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Volumn 302, Issue 9, 2012, Pages

Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: Role for triglyceride content reduction

Author keywords

Adipocytes; Carbonyl cyanidep trifluoromethoxyphenylhydrazone; Mitoproteome; Tumor necrosis factor

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; FATTY ACID; MITOCHONDRIAL PROTEIN; PYRUVATE CARBOXYLASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860536507     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00117.2011     Document Type: Article
Times cited : (7)

References (87)
  • 1
    • 77953809992 scopus 로고    scopus 로고
    • Redox-optimized ROS balance: A unifying hypothesis
    • Aon MA, Cortassa S, O'Rourke B. Redox-optimized ROS balance: a unifying hypothesis. Biochim Biophys Acta 1797: 865-877, 2010.
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 865-877
    • Aon, M.A.1    Cortassa, S.2    O'Rourke, B.3
  • 2
    • 77049197836 scopus 로고
    • Tissue fractionation studies. 5. The association of acid phosphatase with a special class of cytoplasmic granules in rat liver
    • Appelmans F, Wattiaux R, De Duve C. Tissue fractionation studies. 5. The association of acid phosphatase with a special class of cytoplasmic granules in rat liver. Biochem J 59: 438-445, 1955.
    • (1955) Biochem J , vol.59 , pp. 438-445
    • Appelmans, F.1    Wattiaux, R.2    de Duve, C.3
  • 3
    • 0037621465 scopus 로고    scopus 로고
    • Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species
    • Aronis A, Melendez JA, Golan O, Shilo S, Dicter N, Tirosh O. Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species. Cell Death Differ 10: 335-344, 2003.
    • (2003) Cell Death Differ , vol.10 , pp. 335-344
    • Aronis, A.1    Melendez, J.A.2    Golan, O.3    Shilo, S.4    Dicter, N.5    Tirosh, O.6
  • 4
    • 0018345721 scopus 로고
    • Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease
    • Atkin BM, Buist NR, Utter MF, Leiter AB, Banker BQ. Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease. Pediatr Res 13: 109-116, 1979.
    • (1979) Pediatr Res , vol.13 , pp. 109-116
    • Atkin, B.M.1    Buist, N.R.2    Utter, M.F.3    Leiter, A.B.4    Banker, B.Q.5
  • 5
    • 76549091356 scopus 로고    scopus 로고
    • Rapid turnover of mitochondrial uncoupling protein 3
    • Azzu V, Mookerjee SA, Brand MD. Rapid turnover of mitochondrial uncoupling protein 3. Biochem J 426: 13-17, 2010.
    • (2010) Biochem J , vol.426 , pp. 13-17
    • Azzu, V.1    Mookerjee, S.A.2    Brand, M.D.3
  • 6
    • 0037453223 scopus 로고    scopus 로고
    • Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release
    • Bae JH, Park JW, Kwon TK. Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release. Biochem Biophys Res Commun 303: 1073-1079, 2003.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 1073-1079
    • Bae, J.H.1    Park, J.W.2    Kwon, T.K.3
  • 7
    • 0034611784 scopus 로고    scopus 로고
    • Medicinal strategies in the treatment of obesity
    • Bray GA, Tartaglia LA. Medicinal strategies in the treatment of obesity. Nature 404: 672-677, 2000.
    • (2000) Nature , vol.404 , pp. 672-677
    • Bray, G.A.1    Tartaglia, L.A.2
  • 8
    • 33749433230 scopus 로고    scopus 로고
    • Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation
    • Brennan JP, Southworth R, Medina RA, Davidson SM, Duchen MR, Shattock MJ. Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. Cardiovasc Res 72: 313-321, 2006.
    • (2006) Cardiovasc Res , vol.72 , pp. 313-321
    • Brennan, J.P.1    Southworth, R.2    Medina, R.A.3    Davidson, S.M.4    Duchen, M.R.5    Shattock, M.J.6
  • 9
    • 77952886003 scopus 로고    scopus 로고
    • Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity
    • Chen GD, Kermany MH, D'Elia A, Ralli M, Tanaka C, Bielefeld EC, Ding D, Henderson D, Salvi R. Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity. Hear Res 265: 63-69, 2010.
