-
1
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M: Isolation of a cDNA clone derived from a bloodborne non-A, non-B viral hepatitis genome. Science 1989; 244:359-362. (Pubitemid 19117877)
-
(1989)
Science
, vol.244
, Issue.4902
, pp. 359-362
-
-
Choo, Q.-L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
2
-
-
84875664203
-
-
www.who.int/immunization/topics/hepatitis-c/en/.
-
-
-
-
4
-
-
0032547938
-
Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
-
DOI 10.1056/NEJM199811193392101
-
McHutchison JG, Gordon SC, Schiff ER, et al.: Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N Engl J Med 1998; 339:1485-1492. (Pubitemid 28543496)
-
(1998)
New England Journal of Medicine
, vol.339
, Issue.21
, pp. 1485-1492
-
-
Mchutchison, J.G.1
Gordon, S.C.2
Schiff, E.R.3
Shiffman, M.L.4
Lee, W.M.5
Rustgi, V.K.6
Goodman, Z.D.7
Ling, M.-H.8
Cort, S.9
Albrecht, J.K.10
-
5
-
-
0036896655
-
Retreatment with interferon plus ribavirin of chronic hepatitis C non-responders to interferon monotherapy: A meta-analysis of individual patient data
-
DOI 10.1136/gut.51.6.864
-
Cammà C, Bruno S, Schepis F, et al.: Retreatment with interferon plus ribavirin of chronic hepatitis C non-responders to interferon monotherapy: a meta-analysis of individual patients data. Gut 2002; 51:864-869. (Pubitemid 35408610)
-
(2002)
Gut
, vol.51
, Issue.6
, pp. 864-869
-
-
Camma, C.1
Bruno, S.2
Schepis, F.3
Lo, I.O.4
Andreone, P.5
Gramenzi, A.G.6
Mangia, A.7
Andriulli, A.8
Puoti, M.9
Spadaro, A.10
Freni, M.11
Di, M.V.12
Cino, L.13
Saracco, G.14
Chiesa, A.15
Crosignani, A.16
Caporaso, N.17
Morisco, F.18
Rumi, M.G.19
Craxi, A.20
more..
-
6
-
-
0035835028
-
Interferon and ribavirin vs interferon alone in the re-treatment of chronic hepatitis C previosly nonresponsive to interferon a meta-analysis of randomized trials
-
Cummings KJ, Lee SM, West ES, et al.: Interferon and ribavirin vs interferon alone in the re-treatment of chronic hepatitis C previously nonresponsive to interferon: a meta-analysis of randomized trials. JAMA 2001; 285:193-199. (Pubitemid 32048522)
-
(2001)
Journal of the American Medical Association
, vol.285
, Issue.2
, pp. 193-199
-
-
Cummings, K.J.1
Lee, S.M.2
West, E.S.3
Cid-Ruzafa, J.4
Fein, S.G.5
Aoki, Y.6
Sulkowski, M.S.7
Goodman, S.N.8
-
7
-
-
65349129985
-
Re-treatment of patients with chronic hepatitis who do not respond to peginterferon-2b
-
Jensen DM, Marcellin P, Freilich B, et al.: Re-treatment of patients with chronic hepatitis who do not respond to peginterferon-2b. Ann Intern Med 2009; 150:528-540.
-
(2009)
Ann Intern Med
, vol.150
, pp. 528-540
-
-
Jensen, D.M.1
Marcellin, P.2
Freilich, B.3
-
8
-
-
67349172961
-
Peginterferon alfa-2b and ribavirin: Effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy
-
Poynard T, Colombo M, Bruix J, et al.: Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy. Gastroenterology 2009; 136:1613-1628.
-
(2009)
Gastroenterology
, vol.136
, pp. 1613-1628
-
-
Poynard, T.1
Colombo, M.2
Bruix, J.3
-
9
-
-
0033920304
-
Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo
-
DOI 10.1128/JVI.74.4.2046-2051.2000
-
Kolykhalov AA MK, Feinstone SM, Rice CM: Hepatitis C virusencoded enzymatic activities and conserved RNA elements in the 3- nontranslated region are essential for virus replication in vivo. J Virol 2000; 74:2046-2051. (Pubitemid 30434065)
-
(2000)
Journal of Virology
, vol.74
, Issue.4
, pp. 2046-2051
-
-
Kolykhalov, A.A.1
Mihalik, K.2
Feinstone, S.M.3
Rice, C.M.4
-
10
-
-
33744457959
-
Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease
-
Lin C KA, Perni RB: Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease. Infect Disord Drug Targets 2006;6:3-16.
