Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 3, 2012, Pages 1512-1518

  Vandermeid, Karl R ^a   Su, Stephanie P ^a   Ward, Keith W ^a   Zhang, Jin Zhong ^a  

^a BAUSCH AND LOMB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GELATINASE A; GELATINASE B; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE; STROMELYSIN 2; TUMOR NECROSIS FACTOR ALPHA; DIAGNOSTIC AGENT; EYE PROTEIN; TEAR PROTEINS;

ADULT; ARTICLE; CORRELATIONAL STUDY; DIAGNOSTIC TEST; DRY EYE; FEMALE; HUMAN; LACRIMAL FLUID; MALE; NORMAL HUMAN; OCULAR SURFACE DISEASE INDEX; OSMOLARITY; PRIORITY JOURNAL; QUESTIONNAIRE; SCHIRMER TEST; TEAR BREAKUP TIME; TEAR OSMOLARITY; TEST STRIP; ANALYSIS OF VARIANCE; METABOLISM; MIDDLE AGED; VISUAL SYSTEM EXAMINATION;

ADULT; ANALYSIS OF VARIANCE; CYTOKINES; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DRY EYE SYNDROMES; EYE PROTEINS; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; OSMOLAR CONCENTRATION; REAGENT STRIPS; TEARS;

EID: 84860580697     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7627     Document Type: Article

References (50)

1. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res. 1999;19:201-211.
2. Zoukhri D. Effect of inflammation on lacrimal gland function. Exp Eye Res. 2006;82:885-898.
3. Lema I, Sobrino T, Duran JA, Brea D, Diez-Feijoo E. Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol. 2009;93:820-824.
4. Acera A, Rocha G, Vecino E, Lema I, Duran JA. Inflammatory markers in the tears of patients with ocular surface disease. Ophthalmic Res. 2008;40:315-321.
5. Massingale ML, Li X, Vallabhajosyula M, Chen D, Wei Y, Asbell PA. Analysis of inflammatory cytokines in the tears of dry eye patients. Cornea. 2009;28:1023-1027.
6. Enriquez-de-Salamanca A, Castellanos E, Stern ME, et al. Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease. Mol Vis. 2010;16:862-873.
7. Vignali DA. Multiplexed particle-based flow cytometric assays. J Immunol Methods. 2000;243:243-255.
8. LaFrance MW, Kehinde LE, Fullard RJ. Multiple cytokine analysis in human tears: an optimized procedure for cytometric bead-based assay. Curr Eye Res. 2008;33:525-544.
9. Green-Church KB, Nichols KK, Kleinholz NM, Zhang L, Nichols JJ. Investigation of the human tear film proteome using multiple proteomic approaches. Mol Vis. 2008;14:456-470.
10. Li K, Chen Z, Duan F, Liang J, Wu K. Quantification of tear proteins by SDS-PAGE with an internal standard protein: a new method with special reference to small volume tears. Graefes Arch Clin Exp Ophthalmol. 2010;248:853-862.
11. Zhou L, Beuerman RW, Chan CM, et al. Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J Proteome Res. 2009;8:4889-4905.
12. Srinivasan S, Joyce E, Boone A, Simpson T, Jones L, Senchyna M. Tear lipocalin and lysozyme concentrations in postmenopausal women. Ophthalmic Physiol Opt. 2010;30:257-266.
13. Pokharel S, Shah DN, Joshi SN, Choudhary M. Tearfilm immunoglobulin E (IgE) level in vernal keratoconjunctivitis by ELISA. Kathmandu Univ Med J (KUMJ). 2009;7:104-108.
14. Sack RA, Sathe S, Beaton A, et al. Is the cystatin-like domain of TSL functionally active in external ocular infections and during the normal diurnal cycle? Exp Eye Res. 2004;78:371-378.
15. Esmaeelpour M, Cai J, Watts P, Boulton M, Murphy PJ. Tear sample collection using cellulose acetate absorbent filters. Ophthalmic Physiol Opt. 2008;28:577-583.
16. Argueso P, Balaram M, Spurr-Michaud S, Keutmann HT, Dana MR, Gipson IK. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome. Invest Ophthalmol Vis Sci. 2002;43:1004-1011.
17. Leonardi A, Sathe S, Bortolotti M, Beaton A, Sack R. Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients. Allergy. 2009;64:710-717.
18. Smith VA, Rishmawi H, Hussein H, Easty DL. Tear film MMP accumulation and corneal disease. Br J Ophthalmol. 2001;85:147-153.
19. Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009;147:198-205.
20. Narayanan S, Miller WL, McDermott AM. Conjunctival cytokine expression in symptomatic moderate dry eye subjects. Invest Ophthalmol Vis Sci. 2006;47:2445-2450.
21. dupont NC, Wang K, Wadhwa PD, Culhane JF, Nelson EL. Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants. J Reprod Immunol. 2005;66:175-191.
22. Cavet ME, Harrington KL, VanDerMeid KR, Ward KW, Zhang JZ. Comparison of the effect of multipurpose contact lens solutions on the viability of cultured corneal epithelial cells. Cont Lens Anterior Eye. 2009;32:171-175.
23. Zhang JZ, Cavet ME, VanDerMeid KR, Salvador-Silva M, Lopez FJ, Ward KW. BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells. Mol Vis. 2009;15:2606-2616.
24. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:75-92.
25. Yoon KC, Jeong IY, Park YG, Yang SY. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea. 2007;26:431-437.
26. Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol. 2000;118:615-621.
27. VanDerMeid KR, Su SP, Krenzer KL, Ward KW, Zhang JZ. A method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using Luminex. Mol Vis. 2011;17: 1056-1063.
28. Shoji J, Kitazawa M, Inada N, et al. Efficacy of tear eosinophil cationic protein level measurement using filter paper for diagnosing allergic conjunctival disorders. Jpn J Ophthalmol. 2003;47:64-68.
29. Morgan E, Varro R, Sepulveda H, et al. Cytometric bead array: a multiplexed assay platform with applications in various areas of biology. Clin Immunol. 2004;110:252-266.
30. Begley CG, Chalmers RL, Abetz L, et al. The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci. 2003;44:4753-4761.
31. Kallarackal GU, Ansari EA, Amos N, Martin JC, Lane C, Camilleri JP. A comparative study to assess the clinical use of Fluorescein Meniscus Time (FMT) with Tear Break up Time (TBUT) and Schirmer's tests (ST) in the diagnosis of dry eyes. Eye. 2002;16:594-600.
32. Saleh TA, McDermott B, Bates AK, Ewings P. Phenol red thread test vs Schirmer's test: a comparative study. Eye. 2006;20:913-915.
33. Moore JE, Graham JE, Goodall EA, et al. Concordance between common dry eye diagnostic tests. Br J Ophthalmol. 2009;93:66-72.
34. Nichols KK, Nichols JJ, Mitchell GL. The lack of association between signs and symptoms in patients with dry eye disease. Cornea. 2004;23:762-770.
35. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995;21:221-232.
36. Mishima S, Gasset A, Klyce SD Jr, Baum JL. Determination of tear volume and tear flow. Invest Ophthalmol. 1966;5:264-276.
37. Scherz W, Dohlman CH. Is the lacrimal gland dispensable? Keratoconjunctivitis sicca after lacrimal gland removal. Arch Ophthalmol. 1975;93:281-283.
38. Fox RI, Kang HI. Pathogenesis of Sjogren's syndrome. Rheum Dis Clin North Am. 1992;18:517-538.
39. Fox RI, Stern M. Sjogren's syndrome: mechanisms of pathogenesis involve interaction of immune and neurosecretory systems. Scand J Rheumatol Suppl. 2002;116:3-13.
40. Barka T, Asbell PA, van der Noen H, Prasad A. Cystatins in human tear fluid. Curr Eye Res. 1991;10:25-34.
41. Inada N, Shoji J, Hoshino M, Sawa M. Evaluation of total and allergen-specific secretory IgA in tears of allergic conjunctival disease patients. Jpn J Ophthalmol. 2007;51:338-342.
42. Paterson CA, O'Rourke MC. Vitamin C levels in human tears. Arch Ophthalmol. 1987;105:376-377.
43. Nakamura Y, Sotozono C, Kinoshita S. Inflammatory cytokines in normal human tears. Curr Eye Res. 1998;17:673-676.
44. Stuchell RN, Feldman JJ, Farris RL, Mandel ID. The effect of collection technique on tear composition. Invest Ophthalmol Vis Sci. 1984;25:374-377.
45. Carreño E, Enriquez-de-Salamanca A, Tesón M, et al. Cytokine and chemokine levels in tears from healthy subjects. Acta Ophthalmol. 2010;88:e250-e258.
46. Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC. Proand anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001;42:2283-2292.
47. Ollivier FJ, Brooks DE, Van Setten GB, et al. Profiles of matrix metalloproteinase activity in equine tear fluid during corneal healing in 10 horses with ulcerative keratitis. Vet Ophthalmol. 2004; 7:397-405.
48. Sullivan BD, Whitmer D, Nichols KK, et al. An objective approach to dry eye disease severity. Invest Ophthalmol Vis Sci. 2010;51: 6125-6130.
49. Suzuki M, Massingale ML, Ye F, et al. Tear osmolarity as a biomarker for dry eye disease severity. Invest Ophthalmol Vis Sci. 2010;51:4557-4561.
50. Lemp MA, Bron AJ, Baudouin C, et al. Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol. 2011;151:792-798.