-
1
-
-
79957918070
-
Could pharma open its drug freezers?
-
A. Mullard Could pharma open its drug freezers? Nat. Rev. Drug Discov. 10 2011 399 400
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 399-400
-
-
Mullard, A.1
-
2
-
-
79957880949
-
Mining for the therapeutic gold
-
F.S. Collins Mining for the therapeutic gold Nat. Rev. Drug Discov. 10 2011 397
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 397
-
-
Collins, F.S.1
-
3
-
-
77649234756
-
How to improve R&D productivity: The pharmaceutical industry's grand challenge
-
S.M. Paul How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discov. 9 2010 203 214
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
-
4
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
M.J. Keiser Predicting new molecular targets for known drugs Nature 462 2009 175 181
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
-
5
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
J.A. DiMasi The price of innovation: new estimates of drug development costs J. Health Econ. 22 2003 185 251
-
(2003)
J. Health Econ.
, vol.22
, pp. 185-251
-
-
Dimasi, J.A.1
-
6
-
-
34547770279
-
New uses for old drugs
-
C.R. Chong, and D.J. Sullivan New uses for old drugs Nature 448 2007 645 646
-
(2007)
Nature
, vol.448
, pp. 645-646
-
-
Chong, C.R.1
Sullivan, D.J.2
-
7
-
-
6444221728
-
Are patents for methods of medical treatment contrary to the ordre public and morality or 'generally inconvenient'?
-
O. Minovetski, and D. Nicol Are patents for methods of medical treatment contrary to the ordre public and morality or 'generally inconvenient'? J. Med. Ethics 30 2004 470 477
-
(2004)
J. Med. Ethics
, vol.30
, pp. 470-477
-
-
Minovetski, O.1
Nicol, D.2
-
8
-
-
4344668661
-
Drug repositioning: Identifying and developing new uses for existing drugs
-
T.T. Ashburn, and K.B. Thor Drug repositioning: identifying and developing new uses for existing drugs Nat. Rev. Drug Discov. 3 2004 673 683
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
9
-
-
64149099072
-
Unpatentable drugs and the standards of patentability
-
B.N. Roin Unpatentable drugs and the standards of patentability Texas Law Rev. 87 2009 503 570
-
(2009)
Texas Law Rev.
, vol.87
, pp. 503-570
-
-
Roin, B.N.1
-
10
-
-
79960304811
-
Drug repurposing and adverse event prediction using high-throughput literature analysis
-
S.N. Deftereos Drug repurposing and adverse event prediction using high-throughput literature analysis Wiley Interdiscip. Rev. Syst. Biol. Med. 3 2011 323 334
-
(2011)
Wiley Interdiscip. Rev. Syst. Biol. Med.
, vol.3
, pp. 323-334
-
-
Deftereos, S.N.1
-
11
-
-
80052218993
-
Drug repositioning: Re-investigating existing drugs for new therapeutic indications
-
B.M. Padhy, and Y.K. Gupta Drug repositioning: re-investigating existing drugs for new therapeutic indications J. Postgrad. Med. 57 2011 153 160
-
(2011)
J. Postgrad. Med.
, vol.57
, pp. 153-160
-
-
Padhy, B.M.1
Gupta, Y.K.2
-
12
-
-
75749150877
-
Are patents impeding medical care and innovation?
-
E.R. Gold Are patents impeding medical care and innovation? PLoS Med. 7 2010 E1000208
-
(2010)
PLoS Med.
, vol.7
, pp. 1000208
-
-
Gold, E.R.1
-
13
-
-
68249134187
-
How much is life worth: Cetuximab, non-small cell lung cancer, and the $440 billion question
-
T. Fojo, and C. Grady How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question J. Natl Cancer Inst. 101 2009 1044 1048
-
(2009)
J. Natl Cancer Inst.
, vol.101
, pp. 1044-1048
-
-
Fojo, T.1
Grady, C.2
-
14
-
-
23044507037
-
Oxymoron no more: The potential of nonprofit drug companies to deliver on the promise of medicines for the developing world
-
V.G. Hale Oxymoron no more: the potential of nonprofit drug companies to deliver on the promise of medicines for the developing world Health Aff. (Millwood) 24 2005 1057 1063
-
(2005)
Health Aff. (Millwood)
, vol.24
, pp. 1057-1063
-
-
Hale, V.G.1
-
16
-
-
33745218506
-
Visceral leishmaniasis (kala-azar): Challenges ahead
-
R.K. Singh Visceral leishmaniasis (kala-azar): challenges ahead Indian J. Med. Res. 123 2006 331 344
-
(2006)
Indian J. Med. Res.