-
(2006)
Infect Disord Drug Targets
, vol.6
, pp. 3-16
-
-
Lin, C.K.A.1
Perni, R.B.2
-
11
-
-
70049099036
-
Assessing risk of bias in included studies
-
Higgins J, Green S, eds. Oxford, England: Cochrane Collaboration
-
Higgins J AD: Assessing risk of bias in included studies. In: Higgins J, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions 5.0.1. Oxford, England: Cochrane Collaboration, 2008.
-
(2008)
Cochrane Handbook for Systematic Reviews of Interventions 5.0.1
-
-
Higgins, J.A.D.1
-
12
-
-
77950945642
-
Ability of treatment week 12 viral response to predict long-term outcome in genotype 1 hepatitis C virus/HIV coinfected patients
-
Van den Eynde E, Tiraboschi JM, Tural C, et al.: Ability of treatment week 12 viral response to predict long-term outcome in genotype 1 hepatitis C virus/HIV coinfected patients. AIDS 2010; 24:975-982.
-
(2010)
AIDS
, vol.24
, pp. 975-982
-
-
Van Den Eynde, E.1
Tiraboschi, J.M.2
Tural, C.3
-
13
-
-
77449158033
-
Rapid HCV-RNA Decline with Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients
-
Reesink HW, Fanning GC, Farha KA, et al.: Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients. Gastroenterology 2010; 138:913-921.
-
(2010)
Gastroenterology
, vol.138
, pp. 913-921
-
-
Reesink, H.W.1
Fanning, G.C.2
Farha, K.A.3
-
14
-
-
77950817619
-
Telaprevir for previously treated chronic HCV infection
-
McHutchison JG, Manns MP, Muir AJ, et al.: Telaprevir for previously treated chronic HCV infection. N Engl J Med. 2010; 362:1292-1303.
-
(2010)
N Engl J Med
, vol.362
, pp. 1292-1303
-
-
McHutchison, J.G.1
Manns, M.P.2
Muir, A.J.3
-
15
-
-
77950873737
-
Ribavirin plus interferon versus interferon for chronic hepatitis C
-
CD005445
-
Brok J, Gluud LL, Gluud C: Ribavirin plus interferon versus interferon for chronic hepatitis C. Cochrane Database Syst Rev 2010:CD005445.
-
(2010)
Cochrane Database Syst Rev
-
-
Brok, J.1
Gluud, L.L.2
Gluud, C.3
-
16
-
-
77953111816
-
Clinical trial investigates two experimental HCV drugs
-
Clinical trial investigates two experimental HCV drugs. AIDS Patient Care STDS 2010; 24:270.
-
(2010)
AIDS Patient Care STDS
, vol.24
, pp. 270
-
-
-
17
-
-
73149113353
-
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
-
Susser S, Welsch C, Wang Y, et al.: Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009; 50:1709-1718.
-
(2009)
Hepatology
, vol.50
, pp. 1709-1718
-
-
Susser, S.1
Welsch, C.2
Wang, Y.3
-
18
-
-
70849104810
-
Effect of HCV RNA Suppression during Peginterferon Alfa-2a Maintenance Therapy on Clinical Outcomes in the HALT-C Trial
-
Shiffman ML, Morishima C, Dienstag JL, et al.: Effect of HCV RNA Suppression During Peginterferon Alfa-2a Maintenance Therapy on Clinical Outcomes in the HALT-C Trial. Gastroenterology 2009; 137:1986-1994.
-
(2009)
Gastroenterology
, vol.137
, pp. 1986-1994
-
-
Shiffman, M.L.1
Morishima, C.2
Dienstag, J.L.3
-
19
-
-
69949124385
-
New hope for a cure for chronic hepatitis C
-
Reesink HW, Weegink CJ: New hope for a cure for chronic hepatitis C. J Hepatol 2009; 51:835-837.