    • (2010) Hear Res , vol.265 , pp. 63-69
    • Chen, G.D.1    Kermany, M.H.2    D'Elia, A.3    Ralli, M.4    Tanaka, C.5    Bielefeld, E.C.6    Ding, D.7    Henderson, D.8    Salvi, R.9
  • 10
    • 61449199440 scopus 로고    scopus 로고
    • Proteomic analysis of mitochondrial proteins of basal and lipolytically (isoproterenol and TNF-alpha)-stimulated adipocytes
    • Cho SY, Park PJ, Shin ES, Lee JH, Chang HK, Lee TR. Proteomic analysis of mitochondrial proteins of basal and lipolytically (isoproterenol and TNF-alpha)-stimulated adipocytes. J Cell Biochem 106: 257-266, 2009.
    • (2009) J Cell Biochem , vol.106 , pp. 257-266
    • Cho, S.Y.1    Park, P.J.2    Shin, E.S.3    Lee, J.H.4    Chang, H.K.5    Lee, T.R.6
  • 11
    • 0037133730 scopus 로고    scopus 로고
    • Characterization of the 5'-flanking region of the rat gene for mitochondrial transcription factor A (Tfam)
    • Choi YS, Lee HK, Pak YK. Characterization of the 5'-flanking region of the rat gene for mitochondrial transcription factor A (Tfam). Biochim Biophys Acta 1574: 200-204, 2002.
    • (2002) Biochim Biophys Acta , vol.1574 , pp. 200-204
    • Choi, Y.S.1    Lee, H.K.2    Pak, Y.K.3
  • 12
    • 0034969250 scopus 로고    scopus 로고
    • Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide
    • Corda S, Laplace C, Vicaut E, Duranteau J. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol 24: 762-768, 2001.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 762-768
    • Corda, S.1    Laplace, C.2    Vicaut, E.3    Duranteau, J.4
  • 14
    • 34147192803 scopus 로고    scopus 로고
    • Visualization and quantification of mitochondrial dynamics in living animal cells
    • De Vos KJ, Sheetz MP. Visualization and quantification of mitochondrial dynamics in living animal cells. Methods Cell Biol 80: 627-682, 2007.
    • (2007) Methods Cell Biol , vol.80 , pp. 627-682
    • de Vos, K.J.1    Sheetz, M.P.2
  • 15
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20: 649-688, 1999.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 16
    • 0034612304 scopus 로고    scopus 로고
    • Ceramide interaction with the respiratory chain of heart mitochondria
    • Di Paola M, Cocco T, Lorusso M. Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry 39: 6660-6668, 2000.
    • (2000) Biochemistry , vol.39 , pp. 6660-6668
    • di Paola, M.1    Cocco, T.2    Lorusso, M.3
  • 21
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
    • García-Ruiz C, Colell A, Marí M, Morales A, Fernández-Checa JC. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem 272: 11369-11377, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 11369-11377
    • García-Ruiz, C.1    Colell, A.2    Marí, M.3    Morales, A.4    Fernández-Checa, J.C.5
  • 22
    • 51149109591 scopus 로고    scopus 로고
    • Complementary methods to assist subcellular fractionation in organellar proteomics
    • Gauthier DJ, Lazure C. Complementary methods to assist subcellular fractionation in organellar proteomics. Expert Rev Proteomics 5: 603-617, 2008.
    • (2008) Expert Rev Proteomics , vol.5 , pp. 603-617
    • Gauthier, D.J.1    Lazure, C.2
  • 23
    • 0037250915 scopus 로고    scopus 로고
    • Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis
    • Goffart S, Wiesner RJ. Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis. Exp Physiol 88: 33-40, 2003.
