메뉴 건너뛰기




Volumn 142, Issue APRIL, 2012, Pages

Targeted therapies in breast cancer

Author keywords

Breast cancer; Predictive marker; Targeted therapy

Indexed keywords

ANASTROZOLE; BEVACIZUMAB; CAPECITABINE; CYCLOPHOSPHAMIDE; DOCETAXEL; DOUBLE STRANDED DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; EVEROLIMUS; GEFITINIB; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MOTESANIB; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PACLITAXEL; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; TAMOXIFEN; TEMSIROLIMUS; TRASTUZUMAB; UNINDEXED DRUG; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR; MTOR PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN TYROSINE KINASE; TARGET OF RAPAMYCIN KINASE; VASCULOTROPIN RECEPTOR;

EID: 84860728326     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: 10.4414/smw.2012.13550     Document Type: Review
Times cited : (10)

References (69)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 79957492068 scopus 로고    scopus 로고
    • Clinical notice for American Society of Clinical Oncology - College of American Pathologists Guideline Recommendations on ER/PgR and HER2 testing in breast cancer
    • Hammond ME, Hayes DF, Wolff AC. Clinical notice for American Society of Clinical Oncology - College of American Pathologists Guideline Recommendations on ER/PgR and HER2 testing in breast cancer. J Clin Oncol. 2011;29:e458.
    • (2011) J Clin Oncol , vol.29
    • Hammond, M.E.1    Hayes, D.F.2    Wolff, A.C.3
  • 3
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff AC, M. Elizabeth H. Hammond, Jared N. Schwartz, et al. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol. 2006;25:118-45.
    • (2006) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Elizabeth, M.2    Hammond, H.3    Schwartz, J.N.4
  • 7
    • 73949090721 scopus 로고    scopus 로고
    • Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutional-based review
    • Dawood S, Broglio K, Buzdar AU, Hortobagyi GN, Giordano SH. Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review. J Clin Oncol. 2010;28:92-8.
    • (2010) J Clin Oncol , vol.28 , pp. 92-98
    • Dawood, S.1    Broglio, K.2    Buzdar, A.U.3    Hortobagyi, G.N.4    Giordano, S.H.5
  • 11
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA, Rugo HS, Vukelja SJ et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol. 2011;29:398-405.
    • (2011) J Clin Oncol , vol.29 , pp. 398-405
    • Burris, H.A.1    Rugo, H.S.2    Vukelja, S.J.3
  • 12
    • 78651458656 scopus 로고    scopus 로고
    • AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
    • Chandarlapaty S, Sawai A, Scaltriti M et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell. 2011;19:58-71.
    • (2011) Cancer Cell , vol.19 , pp. 58-71
    • Chandarlapaty, S.1    Sawai, A.2    Scaltriti, M.3
  • 13
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol. 2011;29:3126-32.
    • (2011) J Clin Oncol , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 14
    • 77649286736 scopus 로고    scopus 로고
    • Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
    • Hsieh AC, Costa M, Zollo O et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010;17:249-61.
    • (2010) Cancer Cell , vol.17 , pp. 249-261
    • Hsieh, A.C.1    Costa, M.2    Zollo, O.3
  • 15
    • 65349110371 scopus 로고    scopus 로고
    • Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A german breast group 26/breast international group 03-05 study
    • von Minckwitz G, du Bois A, Schmidt M et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study. J Clin Oncol. 2009;27:1999-2006.
    • (2009) J Clin Oncol , vol.27 , pp. 1999-2006
    • Von Minckwitz, G.1    Du Bois, A.2    Schmidt, M.3
  • 16
    • 80053362290 scopus 로고    scopus 로고
    • Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer
    • von Minckwitz G, Schwedler K, Schmidt M et al. Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer. Eur J Cancer. 2011;47:2273-81.
    • (2011) Eur J Cancer , vol.47 , pp. 2273-2281
    • Von Minckwitz, G.1    Schwedler, K.2    Schmidt, M.3
  • 17
    • 62449338902 scopus 로고    scopus 로고
    • Effects of food on the relative bioavailability of lapatinib in cancer patients
    • Koch KM, Reddy NJ, Cohen RB et al. Effects of food on the relative bioavailability of lapatinib in cancer patients. J Clin Oncol. 2009;27:1191-6.
