Expression of STAT3, MMP-1 and TIMP-1 in gastric cancer and correlation with pathological features

Molecular Medicine Reports

Volumn 5, Issue 6, 2012, Pages 1438-1442

  Cai, Qin Wei ^a   Li, Jun ^a   Li, Xue Qin ^a   Wang, Jian Qiang ^a   Huang, Yuan ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

Gastric cancer; Matrix metalloproteinase 1; Signal transducer and activator of transcription 3; Tissue inhibitor of metalloproteinase 1

Indexed keywords

BETA ACTIN; INTERSTITIAL COLLAGENASE; MESSENGER RNA; STAT3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADULT; AGED; ARTICLE; CANCER CELL; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; STOMACH CANCER;

ADULT; AGED; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 1; MIDDLE AGED; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; STOMACH NEOPLASMS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84860744645     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.849     Document Type: Article

References (25)

1. Shah MA and Schwartz GK: Treatment of metastatic esophagus and gastric cancer. Semin Oncol 31: 574-587, 2004. (Pubitemid 39089070)
2. Huang S and JW Y: Situation and dispute of gastric cancer therapy between Oriental countries and Western countries. J Int Oncol 36: 689-692, 2009.
3. Lv W and L C: Current status and recent developments in molecular targeted therapy against gastric cancer. World Chin J Dig 15: 2672-2678, 2007.
4. Darnell JE Jr: STATs and gene regulation. Science 277: 1630-1635, 1997.
5. Deng JY, Sun D, Liu XY, Pan Y and Liang H: STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer. World J Gastroenterol 16: 5380-5387, 2010.
6. Lee J, Kang WK, Park JO, et al: Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. APMIS 117: 598-606, 2009.
7. Kanda N, Seno H, Konda Y, et al: STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene 23: 4921-4929, 2004. (Pubitemid 38932164)
8. Kim DY, Cha ST, Ahn DH, et al: STAT3 expression in gastric cancer indicates a poor prognosis. J Gastroenterol Hepatol 24: 646-651, 2009.
9. Huang W, Yu LF, Zhong J, et al: Stat3 is involved in angiotensin II-induced expression of MMP2 in gastric cancer cells. Dig Dis Sci 54: 2056-2062, 2009.
10. Shi M, Liu D, Duan H, et al: Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. Mol Cancer 9: 269, 2010.
11. Zugowski C, Lieder F, Muller A, et al: STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter. Biol Chem 392: 449-459, 2011.
12. Tsareva SA, Moriggl R, Corvinus FM, et al: Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 9: 279-291, 2007. (Pubitemid 46608295)
13. Kemik O, Kemik AS, Sumer A, et al: Levels of matrix metalloproteinase- 1 and tissue inhibitors of metalloproteinase-1 in gastric cancer. World J Gastroenterol 17: 2109-2112, 2011.
14. Zhou GQ and L W: Expression of MMP1 and TIMP1 genes in gastric cancer and its clinic significance. Chin J Hemorheol 19: 78-81, 2009.
15. Nagase H and Woessner JF Jr: Matrix metalloproteinases. J Biol Chem 274: 21491-21494, 1999. (Pubitemid 129519680)
16. Brew K, Dinakarpandian D and Nagase H: Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta 1477: 267-283, 2000. (Pubitemid 30119906)
17. Bourboulia D and Stetler-Stevenson WG: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 20: 161-168, 2010.
18. Takeda K and Akira S: STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev 11: 199-207, 2000. (Pubitemid 30337459)
19. Lassmann S, Schuster I, Walch A, et al: STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3- inducible targets linked to cell survival and proliferation. J Clin Pathol 60: 173-179, 2007.
20. Zhang C and Zhong CH: STAT3: a critical transcription activator in angiogenesis. Med Res Rev 28: 185-200, 2008. (Pubitemid 351281185)
21. Yang J, Chatterjee-Kishore M, Staugaitis SM, et al: Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res 65: 939-947, 2005. (Pubitemid 40216455)
22. Liu Z, Hazan-Halevy I, Harris DM, et al: STAT-3 activates NF-kappaB in chronic lymphocytic leukemia cells. Mol Cancer Res 9: 507-515, 2011.
23. Braunstein J, Brutsaert S, Olson R and Schindler C: STATs dimerize in the absence of phosphorylation. J Biol Chem 278: 34133-34140, 2003. (Pubitemid 37553254)
24. Surlin V, Ioana M and Plesea IE: Genetic patterns of metalloproteinases and their tissular inhibitors - clinicopathologic and prognostic significance in colorectal cancer. Rom J Morphol Embryol 52: 231-236, 2011.
25. Tsareva SA, Wagner S, Muller A, Corvinus F and Friedrich K: Cell-cell contacts induce STAT3 activity in colon carcinoma cells through an autocrine stimulation loop. J Cancer Res Clin Oncol 137: 857-863, 2011.