    • (2003) Exp Physiol , vol.88 , pp. 33-40
    • Goffart, S.1    Wiesner, R.J.2
  • 24
    • 0028049078 scopus 로고
    • Differential regulation of respiratory chain subunits by a CREB-dependent signal transduction pathway. Role of cyclic AMP in cytochrome c and COXIV gene expression
    • Gopalakrishnan L, Scarpulla RC. Differential regulation of respiratory chain subunits by a CREB-dependent signal transduction pathway. Role of cyclic AMP in cytochrome c and COXIV gene expression. J Biol Chem 269: 105-113, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 105-113
    • Gopalakrishnan, L.1    Scarpulla, R.C.2
  • 25
    • 0031011211 scopus 로고    scopus 로고
    • A mouse model for mitochondrial myopathy and cardiomy-opathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator
    • Graham BH, Waymire KG, Cottrell B, Trounce IA, MacGregor GR, Wallace DC. A mouse model for mitochondrial myopathy and cardiomy-opathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat Genet 16: 226-234, 1997.
    • (1997) Nat Genet , vol.16 , pp. 226-234
    • Graham, B.H.1    Waymire, K.G.2    Cottrell, B.3    Trounce, I.A.4    Macgregor, G.R.5    Wallace, D.C.6
  • 26
    • 40749088919 scopus 로고    scopus 로고
    • Upregulation of pentraxin-3 in human endothelial cells after lysophosphatidic acid exposure
    • Gustin C, Delaive E, Dieu M, Calay D, Raes M. Upregulation of pentraxin-3 in human endothelial cells after lysophosphatidic acid exposure. Arterioscler Thromb Vasc Biol 28: 491-497, 2008.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 491-497
    • Gustin, C.1    Delaive, E.2    Dieu, M.3    Calay, D.4    Raes, M.5
  • 27
    • 3142777700 scopus 로고    scopus 로고
    • Shift in the localization of sites of hydrogen peroxide production in brain mitochondria by mitochondrial stress
    • Gyulkhandanyan AV, Pennefather PS. Shift in the localization of sites of hydrogen peroxide production in brain mitochondria by mitochondrial stress. J Neurochem 90: 405-421, 2004.
    • (2004) J Neurochem , vol.90 , pp. 405-421
    • Gyulkhandanyan, A.V.1    Pennefather, P.S.2
  • 28
    • 24944539642 scopus 로고    scopus 로고
    • Endolysosomal transport of newly-synthesized ca-thepsin D in a sucrose model of lysosomal storage
    • Hamer I, Jadot M. Endolysosomal transport of newly-synthesized ca-thepsin D in a sucrose model of lysosomal storage. Exp Cell Res 309: 284-295, 2005.
    • (2005) Exp Cell Res , vol.309 , pp. 284-295
    • Hamer, I.1    Jadot, M.2
  • 29
    • 0035502402 scopus 로고    scopus 로고
    • Mitochondrial uncoupling as a target for drug development for the treatment of obesity
    • Harper JA, Dickinson K, Brand MD. Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev 2: 255-265, 2001.
    • (2001) Obes Rev , vol.2 , pp. 255-265
    • Harper, J.A.1    Dickinson, K.2    Brand, M.D.3
  • 30
    • 67651237067 scopus 로고    scopus 로고
    • Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle
    • Hood DA. Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Appl Physiol Nutr Metab 34: 465-472, 2009.
    • (2009) Appl Physiol Nutr Metab , vol.34 , pp. 465-472
    • Hood, D.A.1
  • 31
    • 63349090059 scopus 로고    scopus 로고
    • Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication
    • Hori A, Yoshida M, Shibata T, Ling F. Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication. Nucleic Acids Res 37: 749-761, 2009.
