MV, et al. Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells. J Clin Oncol 2000; 18:3894-903; PMID:11099318.
    • (2000) J Clin Oncol , vol.18 , pp. 3894-3903
    • Small, E.J.1    Fratesi, P.2    Reese, D.M.3    Strang, G.4    Laus, R.5    Peshwa, M.V.6
  • 31
    • 33745304967 scopus 로고    scopus 로고
    • Combination immunotherapy with prostatic acid phosphatase pulsed antigen-presenting cells (provenge) plus bevacizumab in patients with serologic progression of prostate cancer after definitive local therapy
    • PMID:16736512
    • Rini BI, Weinberg V, Fong L, Conry S, Hershberg RM, Small EJ. Combination immunotherapy with prostatic acid phosphatase pulsed antigen-presenting cells (provenge) plus bevacizumab in patients with serologic progression of prostate cancer after definitive local therapy. Cancer 2006; 107:67-74; PMID:16736512; http://dx.doi.org/10.1002/cncr.21956.
    • (2006) Cancer , vol.107 , pp. 67-74
    • Rini, B.I.1    Weinberg, V.2    Fong, L.3    Conry, S.4    Hershberg, R.M.5    Small, E.J.6
  • 32
    • 22544458183 scopus 로고    scopus 로고
    • Antigen-presenting cells 8015 (Provenge) in patients with androgen-dependent, biochemically relapsed prostate cancer
    • PMID:15992463
    • Beinart G, Rini BI, Weinberg V, Small EJ. Antigen-presenting cells 8015 (Provenge) in patients with androgen-dependent, biochemically relapsed prostate cancer. Clin Prostate Cancer 2005; 4:55-60; PMID:15992463.
    • (2005) Clin Prostate Cancer , vol.4 , pp. 55-60
    • Beinart, G.1    Rini, B.I.2    Weinberg, V.3    Small, E.J.4
  • 33
    • 33746012881 scopus 로고    scopus 로고
    • Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
    • PMID:16809734
    • Small EJ, Schellhammer PF, Higano CS, Redfern CH, Nemunaitis JJ, Valone FH, et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 2006; 24:3089-94; PMID:16809734; http://dx.doi.org/10.1200/JCO.2005.04.5252.
    • (2006) J Clin Oncol , vol.24 , pp. 3089-3094
    • Small, E.J.1    Schellhammer, P.F.2    Higano, C.S.3    Redfern, C.H.4    Nemunaitis, J.J.5    Valone, F.H.6
  • 34
    • 78649750575 scopus 로고    scopus 로고
    • Immuno-oncology biomarkers 2010 and beyond: Perspectives from the iSBTc/SITC biomarker task force
    • PMID:21138581
    • Butterfield LH, Disis ML, Khleif SN, Balwit JM, Marincola FM. Immuno-oncology biomarkers 2010 and beyond: perspectives from the iSBTc/SITC biomarker task force. J Transl Med 2010; 8:130; PMID:21138581; http://dx.doi.org/10.1186/1479-5876-8-130.
    • (2010) J Transl Med , vol.8 , pp. 130
    • Butterfield, L.H.1    Disis, M.L.2    Khleif, S.N.3    Balwit, J.M.4    Marincola, F.M.5
  • 35
    • 79951879520 scopus 로고    scopus 로고
    • Correlation between product parameters and overall survival in three trials of sipuleucel-T, an autologous active cellular immunotherapy for the treatment of prostate cancer
    • abstract 4552
    • Stewart FP, Dela Rosa C, Sheikh NA, McNeel DG, Frohlich MW, Urdal DL, et al. Correlation between product parameters and overall survival in three trials of sipuleucel-T, an autologous active cellular immunotherapy for the treatment of prostate cancer. [abstract 4552]. J Clin Oncol 2010; 28.
    • (2010) J Clin Oncol , vol.28
    • Stewart, F.P.1    Dela Rosa, C.2    Sheikh, N.A.3    McNeel, D.G.4    Frohlich, M.W.5    Urdal, D.L.6
  • 37
    • 79960337024 scopus 로고    scopus 로고
    • Randomized trial of autologous cellular immunotherapy with sipuleucel-T in androgen-dependent prostate cancer
    • PMID:21558406
    • Beer TM, Bernstein GT, Corman JM, Glode LM, Hall SJ, Poll WL, et al. Randomized trial of autologous cellular immunotherapy with sipuleucel-T in androgen-dependent prostate cancer. Clin Cancer Res 2011; 17:4558-67; PMID:21558406; http://dx.doi.org/10.1158/1078-0432.CCR-10-3223.