-
(2009)
J Hepatol
, vol.51
, pp. 835-837
-
-
Reesink, H.W.1
Weegink, C.J.2
-
21
-
-
65649147492
-
A review of current anti-HCV treatment regimens and possible future strategies
-
Neukam K, Macias J, Mira JA, Pineda JA: A review of current anti-HCV treatment regimens and possible future strategies. Expert Opin Pharmacother 2009; 10:417-433.
-
(2009)
Expert Opin Pharmacother
, vol.10
, pp. 417-433
-
-
Neukam, K.1
Macias, J.2
Mira, J.A.3
Pineda, J.A.4
-
22
-
-
72049091881
-
PROVE3 final results and 1-year durability of SVR with telaprevir-based regimen in hepatitis C genotype 1-infected patients with prior non-response, viral breakthrough or relapse to peginterferon-alfa-2a/b and ribavirin therapy
-
McHutchison JG, Manns MP, Muir A, et al.: PROVE3 final results and 1-year durability of SVR with telaprevir-based regimen in hepatitis C genotype 1-infected patients with prior non-response, viral breakthrough or relapse to peginterferon-alfa-2a/b and ribavirin therapy. Hepatology 2009; 50:334A-335A.
-
(2009)
Hepatology
, vol.50
-
-
McHutchison, J.G.1
Manns, M.P.2
Muir, A.3
-
23
-
-
65449152185
-
Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
-
McHutchison JG, Everson GT, Gordon SC, et al.: Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009; 360:1827-1838.
-
(2009)
N Engl J Med
, vol.360
, pp. 1827-1838
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
24
-
-
72049123335
-
Virological analysis of patients receiving telaprevir administered q8h or q12h with peginterferon-alfa-2a or -alfa- 2b and ribavirin in treatment - naive patients with genotype 1 hepatitis C: Study C208
-
Marcellin P, Forns X, Goeser T, Ferenci P, et al.: Virological analysis of patients receiving telaprevir administered q8h or q12h with peginterferon-alfa-2a or -alfa- 2b and ribavirin in treatment - naive patients with genotype 1 hepatitis C: study C208. Hepatology 2009; 50:395A.
-
(2009)
Hepatology
, vol.50
-
-
Marcellin, P.1
Forns, X.2
Goeser, T.3
Ferenci, P.4
-
25
-
-
67650541547
-
Telaprevir in hepatitis C genotype-1-infected patients with prior non-response, viral breakthrough or relapse to peginterferonalfa-2A/B and ribavirin therapy: SVR results of the PROVE3 study
-
Manns MM: Telaprevir in hepatitis C genotype-1-infected patients with prior non-response, viral breakthrough or relapse to peginterferonalfa-2A/B and ribavirin therapy: SVR results of the PROVE3 study. J Hepatol 2009; 50:S379.
-
(2009)
J Hepatol
, vol.50
-
-
Manns, M.M.1
-
26
-
-
65349129985
-
Re-treatment of Patients with Chronic Hepatitis C Who Do Not Respond to Peginterferon-alpha 2b A Randomized Trial
-
Jensen DM, Marcellin P, Freilich B, et al.: Re-treatment of Patients With Chronic Hepatitis C Who Do Not Respond to Peginterferon-alpha 2b A Randomized Trial. Ann intern Med 2009; 150:528-540.
-
(2009)
Ann Intern Med
, vol.150
, pp. 528-540
-
-
Jensen, D.M.1
Marcellin, P.2
Freilich, B.3
-
27
-
-
78751621897
-
Accelerated clinical trial design to assess the safety, tolerability and anti-viral activity of PHX1766, a novel HCV NS3/4A protease inhibitor, in healthy volunteers and chronic hepatitis C patients
-
Hotho D, de Bruijne J, O'Farrell A, et al.: Accelerated clinical trial design to assess the safety, tolerability and anti-viral activity of PHX1766, a novel HCV NS3/4A protease inhibitor, in healthy volunteers and chronic hepatitis C patients. Hepatology 2009; 50:1031A-1032A.
-
(2009)
Hepatology
, vol.50
-
-
Hotho, D.1
De Bruijne, J.2
O'Farrell, A.3
-
28
-
-
65449171953
-
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
-
Hezode C, Forestier N, Dusheiko G, Ferenci P, Pol S, Goeser T: Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009; 360:1839-1850.