    • (2009) J Clin Oncol , vol.27 , pp. 1191-1196
    • Koch, K.M.1    Reddy, N.J.2    Cohen, R.B.3
  • 18
    • 68949125530 scopus 로고    scopus 로고
    • Effects of food on bioavailability of lapatinib: Useful data, wrong conclusion
    • author reply e43
    • Tannock IF. Effects of food on bioavailability of lapatinib: useful data, wrong conclusion. J Clin Oncol. 2009;27:e42; author reply e43.
    • (2009) J Clin Oncol , vol.27
    • Tannock, I.F.1
  • 20
    • 82955163167 scopus 로고    scopus 로고
    • Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases
    • Lin NU, Eierman W, Greil R, et al. Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases. J Neurooncol. 2011.
    • (2011) J Neurooncol
    • Lin, N.U.1    Eierman, W.2    Greil, R.3
  • 21
    • 69849105168 scopus 로고    scopus 로고
    • Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as firstline treatment in HER2-negative or unknown metastatic breast cancer
    • Finn RS, Press MF, Dering J, et al. Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as firstline treatment in HER2-negative or unknown metastatic breast cancer. J Clin Oncol. 2009;27:3908-15.
    • (2009) J Clin Oncol , vol.27 , pp. 3908-3915
    • Finn, R.S.1    Press, M.F.2    Dering, J.3
  • 22
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen JJ, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol. 2009;27:5538-46.
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen, J.J.2    Pivot, X.3
  • 23
    • 57149096463 scopus 로고    scopus 로고
    • Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
    • Di Leo A, Gomez HL, Aziz Z, et al. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol. 2008;26:5544-52.
    • (2008) J Clin Oncol , vol.26 , pp. 5544-5552
    • Di Leo, A.1    Gomez, H.L.2    Aziz, Z.3
  • 24
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM et al. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010;28:1124-30.
    • (2010) J Clin Oncol , vol.28 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 25
    • 66149093901 scopus 로고    scopus 로고
    • Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: Final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study
    • Kaufman B, Trudeau M, Awada A, et al. Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study. Lancet Oncol. 2009;10:581-8.
    • (2009) Lancet Oncol , vol.10 , pp. 581-588
    • Kaufman, B.1    Trudeau, M.2    Awada, A.3
  • 26
    • 61649118623 scopus 로고    scopus 로고
    • Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- Or second-line trastuzumab-containing regimens
    • Blackwell KL, Pegram MD, Tan-Chiu E, et al. Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumab-containing regimens. Ann Oncol. 2009;20:1026-31.
    • (2009) Ann Oncol , vol.20 , pp. 1026-1031
    • Blackwell, K.L.1    Pegram, M.D.2    Tan-Chiu, E.3
  • 27
    • 77954745034 scopus 로고    scopus 로고
    • Phase II study to evaluate the efficacy and safety of neoadjuvant lapatinib plus paclitaxel in patients with inflammatory breast cancer
    • Boussen H, Cristofanilli M, Zaks T, DeSilvio M, Salazar V, Spector N. Phase II study to evaluate the efficacy and safety of neoadjuvant lapatinib plus paclitaxel in patients with inflammatory breast cancer. J Clin Oncol. 2010;28:3248-55.
    • (2010) J Clin Oncol , vol.28 , pp. 3248-3255
    • Boussen, H.1    Cristofanilli, M.2    Zaks, T.3    DeSilvio, M.4    Salazar, V.5    Spector, N.6
  • 28
    • 79251587195 scopus 로고    scopus 로고
    • Integrating bevacizumab, everolimus, and lapatinib into current neoadjuvant chemotherapy regimen for primary breast cancer. Safety results of the GeparQuinto trial
    • von Minckwitz G, Eidtmann H, Loibl S, et al. Integrating bevacizumab, everolimus, and lapatinib into current neoadjuvant chemotherapy regimen for primary breast cancer. Safety results of the GeparQuinto trial. Ann Oncol. 2011;22:301-6.
    • (2011) Ann Oncol , vol.22 , pp. 301-306
    • Von Minckwitz, G.1    Eidtmann, H.2    Loibl, S.3
  • 29
    • 79951997890 scopus 로고    scopus 로고
    • Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers
    • Dave B, Migliaccio I, Gutierrez MC, et al. Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers. J Clin Oncol. 2011;29:166-73.
    • (2011) J Clin Oncol , vol.29 , pp. 166-173
    • Dave, B.1    Migliaccio, I.2    Gutierrez, M.C.3
  • 30
    • 80051578430 scopus 로고    scopus 로고
    • Neuregulin- 1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers
    • Wilson TR, Lee DY, Berry L, Shames DS, Settleman J. Neuregulin- 1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell. 2011;20:158-72.