    • (2009) Nucleic Acids Res , vol.37 , pp. 749-761
    • Hori, A.1    Yoshida, M.2    Shibata, T.3    Ling, F.4
  • 34
    • 33646579537 scopus 로고    scopus 로고
    • Anaplerotic roles of pyruvate carboxylase in mammalian tissues
    • Jitrapakdee S, Vidal-Puig A, Wallace JC. Anaplerotic roles of pyruvate carboxylase in mammalian tissues. Cell Mol Life Sci 63: 843-854, 2006.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 843-854
    • Jitrapakdee, S.1    Vidal-Puig, A.2    Wallace, J.C.3
  • 35
    • 0033563213 scopus 로고    scopus 로고
    • Structure, function and regulation of pyruvate carboxylase
    • Jitrapakdee S, Wallace JC. Structure, function and regulation of pyruvate carboxylase. Biochem J 340: 1-16, 1999.
    • (1999) Biochem J , vol.340 , pp. 1-16
    • Jitrapakdee, S.1    Wallace, J.C.2
  • 36
    • 0034505937 scopus 로고    scopus 로고
    • Protein degradation in mitochondria
    • Kaser M, Langer T. Protein degradation in mitochondria. Semin Cell Dev Biol 11: 181-190, 2000.
    • (2000) Semin Cell Dev Biol , vol.11 , pp. 181-190
    • Kaser, M.1    Langer, T.2
  • 37
    • 33750633422 scopus 로고    scopus 로고
    • A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability
    • Kim GJ, Fiskum GM, Morgan WF. A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability. Cancer Res 66: 10377-10383, 2006.
    • (2006) Cancer Res , vol.66 , pp. 10377-10383
    • Kim, G.J.1    Fiskum, G.M.2    Morgan, W.F.3
  • 38
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96: 2914-2923, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 39
    • 0029894407 scopus 로고    scopus 로고
    • Reduction of dietary obesity in aP2-Ucp transgenic mice: Physiology and adipose tissue distribution
    • Kopecky J, Hodny Z, Rossmeisl M, Syrovy I, Kozak LP. Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution. Am J Physiol Endocrinol Metab 270: E768-E775, 1996.
    • (1996) Am J Physiol Endocrinol Metab , vol.270
    • Kopecky, J.1    Hodny, Z.2    Rossmeisl, M.3    Syrovy, I.4    Kozak, L.P.5
  • 42
    • 0030729851 scopus 로고    scopus 로고
    • High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
    • Korshunov SS, Skulachev VP, Starkov AA. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett 416: 15-18, 1997.
    • (1997) FEBS Lett , vol.416 , pp. 15-18
    • Korshunov, S.S.1    Skulachev, V.P.2    Starkov, A.A.3
  • 44
    • 1542615522 scopus 로고    scopus 로고
    • Improved Ruthenium II tris (bathophenantroline disulfonate) staining and destaining protocol for a better signal-to-background ratio and improved baseline resolution
    • Lamanda A, Zahn A, Röder D, Langen H. Improved Ruthenium II tris (bathophenantroline disulfonate) staining and destaining protocol for a better signal-to-background ratio and improved baseline resolution. Pro-teomics 4: 599-608, 2004.
    • (2004) Pro-teomics , vol.4 , pp. 599-608
    • Lamanda, A.1    Zahn, A.2    Röder, D.3    Langen, H.4
  • 45
    • 0036906665 scopus 로고    scopus 로고
    • Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins
    • Legros F, Lombès A, Frachon P, Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell 13: 4343-4354, 2002.
    • (2002) Mol Biol Cell , vol.13 , pp. 4343-4354
    • Legros, F.1    Lombès, A.2    Frachon, P.3    Rojo, M.4
  • 46
    • 36948999822 scopus 로고    scopus 로고
    • Alteration of mitochondrial oxidative capacity during porcine preadipocyte differentiation and in response to leptin
    • Luo GF, Yu TY, Wen XH, Li Y, Yang GS. Alteration of mitochondrial oxidative capacity during porcine preadipocyte differentiation and in response to leptin. Mol Cell Biochem 307: 83-91, 2008.