, vol.123
, pp. 331-344
-
-
Singh, R.K.1
-
17
-
-
77953227569
-
The economic impact of visceral leishmaniasis on rural households in one endemic district of Bihar, India
-
R. Sarnoff The economic impact of visceral leishmaniasis on rural households in one endemic district of Bihar, India Trop. Med. Int. Health 15 2010 42 49
-
(2010)
Trop. Med. Int. Health
, vol.15
, pp. 42-49
-
-
Sarnoff, R.1
-
18
-
-
34250717991
-
Injectable paromomycin for visceral leishmaniasis in India
-
S. Sundar Injectable paromomycin for visceral leishmaniasis in India N. Engl. J. Med. 356 2007 2571 2581
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 2571-2581
-
-
Sundar, S.1
-
19
-
-
78049520806
-
Antabuse (disulfiram) as a pilot case of nonprofit drug
-
B. Cvek Antabuse (disulfiram) as a pilot case of nonprofit drug Int. J. Cancer 127 2010 2486
-
(2010)
Int. J. Cancer
, vol.127
, pp. 2486
-
-
Cvek, B.1
-
20
-
-
79959709444
-
Antabuse repurposing: We need more knowledge and wide international support
-
(Epub ahead of print)
-
B. Cvek Antabuse repurposing: we need more knowledge and wide international support Int. J. Cancer 129 2011 1286 1287 (Epub ahead of print)
-
(2011)
Int. J. Cancer
, vol.129
, pp. 1286-1287
-
-
Cvek, B.1
-
21
-
-
79953131985
-
Cancer research and the $90 billion metaphor
-
E. Marshall Cancer research and the $90 billion metaphor Science 331 2011 1540 1541
-
(2011)
Science
, vol.331
, pp. 1540-1541
-
-
Marshall, E.1
-
22
-
-
38349038425
-
'Westernizing' women's risks? Breast cancer in low-income countries
-
P. Porter 'Westernizing' women's risks? Breast cancer in low-income countries N. Engl. J. Med. 358 2008 213 216
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 213-216
-
-
Porter, P.1
-
23
-
-
79953180043
-
Optimization of breast cancer management in low-resource and middle-resource countries: Executive summary of the Breast Health Global Initiative consensus 2010
-
B.O. Anderson Optimization of breast cancer management in low-resource and middle-resource countries: executive summary of the Breast Health Global Initiative consensus 2010 Lancet Oncol. 12 2011 387 398
-
(2011)
Lancet Oncol.
, vol.12
, pp. 387-398
-
-
Anderson, B.O.1
-
25
-
-
79955778144
-
Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm
-
P. Wicks Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm Nat. Biotechnol. 29 2011 411 414
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 411-414
-
-
Wicks, P.1
-
26
-
-
67149130229
-
Repurposing with a difference
-
M.S. Boguski Repurposing with a difference Science 324 2009 1394 1395
-
(2009)
Science
, vol.324
, pp. 1394-1395
-
-
Boguski, M.S.1
-
27
-
-
48149090212
-
The value of proteasome inhibition in cancer. Can the old drug, disulfiram, has a bright new future as a novel proteasome inhibitor?
-
B. Cvek, and Z. Dvorak The value of proteasome inhibition in cancer. Can the old drug, disulfiram, has a bright new future as a novel proteasome inhibitor? Drug Discov. Today 13 2008 716 722
-
(2008)
Drug Discov. Today
, vol.13
, pp. 716-722
-
-
Cvek, B.1
Dvorak, Z.2
-
28
-
-
79951688311
-
Targeting malignancies with disulfiram (Antabuse): Multidrug resistance, angiogenesis, and proteasome
-
B. Cvek Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome Curr. Cancer Drug Targets 11 2011 332 337
-
(2011)
Curr. Cancer Drug Targets
, vol.11
, pp. 332-337
-
-
Cvek, B.1
-
29
-
-
33744498923
-
The status of disulfiram: A half of a century later
-
J.J. Suh The status of disulfiram: a half of a century later J. Clin. Psychopharmacol. 26 2006 290 302
-
(2006)
J. Clin. Psychopharmacol.
, vol.26
, pp. 290-302
-
-
Suh, J.J.1
-
30
-
-
0018776608
-
Inhibition of N-n-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in rats by administration of disulfiram in the diet
-
C.C. Irving Inhibition of N-n-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in rats by administration of disulfiram in the diet Cancer Res. 39 1979 3040 3043
-
(1979)
Cancer Res.
