Food Proteins or Their Hydrolysates as Regulators of Satiety

Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals

Volumn , Issue , 2010, Pages 135-148

  Foltz, Martin ^a   Portier, Mylene ^b   Tomé, Daniel ^b  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^b AGROPARISTECH   (France)

Author keywords

Energy expenditure and glucose metabolic signals in protein induced satiety; Food proteins or their hydrolysates as regulators of satiety; High protein preload and high protein meal induced satiety and food intake inhibition; Peripheral, gut derived satiety hormones; Plasma amino acids as central satiety signals; Protein induced satiety and central neuronal pathways; Protein induced satiety and food intake inhibition; Protein induced satiety mechanisms; Roles of protein sources and types in protein induced satiety; Satiety and food intake inhibition in high protein diets

Indexed keywords

EID: 84860568948     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780813811048.ch10     Document Type: Chapter

References (84)

1. Anderson GH, Li ET, Glanville NT. 1984. Brain mechanisms and the quantitative and qualitative aspects of food intake. Brain Research Bulletin 12: 167-173.
2. Anderson GH, Tecimer SN, Shah D, Zafar TA. 2004. Protein source, quantity, and time of consumption determine the effect of proteins on short-term food intake in young men. J Nutrition 134: 3011-3015.
3. Anderson J, Fuller J, Patterson K, Blair R, Tabor A. 2007. Soy compared to casein meal replacement shakes with energy-restricted diets for obese women: Randomized controlled trial. Metabolism 56 (2): 280-288.
4. Arciero PJ, Gentile CL, Pressman R, Everett M, Ormsbee MJ, Martin J, Santamore J, Gorman L, Fehling PC, Vukovich MD, Nindl BC. 2008. Moderate protein intake improves total and regional body composition and insulin sensitivity in overweight adults. Metabolism 57: 757-765.
5. Aziz A, Anderson GH. 2003. Exendin-4, a GLP-1 receptor agonist, interacts with proteins and their products of digestion to suppress food intake in rats. J Nutrition 133 (7): 2326-2330.
6. Azzout-Marniche D, Gaudichon C, Blouet C, Bos C, Mathé V, Huneau JF, Tomé D. 2007. Liver glyconeogenesis: A pathway to cope with postprandial amino acid excess in high-protein fed rats? Amer J Physiology-Regulatory, Integrative and Comparative Physiology 292: R1400-1407.
7. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Asckenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123: 493-505.
8. Bassil MS, Hwalla N, Obeid OA. 2007. Meal pattern of rats maintained on histidine-, leucine-, or tyrosine-supplemented diet. Obesity 15 (3): 623-626.
9. Bensaid A, Tomé D, Gietzen D, Even P, Morens C, Gausseres N, Fromentin G. 2002. Protein is more potent than carbohydrate for reducing appetite in rats. Physiology and Behavior 75: 577-582.
10. Bensaid A, Tomé D, L'Heureux-Bourdon D, Even P, Gietzen D, Morens C, Gaudichon C, Larue-Achagiotis C, Fromentin G. 2003. A high-protein diet enhances satiety without conditioned taste aversion in the rat. Physiology and Behavior 78: 311-320.
11. Bertenshaw EJ, Lluch A, Yeomans MR. 2008. Satiating effects of protein but not carbohydrate consumed in a between-meal beverage context. Physiology and Behavior 93: 427-436.
12. Beucher S, Levenez F, Yvon M, Corring T. 1994. Effects of gastric digestive products from casein on CCK release by intestinal cells in rats. J Nutritional Biochemistry 5: 578-594.
13. Blom WA, Lluch A, Stafleu A, Vinoy S, Holst JJ, Schaafsma G, Hendriks HF. 2006. Effect of a high-protein breakfast on the postprandial ghrelin response. Amer J Clinical Nutrition 83: 211-220.
14. Blundell JE, Latham CJ. 1978. Pharmacological manipulations of feeding behaviour: Possible influences of serotonin and dopamine on feeding behaviour. In: S Garattini, R Samanin, eds., Central Mechanisms of Anorectic Drugs, 41-80. New York: Raven Press.
15. Bowen J, Noakes M, Clifton PM. 2007. Appetite hormones and energy intake in obese men after consumption of fructose, glucose and whey protein beverages. Intl J Obesity (London) 31: 1696-1703.
16. Bowen J, Noakes M, Clifton PM. 2006a. Appetite regulatory hormone responses to various dietary proteins differ by body mass index status despite similar reductions in ad libitum energy intake. J Clinical Endocrinology and Metabolism 91: 2913-2919.