    • (2011) Cancer Cell , vol.20 , pp. 158-172
    • Wilson, T.R.1    Lee, D.Y.2    Berry, L.3    Shames, D.S.4    Settleman, J.5
  • 31
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol. 2010;28:1138-44.
    • (2010) J Clin Oncol , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 32
    • 79952274439 scopus 로고    scopus 로고
    • Neoadjuvant pertuzumab and trastuzumab: Antitumor safety analysis of a randomized phase II study ('Neosphere')
    • abstr S3-2
    • Gianni L, Pienkowski T, Im YH, et al. Neoadjuvant pertuzumab and trastuzumab: antitumor safety analysis of a randomized phase II study ('Neosphere'). SABCS. 2010; abstr S3-2.
    • (2010) SABCS
    • Gianni, L.1    Pienkowski, T.2    Im, Y.H.3
  • 33
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J, Cortes J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012;366:109-19.
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortes, J.2    Kim, S.B.3
  • 34
    • 77950497981 scopus 로고    scopus 로고
    • Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2- Positive breast cancer
    • Burstein HJ, Sun Y, Dirix LY, et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2- positive breast cancer. J Clin Oncol. 2010;28:1301-7.
    • (2010) J Clin Oncol , vol.28 , pp. 1301-1307
    • Burstein, H.J.1    Sun, Y.2    Dirix, L.Y.3
  • 35
    • 79960985354 scopus 로고    scopus 로고
    • HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
    • Modi S, Stopeck A, Linden H, et al. HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res. 2011;17:5132-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 5132-5139
    • Modi, S.1    Stopeck, A.2    Linden, H.3
  • 36
    • 79960983010 scopus 로고    scopus 로고
    • Why is this effective HSP90 inhibitor not being developed in HER2+ breast cancer?
    • Arteaga CL. Why is this effective HSP90 inhibitor not being developed in HER2+ breast cancer? Clin Cancer Res. 2011;17:4919-21.
    • (2011) Clin Cancer Res , vol.17 , pp. 4919-4921
    • Arteaga, C.L.1
  • 38
    • 79951841310 scopus 로고    scopus 로고
    • Exploratory subset analysis according to prior endocrine treatment of two randomized phase II trials comparing gefitinib with placebo in combination with tamoxifen or anastrozole in hormone receptor positive metastatic breast cancer
    • abstr 1014
    • Cristofanilli M SRVV, et al. Exploratory subset analysis according to prior endocrine treatment of two randomized phase II trials comparing gefitinib with placebo in combination with tamoxifen or anastrozole in hormone receptor positive metastatic breast cancer. J Clin Oncol. 2009;27:suppl; abstr 1014.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Cristofanilli, M.S.R.V.V.1
  • 39
    • 84860389233 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: Possible implications for targeted therapy
    • Teng YH, Tan WJ, Thike AA, et al. Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy. Breast Cancer Res. 2011;13:R35.
    • (2011) Breast Cancer Res , vol.13
    • Teng, Y.H.1    Tan, W.J.2    Thike, A.A.3
  • 40
    • 34447106387 scopus 로고    scopus 로고
    • Phase III study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer
    • abstr 6091
    • Chow LSY JJ, Baselga J, et al. Phase III study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer. Breast Cancer Res Treat. 2006;97:suppl; abstr 6091.
    • (2006) Breast Cancer Res Treat , vol.97 , Issue.SUPPL.
    • Chow, L.S.Y.J.J.1    Baselga, J.2
  • 41
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P, et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol. 2009;27:2630-7.
    • (2009) J Clin Oncol , vol.27 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    Van Dam, P.3
  • 42
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. New Engl J Med. 2012;366:520-9.
    • (2012) New Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 43
    • 80052505248 scopus 로고    scopus 로고
    • Src: A potential target for the treatment of triple-negative breast cancer
    • Tryfonopoulos D, Walsh S, Collins DM, et al. Src: a potential target for the treatment of triple-negative breast cancer. Ann Oncol. 2011;22:2234-40.
    • (2011) Ann Oncol , vol.22 , pp. 2234-2240
    • Tryfonopoulos, D.1    Walsh, S.2    Collins, D.M.3
  • 44
    • 80052860747 scopus 로고    scopus 로고
    • Phase II trial of dasatinib in patients with metastatic breast cancer using real-time pharmacodynamic tissue biomarkers of Src inhibition to escalate dosing
    • Herold CI, Chadaram V, Peterson BL, et al. Phase II trial of dasatinib in patients with metastatic breast cancer using real-time pharmacodynamic tissue biomarkers of Src inhibition to escalate dosing. Clin Cancer Res. 2011;17:6061-70.
