Characterization and pharmacokinetics of coenzyme Q 10 nanoparticles prepared by a rapid expansion of supercritical solution process

Pharmazie

Volumn 67, Issue 2, 2012, Pages 161-167

  Meng, Xiangdong ^a   Zu, Yuangang ^a   Zhao, Xiuhua ^a   Li, Qingyong ^a   Jiang, Shougang ^a   Sang, Mei ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NANOPARTICLE; UBIDECARENONE; UBIDECARENONE NANOPARTICLE; UNCLASSIFIED DRUG; ANTIOXIDANT; DRUG DERIVATIVE; UBIQUINONE; WATER;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG SOLUBILITY; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NANOPHARMACEUTICS; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SCANNING ELECTRON MICROSCOPY; SUPERCRITICAL FLUID; X RAY DIFFRACTION; ANIMAL; ELECTROCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT; PARTICLE SIZE; RADIATION SCATTERING; SOLUBILITY; SOLUTION AND SOLUBILITY; SUPERCRITICAL FLUID CHROMATOGRAPHY; SURFACE PROPERTY; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, SUPERCRITICAL FLUID; ELECTROCHEMISTRY; LIGHT; MALE; MASS SPECTROMETRY; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, WISTAR; SCATTERING, RADIATION; SOLUBILITY; SOLUTIONS; SURFACE PROPERTIES; UBIQUINONE; WATER; X-RAY DIFFRACTION;

EID: 84860630115     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2012.1086     Document Type: Article

References (25)

1. Ana AM, Ana VMN, Teresa C, Catarina MMD (2004) Solubility of coenzyme Q10 in supercritical carbon dioxide. J Supercritical Fluids 28:201-206.
2. Ankola DD,Viswanad B, BhardwajV, Ramarao P,KumarMN(2007) Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: Can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? Eur J Pharm Biopharm 67: 361-369.
3. Byrappa K, Ohara S, Adschiri T (2008) Nanoparticles synthesis using supercritical fluid technology-towards biomedical applications. Adv Drug Deliv Rev 60: 299-327.
4. Charpentier PA, Jia M, Lucky RA (2008) Study of the RESS process for producing beclomethasone-17, 21-dipropionate particles suitable for pulmonary delivery, AAPS Pharm Sci Tech 9: 39-46.
5. Desai MP, Labhasetwar V, Amidon GL, Levy RJ (1996) Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res 13: 1838-1845.
6. Hatanaka J, Kimura Y, Lai-Fu Z, Onoue S, Yamada S (2008) Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q10 formulations. Int J Pharm 363: 112-117.
7. Gao XY, Nishimura K, Hirayama F, Arima H, Uekama K, Schmid G, Terao K, Nakata D, Fukumi H (2006) Enhanced dissolution and oral bioavailability of coenzyme Q10 in dogs by inclusion complexation with α-cyclodextrin. Asian J Pharm 1: 95-102.
8. Kang BK, Lee SJ, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH (2004) Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 274: 65-73.
9. Kobayashi Y, Ito S, Itai S, Yamamoto K (2000) Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate. Int J Pharm 193: 137-146.
10. Kommuru TR, Gurley B, Khan MA, Reddy IK (2001) Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm 212: 233-246.
11. Kwon SS, Nam YS, Lee JS, Ku BS, Han SH, Lee JY, Chang IS (2002) Preparation and characterization of coenzyme Q10-loaded PMMA nanoparticles by a newemulsification process based on microfluidization. J Colloids Surf A 210: 95-104.
12. Lee WC, Tsai TH (2010) Preparation and characterization of liposomal coenzyme Q10 for in vivo topical application. Int J Pharm 395: 78-83.
13. Li L, Pabbisetty D, Carvalho P, Avery MA, Avery BA (2008) Analysis of CoQ10 in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. J Pharma Biomed Analysis 46: 137-142.
14. Nehilla BJ, Bergkvist M, Popat KC, DesaiTA(2008) Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles. Int J Pharm 348: 107-114.
15. Nepal PR, Han HK, Choi HK (2010) Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation. Int J Pharm 383: 147-153.
16. Palamakula A, Khan MA (2004) Evaluation of cytotoxicity of oils used in coenzyme Q10 Self-Emulsifying Drug Delivery Systems (SEDDS). Int J Pharm 273: 63-73.
17. Pardeike J, Schwabe K, Müller RH (2010) Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect. Int J Pharm 396: 166-173.
18. Patravale VB, Date AA, Kulkarni RM (2004) Nanosuspensions: a promising drug delivery strategy. J Pharm Pharmacol 56: 827-840.
19. Pepe S, Marasco SF, Haas SJ, Sheeran FL, Krum H, Rosenfeldt FL (2007) Coenzyme Q10 in cardiovascular disease. Mitochondrion 7S: 154-167.
20. Teeranachaideekul V, Souto EB, Junyaprasert VB, Müller RH (2007) Cetyl palmitate-based NLC for topical delivery of Coenzyme Q10-Development, physicochemical characterization and in vitro release studies. Eur J Pharm Biopharm 67: 141-148.
21. Terao K, Nakata D, Fukumi H, Schmid G, Arima H, Hirayama F, Uekama K (2006) Enhancement of oral bioavailability of coenzyme Q10 by complexation with α-cyclodextrin in healthy adults. Nutr Res 26: 503-508.
22. Tian F, Sandler N. Aaltonen J, Lang C, Saville DJ, Gordon KC Strachan CJ, Rantanen J, Rades T (2007) Influence of polymorphic form, morphology, and excipient interactions on the dissolution of carbamazepine compacts. J Pharm Sci 96: 584-594.
23. Thanatuksorn P, Kawai K, Hayakawa M, Hayashi M, Kajiwara K (2009) Improvement of the oral bioavailability of coenzyme Q10 by emulsification with fats and emulsifiers used in the food industry. Food Sci Tech 42: 385-390.
24. Zhang J, Wang S (2009) Topical use of Coenzyme Q10-loaded liposomes coated with trimethyl chitosan:Tolerance, precorneal retention and anticataract effect. Int J Pharm 372: 66-75.
25. Zhang Y, Aberg F, Appelkvist EL, Dallner G, Ernster L (1995) Uptake of dietary coenzyme Q supplement is limited in rats. J Nutrition 125: 446-453.