17. Bowen J, Noakes M, Trenerry C, Clifton PM. 2006b. Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men. J Clinical Endocrinology and Metabolism 91: 1477-1483.
18. Calbet JA, Holst JJ. 2004. Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptides hydrolysates in humans. Eur J Nutrition 43 (3): 127-139.
19. Chelikani PK, Haver AC, Reidelberger RD. 2005. Intravenous infusion of glucagonlike peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats. Amer J Physiology-Regulatory, Integrative and Comparative Physiology 288 (6): R1695-1706.
20. Choi S, Lee M, Shiu AL, Yo SJ, Aponte GW. 2007a. Identification of a protein hydrolysate responsive G protein-coupled receptors in enterocytes. Amer J Physiology-Gastrointestinal and Liver Physiology 292: G98-112.
21. Choi S, Lee M, Shiu AL, Yo SJ, Hallden G, Aponte GW. 2007b. GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Amer J Physiology-Gastrointestinal and Liver Physiology 292: G1366-1375.
22. Cordier-Bussat M, Bernard C, Haouche S, Roche C, Abello J, Chayvialle JA, Cuber JC. 1997. Peptones stimulates cholecystokinin secretion and gene transcription in the intestinal cells line STC-1. Endocrinology 138: 1137-1144.
23. Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. 2006. Hypothalamic mTOR signaling regulates food intake. Science 312: 927-930.
24. Covasa M, Ritter RC. 2001. Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors . Peptides 22: 1339-1348.
25. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ. 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411: 480-484.
26. Cummings DE, Overduin J. 2007. Gastrointestinal regulation of food intake. J Clinical Investigation 117: 13-23.
27. Darcel NP, Liou AP, Tomé D, Raybould HE. 2005. Activation of vagal afferents in the rat duodenum by protein digests requires PepT1. J Nutrition 135: 1491-1495.
28. Diepvens K, Häberer D, Westerterp-Plantenga M. 2008. Different proteins and biopeptides differently affect satiety and anorexigenic/ orexigenic hormones in healthy humans. Intl J Obesity 32: 510-518.
29. Douglas BR, Woutersen RA, Jansen JB, de Jong AJ, Lamers CB. 1988. The influence of different nutrients on plasma cholecystokinin levels in the rat. Experientia 44: 21-23.
30. Faipoux R, Tomé D, Gougis S, Darcel N, Fromentin G. 2008. Proteins activate satiety-related neuronal pathways in the brainstem and hypothalamus of rats. J Nutrition 138: 1172-1178.
31. Foltz M, Ansems P, Schwarz J, Tasker MC, Lourbakos A, Gerhardt CC. 2008. Protein hydrolysates induce CCK release from enteroendocrine cells and act as partial agonist of the CCK 1 receptor. J Agricultural and Food Chemistry 56: 837-843.
32. Froetschel MA, Azain MJ, Edwards GL, Barb CR, Amos HE. 2001. Opioid and cholecystokinin antagonists alleviate gastric inhibition of food intake by premeal loads of casein in meal-fed rats. J Nutrition 131 (12): 3270-3276.
33. Glatzle J, Kreis ME, Kawano K, Raybould HE, Zittel TT. 2001. Postprandial neuronal activation in the nucleus of the solitary tract is partly mediated by CCK-A receptors. Amer J Physiology 281: R222-229.
34. Häberer D, Tasker MC, Foltz M, Diepvens K, Geary N, Langhans W. Intragastric infusion of pea protein hydrolysate reduces test meal size more than pea protein in rats. Submitted for publication in Physiology and Behavior.
35. Habold C, Foltzer-Jourdainne C, Le Maho Y, Lignot JH, Oudart H. 2005. Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats. J Physiology 566: 575-586.
36. Hall WL, Millward DJ, Long SJ, Morgan LM. 2003. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutrition 89: 239-248.
37. Jean C, Rome S, Mathe V, Huneau JF, Aattouri N, Fromentin G, Achagiotis CL, Tomé D. 2001. Metabolic evidence for adaptation to a high protein diet in rats. J Nutrition 131: 91-98.
38. Johnson J, Vickers Z. 1993. Effects of flavor and macronutrient composition of food servings on liking, hunger and subsequent intake. Appetite 21: 25-39.
39. Johnstone AM, Horgan GW, Murison SD, Bremner DM, Lobley GE. 2008. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. Amer J Clinical Nutrition 87: 44-55.
40. Kasaoka S, Kawahara Y, Inoue S, Tsuji M, Kato H, Tsuchiya T, Okuda H, Nakajima S. 2005. Gender effects in dietary histidine-induced anorexia. Nutrition 21 (7-8): 855-858.
