Factors predicting the appearance of neutropenia in patients with advanced pancreatic cancer undergoing gemcitabine therapy

Hepato-Gastroenterology

Volumn 59, Issue 115, 2012, Pages 894-898

  Yoneyama, Keiichiro ^a   Katsumoto, Emi ^a   Kurihara, Tatsuya ^a   Kogo, Mari ^a   Ikegami, Akitoshi ^b   Imawari, Michiro ^b   Shimada, Ken ^c   Yoshikumi, Hiroki ^d   Inoue, Kazuaki ^d   Kiuchi, Yuji ^a  

^a SHOWA UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SHOWA UNIVERSITY NORTHERN YOKOHAMA HOSPITAL   (Japan)

^d SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Gemcitabine hydrochloride; Neutropenia; Pancreatic cancer; Toxicity index

Indexed keywords

CA 19-9 ANTIGEN; GEMCITABINE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; DISEASE SEVERITY; FEMALE; HUMAN; LEUKOCYTE COUNT; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEUTROPENIA; PANCREAS CANCER; PREDICTION; PRIORITY JOURNAL; TREATMENT OUTCOME; UNIVARIATE ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; CA-19-9 ANTIGEN; DEOXYCYTIDINE; FEMALE; HUMANS; LEUKOCYTE COUNT; LIVER NEOPLASMS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUTROPENIA; ODDS RATIO; PANCREATIC NEOPLASMS; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84860533168     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge11567     Document Type: Article

References (17)

1. Lowenfels AB, Maisonneuve P: Epidemiology and prevention of pancreatic cancer. Jpn J Clin Oncol 2004; 34:238-244. (Pubitemid 43102883)
2. Yip D, Karapetis C, Strickland A, et al.: Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer (Review): Cochrance Databese Syst Rev 2006; 19:CD002093.
3. Palmer KR, Kerr M, Knowles G, et al.: Chemotherapy prolongs survival in inoperable pancreatic carcinoma. Br J Surg 1994; 81:882-885. (Pubitemid 24204817)
4. Glimelius B, Hoffman K, Sjödén PO, et al.: Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 1996; 7:593-600. (Pubitemid 26285639)
5. Burris HA 3rd, Moore MJ, Andersen J, et al.: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15:2403-2413. (Pubitemid 27251144)
6. Frei E 3rd, Canellos GP: Dose: a critical factor in cancer chemotherapy. Am J Med 1980; 69:585-594.
7. Oken MM, Creech RH, Tormey DC, et al.: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 5:649-655. (Pubitemid 13149996)
8. th eds. Tokyo, Japan: Kinbara co; 2009: 1-11.
9. Japanese translation of common terminology criteria for adverse events (CTCAE), and instructions and guidelines. Int J Clin Oncol 2004; 9(Suppl 3):1-82.
10. Kalser MH, Barkin J, MacIntyre JM: Pancreatic cancer. Assessment of prognosis by clinical presentation. Cancer 1985; 56:397-402. (Pubitemid 15031666)
11. Nakao A, Oshima K, Nomoto S, et al.: Clinical usefulness of CA-19-9 in pancreatic carcinoma. Semin Surg Oncol 1998; 15:15-22. (Pubitemid 28331156)
12. Safi F, Schlosser W, Falkenreck S, et al.: Prognostic value of CA 19-9 serum course in pancreatic cancer. Hepatogastroenterology 1998; 45:253-259. (Pubitemid 28067563)
13. Montgomery RC, Hoffman JP, Riley LB, et al.: Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas. Ann Surg Oncol 1997; 4:551-556. (Pubitemid 127725501)
14. Ferrone CR, Finkelstein DM, Thayer SP, et al.: Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma. J Clin Oncol 2006; 24:2897-2902. (Pubitemid 46630592)
15. Takada A, Ohmori K, Takahashi N, et al.: Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A. Biochem Biophys Res Commun 1991; 179: 713-719.
16. Takada A, Ohmori K, Yoneda T, et al.: Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res 1993; 53: 354-361. (Pubitemid 23031849)
17. Kannagi R: Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer. Glycoconj J 1997; 14:577-584.