-
(2009)
N Engl J Med
, vol.360
, pp. 1839-1850
-
-
Hezode, C.1
Forestier, N.2
Dusheiko, G.3
Ferenci, P.4
Pol, S.5
Goeser, T.6
-
29
-
-
67650694267
-
Activity of telaprevir alone or in combination with peginterferon alfa-2a and ribavirin in treatment-naive genotype 2 and 3 hepatitis C patients: Interim results of study C209
-
Foster GR, Hezode C, Bronowicki JP, et al.: Activity of telaprevir alone or in combination with peginterferon alfa-2a and ribavirin in treatment-naive genotype 2 and 3 hepatitis C patients: interim results of study C209. J Hepatol 2009; 50:S22.
-
(2009)
J Hepatol
, vol.50
-
-
Foster, G.R.1
Hezode, C.2
Bronowicki, J.P.3
-
30
-
-
77951296979
-
Telaprevir, peginterferon alfa - 2a and ribavirin improved rates of sustained virologic response (SVR) in "Difficult-to-Cure" patients with chronic hepatitis C (CHC): A pooled analysis from the PROVEl and PROVE2 trials
-
Everson GT, Dusheiko GM, Ferenci P, et al.: Telaprevir, peginterferon alfa - 2a and ribavirin improved rates of sustained virologic response (SVR) in "Difficult-to-Cure" patients with chronic hepatitis C (CHC) : a pooled analysis from the PROVEl and PROVE2 trials. Hepatology 2009; 50:1025A.
-
(2009)
Hepatology
, vol.50
-
-
Everson, G.T.1
Dusheiko, G.M.2
Ferenci, P.3
-
31
-
-
84875636125
-
SVR results of PROVE3, a phase 2B clinical trial assessing safety and efficacy of telaprevir in hepatitis C genotype-1-infected patients with prior non-response, viral breakthrough or relapse to peginterferon-alfa-2a/b and ribavirin therapy
-
Di Bisceglie AM, Muir AMJ, Adda N, et al.: SVR results of PROVE3, a phase 2B clinical trial assessing safety and efficacy of telaprevir in hepatitis C genotype-1-infected patients with prior non-response, viral breakthrough or relapse to peginterferon-alfa-2a/b and ribavirin therapy. Gastroenterology 2009; 136:116A.
-
(2009)
Gastroenterology
, vol.136
-
-
Di Bisceglie, A.M.1
Muir, A.M.J.2
Adda, N.3
-
32
-
-
67650694266
-
Results of a proof of concept study (C210) of telaprevir monotherapy and in combination with peginterferon ALFA-2A and ribavirin in treatment-naive genotype 4 HCV patients
-
Benhamou Y, Moussalli J, Ratziu V, et al.: Results of a proof of concept study (C210) of telaprevir monotherapy and in combination with peginterferon ALFA-2A and ribavirin in treatment-naive genotype 4 HCV patients. J Hepatol 2009; 50:S6.
-
(2009)
J Hepatol
, vol.50
-
-
Benhamou, Y.1
Moussalli, J.2
Ratziu, V.3
-
33
-
-
72949122128
-
Comment on the PROVE1 and PROVE2 clinical trials: "I was taking a picture of Rapid Virological Response with telaprevir, but the background is unfocused!"
-
Baiocchi L, Lenci I, Carbone M, Angelico M: Comment on the PROVE1 and PROVE2 clinical trials: "I was taking a picture of Rapid Virological Response with telaprevir, but the background is unfocused!". Hepatology 2009; 50:1676-1677.
-
(2009)
Hepatology
, vol.50
, pp. 1676-1677
-
-
Baiocchi, L.1
Lenci, I.2
Carbone, M.3
Angelico, M.4
-
34
-
-
61849083229
-
Telaprevir in combination with peginterferon-alfa-2a with or without ribavirin in the treatment of chronic hepatitis C: Final results of the PROVE2 study
-
Zeuzem S, Hezode C, Ferenci P, et al.: Telaprevir in combination with peginterferon-alfa-2a with or without ribavirin in the treatment of chronic hepatitis C: final results of the PROVE2 study. Hepatology 2008; 48:418A-419A.
