Imaging of podocyte foot processes by fluorescence microscopy

Journal of the American Society of Nephrology

Volumn 23, Issue 5, 2012, Pages 785-791

  Grgic, Ivica ^a,b   Brooks, Craig R ^a   Hofmeister, Andreas F ^a,b   Bijol, Vanesa ^a   Bonventre, Joseph V ^a,c,d   Humphreys, Benjamin D ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CD31 ANTIGEN; HYDROXYTAMOXIFEN; NEPHRIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TAMOXIFEN;

ARTICLE; BOWMAN CAPSULE; FLUORESCENCE MICROSCOPY; GLOMERULAR FILTRATION BARRIER; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; SIGNAL NOISE RATIO; TRANSGENIC MOUSE;

EID: 84860606114     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011100988     Document Type: Article

References (25)

1. Wiggins RC: The spectrum of podocytopathies: A unifying view of glomerular diseases. Kidney Int 71: 1205-1214, 2007
2. Shirato I: Podocyte process effacement in vivo. Microsc Res Tech 57: 241-246, 2002
3. Andrews P: Morphological alterations of the glomerular (visceral) epithelium in response to pathological and experimental situations. J Electron Microsc Tech 9: 115-144, 1988
4. Peti-Peterdi J, Toma I, Sipos A, Vargas SL: Multiphoton imaging of renal regulatory mechanisms. Physiology (Bethesda) 24: 88-96, 2009
5. Patterson G, Davidson M, Manley S, Lippincott-Schwartz J: Superresolution imaging using single-molecule localization. Annu Rev Phys Chem 61: 345-367, 2010
6. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA, Brenner DA, Breindl M: Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Gene Expr 8: 151-163, 1999 (Pubitemid 30013568)
7. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M, Brenner DA, Rippe RA: DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology 37: 267-276, 2003 (Pubitemid 36152525)
8. Lin SL, Kisseleva T, Brenner DA, Duffield JS: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173: 1617-1627, 2008
9. Soriano P: Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71, 1999
10. Muzumdar MD, Tasic B, Miyamichi K, Li L, Luo L: A global double-fluorescent Cre reporter mouse. Genesis 45: 593-605, 2007 (Pubitemid 350013057)
11. Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, Gu H, Ng LL, Palmiter RD, Hawrylycz MJ, Jones AR, Lein ES, Zeng H: A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13: 133-140, 2010
12. Yamada E: The fine structure of the renal glomerulus of the mouse. J Histochem Cytochem 3: 309, 1955
13. Seiler MW, Venkatachalam MA, Cotran RS: Glomerular epithelium: Structural alterations induced by polycations. Science 189: 390-393, 1975
14. Kerjaschki D: Polycation-induced dislocation of slit diaphragms and formation of cell junctions in rat kidney glomeruli: The effects of low temperature, divalent cations, colchicine, and cytochalasin B. Lab Invest 39: 430-440, 1978
15. Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, Reiser J, Mundel P: Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J Clin Invest 115: 1188-1198, 2005 (Pubitemid 40629037)
16. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB: Nephrin ectodomain engagement results in Src kinase activation,nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 116: 1346-1359, 2006
17. Garg P, Verma R, Cook L, Soofi A, Venkatareddy M, George B, Mizuno K, Gurniak C, Witke W, Holzman LB: Actindepolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture. J Biol Chem 285: 22676-22688, 2010
18. Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, Elger M, Kriz W, Floege J, Moeller MJ: Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 20: 333-343, 2009
19. Sagrinati C, Netti GS, Mazzinghi B, Lazzeri E, Liotta F, Frosali F, Ronconi E, Meini C, Gacci M, Squecco R, Carini M, Gesualdo L, Francini F, Maggi E, Annunziato F, Lasagni L, Serio M, Romagnani S, Romagnani P: Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol 17: 2443-2456, 2006 (Pubitemid 44300960)
20. Ohse T, Vaughan MR, Kopp JB, Krofft RD, Marshall CB, Chang AM, Hudkins KL, Alpers CE, Pippin JW, Shankland SJ: De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease. Am J Physiol Renal Physiol 298: F702-F711, 2010
21. Lazzeri E, Mazzinghi B, Romagnani P: Regeneration and the kidney. Curr Opin Nephrol Hypertens 19: 248-253, 2010
22. Pleniceanu O, Harari-Steinberg O, Dekel B: Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram? Stem Cells 28: 1649-1660, 2010
23. Sugimoto H, Mundel TM, Sund M, Xie L, Cosgrove D, Kalluri R: Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci USA 103: 7321-7326, 2006 (Pubitemid 43727831)
24. Prodromidi EI, Poulsom R, Jeffery R, Roufosse CA, Pollard PJ, Pusey CD, Cook HT: Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells 24: 2448-2455, 2006 (Pubitemid 44674305)
25. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV: Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2: 284-291, 2008 (Pubitemid 351298594)