41. Kasaoka S, Tsuboyama-Kasaoka N, Kawahara Y, Inoue S, Tsuji M, Ezaki O, Kato H, Tsuchiya T, Okuda H, Nakajima S. 2004. Histidine supplementation suppresses food intake and fat accumulation in rats. Nutrition 20 (11-12): 991-966.
42. Kieffer TJ, Habener JF. 1999. The glucagon-like peptides. Endocrinology Review 20 (6): 876-913.
43. Kimura N, Tokunaga C, Dalal S, Richardson C, Yoshino K, Hara K, Kemp BE, Witters LA, Mimura O, Yonezawa K. 2003. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells 8: 65-79.
44. Kreymann B, Williams G, Ghatei MA, Bloom SR. 1987. Glucagon-like peptide-1 7-36: A physiological incretin in man. Lancet 2 (8571): 1300-1304.
45. Lang V, Bellisle F, Alamowitch C, Craplet C, Bornet FR, Slama G, Guy-Grand B. 1999. Varying the protein source in mixed meal modifies glucose, insulin and glucagon kinetics in healthy men, has weak effects on subjective satiety and fails to affect food intake. Eur J Clinical Nutrition 53 (12): 959-965.
46. Lang V, Bellisle F, Oppert JM, Craplet C, Bornet FR, Slama G, Guy-Grand B. 1998. Satiating effect of proteins in healthy subjects: A comparison of egg albumin, casein, gelatin, soy protein, pea protein, and wheat gluten. Amer J Clinical Nutrition 67: 1197-1204.
47. Leidy HJ, Carnell NS, Mattes RD, Campbell WW. 2007. Higher protein intake preserves lean mass and satiety with weight loss in pre-obese and obese women. Obesity (Silver Spring) 15: 421-429.
48. Lejeune MP, Westerterp KR, Adam TC, Luscombe-Marsh ND, Westerterp-Plantenga MS. 2006. Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Amer J Clinical Nutrition 83: 89-94.
49. L'Heureux-Bouron D, Tomé D, Rampin O, Even PC, Larue-Achagiotis C, Fromentin G. 2003. Total subdiaphragmatic vagotomy does not suppress high protein diet-induced food intake depression in rats. J Nutrition 133: 2639-2642.
50. Liddle RA. 1995. Regulation of cholecystokinin secretion by intraluminal releasing factors. Amer J Physiology 269: G319-327.
51. Little T, Horowitz M, Feinle-Bisset C. 2005. Role of cholecystokinin in appetite control and body weight regulation. Obesity Review 6: 297-306.
52. Marmonier C, Chapelot D, Fantino M, Louis-Sylvestre J. 2002. Snacks consumed in a nonhungry state have poor satiating efficiency: Influence of snack composition on substrate utilization and hunger. Amer J Clinical Nutrition 76 (3): 518-528.
53. Marmonier C, Chapelot D, Louis-Sylvestre J. 2000. Effects of macronutrient content and energy density of snacks consumed in a satiety state on the onset of the next meal. Appetite 34: 161-168.
54. Martin G, Ferrier B, Conjard A, Martin M, Nazaret R, Boghossian M, Saadé F, Mancuso C, Durozard D, Beverel G. 2007. Glutamine gluconeogenesis in the small intestine of 72 h-fasted adult rats is undetectable. Biochemical J 401: 465-473.
55. Meguid MM, Fetissov SO, Varma M, Sato T, Zhang L, Laviano A, Rossi-Fanelli F. 2000. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 16 (10): 843-857.
56. Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C, Rajas F, Zitoun C. 2005. Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein. Cell Metabolism 2: 321-329.
57. Mojsov S, Weir GC, Habener JF. 1987. Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clinical Invesigation 79 (2): 616-619.
58. Moran LJ, Luscombe-Marsh ND, Noakes M, Wittert GA, Keogh JB, Clifton PM. 2005. The satiating effect of dietary protein is unrelated to postprandial ghrelin secretion. J Clinical Endocrinology and Metabolism 90: 5205-5211.
59. Morrison CD, Xi X, White CL, Ye J, Martin RJ. 2007. Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism. Amer J Physiology-Endocrinology and Metabolism 293: E165-171.
60. Nauck MA, Niedereichholz U, Ettler R, Holst JJ, Orskov C, Ritzel R, Schmiegel WH. 1997. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Amer J Physiology 273 (5 Pt 1): E981-988.
61. Nemoz-Gaillard E, Bernard C, Abello J, Cordier-Bussat M, Chayvialle JA, Cuber JC. 1998. Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells. Endocrinology 139: 932-938.
62. Nishi T, Hara H, Asano K, Tomita F. 2003. The soybean beta-conglycinin beta 51-63 fragment suppresses appetite by stimulating cholecystokinin release in rats. J Nutrition 133: 2537-2542.