-
(2008)
Hepatology
, vol.48
-
-
Zeuzem, S.1
Hezode, C.2
Ferenci, P.3
-
35
-
-
46249108979
-
Drugs in development for hepatitis C
-
DOI 10.2165/00003495-200868100-00002
-
Stauber RE, Kessler HH: Drugs in development for hepatitis C. Drugs 2008; 68:1347-1359. (Pubitemid 351913433)
-
(2008)
Drugs
, vol.68
, Issue.10
, pp. 1347-1359
-
-
Stauber, R.E.1
Kessler, H.H.2
-
36
-
-
67650686073
-
Viral responses in African-Americans, Latinos and Caucasians in the US phase 2 study (PROVE1) of telaprevir with peginterferon a-2a and ribavirin in treatment-naive genotype 1-infected subjects with hepatitis C
-
Muir AJ, Lawitz EJ, McHutchison JG, et al.: Viral responses in African-Americans, Latinos and Caucasians in the US phase 2 study (PROVE1) of telaprevir with peginterferon a-2a and ribavirin in treatment-naive genotype 1-infected subjects with hepatitis C. Hepatology 2008; 48:1131A.
-
(2008)
Hepatology
, vol.48
-
-
Muir, A.J.1
Lawitz, E.J.2
McHutchison, J.G.3
-
37
-
-
56949095197
-
A phase 2b study of telaprevir with peginterferon-alfa-2a and ribavirin in hepatitis C genotype 1 null and partial responders and relapsers following a prior course of peginterferon-alfa-2a/b and ribavirin therapy: PROVE3 interim results
-
McHutchison JG, Shiffman ML, Terrault N, et al.: A phase 2b study of telaprevir with peginterferon-alfa-2a and ribavirin in hepatitis C genotype 1 null and partial responders and relapsers following a prior course of peginterferon-alfa-2a/b and ribavirin therapy: PROVE3 interim results. Hepatology 2008; 48:269A-270A.
-
(2008)
Hepatology
, vol.48
-
-
McHutchison, J.G.1
Shiffman, M.L.2
Terrault, N.3
-
38
-
-
46249132509
-
PROVE1: Results from a phase 2 study of telaprevir with peginterferon alfa-2a and ribavirin in treatment-naive subjects with hepatitis C
-
McHutchison JG, Everson GT, Gordon SC, et al.: PROVE1: results from a phase 2 study of telaprevir with peginterferon alfa-2a and ribavirin in treatment-naive subjects with hepatitis C. J Hepatol 2008; 48:S4.
-
(2008)
J Hepatol
, vol.48
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
39
-
-
47949084830
-
Hepatitis C protease and polymerase inhibitors in development
-
Liu-Young G, Kozal MJ: Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS 2008; 22:449-457.
-
(2008)
AIDS Patient Care STDS
, vol.22
, pp. 449-457
-
-
Liu-Young, G.1
Kozal, M.J.2
-
40
-
-
49949086421
-
Inflammatory markers neopterin and alanine aminotransferase in HCV patients treated with HCV NS3.4A protease inhibitor telaprevir (VX-950) and/or peginterferon alfa-2a
-
Gelderblom HC, Zeuzem S, Weegink CJ, et al.: Inflammatory markers neopterin and alanine aminotransferase in HCV patients treated with HCV NS3.4A protease inhibitor telaprevir (VX-950) and/or peginterferon alfa-2a. Scand J Gastroenterol 2008; 43:1122-1127.
-
(2008)
Scand J Gastroenterol
, vol.43
, pp. 1122-1127
-
-
Gelderblom, H.C.1
Zeuzem, S.2
Weegink, C.J.3
-
41
-
-
65649112149
-
Phase 2 study of telaprevir administered q8h orq12h with peginterferon-alfa-2a or -alfa-2b and ribavirin in treatment-naive subjects with genotype 1 hepatitis C: Week 4 interim results
-
Forns X, Marcellin P, Goeser T, et al.: Phase 2 study of telaprevir administered q8h orq12h with peginterferon-alfa-2a or -alfa-2b and ribavirin in treatment-naive subjects with genotype 1 hepatitis C: week 4 interim results. Hepatology 2008; 48:1136A-1137A.
