The elegance of the gastric mucosal barrier: Designed by nature for nature

Gut

Volumn 61, Issue 6, 2012, Pages 787-788

  McColl, Kenneth E L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; HISTAMINE H2 RECEPTOR ANTAGONIST; INTERLEUKIN 1; OMEPRAZOLE; PEPSIN A; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROTON; PROTON PUMP INHIBITOR;

ACID SECRETION; AUTOREGULATION; CHEMICAL ENVIRONMENT; COLUMNAR EPITHELIUM; DEFENSE MECHANISM; DIFFUSION; DIGESTION; DUODENUM; GASTRIC MUCOSAL BARRIER; HELICOBACTER PYLORI; HUMAN; METAPLASIA; NOTE; PRIORITY JOURNAL; PYLORUS; STOMACH ATROPHY; STOMACH FUNCTION; STOMACH JUICE; STOMACH MUCOSA; STOMACH MUCOSA INJURY; STOMACH MUCUS; STOMACH PARIETAL CELL; STOMACH PH; STOMACH PROTECTION; STOMACH ULCER; TISSUE REPAIR;

ANIMALS; FAMOTIDINE; FEMALE; GASTRIC ACID; MALE; OMEPRAZOLE; STOMACH; WOUND HEALING;

EID: 84860575722     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-301612     Document Type: Note

References (10)

1. Stadelmann O, Elster K, Stolte M, et al. The peptic gastric ulcer - histopographic and functional investigations. Scand J Gastroent 1971;6:613-23.
2. Allen A, Flemström G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 2005;288:C1-19.
3. Engel E, Guth PH, Nishizaki Y, et al. Barrier function of the gastric mucus gel. Am J Physiol 1995;32: G994-9. (Pubitemid 26023276)
4. Phillipson M, Atuma C, Henriksnäs J, et al. The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH. Am J Physiol Gastrointest Liver Physiol 2002;282: G211-19. (Pubitemid 34651676)
5. Laine L, Takeuchi K, Tarnawski A. Reviews in basic and clinical gastroenterology. Gastroenterology 2008;135:41-60.
6. Baumgartner HK, Montrose MH. Regulated alkali secretion acts in tandem with unstirred layers to regulate mouse gastric surface pH. Gastroenterology 2004;126:774-83. (Pubitemid 38298326)
7. Gannon B, Browning J, O'Brien P, et al. Mucosal microvascular architecture of the fundus and body of human stomach. Gastroenterology 1984;86:866-75. (Pubitemid 14132469)
8. Demitrack E, Aihara E, Montrose M. Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage. Gut 2012;61:804-11.
9. Wolfe MM, Nompleggi DJ. Cytokine inhibition of gastric acid secretionda little goes a long way. Gastroenterology 1992;102:2177-8.
10. Starodub OT, Demitrack ES, Baumgartner HK, et al. Disruption of the Cox-1 gene slows repair of microscopic lesions in the mouse gastric epithelium. Am J Physiol Cell Physiol 2008;294:C223-32.