63. Phifer CB, Berthoud HR. 1998. Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem. Amer J Physiology-Endocrinology and Metabolism 274: R1725-1723.
64. Pichon L, Huneau JF, Fromentin G, Tomé D. 2006. A high-protein, high-fat, carbohydrate-free diet reduces energy intake, hepatic lipogenesis, and adiposity in rats. J Nutrition 136: 1256-1260.
65. Pichon L, Potier M, Tomé D, Mikogami T, Laplaize B, Martin-Rouas C, Fromentin G. 2008. High-protein diets containing different milk protein fractions differently influence energy intake and adiposity in the rat. Br J Nutrition 99: 739-748.
66. Porrini M, Santangelo A, Crovetti R, Riso P, Testolin G, Blundell JE. 1997. Weight, protein, fat, and timing of preloads affect food intake. Physiology and Behavior 62 (3): 563-570.
67. Pupovac J, Anderson GH. 2002. Dietary peptides induce satiety via cholecystokinin-A and peripheral opioid receptors in rats. J Nutrition 132: 2775-2780.
68. Raben A, Agerholm-Larsen L, Flint A, Holst JJ, Astrup A. 2003. Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake. Amer J Clinical Nutrition 77: 91-100.
69. Raybould HE. 1998. Does your gut taste? Sensory transduction in the gastrointestinal tract. News in Physiological Sciences 13: 275-280.
70. Raybould HE, Lloyd KC. 1994. Integration of postprandial function in the proximal gastrointestinal tract. Role of CCK and sensory pathways. Annals of the NY Academy of Sciences 713: 143-156.
71. Reidelberger RD. 1994. Cholecystokinin and control of food intake. J Nutrition 124 (8 Suppl): 1327-1333S.
72. Reidelberger RD, Heimann D, Kelsey L, Hulce M. 2003. Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats. Amer J Physiology-Regulatory, Integrative and Comparative Physiology 284: R389-398.
73. Reidelberger RD, Hernandez J, Fritzsch B, Hulce M. 2004. Abdominal vagal mediation of the satiety effects of CCK in rats. Amer J Physiology-Regulatory, Integrative and Comparative Physiology 286: R1005-1012.
74. Rolls RJ, Hetherington M, Burley VJ. 1988. The specificity of satiety: The influence of foods of different macronutrient content on the development of satiety. Physiology and Behavior 43: 145-153.
75. Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA, Franchini KG, Velloso LA, Saad MJ, Carvalheira JB. 2008. A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet induced weight loss. Diabetes 57: 594-605.
76. Rubio-Aliaga I, Daniel H. 2002. Mammalian peptide transporters as targets for drug delivery. Trends in Pharmacological Sciences 23 (9): 434-440.
77. Smeets AJ, Soenen S, Luscombe-Marsh ND, Ueland O, Westerterp-Plantenga MS. 2008. Energy expenditure, satiety, and plasma ghrelin, glucagon-like peptide 1, and peptide tyro sine-tyrosine concentrations following a single high-protein lunch. J Nutrition 138: 698-702.
78. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR. 1996. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 (6560): 69-72.
79. Veldhorst M, Smeets A, Soenen S, Hochstenbach-Waelen A, Hursel R, Diepvens K, Lejeune M, Luscombe-Marsh N, Westerterp-Plantenga M. 2008. Protein-induced satiety: Effects and mechanisms of different proteins. Physiology and Behavior 94: 300-307.
80. Verdich C, Flint A, Gutzwiller JP, Näslund E, Beglinger C, Hellstrom PM, Long SJ, Morgan LM, Holst JJ, Astrup A. 2001. A meta-analysis of the effect of glucagonlike peptide-1 (7-36) amide on ad libitum energy intake in humans. J Clinical Endocrinology and Metabolism 86 (9): 4382-4389.
81. Westerterp-Plantenga MS, Rolland V, Wilson SA, Westerterp KR. 1999. Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs high fat diets measured in a respiration chamber. Eur J Clinical Nutrition 53 (6): 495-502.
82. White W, Schwartz GJ, Moran TH. 2000. Role of endogenous CCK in the inhibition of gastric emptying by peptone and Intralipid in rats. Regulatory Peptides 88: 47-53.
83. Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH. 2007. Increasing dietary leucine intake reduces diet induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56: 1647-1654.
84. Zittel TT, de Giorgio R, Sternini C, Raybould HE. 1994. Fos protein expression in the nucleus of the solitary tract in response to intestinal nutrients in awake rats. Brain Research 663: 266-270.