    • (2008) Mol Cell Biochem , vol.307 , pp. 83-91
    • Luo, G.F.1    Yu, T.Y.2    Wen, X.H.3    Li, Y.4    Yang, G.S.5
  • 47
    • 23644434842 scopus 로고    scopus 로고
    • Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
    • MacLellan JD, Gerrits MF, Gowing A, Smith PJ, Wheeler MB, Harper ME. Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes 54: 2343-2350, 2005.
    • (2005) Diabetes , vol.54 , pp. 2343-2350
    • Maclellan, J.D.1    Gerrits, M.F.2    Gowing, A.3    Smith, P.J.4    Wheeler, M.B.5    Harper, M.E.6
  • 49
    • 26244465857 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import
    • Mercy L, Pauw A, Payen L, Tejerina S, Houbion A, Demazy C, Raes M, Renard P, Arnould T. Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import. FEBS J 272: 5031-5055, 2005.
    • (2005) FEBS J , vol.272 , pp. 5031-5055
    • Mercy, L.1    Pauw, A.2    Payen, L.3    Tejerina, S.4    Houbion, A.5    Demazy, C.6    Raes, M.7    Renard, P.8    Arnould, T.9
  • 51
    • 0033559856 scopus 로고    scopus 로고
    • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyl-transferase is a novel target
    • Muoio DM, Seefeld K, Witters LA, Coleman RA. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyl-transferase is a novel target. Biochem J 338: 783-791, 1999.
    • (1999) Biochem J , vol.338 , pp. 783-791
    • Muoio, D.M.1    Seefeld, K.2    Witters, L.A.3    Coleman, R.A.4
  • 52
    • 26244435944 scopus 로고    scopus 로고
    • Keynote review: The adipocyte as a drug discovery target
    • Nawrocki AR, Scherer PE. Keynote review: the adipocyte as a drug discovery target. Drug Discov Today 10: 1219-1230, 2005.
    • (2005) Drug Discov Today , vol.10 , pp. 1219-1230
    • Nawrocki, A.R.1    Scherer, P.E.2
  • 53
    • 77449138454 scopus 로고    scopus 로고
    • Suppressing the activity of ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake
    • Nie Y, Wong C. Suppressing the activity of ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake. J Cell Mol Med 13: 3051-3060, 2008.
    • (2008) J Cell Mol Med , vol.13 , pp. 3051-3060
    • Nie, Y.1    Wong, C.2
  • 55
    • 77649198252 scopus 로고    scopus 로고
    • Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant- negative form of AMP-activated protein kinase
    • Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi Y, Ueki K, Kadowaki T. Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant- negative form of AMP-activated protein kinase. Endocr J 57: 141-152, 2010.
    • (2010) Endocr J , vol.57 , pp. 141-152
    • Okazaki, Y.1    Eto, K.2    Yamashita, T.3    Okamoto, M.4    Ohsugi, M.5    Noda, M.6    Terauchi, Y.7    Ueki, K.8    Kadowaki, T.9
  • 56
    • 5444224643 scopus 로고    scopus 로고
    • Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues
    • Pendergrass W, Wolf N, Poot M. Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues. Cytometry A 61: 162-169, 2004.
    • (2004) Cytometry A , vol.61 , pp. 162-169
    • Pendergrass, W.1    Wolf, N.2    Poot, M.3
  • 57
    • 0015431117 scopus 로고
    • Lysosomes of the arterial wall. I. Isolation and subcellular fractionation of cells from normal rabbit aorta
    • Peters TJ, Müller M, De Duve C. Lysosomes of the arterial wall. I. Isolation and subcellular fractionation of cells from normal rabbit aorta. J Exp Med 136: 1117-1139, 1972.
    • (1972) J Exp Med , vol.136 , pp. 1117-1139
    • Peters, T.J.1    Müller, M.2    de Duve, C.3
  • 58
    • 33745851905 scopus 로고    scopus 로고
    • Toward the complete yeast mitochondrial proteome: Multidimensional separation techniques for mitochondrial proteomics
    • Reinders J, Zahedi RP, Pfanner N, Meisinger C, Sickmann A. Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-1554, 2006.