-
(2008)
Hepatology
, vol.48
-
-
Forns, X.1
Marcellin, P.2
Goeser, T.3
-
42
-
-
84860583363
-
Status of pat ients with chronic hepatitis C after a pretreatment period of 14 days with Telaprevir (VX-950) und a following antiviral therapy with Peg-interferon-alfa-2a (Peg-IFN-2s) and ribavirin (RBV)
-
Forestier N, Sarrazin C, Friedrich-Rust M, Zeuzem S: Status of pat ients with chronic hepatitis C after a pretreatment period of 14 days with Telaprevir (VX-950) und a following antiviral therapy with Peg-interferon-alfa-2a (Peg-IFN-2s) and ribavirin (RBV). Zeitschrift fur Gastroenterologie 2008; 46:145.
-
(2008)
Zeitschrift fur Gastroenterologie
, vol.46
, pp. 145
-
-
Forestier, N.1
Sarrazin, C.2
Friedrich-Rust, M.3
Zeuzem, S.4
-
43
-
-
46249130673
-
Treatment of chronic hepatitis C with telaprevir (TVR) in combination with peginterferon-alfa-2a with or without ribavirin: Further interim analysis results of the PROVE2 study
-
Dusheiko GM, Hezode C, Pol S, et al.: Treatment of chronic hepatitis C with telaprevir (TVR) in combination with peginterferon-alfa-2a with or without ribavirin: further interim analysis results of the PROVE2 study. J Hepatol 2008; 48:S26.
-
(2008)
J Hepatol
, vol.48
-
-
Dusheiko, G.M.1
Hezode, C.2
Pol, S.3
-
44
-
-
42349096110
-
Final results of patients receiving peg-interferon-alfa-2a (Peg-IFN) and ribavirin (RBV) after a 14-day study of the hepatitis C protease inhibitor telaprevir (VX-950), with Peg-IFN
-
Weegink CJ, Forestier N, Jansen PL, Zeuzem S, Reesink HW: Final results of patients receiving peg-interferon-alfa-2a (Peg-IFN) and ribavirin (RBV) after a 14-day study of the hepatitis C protease inhibitor telaprevir (VX-950), with Peg-IFN. Hepatology 2007; 46:819A.
-
(2007)
Hepatology
, vol.46
-
-
Weegink, C.J.1
Forestier, N.2
Jansen, P.L.3
Zeuzem, S.4
Reesink, H.W.5
-
45
-
-
36048964833
-
Proteaseinhibitoren in der therapie der chronischen hepatitis C - Kommentar
-
DOI 10.1055/s-2007-963473
-
Vermehren J, Sarrazin C: Protease inhibitors in the treatment of chronic hepatitis C: Commentary. Zeitschrift fur Gastroenterologie 2007; 45:1085-1088. (Pubitemid 350083278)
-
(2007)
Zeitschrift fur Gastroenterologie
, vol.45
, Issue.10
, pp. 1085-1088
-
-
Vermehren, J.1
Sarrazin, C.2
-
46
-
-
34247594930
-
Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir
-
DOI 10.1053/j.gastro.2007.02.037, PII S0016508507003940
-
Sarrazin C, Kieffer TL, Bartels D, et al.: Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir. Gastroenterology 2007; 132:1767-1777. (Pubitemid 46677938)
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1767-1777
-
-
Sarrazin, C.1
Kieffer, T.L.2
Bartels, D.3
Hanzelka, B.4
Muh, U.5
Welker, M.6
Wincheringer, D.7
Zhou, Y.8
Chu, H.9
Lin, C.10
Weegink, C.11
Reesink, H.12
Zeuzem, S.13
Kwong, A.D.14
-
47
-
-
41749110164
-
PROVE2: Phase Il sstudy of VX950 (telaprevir) in combination with peginterferon alfa2A with or without ribavirin in subjects with chronic hepatitis C,first interim analysis
-
Zeuzem S, Hezode C, Ferenci P, et al.: PROVE2: Phase Il sstudy of VX950 (telaprevir) in combination with peginterferon alfa2A with or without ribavirin in subjects with chronic hepatitis C,first interim analysis. Hepatology 2007; 46:268A-269A.
