Soluble ST2 as a diagnostic and prognostic marker for acute heart failure syndromes

Open Biomarkers Journal

Volumn 5, Issue 1, 2012, Pages 1-8

  Henry Okafor, Queen ^a,b   Collins, Sean P ^c   Jenkins, Cathy A ^a   Miller, Karen F ^b   Maron, David J ^a,b   Naftilan, Allen J ^a   Weintraub, Neal ^c   Fermann, Gregory J ^c   McPherson, John ^a   Menon, Santosh ^d   Sawyer, Douglas B ^a   Storrow, Alan B ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d CHRIST HOSPITAL   (United States)

Author keywords

Acute heart failure; Diagnosis; Prognosis; Soluble ST2

Indexed keywords

ACETYLSALICYLIC ACID; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; INTERLEUKIN 1 RECEPTOR; PROTEIN ST2; STEROID; UNCLASSIFIED DRUG;

ACUTE HEART FAILURE; ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FRAMINGHAM RISK SCORE; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; TERTIARY HEALTH CARE;

EID: 84860675846     PISSN: None     EISSN: 18753183     Source Type: Journal    
DOI: 10.2174/1875318301205010001     Document Type: Article

References (28)

1. Flaherty JD, Bax JJ, De Luca L, et al. Acute heart failure syndromes in patients with coronary artery disease early assessment and treatment. J Am Coll Cardiol 2009; 53(3): 254-263.
2. Gheorghiade M, Zannad F, Sopko G, et al. Acute heart failure syndromes: current state and framework for future research. Circulation 2005; 112(25): 3958-3968.
3. Braunwald E. Biomarkers in heart failure. N Engl J Med 2008; 358(20): 2148-2159.
4. Lee DS, Vasan RS. Novel markers for heart failure diagnosis and prognosis. Curr Opin Cardiol 2005; 20(3): 201-210.
5. Kieser A, Goodnight J, Kolch W, Mischak H, Mushinski JF. Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes. FEBS Lett 1995; 372(2-3): 189-193.
6. Weinberg EO, Shimpo M, Hurwitz S, Tominaga S, Rouleau JL, Lee RT. Identification of serum soluble ST2 receptor as a novel heart failure biomarker. Circulation 2003; 107(5): 721-726.
7. Yanagisawa K, Tsukamoto T, Takagi T, Tominaga S. Murine ST2 gene is a member of the primary response gene family induced by growth factors. FEBS Lett 1992; 302(1): 51-53.
8. Kumar S, Minnich MD, Young PR. ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1. J Biol Chem 1995; 270(46): 27905-27913.
9. Kuroiwa K, Li H, Tago K, Iwahana H, et al. Construction of ELISA system to quantify human ST2 protein in sera of patients. Hybridoma 2000; 19(2): 151-159.
10. Pascual-Figal DA, Ordonez-Llanos J, Tornel PL, et al. Soluble ST2 for predicting sudden cardiac death in patients with chronic heart failure and left ventricular systolic dysfunction. J Am Coll Cardiol 2009; 54(23): 2174-2179.
11. Mulrow CD, Lucey CR, Farnett LE. Discriminating causes of dyspnea through clinical examination. J Gen Intern Med 1993; 8(7): 383-392.
12. Schmitt BP, Kushner MS, Wiener SL. The diagnostic usefulness of the history of the patient with dyspnea. J Gen Intern Med 1986; 1(6): 386-393.
13. Lindenfeld J, Albert NM, Boehmer JP, et al. HFSA 2010 Comprehensive Heart Failure Practice Guideline. J Card Fail 2010; 16(6): e1-e194.
14. Grantham JA, Borgeson DD, Burnett JC Jr. BNP: pathophysiological and potential therapeutic roles in acute congestive heart failure. Am J Physiol 1997; 272(4 Pt 2): R1077-R1083.
15. Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 2002; 347(3): 161-167.
16. Maisel AS, Peacock WF, Shah KS, et al. Acoustic cardiography S3 detection use in problematic subgroups and B-type natriuretic peptide gray zone: secondary results from the Heart failure and Audicor technology for Rapid Diagnosis and Initial Treatment Multinational Investigation. Am J Emerg Med 2011; 29(8): 924-931.
17. Harrell FE Jr. Design: Design Package. 2009: Available from: http://CRAN.R-project.org/package=Design.
18. Zeileis A, Hothorn T. Diagnostic checking in regression relationships. R News. 2002; 2(3): 7-10.
19. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria 2010; Available from: http: //www.R-project.org/.
20. Harrell FE Jr. Hmisc: Harrell Miscellaneous. 2010; Available from: http: //CRAN.R-project.org/package=Hmisc
21. Hamilton LC, Stata Corporation. Stata release 11. College Station (Tex.): Stata Press; 2009.
22. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics 1988; 44(3): 837-845.
23. Dieplinger B, Gegenhuber A, Haltmayer M, Mueller T. Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath. Heart 2009; 95(18): 1508-1513.
24. Mueller T, Dieplinger B, Gegenhuber A, Poelz W, Pacher R, Haltmayer M. Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure. Clin Chem 2008; 54(4): 752-756.
25. Januzzi JL Jr., Peacock WF, Maisel AS, et al. Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study. J Am Coll Cardiol 2007; 50(7): 607-613.
26. Boisot S, Beede J, Isakson S, et al. Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure. J Card Fail 2008; 14(9): 732-738.
27. Maisel A, Mehra MR. Understanding B-type natriuretic peptide and its role in diagnosing and monitoring congestive heart failure. Clin Cornerstone 2005; 7 (Suppl 1): S7-S17.
28. Maisel A, Mueller C, Adams K Jr, et al. State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail 2008; 10(9): 824-839.