    • (2006) J Proteome Res , vol.5 , pp. 1543-1554
    • Reinders, J.1    Zahedi, R.P.2    Pfanner, N.3    Meisinger, C.4    Sickmann, A.5
  • 61
    • 0033823015 scopus 로고    scopus 로고
    • Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue
    • Rossmeisl M, Syrový I, Baumruk F, Flachs P, Janovská P, Kopecký J. Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue. FASEB J 14: 1793-1800, 2000.
    • (2000) FASEB J , vol.14 , pp. 1793-1800
    • Rossmeisl, M.1    Syrový, I.2    Baumruk, F.3    Flachs, P.4    Janovská, P.5    Kopecký, J.6
  • 63
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88: 611-638, 2008.
    • (2008) Physiol Rev , vol.88 , pp. 611-638
    • Scarpulla, R.C.1
  • 64
    • 0026713818 scopus 로고
    • Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation
    • Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem 267: 5317-5323, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 5317-5323
    • Schulze-Osthoff, K.1    Bakker, A.C.2    Vanhaesebroeck, B.3    Beyaert, R.4    Jacob, W.A.5    Fiers, W.6
  • 66
    • 0029927505 scopus 로고    scopus 로고
    • Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
    • Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68: 850-858, 1996.
    • (1996) Anal Chem , vol.68 , pp. 850-858
    • Shevchenko, A.1    Wilm, M.2    Vorm, O.3    Mann, M.4
  • 67
    • 34147147434 scopus 로고    scopus 로고
    • Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism
    • Si Y, Palani S, Jayaraman A, Lee K. Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism. J Lipid Res 48: 826-836, 2007.
    • (2007) J Lipid Res , vol.48 , pp. 826-836
    • Si, Y.1    Palani, S.2    Jayaraman, A.3    Lee, K.4
  • 68
    • 70349165556 scopus 로고    scopus 로고
    • Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes
    • Si Y, Shi H, Lee K. Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. PLoS One 4: e7000, 2009.
    • (2009) PLoS One , vol.4
    • Si, Y.1    Shi, H.2    Lee, K.3
  • 69
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 104: 531-543, 2001.
    • (2001) Cell , vol.104 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 70
    • 0042433242 scopus 로고    scopus 로고
    • Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state
    • Starkov AA, Fiskum G. Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J Neurochem 86: 1101-1107, 2003.
    • (2003) J Neurochem , vol.86 , pp. 1101-1107
    • Starkov, A.A.1    Fiskum, G.2
  • 72
    • 0038287874 scopus 로고    scopus 로고
    • Effects of mitochondrial uncoupling on adipocyte intracellular Ca(2+) and lipid metabolism
    • Sun X, Zemel MB. Effects of mitochondrial uncoupling on adipocyte intracellular Ca(2+) and lipid metabolism. J Nutr Biochem 14: 219-226, 2003.
    • (2003) J Nutr Biochem , vol.14 , pp. 219-226
    • Sun, X.1    Zemel, M.B.2
  • 73
    • 62149139816 scopus 로고    scopus 로고
    • Mid mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-indepen-dent mechanism, whereas TNFalpha-induced de-differentiation is PPAR-gamma dependent
    • Tejerina S, De Pauw A, Vankoningsloo S, Houbion A, Renard P, De Longueville F, Raes M, Arnould T. Mid mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-indepen-dent mechanism, whereas TNFalpha-induced de-differentiation is PPAR-gamma dependent. J Cell Sci 122: 145-155, 2009.
    • (2009) J Cell Sci , vol.122 , pp. 145-155
    • Tejerina, S.1    de Pauw, A.2    Vankoningsloo, S.3    Houbion, A.4    Renard, P.5    de Longueville, F.6    Raes, M.7    Arnould, T.8
  • 74
    • 33947592809 scopus 로고    scopus 로고
    • Moderate dependence of ROS formation on DeltaPsim in isolated brain mitochondria supported by NADH-linked substrates
    • Tretter L, Adam-Vizi V. Moderate dependence of ROS formation on DeltaPsim in isolated brain mitochondria supported by NADH-linked substrates. Neurochem Res 32: 569-575, 2007.