-
(2007)
Hepatology
, vol.46
-
-
Zeuzem, S.1
Hezode, C.2
Ferenci, P.3
-
48
-
-
42149167753
-
Evaluation of viral variants during a phase 2 study (PROVE2) of telaprevir with peginterferon alfa-2A and ribavirin in treatment-naive HCV genotype 1-infected patients
-
Pawlotsky J, Kieffer T, Zhou Y, et al.: Evaluation of viral variants during a phase 2 study (PROVE2) of telaprevir with peginterferon alfa-2A and ribavirin in treatment-naive HCV genotype 1-infected patients. Hepatology 2007; 46:862A.
-
(2007)
Hepatology
, vol.46
-
-
Pawlotsky, J.1
Kieffer, T.2
Zhou, Y.3
-
49
-
-
34247891055
-
Results of an interim analysis of a phase 2 study of telaprevir (VX-950) with peginterferon alpha-2a and ribavirin in previously untreated subjects with hepatitis C
-
McHutchison JG, Everson GT, Gordon S, et al.: Results of an interim analysis of a phase 2 study of telaprevir (VX-950) with peginterferon alpha-2a and ribavirin in previously untreated subjects with hepatitis C. J Hepatol 2007; 46:5296.
-
(2007)
J Hepatol
, vol.46
, pp. 5296
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.3
-
50
-
-
34548758435
-
Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
-
DOI 10.1002/hep.21781
-
Kieffer TL, Sarrazin C, Miller JS, et al.: Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology 2007; 46:631-639. (Pubitemid 47436107)
-
(2007)
Hepatology
, vol.46
, Issue.3
, pp. 631-639
-
-
Kieffer, T.L.1
Sarrazin, C.2
Miller, J.S.3
Welker, M.W.4
Forestier, N.5
Reesink, H.W.6
Kwong, A.D.7
Zeuzem, S.8
-
51
-
-
36749079979
-
Interim analysis results from a phase 2 study of telaprevir with peginterferon alfa-2a and ribavirin in treatment-naive subjects with hepatitis C
-
Jacobson IM, Everson GT, Gordon SC, et al.: Interim analysis results from a phase 2 study of telaprevir with peginterferon alfa-2a and ribavirin in treatment-naive subjects with hepatitis C. Hepatology 2007; 46:315A-316A.
-
(2007)
Hepatology
, vol.46
-
-
Jacobson, I.M.1
Everson, G.T.2
Gordon, S.C.3
-
52
-
-
36348947218
-
Neopterin and ALT as markers of inflammation in chronic hepatitis C patients during administration of the HCV NS3-4a protease inhibitor telaprevir (VX-950) in combination with peginterferon alfa 2a
-
Gelderblom HC, Zeuzem S, Weegink CJ, et al.: Neopterin and ALT as markers of inflammation in chronic hepatitis C patients during administration of the HCV NS3-4a protease inhibitor telaprevir (VX-950) in combination with peginterferon alfa 2a. J Hepatol 2007; 46:S224-S225.
-
(2007)
J Hepatol
, vol.46
-
-
Gelderblom, H.C.1
Zeuzem, S.2
Weegink, C.J.3
-
53
-
-
34548118227
-
Ultrasound Evaluation of Perihepatic Lymph Nodes During Antiviral Therapy with the Protease Inhibitor Telaprevir (VX-950) in Patients with Chronic Hepatitis C Infection
-
DOI 10.1016/j.ultrasmedbio.2007.02.017, PII S030156290700110X
-
Friedrich-Rust M, Forestier N, Sarrazin C, Reesink HW, Herrmann E, Zeuzem S: Ultrasound Evaluation of Perihepatic Lymph Nodes During Antiviral Therapy with the Protease Inhibitor Telaprevir (VX-950) in Patients with Chronic Hepatitis C Infection. Ultrasound Med Biol 2007; 33:1362-1367. (Pubitemid 47302190)
-
(2007)
Ultrasound in Medicine and Biology
, vol.33
, Issue.9
, pp. 1362-1367
-
-
Friedrich-Rust, M.1
Forestier, N.2
Sarrazin, C.3
Reesink, H.W.4
Herrmann, E.5
Zeuzem, S.6
-
54
-
-
84875637555
-
Status of patients with chronic hepatitis C after a 14-day pre-treatment with Telaprevir (VX-950) followed by an anti-viral therapy with Peg-interferon-alpha-2a (Peg-IFN-2a) and Ribavirin (RBV)
-
Forestier N, Sarrazin C, Friedrich-Rust M, et al.: Status of patients with chronic hepatitis C after a 14-day pre-treatment with Telaprevir (VX-950) followed by an anti-viral therapy with Peg-interferon-alpha-2a (Peg-IFN-2a) and Ribavirin (RBV). Zeitschrift fur Gastroenterologie 2007; 45:841.