, vol.39
, pp. 3040-3043
-
-
Irving, C.C.1
-
31
-
-
0020538526
-
The effect of disulfiram on the carcinogenecity of N-butyl-N-(3- carboxypropyl)nitrosamine in the rat
-
C.C. Irving The effect of disulfiram on the carcinogenecity of N-butyl-N-(3-carboxypropyl)nitrosamine in the rat Carcinogenesis 4 1983 617 620
-
(1983)
Carcinogenesis
, vol.4
, pp. 617-620
-
-
Irving, C.C.1
-
32
-
-
0023248392
-
Influence of disulfiram on the metabolism of the urinary bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine
-
C.C. Irving, and D.S. Daniel Influence of disulfiram on the metabolism of the urinary bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine Carcinogenesis 8 1987 1309 1315
-
(1987)
Carcinogenesis
, vol.8
, pp. 1309-1315
-
-
Irving, C.C.1
Daniel, D.S.2
-
33
-
-
33751285781
-
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
-
D. Chen Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity Cancer Res. 66 2006 10425 10433
-
(2006)
Cancer Res.
, vol.66
, pp. 10425-10433
-
-
Chen, D.1
-
34
-
-
54549114503
-
Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells
-
B. Cvek Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells J. Med. Chem. 51 2008 6256 6258
-
(2008)
J. Med. Chem.
, vol.51
, pp. 6256-6258
-
-
Cvek, B.1
-
35
-
-
0017338345
-
Spontaneous regression of breast cancer
-
E.F. Lewison Spontaneous regression of breast cancer Prog. Clin. Biol. Res. 12 1977 47 53
-
(1977)
Prog. Clin. Biol. Res.
, vol.12
, pp. 47-53
-
-
Lewison, E.F.1
-
36
-
-
0027336041
-
Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study
-
P. Dufour Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: a randomized study Biotherapy 6 1993 9 12
-
(1993)
Biotherapy
, vol.6
, pp. 9-12
-
-
Dufour, P.1
-
37
-
-
0019436936
-
The actions and metabolic fate of disulfiram
-
D.I. Eneanya The actions and metabolic fate of disulfiram Annu. Rev. Pharmacol. Toxicol. 21 1981 575 596
-
(1981)
Annu. Rev. Pharmacol. Toxicol.
, vol.21
, pp. 575-596
-
-
Eneanya, D.I.1
-
38
-
-
0020033519
-
Human aldehyde dehydrogenase: Mechanism of inhibition of disulfiram
-
R.C. Vallari, and R. Pietruszko Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram Science 216 1982 637 639
-
(1982)
Science
, vol.216
, pp. 637-639
-
-
Vallari, R.C.1
Pietruszko, R.2
-
39
-
-
0023679964
-
Randomized, double-blind, placebo-controlled trial of ditiocarb sodium (Imuthiol) in human immunodeficiency virus infection
-
J.M. Lang Randomized, double-blind, placebo-controlled trial of ditiocarb sodium (Imuthiol) in human immunodeficiency virus infection Lancet 332 1988 702 706
-
(1988)
Lancet
, vol.332
, pp. 702-706
-
-
Lang, J.M.1
-
40
-
-
0025361607
-
Inhibition of HIV progression by ditiocarb. German DTC study group
-
E.C. Reisinger Inhibition of HIV progression by ditiocarb. German DTC study group Lancet 335 1990 679 682
-
(1990)
Lancet
, vol.335
, pp. 679-682
-
-
Reisinger, E.C.1
-
41
-
-
0025844784
-
Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS. A randomized, double-blind, placebo-controlled, multicenter study
-
E.M. Hersh Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS. A randomized, double-blind, placebo-controlled, multicenter study JAMA 265 1991 1538 1544
-
(1991)
JAMA
, vol.265
, pp. 1538-1544
-
-
Hersh, E.M.1
-
42
-
-
67649101425
-
Failure of ditiocarb (diethyldithiocarbamate) therapy: Was diet the reason?
-
B. Cvek Failure of ditiocarb (diethyldithiocarbamate) therapy: was diet the reason? Curr. HIV Res. 7 2009 254
-
(2009)
Curr. HIV Res.
, vol.7
, pp. 254
-
-
Cvek, B.1
-
43
-
-
0030918876
-
The origin of an EPR signal observed in dithiocarbamate-loaded tissues. Copper(II)-dithiocarbamate complexes account for the narrow hyperfine lines
-
Y. Suzuki The origin of an EPR signal observed in dithiocarbamate-loaded tissues. Copper(II)-dithiocarbamate complexes account for the narrow hyperfine lines Biochim. Biophys. Acta 1335 1997 242 245
-
(1997)
Biochim. Biophys. Acta
, vol.1335
, pp. 242-245
-
-
Suzuki, Y.1
-
44
-
-
4644235752
-
Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
-
S.S. Brar Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease Mol. Cancer Ther. 3 2004 1049 1060
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1049-1060
-
-
Brar, S.S.1
|