Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins

Malaria Journal

Volumn 11, Issue , 2012, Pages

  Bagnaresi, Piero ^a   Barros, Nilana M T ^a   Assis, Diego M ^a   Melo, Pollyana M S ^a   Fonseca, Raphael G ^a   Juliano, Maria A ^a   Pesquero, João B ^a   Juliano, Luiz ^a   Rosenthal, Philip J ^b   Carmona, Adriana K ^a   Gazarini, Marcos L ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; FALCIPAIN 2; FALCIPAIN 3; FLUO 3; KININ; KININOGEN; UNCLASSIFIED DRUG; CALCIUM;

ARTICLE; BIOLOGICAL ACTIVITY; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL ACTIVITY; GUINEA PIG; HEMODYNAMICS; HUMAN; HUMAN CELL; ILEUM CONTRACTION; MALARIA; MASS SPECTROMETRY; NONHUMAN; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PROTEIN DEGRADATION; ANIMAL; DRUG EFFECT; ENDOTHELIUM CELL; ENZYMOLOGY; ILEUM; METABOLISM; MUSCLE CONTRACTION;

ANIMALS; CALCIUM; CYSTEINE ENDOPEPTIDASES; ENDOTHELIAL CELLS; GUINEA PIGS; HUMANS; ILEUM; KININOGENS; KININS; MASS SPECTROMETRY; MUSCLE CONTRACTION; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PROTEOLYSIS;

EID: 84860561394     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-156     Document Type: Article

References (22)

1. Hemoglobin degradation. Goldberg DE, Curr Top Microbiol Immunol 2005 295 275 2912 10.1007/3-540-29088-5-11 16265895
2. Roles of proteases during invasion and egress by Plasmodium and Toxoplasma. Dowse TJ, Koussis K, Blackman MJ, Soldati-Favre D, Subcell Biochem 2008 47 121 139 10.1007/978-0-387-78267-6-10 18512347
3. Cysteine proteases of malaria parasites. Rosenthal PJ, Int J Parasitol 2004 34 1489 1499 10.1016/j.ijpara.2004.10.003 15582526
4. Plasmodium food vacuole plasmepsins are activated by falcipains. Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE, J Biol Chem 2008 283 12870 12876 10.1074/jbc.M708949200 18308731
5. Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites. Gamboa De Dominguez ND, Rosenthal PJ, Blood 1996 87 4448 4454 8639807 (Pubitemid 26152287)
6. Anticoagulant properties of the vascular endothelium. Bombeli T, Mueller M, Haeberli A, Thromb Haemost 1997 77 408 423 9065986 (Pubitemid 27121001)
7. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ, PLoS One 2009 4 5156 10.1371/journal.pone.0005156 19357776
8. Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum. Sijwali PS, Koo J, Singh N, Rosenthal PJ, Mol Biochem Parasitol 2006 150 96 106 10.1016/j.molbiopara.2006. 06.013 16890302 (Pubitemid 44332580)
9. Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Sijwali PS, Rosenthal PJ, Proc Natl Acad Sci U S A 2004 101 4384 4389 10.1073/pnas. 0307720101 15070727 (Pubitemid 38437421)
10. Systemic endothelial activation occurs in both mild and severe malaria. Correlating dermal microvascular endothelial cell phenotype and soluble cell adhesion molecules with disease severity. Turner GD, Ly VC, Nguyen TH, Tran TH, Nguyen HP, Bethell D, Wyllie S, Louwrier K, Fox SB, Gatter KC, Day NP, Tran TH, White NJ, Berendt AR, Am J Pathol 1998 152 1477 1487 1477 9626052 (Pubitemid 28275006)
11. Neutrophil-mediated damage to human vascular endothelium. Role of cytokine activation. Westlin WF, Gimbrone MA, Am J Pathol 1993 142 117 128 8424450 (Pubitemid 23026916)
12. Nitric oxiDe in the regulation of blood flow and arterial pressure. Umans JG, Levi R, Annu Rev Physiol 1995 57 771 790 10.1146/annurev.ph.57.030195. 004011 7539996
13. Nitric oxiDe bioavailability in malaria. Sobolewski P, Gramaglia I, Frangos J, Intaglietta M, Van der HeyDe HC, Trends Parasitol 2005 21 415 422 10.1016/j.pt.2005.07.002 16039159 (Pubitemid 41116717)
14. Kinin-mediated activation of endothelial no formation: possible role during myocardial ischemia. Hecker M, Fleming I, Busse R, Agents Actions Suppl 1995 45 119 127 7717169
15. Bioregulation of kinins: kallikreins, kininogens, and kininases. Bhoola KD, Figueroa CD, Worthy K, Pharmacol Rev 1992 44 1 80 1313585
16. Kinins in humans. Duncan AM, Kladis A, Jennings GL, Dart AM, Esler M, Campbell DJ, Am J Physiol Regul Integr Comp Physiol 2000 278 897 R904 10749777
17. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F, Adam A, J Pharmacol Sci 2005 99 6 38 10.1254/jphs.SRJ05001X 16177542 (Pubitemid 41366887)
18. Kinin formation: mechanisms and role in inflammatory disorders. Proud D, Kaplan AP, Annu Rev Immunol 1988 6 49 83 10.1146/annurev.iy.06.040188.000405 3289575 (Pubitemid 19141577)
19. Differential regulation of inducible and endothelial nitric oxiDe synthase by kinin B1 and B2 receptors. Kuhr F, Lowry J, Zhang Y, Brovkovych V, Skidgel RA, Neuropeptides 44 145 154
20. Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi. Del Nery E, Juliano MA, Lima AP, Scharfstein J, Juliano L, J Biol Chem 13 198 209
21. Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria. Barbier M, Faille D, Loriod B, Textoris J, Camus C, Puthier D, Flori L, Wassmer SC, Victorero G, Alessi MC, Fusai T, Nguyen C, Grau GE, Rihet P, PLoS One 2011 6 19651 10.1371/journal.pone. 0019651 21603600
22. Effect of gamma-aminobutyryl-choline upon the electrical activity of the cerebral cortex. Takahashi H, Nagashima A, Koshino C, Nature 1958 182 1443 1444 10.1038/1821443a0 13600357