Macrophage subsets in human atherosclerosis

Circulation Research

Volumn 110, Issue 9, 2012, Pages

  Finn, Aloke V ^a,b   Saeed, Omar ^a,b   Virmani, Renu ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CVPATH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; CD163 ANTIGEN; CD68 ANTIGEN; GAMMA INTERFERON; HAPTOGLOBIN; HIGH DENSITY LIPOPROTEIN 3; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MANNOSE RECEPTOR; MESSENGER RNA;

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL SUBPOPULATION; CYTOKINE PRODUCTION; DISEASE COURSE; FOAM CELL; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LETTER; MACROPHAGE; MICROENVIRONMENT; MONOCYTE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

CHOLESTEROL; HUMANS; MACROPHAGES; ORPHAN NUCLEAR RECEPTORS; PHAGOCYTOSIS; PLAQUE, ATHEROSCLEROTIC; PPAR GAMMA;

EID: 84860756054     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.268714     Document Type: Letter

References (4)

1. Chinetti-Gbaguidi G, Baron M, Bouhlel MA, Vanhoutte J, Copin C, Sebti Y, Derudas B, Mayi T, Bories G, Tailleux A, Haulon S, Zawadzki C, Jude B, Staels B. Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPAR and LXR pathways. Circ Res. 2011;108:985-995.
2. Finn AV, Nakano M, Polavarapu R, Karmali V, Saeed O, Zhao X, Yazdani S, Otsuka F, Davis T, Habib A, Narula J, Kolodgie FD, Virmani R. Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques. J Am Coll Cardiol. 2012;59:166-177.
3. Boyle JJ, Harrington HA, Piper E, Elderfield K, Stark J, Landis RC, Haskard DO. Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. Am J Pathol. 2009;174:1097-1108.
4. Saeed O, Otsuka F, Polavarapu R, et al. Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32: 299-307.