-
(2007)
Zeitschrift fur Gastroenterologie
, vol.45
, pp. 841
-
-
Forestier, N.1
Sarrazin, C.2
Friedrich-Rust, M.3
-
55
-
-
34247565001
-
Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C
-
DOI 10.1002/hep.21774
-
Forestier N, Reesink HW, Weegink CJ, et al.: Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C. Hepatology 2007; 46:640-648. (Pubitemid 47436108)
-
(2007)
Hepatology
, vol.46
, Issue.3
, pp. 640-648
-
-
Forestier, N.1
Reesink, H.W.2
Weegink, C.J.3
McNair, L.4
Kieffer, T.L.5
Chu, H.-M.6
Purdy, S.7
Jansen, P.L.M.8
Zeuzem, S.9
-
56
-
-
33749360242
-
Rapid Decline of Viral RNA in Hepatitis C Patients Treated With VX-950: A Phase Ib, Placebo-Controlled, Randomized Study
-
DOI 10.1053/j.gastro.2006.07.013, PII S0016508506015393
-
Reesink HW, Zeuzem S, Weegink CJ, et al.: Rapid Decline of Viral RNA in Hepatitis C Patients Treated With VX950: A Phase Ib, Placebo-Controlled, Randomized Study. Gastroenterology 2006; 131:997-1002. (Pubitemid 44498690)
-
(2006)
Gastroenterology
, vol.131
, Issue.4
, pp. 997-1002
-
-
Reesink, H.W.1
Zeuzem, S.2
Weegink, C.J.3
Forestier, N.4
Van Vliet, A.5
Van De, W.D.R.J.6
McNair, L.7
Purdy, S.8
Kauffman, R.9
Alam, J.10
Jansen, P.L.M.11
-
57
-
-
33747783479
-
Initial results of a 14-day study of the hepatitis C virus inhibitor protease VX-950, in combination with peginterferon-apha-2a
-
Reesink HW, Forestier N, Weegink CJ, et al.: Initial results of a 14-day study of the hepatitis C virus inhibitor protease VX-950, in combination with peginterferon-apha-2a. J Hepatol 2006; 44:S272.
-
(2006)
J Hepatol
, vol.44
-
-
Reesink, H.W.1
Forestier, N.2
Weegink, C.J.3
-
58
-
-
33644945037
-
HEP DART 2005 - HCV therapeutics
-
Inchauspe G: HEP DART 2005 - HCV therapeutics. IDrugs 2006; 9:168-170.
-
(2006)
IDrugs
, vol.9
, pp. 168-170
-
-
Inchauspe, G.1
-
59
-
-
33847661212
-
Current status of subjects receiving peg-interferon-alfa-2A (peg-ifn) and ribavirin (RBV) after a 14-day study of the hepatitis C protease inhibitor telaprevir (VX-950), with peg-ifn
-
Forestier N, Weegink CJ, Purdy S, et al.: Current status of subjects receiving peg-interferon-alfa-2A (peg-ifn) and ribavirin (RBV) after a 14-day study of the hepatitis C protease inhibitor telaprevir (VX-950), with peg-ifn. Hepatology 2006; 44:614A-615A.
-
(2006)
Hepatology
, vol.44
-
-
Forestier, N.1
Weegink, C.J.2
Purdy, S.3
-
60
-
-
33646838013
-
Pharmacokinetics of VX-950, and its effect on hepatitis C viral dynamics
-
Chu HM, Herrmann E, Reesink HW, et al.: Pharmacokinetics of VX-950, and its effect on hepatitis C viral dynamics. Hepatology 2005; 42:694A-695A.
-
(2005)
Hepatology
, vol.42
-
-
Chu, H.M.1
Herrmann, E.2
Reesink, H.W.3
|