    • (2011) Clin Cancer Res , vol.17 , pp. 6061-6070
    • Herold, C.I.1    Chadaram, V.2    Peterson, B.L.3
  • 45
    • 84857546448 scopus 로고    scopus 로고
    • Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy
    • AOP doi:10.1093/annonc/mdr261
    • Campone M, Bondarenko I, Brincat S, et al. Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy. Ann Oncol. 2011 AOP doi:10.1093/annonc/mdr261.
    • (2011) Ann Oncol
    • Campone, M.1    Bondarenko, I.2    Brincat, S.3
  • 46
    • 80052168685 scopus 로고    scopus 로고
    • The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
    • Helleday T. The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings. Mol Oncol. 2011;5:387-93.
    • (2011) Mol Oncol , vol.5 , pp. 387-393
    • Helleday, T.1
  • 47
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of "BRCAness" in sporadic cancers
    • Turner N, Tutt A, Ashworth A. Hallmarks of "BRCAness" in sporadic cancers. Nat Rev Cancer. 2004;4:814-9.
    • (2004) Nat Rev Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 48
    • 79957562586 scopus 로고    scopus 로고
    • CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/ triple-negative breast cancer
    • Stefansson OA, Jonasson JG, Olafsdottir K, et al. CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/ triple-negative breast cancer. Epigenetics. 2011;6:638-49.
    • (2011) Epigenetics , vol.6 , pp. 638-649
    • Stefansson, O.A.1    Jonasson, J.G.2    Olafsdottir, K.3
  • 49
    • 79960150694 scopus 로고    scopus 로고
    • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
    • Johnson N, Li YC, Walton ZE, et al. Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med. 2011;17:875-82.
    • (2011) Nat Med , vol.17 , pp. 875-882
    • Johnson, N.1    Li, Y.C.2    Walton, Z.E.3
  • 50
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med. 2011;364:205-14.
    • (2011) N Engl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.E.3
  • 51
    • 80052330662 scopus 로고    scopus 로고
    • A randomized phase III study of iniparib in combination with gemcitabine/carboplatin in metastatic triple-negative breast cancer
    • abstr 1007
    • O'Shaughnessy J, Schwartzberg LS, Danso MA, et al. A randomized phase III study of iniparib in combination with gemcitabine/carboplatin in metastatic triple-negative breast cancer. J Clin Oncol. 2011;29:suppl;abstr 1007.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • O'Shaughnessy, J.1    Schwartzberg, L.S.2    Danso, M.A.3
  • 52
    • 80052535308 scopus 로고    scopus 로고
    • PARP inhibitors stumble in breast cancer
    • Guha M. PARP inhibitors stumble in breast cancer. Nat Biotechnol. 2011;29:373-4.
    • (2011) Nat Biotechnol , vol.29 , pp. 373-374
    • Guha, M.1
  • 53
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet. 2010;376:235-44.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 54
    • 79957940705 scopus 로고    scopus 로고
    • Cytoplasmic poly(adenosine diphosphate-ribose) polymerase expression is predictive and prognostic in patients with breast cancer treated with neoadjuvant chemotherapy
    • von Minckwitz G, Muller BM, Loibl S, et al. Cytoplasmic poly(adenosine diphosphate-ribose) polymerase expression is predictive and prognostic in patients with breast cancer treated with neoadjuvant chemotherapy. J Clin Oncol. 2011;29:2150-7.
    • (2011) J Clin Oncol , vol.29 , pp. 2150-2157
    • Von Minckwitz, G.1    Muller, B.M.2    Loibl, S.3
  • 55
  • 56
    • 80051642095 scopus 로고    scopus 로고
    • Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
    • Norquist B, Wurz KA, Pennil CC, et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol. 2011;29:3008-15.
    • (2011) J Clin Oncol , vol.29 , pp. 3008-3015
    • Norquist, B.1    Wurz, K.A.2    Pennil, C.C.3
  • 57
    • 84856291930 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer
    • von Minckwitz G, Eidtmann H, Rezai M, et al. Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer. N Engl J Med. 2012;366:299-309.