    • (2011) Clin Cancer Res , vol.17 , pp. 4558-4567
    • Beer, T.M.1    Bernstein, G.T.2    Corman, J.M.3    Glode, L.M.4    Hall, S.J.5    Poll, W.L.6
  • 38
    • 33748279103 scopus 로고    scopus 로고
    • Molecular markers and their prognostic impact in patients with advanced prostate cancer undergoing intermittent androgen suppression
    • PMID:16702984
    • Augustin H, Freibauer C, Bayer L, Lunglmayr G, Tschurlovich F, Kuber W, et al. Molecular markers and their prognostic impact in patients with advanced prostate cancer undergoing intermittent androgen suppression. Prostate Cancer Prostatic Dis 2006; 9:279-83; PMID:16702984; http://dx.doi.org/10.1038/sj.pcan. 4500883.
    • (2006) Prostate Cancer Prostatic Dis , vol.9 , pp. 279-283
    • Augustin, H.1    Freibauer, C.2    Bayer, L.3    Lunglmayr, G.4    Tschurlovich, F.5    Kuber, W.6
  • 39
    • 20644466423 scopus 로고    scopus 로고
    • PSA bouncing after short term androgen deprivation and 3D-conformal radiotherapy for localized prostate adenocarcinoma and the relationship with the kinetics of testosterone
    • PMID:15967250
    • Akyol F, Ozyigit G, Selek U, Karabulut E. PSA bouncing after short term androgen deprivation and 3D-conformal radiotherapy for localized prostate adenocarcinoma and the relationship with the kinetics of testosterone. Eur Urol 2005; 48:40-5; PMID:15967250; http://dx.doi.org/10.1016/j.eururo.2005.04.007.
    • (2005) Eur Urol , vol.48 , pp. 40-45
    • Akyol, F.1    Ozyigit, G.2    Selek, U.3    Karabulut, E.4
  • 40
    • 17844374323 scopus 로고    scopus 로고
    • PSA doubling time kinetics during prostate cancer biochemical relapse after external beam radiation therapy
    • PMID:15850915
    • Bates AT, Pickles T, Paltiel C. PSA doubling time kinetics during prostate cancer biochemical relapse after external beam radiation therapy. Int J Radiat Oncol Biol Phys 2005; 62:148-53; PMID:15850915; http://dx.doi.org/10. 1016/j.ijrobp.2004.09.048.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 148-153
    • Bates, A.T.1    Pickles, T.2    Paltiel, C.3
  • 41
    • 41949104346 scopus 로고    scopus 로고
    • Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
    • Prostate Cancer Clinical Trials Working Group. PMID:18309951
    • Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, et al.; Prostate Cancer Clinical Trials Working Group. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol 2008; 26:1148-59; PMID:18309951; http://dx.doi.org/10.1200/JCO.2007.12.4487.
    • (2008) J Clin Oncol , vol.26 , pp. 1148-1159
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3    Morris, M.4    Sternberg, C.N.5    Carducci, M.A.6
  • 42
    • 33947355892 scopus 로고    scopus 로고
    • The association between measures of progression and survival in castrate-metastatic prostate cancer
    • PMID:17332293
    • Scher HI, Warren M, Heller G. The association between measures of progression and survival in castrate-metastatic prostate cancer. Clin Cancer Res 2007; 13:1488-92; PMID:17332293; http://dx.doi.org/10.1158/1078-0432.CCR-06- 1885.
    • (2007) Clin Cancer Res , vol.13 , pp. 1488-1492
    • Scher, H.I.1    Warren, M.2    Heller, G.3
  • 43
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
    • PMID:20100959
    • Kantoff PW, Schuetz TJ, Blumenstein BA, Glode LM, Bilhartz DL, Wyand M, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol 2010; 28:1099-105; PMID:20100959; http://dx.doi.org/10.1200/JCO.2009.25.0597.
    • (2010) J Clin Oncol , vol.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3    Glode, L.M.4    Bilhartz, D.L.5    Wyand, M.6
  • 44
    • 79951826832 scopus 로고    scopus 로고
    • Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: The growth rate constant as an indicator of therapeutic efficacy
    • PMID:21106727
    • Stein WD, Gulley JL, Schlom J, Madan RA, Dahut W, Figg WD, et al. Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy. Clin Cancer Res 2011; 17:907-17; PMID:21106727; http://dx.doi.org/10.1158/1078-0432. CCR-10-1762.
    • (2011) Clin Cancer Res , vol.17 , pp. 907-917
    • Stein, W.D.1    Gulley, J.L.2    Schlom, J.3    Madan, R.A.4    Dahut, W.5    Figg, W.D.6
  • 45
    • 79959196581 scopus 로고    scopus 로고
    • Immunotherapy for prostate cancer: Recent advances, lessons learned and areas for further research
    • PMID:21680544
    • Gulley JL, Drake CG. Immunotherapy for prostate cancer: recent advances, lessons learned and areas for further research. Clin Cancer Res 2011; 17:3884-91; PMID:21680544; http://dx.doi.org/10.1158/1078-0432.CCR-10-2656.