    • (2007) Neurochem Res , vol.32 , pp. 569-575
    • Tretter, L.1    Adam-Vizi, V.2
  • 76
    • 0033612301 scopus 로고    scopus 로고
    • The protein import motor of mitochondria: Unfolding and trapping of prepro-teins are distinct and separable functions of matrix Hsp70
    • Voisine C, Craig EA, Zufall N, von Ahsen O, Pfanner N, Voos W. The protein import motor of mitochondria: unfolding and trapping of prepro-teins are distinct and separable functions of matrix Hsp70. Cell 97: 565-574, 1999.
    • (1999) Cell , vol.97 , pp. 565-574
    • Voisine, C.1    Craig, E.A.2    Zufall, N.3    von Ahsen, O.4    Pfanner, N.5    Voos, W.6
  • 77
    • 56349153028 scopus 로고    scopus 로고
    • Protein transport machineries for precursor translocation across the inner mitochondrial membrane
    • Wagner K, Mick DU, Rehling P. Protein transport machineries for precursor translocation across the inner mitochondrial membrane. Biochim Biophys Acta 1793: 52-59, 2009.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 52-59
    • Wagner, K.1    Mick, D.U.2    Rehling, P.3
  • 78
    • 0033525773 scopus 로고    scopus 로고
    • Mitochondrial diseases in man and mouse
    • Wallace DC. Mitochondrial diseases in man and mouse. Science 283: 1482-1488, 1999.
    • (1999) Science , vol.283 , pp. 1482-1488
    • Wallace, D.C.1
  • 79
    • 0038162526 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and oxidative stress in mitochondrial diseases
    • Wei YH, Lee HC. Mitochondrial DNA mutations and oxidative stress in mitochondrial diseases. Adv Clin Chem 37: 83-128, 2003.
    • (2003) Adv Clin Chem , vol.37 , pp. 83-128
    • Wei, Y.H.1    Lee, H.C.2
  • 81
    • 0141961773 scopus 로고    scopus 로고
    • Decreased energy levels can cause and sustain obesity
    • Wlodek D, Gonzales M. Decreased energy levels can cause and sustain obesity. J Theor Biol 225: 33-44, 2003.
    • (2003) J Theor Biol , vol.225 , pp. 33-44
    • Wlodek, D.1    Gonzales, M.2
  • 84
    • 33644552417 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mito-chondrial morphology
    • Yu T, Robotham JL, Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mito-chondrial morphology. Proc Natl Acad Sci USA 103: 2653-2658, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2653-2658
    • Yu, T.1    Robotham, J.L.2    Yoon, Y.3
  • 85
    • 0032780688 scopus 로고    scopus 로고
    • On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes
    • Zaid A, Li R, Luciakova K, Barath P, Nery S, Nelson BD. On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes. J Bioenerg Biomembr 31: 129-135, 1999.
    • (1999) J Bioenerg Biomembr , vol.31 , pp. 129-135
    • Zaid, A.1    Li, R.2    Luciakova, K.3    Barath, P.4    Nery, S.5    Nelson, B.D.6
  • 86
    • 0036789186 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP
    • Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg AS. Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes 51: 2929-2935, 2002.
    • (2002) Diabetes , vol.51 , pp. 2929-2935
    • Zhang, H.H.1    Halbleib, M.2    Ahmad, F.3    Manganiello, V.C.4    Greenberg, A.S.5
  • 87
    • 0028842233 scopus 로고
    • Regulation of pyruvate carboxylase in 3T3-L1 cells
    • Zhang J, Xia WL, Ahmad F. Regulation of pyruvate carboxylase in 3T3-L1 cells. Biochem J 306: 205-210, 1995.
    • (1995) Biochem J , vol.306 , pp. 205-210
    • Zhang, J.1    Xia, W.L.2    Ahmad, F.3


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