    • (2012) N Engl J Med , vol.366 , pp. 299-309
    • Von Minckwitz, G.1    Eidtmann, H.2    Rezai, M.3
  • 58
    • 84856253589 scopus 로고    scopus 로고
    • Bevacizumab added to neoadjuvant chemotherapy for breast cancer
    • Bear HD, Tang G, Rastogi P, et al. Bevacizumab added to neoadjuvant chemotherapy for breast cancer. N Engl J Med. 2012;366:310-20.
    • (2012) N Engl J Med , vol.366 , pp. 310-320
    • Bear, H.D.1    Tang, G.2    Rastogi, P.3
  • 59
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007;357:2666-76.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 60
    • 73349120007 scopus 로고    scopus 로고
    • Independent review of E2100: A phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer
    • Gray R, Bhattacharya S, Bowden C, Miller K, Comis RL. Independent review of E2100: a phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer. J Clin Oncol. 2009;27:4966-72.
    • (2009) J Clin Oncol , vol.27 , pp. 4966-4972
    • Gray, R.1    Bhattacharya, S.2    Bowden, C.3    Miller, K.4    Comis, R.L.5
  • 61
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol. 2010;28:3239-47.
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 62
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, doubleblind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Dieras V, Glaspy J, et al. RIBBON-1: randomized, doubleblind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol. 2011;29:1252-60.
    • (2011) J Clin Oncol , vol.29 , pp. 1252-1260
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3
  • 63
    • 82455199216 scopus 로고    scopus 로고
    • Final overall survival results and effect of prolonged (>/=1 year) first-line bevacizumab-containing therapy for metastatic breast cancer in the ATHENA trial
    • Smith I, Pierga JY, Biganzoli L, et al. Final overall survival results and effect of prolonged (>/=1 year) first-line bevacizumab-containing therapy for metastatic breast cancer in the ATHENA trial. Breast Cancer Res Treat. 2011;130:133-43.
    • (2011) Breast Cancer Res Treat , vol.130 , pp. 133-143
    • Smith, I.1    Pierga, J.Y.2    Biganzoli, L.3
  • 64
    • 79952083872 scopus 로고    scopus 로고
    • Congestive heart failure risk in patients with breast cancer treated with bevacizumab
    • Choueiri TK, Mayer EL, Je Y, et al. Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol. 2011;29:632-8.
    • (2011) J Clin Oncol , vol.29 , pp. 632-638
    • Choueiri, T.K.1    Mayer, E.L.2    Je, Y.3
  • 65
    • 80052428282 scopus 로고    scopus 로고
    • First-line bevacizumab-containing therapy for breast cancer: Results in patients aged >=70 years treated in the ATHENA study
    • Biganzoli L, Di Vincenzo E, Jiang Z, et al. First-line bevacizumab-containing therapy for breast cancer: results in patients aged >=70 years treated in the ATHENA study. Ann Oncol. 2012;23:111-8.
    • (2012) Ann Oncol , vol.23 , pp. 111-118
    • Biganzoli, L.1    Di Vincenzo, E.2    Jiang, Z.3
  • 66
    • 79955851306 scopus 로고    scopus 로고
    • Prospective analysis of the impact of VEGF-A gene polymorphisms on the pharmacodynamics of bevacizumab-based therapy in metastatic breast cancer patients
    • Etienne-Grimaldi MC, Formento P, Degeorges A, et al. Prospective analysis of the impact of VEGF-A gene polymorphisms on the pharmacodynamics of bevacizumab-based therapy in metastatic breast cancer patients. Br J Clin Pharmacol. 2011;71:921-8.
    • (2011) Br J Clin Pharmacol , vol.71 , pp. 921-928
    • Etienne-Grimaldi, M.C.1    Formento, P.2    Degeorges, A.3
  • 67
    • 79953196070 scopus 로고    scopus 로고
    • Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: A phase 2, randomised, double-blind, placebo-controlled study
    • Martin M, Roche H, Pinter T, et al. Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol. 2011;12:369-76.
    • (2011) Lancet Oncol , vol.12 , pp. 369-376
    • Martin, M.1    Roche, H.2    Pinter, T.3
  • 68
    • 80051713290 scopus 로고    scopus 로고
    • Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: A phase III, randomized, open-label trial
    • Robert NJ, Saleh MN, Paul D, et al. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial. Clin Breast Cancer. 2011;11:82-92.
    • (2011) Clin Breast Cancer , vol.11 , pp. 82-92
    • Robert, N.J.1    Saleh, M.N.2    Paul, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.