Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells

Oncology Reports

Volumn 27, Issue 6, 2012, Pages 1835-1842

  Li, Jun ^a   Liang, Shanhui ^a   Jin, Hongyan ^a   Xu, Congjian ^a   Ma, Duan ^a   Lu, Xin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Invasion; microRNA; Migration; Ovarian cancer; Tiam1

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MICRORNA; MICRORNA 183; MICRORNA 22; MICRORNA 31; TIAM 1 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METASTASIS; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS;

CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; MICRORNAS; NEOPLASM INVASIVENESS; OVARIAN NEOPLASMS; OVARY; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84860751478     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1744     Document Type: Article

References (20)

1. Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A and Collard JG: Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for rho-like proteins. Cell 77: 537-549, 1994.
2. Adams HR III, Chen R, Liu Z and Whitehead IP: Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein. Breast Cancer Res 12: R69, 2010.
3. Moriarty CH, Pursell B and Mercurio AM: miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem 285: 20541-20546, 2010.
4. Walch A, Seidl S, Hermannstadter C, Rauser S, Deplazes J, Langer R, von Weyhern CH, Sarbia M, Busch R, Feith M, Gillen S, Hofler H and Luber B: Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol 21: 544-552, 2008. (Pubitemid 351589660)
5. Liu L, Zhang Q, Zhang Y, Wang S and Ding Y: Lentivirus-mediated silencing of Tiam1 gene influences multiple functions of a human colorectal cancer cell line. Neoplasia 8: 917-924, 2006. (Pubitemid 44706241)
6. Cottonham CL, Kaneko S and Xu L: miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J Biol Chem 285: 35293-35302, 2010.
7. Engers R, Mueller M, Walter A, Collard JG, Willers R and Gabbert HE: Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer 95: 1081-1086, 2006. (Pubitemid 44606836)
8. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
9. Li J, Liang S, Yu H, Zhang J, Ma D and Lu X: An inhibitory effect of miR-22 on cell migration and invasion in ovarian cancer. Gynecol Oncol 119: 543-548, 2010.
10. Bai F, Feng J, Cheng Y, Shi J, Yang R and Cui H: Analysis of gene expression patterns of ovarian cancer cell lines with different metastatic potentials. Int J Gynecol Cancer 16: 202-209, 2006.
11. Kawazoe N, Watabe M, Masuda Y, Nakajo S and Nakaya K: Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. Oncogene 18: 2413-2421, 1999. (Pubitemid 29206154)
12. Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC and Collard JG: Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278: 1464-1466, 1997. (Pubitemid 27509819)
13. Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ and Murakami Y: CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem 285: 15511-15522, 2010.
14. Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA and Fuentes EJ: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J Mol Biol 398: 730-746, 2010.
15. Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H and Collard JG: The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281: 543-548, 2006. (Pubitemid 43671217)
16. Xu K, Rajagopal S, Klebba I, Dong S, Ji Y, Liu J, Kuperwasser C, Garlick JA, Naber SP and Buchsbaum RJ: The role of fibroblast Tiam1 in tumor cell invasion and metastasis. Oncogene 29: 6533-6542, 2010.
17. Buongiorno P, Pethe VV, Charames GS, Esufali S and Bapat B: Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. Mol Cancer 7: 73, 2008.
18. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A and Mendell JT: Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 40: 43-50, 2008.
19. Dahiya N, Sherman-Baust CA, Wang TL, Davidson B, Shih I, Zhang Y, Wood WR, Becker KG and Morin PJ: MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One 3: 2436, 2008.
20. Creighton CJ, Fountain MD, Yu Z, Nagaraja AK, Zhu H, Khan M, Olokpa E, Zariff A, Gunaratne PH, Matzuk MM and Anderson ML: Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers. Cancer Res 70: 1906-1915, 2010.