    • (2011) Clin Cancer Res , vol.17 , pp. 3884-3891
    • Gulley, J.L.1    Drake, C.G.2
  • 46
    • 77957787538 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines in prostate cancer: The paradox of improved survival without changes in time to progression
    • PMID:20798195
    • Madan RA, Gulley JL, Fojo T, Dahut WL. Therapeutic cancer vaccines in prostate cancer: the paradox of improved survival without changes in time to progression. Oncologist 2010; 15:969-75; PMID:20798195; http://dx.doi.org/10. 1634/theoncologist.2010-0129.
    • (2010) Oncologist , vol.15 , pp. 969-975
    • Madan, R.A.1    Gulley, J.L.2    Fojo, T.3    Dahut, W.L.4
  • 47
    • 79960577634 scopus 로고    scopus 로고
    • Immunotherapies in clinical trials: Do they demand different evaluation tools?
    • PMID:21551417
    • Tuma RS. Immunotherapies in clinical trials: do they demand different evaluation tools? J Natl Cancer Inst 2011; 103:780-1; PMID:21551417; http://dx.doi.org/10.1093/jnci/djr184.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 780-781
    • Tuma, R.S.1
  • 48
    • 16844362403 scopus 로고    scopus 로고
    • Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses
    • PMID:15788693
    • Kudo-Saito C, Schlom J, Hodge JW. Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses. Clin Cancer Res 2005; 11:2416-26; PMID:15788693; http://dx.doi.org/ 10.1158/1078-0432.CCR-04-1380.
    • (2005) Clin Cancer Res , vol.11 , pp. 2416-2426
    • Kudo-Saito, C.1    Schlom, J.2    Hodge, J.W.3
  • 49
    • 84860720427 scopus 로고    scopus 로고
    • Time to disease-related pain after sipuleucel-T in asymptomatic patients with metastatic castrate-resistant prostate cancer (mCRPC): Results from three randomized phase III trials
    • Small EJ, Higano CS, Kantoff PW, Whitmore JB, Frohlich MW, Petrylak DP. Time to disease-related pain after sipuleucel-T in asymptomatic patients with metastatic castrate-resistant prostate cancer (mCRPC): Results from three randomized phase III trials. J Clin Oncol 2011; 29.
    • (2011) J Clin Oncol , vol.29
    • Small, E.J.1    Higano, C.S.2    Kantoff, P.W.3    Whitmore, J.B.4    Frohlich, M.W.5    Petrylak, D.P.6
  • 50
    • 80051548463 scopus 로고    scopus 로고
    • Integrated safety data from 4 randomized, double-blind, controlled trials of autologous cellular immunotherapy with sipuleucel-T in patients with prostate cancer
    • PMID:21788048
    • Hall SJ, Klotz L, Pantuck AJ, George DJ, Whitmore JB, Frohlich MW, et al. Integrated safety data from 4 randomized, double-blind, controlled trials of autologous cellular immunotherapy with sipuleucel-T in patients with prostate cancer. J Urol 2011; 186:877-81; PMID:21788048; http://dx.doi.org/10.1016/j. juro.2011.04.070.
    • (2011) J Urol , vol.186 , pp. 877-881
    • Hall, S.J.1    Klotz, L.2    Pantuck, A.J.3    George, D.J.4    Whitmore, J.B.5    Frohlich, M.W.6
  • 51
    • 84860729530 scopus 로고    scopus 로고
    • Safety of leukapheresis in prostate cancer patients receiving sipuleucel-T
    • Flanigan R, Price T, Whitmore J, Holman J. Safety of leukapheresis in prostate cancer patients receiving sipuleucel-T. J Urol 2011; 185:261; http://dx.doi.org/10.1016/j.juro.2011.02.1548.
    • (2011) J Urol , vol.185 , pp. 261
    • Flanigan, R.1    Price, T.2    Whitmore, J.3    Holman, J.4
  • 52
    • 84861988397 scopus 로고    scopus 로고
    • Development of sipuleucel-T: Autologous cellular immunotherapy for the treatment of metastatic castrate resistant prostate cancer
    • In press; PMID:22122856
    • Sims RB. Development of sipuleucel-T: Autologous cellular immunotherapy for the treatment of metastatic castrate resistant prostate cancer. Vaccine 2011; In press; PMID:22122856; http://dx.doi.org/10.1016/j.vaccine.2011.11.058.
    • (2011) Vaccine
    • Sims, R.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.