Immunomodulatory activity of diethylcarbamazine on humoral, cellular cytokine response and respiratory burst in BALB/c mice

Immunopharmacology and Immunotoxicology

Volumn 34, Issue 3, 2012, Pages 477-483

  Medina De La Garza, Carlos E ^a   Guerrero Ramírez, Graciela ^a   García Hernández, Marisela ^a   Castro Corona, M Angeles ^a   Torres López, Ernesto ^a   Brattig, Norbert W ^b   Salinas Carmona, Mario C ^a  

^a UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Antibody production; Cytokines; Diethylcarbamazine; Immunomodulation; Respiratory burst

Indexed keywords

DIETHYLCARBAMAZINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; TETANUS TOXOID;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; BLOOD; CONTROLLED STUDY; CYTOKINE RESPONSE; FEMALE; FLOW CYTOMETRY; MALE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; RESPIRATORY BURST;

ANIMALS; CYTOKINES; DIETHYLCARBAMAZINE; FEMALE; IMMUNITY, HUMORAL; IMMUNOLOGIC FACTORS; LIPOPOLYSACCHARIDES; LIPOXYGENASE INHIBITORS; MALE; MICE; MICE, INBRED BALB C; MONOCYTES; NEUTROPHILS; RESPIRATORY BURST; TETANUS TOXOID;

ANIMALIA; MUS;

EID: 84860749715     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2011.630008     Document Type: Article

References (23)

1. van den Enden, E. Pharmacotherapy of helminth infection. Expert Opin Pharmacother 2009, 10, 435-451.
2. Maizels, R.M., Denham, D.A. Diethylcarbamazine (DEC): Immunopharmacological interactions of an anti-filarial drug. Parasitology 1992, 105, 49-60.
3. Peixoto, C.A., Rocha, A., Aguiar-Santos, A., Florcio, M.S. The effects of diethylcarbamazine on the ultrastructure of microfilariae of Wuchereria bancrofti in vivo and in vitro. Parasitol Res 2004, 92, 513-517. (Pubitemid 38658349)
4. Peixoto, C.A., Santos, A.C., Ayres, C.F. Molecular evidence for apoptosis in microfilariae of Wuchereria bancrofti induced by diethylcarbamazine. Parasitol Res 2008, 103, 717-721.
5. Kanesa-thasan, N., Douglas, J.G., Kazura, J.W. Diethylcarbamazine inhibits endothelial and microfilarial prostanoid metabolism in vitro. Mol Biochem Parasitol 1991, 49, 11-19.
6. McGarry, H.F., Plant, L.D., Taylor, M.J. Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitricoxide synthase and the cyclooxygenase pathway. Filaria J 2005, 4, 4.
7. King, C.H., Greene, B.M., Spagnuolo, P.J. Diethylcarbamazine citrate, an antifilarial drug, stimulates human granulocyte adherence. Antimicrob Agents Chemother 1983, 24, 453-456. (Pubitemid 13007369)
8. Medina-De la Garza, C.E., Brattig, N.W., Tischendorf, F.W., Jarrett, J.M. Serum-dependent interaction of granulocytes with Onchocerca volvulus microfilariae in generalized and chronic hyper-reactive diethylcarbamazine. Trans R Soc Trop Med Hyg 1990, 84, 701-706. (Pubitemid 20358590)
9. Cesbron, J.Y., Capron, A., Vargaftig, B.B., Lagarde, M., Pincemail, J., Braquet, P., Taelman, H., Joseph, M. Platelets mediate the action of diethylcarbamazine on microfilariae. Nature 1987, 325, 533-536. (Pubitemid 17056735)
10. Kitchen, L.W. Effect of diethylcarbamazine on cats given feline leukaemia virus vaccine. Vaccine 1987, 5, 266-267. (Pubitemid 18047353)
11. Kitchen, L.W., Mather, F.J., Cotter, S.M. Effect of continuous oral diethylcarbamazine treatment on lymphocyte counts of feline leukemia virus-infected cats. J Clin Lab Immunol 1988, 27, 179-181. (Pubitemid 19116726)
12. Kitchen, L.W., Weston, C.M., Day, S.P. Diethylcarbamazine-related antimicrobial activity in Mycobacterium tuberculosis-infected blood. J Antimicrob Chemother 1998, 42, 241-243. (Pubitemid 28393594)
13. Salinas-Carmona, M.C., Welsh, O., Casillas, S.M. Enzyme-linked immunosorbent assay for serological diagnosis of Nocardia brasiliensis and clinical correlation with mycetoma infections. J Clin Microbiol 1993, 31, 2901-2906. (Pubitemid 23318376)
14. Re, G.H., Hall, A.P. Plasma levels of diehytlcarbamazine in man. Transactions of the Royal Society of Tropical Medicine and Hygiene 1977, 71, 542-543.
15. Horii, Y., Aoki, Y. Plasma levels of diethylcarbamazine and their effects on implanted microfilariae of Brugia pahangi in Rats. J Vet Med Sci 5910:961-963.
16. Roy, T.K., Satyavan, S., Srivastava, V.M. Comparative tissue distribution and urinary excretion of diethylcarbamazine and centperazine. Indian J Med Res 1981, 74, 565-571. (Pubitemid 12190141)
17. Bolla, S., Ramesh, R.B., Srinivasu, P., Rambhau, D., Bhaskara, R.J. Pharmacokinetics of diethylcarbamazine after single oral dose at two different times of day in human subjects. J Clin Pharmacol 2002, 42, 327-331. (Pubitemid 34163480)
18. Emmend?ffer, A., Hecht, M., Lohmann-Matthes, M.L., Roesler, J. A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123. J Immunol Methods 1990, 131, 269-275. (Pubitemid 20241527)
19. Kitchen, L.W., Ross, J.A., Hernandez, J.E., Zarraga, A.L., Mather, F.J. Effect of administration of diethylcarbamazine on experimental bacterial and fungal infections in mice. Int J Antimicrob Agents 1992, 1, 259-267.
20. Gopinath, R., Hanna, L.E., Kumaraswami, V., Perumal, V., Kavitha, V., Vijayasekaran, V., Nutman, T.B. Perturbations in eosinophil homeostasis following treatment of lymphatic filariasis. Infect Immun 2000, 68, 93-99. (Pubitemid 30016682)
21. Medina-De la Garza, C.E., Brattig, N.W., Salinas-Carmona, M.C. In vitro RANTES production by diethylcarbamazine and ivermectin. The FASEB Journal 2000, 14, 1091.
22. Pascual, C., Gonzez, R., Romay, C. Drugs effects on superoxide generation and chemiluminescence response of human leukocytes. Agents Actions 1991, 32, 277-282.
23. Gutirez-Pe?, E.J., Knab, J., Btner, D.W. Neutrophil granule proteins: Evidence for the participation in the host reaction to skin microfilariae of Onchocerca volvulus after diethylcarbamazine administration. Parasitology 1996, 113, 403-414. (Pubitemid 26333625)