Combination DLL4 with Jagged1-siRNA can enhance inhibition of the proliferation and invasiveness activity of human gastric carcinoma by Notch1/VEGF pathway

Hepato-Gastroenterology

Volumn 59, Issue 115, 2012, Pages 924-929

  Sun, Hua Wen ^a   Wu, Chong ^a   Tan, Hai Yan ^a   Wang, Qiu Shuang ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Carcinoma; DLL4 and Jagged1 siRNA; Inhibition; Invasiveness; Proliferation; siRNA

Indexed keywords

ENDOSTATIN; JAGGED1; NOTCH1 RECEPTOR; PEPTIDES AND PROTEINS; PROTEIN DLL4; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN;

APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CANCER CELL CULTURE; CANCER CONTROL; CANCER INHIBITION; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENETIC VECTORS; HEK293 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; RECEPTOR, NOTCH1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TIME FACTORS; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84860523901     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge11484     Document Type: Article

References (48)

1. Radtke F, Raj K: The role of Notch in tumorigenesis: Oncogene or tumour suppressor? Nature RevCancer 2003; 3:756-67 (Pubitemid 37328814)
2. Wang XD, Shou J, Wong P, French DM, Gao WQ: The application of DNA sequencing in studying haplotypes of PAI-1 gene in patients with coronary artery disease. J Biol Chem 2004; 279:24733-44.
3. Leong KG, Karsan A: Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006; 107:2223-33. (Pubitemid 43345539)
4. Shih, IeM, Wang, TL: Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res 2007; 5:1879-82.
5. Scorey N, Fraser SP, Patel P, Pridgeon C, Dallman MJ, Djamgoz MB: Notch signalling and voltagegated Na+ channel activity in human prostate cancer cells: independent modulation of in vitro motility. Prostate Cancer Prostatic Dis 2006; 9:399-406. (Pubitemid 44843133)
6. Zeng Q, Li S, Chepeha DB, Giordano TJ, et al.: Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 2005; 1:13-23. (Pubitemid 40991811)
7. Hellström M, Phng LK, Hofmann JJ, et al.: Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007; 445:776-80. (Pubitemid 46279716)
8. Noguera-Troise I, Daly C, Papadopoulos NJ, et al.: Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006; 444(7122):1032-7. (Pubitemid 46018516)
9. Pan Q, Bao LW, Merajver SD: Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade. Mol Cancer Res 2003; 1:701-6. (Pubitemid 37025588)
10. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66:649-61. (Pubitemid 121001701)
11. Stylianou S, Clarke RB, Brennan K: Aberrant activation of notch signaling in human breast cancer. Cancer Res 2006; 66:1517-25. (Pubitemid 43259933)
12. Dang L, Fan X, Chaudhy A, Wang M, Gaiano N, Eberhart CG: Notch3 signaling initiates choroid plexus tumor formation. Oncogene 2006; 25:487-91. (Pubitemid 43117634)
13. Taylor KL, Henderson AM, Hughes CC: Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc Res 2002; 64:372-83. (Pubitemid 35370739)
14. Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH: Downregulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 2006; 66:2778-84.
15. Leong KG, Karsan A: Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006; 107:2223-33. (Pubitemid 43345539)
16. Koch U, Radtke F: Notch and cancer: a double-edged sword. Cell Mol Life Sci 2007; 64:2746-62. (Pubitemid 351152259)
17. Executive Yuan: Taiwan area: Death rate of ten leading sites of malignant neoplasms. Taiwan: Department of Health, Executive Yuan; 2006; p.160-73.
18. Terry M, Gaudet M, Gammon M: The epidemiology of gastric cancer. Semin Radiat Oncol 2002; 12:111-27. (Pubitemid 34522348)
19. Gonzalez C, Sala N, Capella G: Genetic susceptibility and gastric cancer risk. Int J Cancer 2002; 100:249-60. (Pubitemid 34728981)
20. Zheng L, Wang L, Ajani J, Xie K: Molecular basis of gastric cancer development and progression. Gastric Cancer 2004; 7:61-77. (Pubitemid 38899656)
21. El-Rifai W, Powell S: Molecular biology of gastric cancer. Semin Radiat Oncol 2002; 12:128-40. (Pubitemid 34522349)
22. Hsu KW, Hsieh RH, Lee YHW, et al.: The activated Notch1 receptor cooperates with α-enolase and MBP-1 in modulating c-myc activity. Mol Cell Biol 2008; 28:4829-42.
23. Chiang Y, Lo C, Chen Y, et al.: Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Br J Pharmacol 2005; 146:352-63. (Pubitemid 41486677)
24. Jin L, Meng C, Han S, et al.: A study on production of monoclonal anti-bodies using SC-M1 cells as immunogen. Med Sci 1987; 8:17-25.
25. Liao WR, Hsieh RH, Hsu KW, et al.: The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1. Carcinogenesis 2007; 28:1867-76.
26. Timmerman LA, Grego-Bessa J, Raya A, et al.: Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 2004; 18:99-115. (Pubitemid 38090691)
27. Watson SA, Grabowska AM, El-Zaatari M, Takhar A: Gastrin-active participant or bystander in gastric carcinogenesis? Nat Rev Cancer 2006; 6:936-46. (Pubitemid 44862678)
28. Smith M, Hold G, Tahara E, El-Omar E: Cellular and molecular aspects of gastric cancer. World J Gastroenterol 2006; 12:2979- 90.
29. Shi H, Xu J, Hu N, Xie H: Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma. World J Gastroenterol 2003; 9:1421-6. (Pubitemid 36992325)
30. Murata H, Kawano S, Tsuji S, et al.: Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. Am J Gastroenterol 1999; 94:451-5. (Pubitemid 29084668)
31. Hu P, Yu J, Zeng Z, et al.: Chemoprevention of gastric cancer by celecoxib in rats. Gut 2004; 53:195-200. (Pubitemid 38125505)
32. Chen JH, Wu CW, Kao HL, et al.: Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor. Cancer Lett 2006; 239:263-70.
33. Yang Z, Zhang X, Gang H, et al.: Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression. Biochem Biophys Res Commun 2007; 358:925-30. (Pubitemid 46802478)
34. Li S, Tong Q, Zhang W, Wang Q, Chen Z, Wu Q: Mechanism of growth inhibitory effects of cyclooxygenase-2inhibitor-NS398 on cancer cells. Cancer Invest 2008; 26:333-7. (Pubitemid 351601387)
35. Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L: Rational targeting of Notch signaling in cancer. Oncogene 2008; 27:5124-31.
36. Katoh M, Katoh M: Notch signaling in gastrointestinal tract (review). Int J Oncol 2007; 30:247-51.
37. Lee D, Moss S: COX-2 inhibition and the prevention of gastric cancer. Digestion 2006; 74:184-6. (Pubitemid 46622788)
38. Jiang X, Wong B: Cyclooxygenase-2 inhibition and gastric can- cer. Curr Pharm Des 2003; 9:2281-8. (Pubitemid 37142441)
39. Fujimura T, Ohta T, Oyama K, Miyashita T, Miwa K: Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. World J Gastroenterol 2006; 12:1336-45.
40. Saukkonen K, Tomasetto C, Narko K, Rio M, Ristimäki A: Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice. Cancer Res 2003; 63:3032-6. (Pubitemid 36735846)
41. Wang AM, Ku HH, Liang YC, Chen YC, Hwu YM, Yeh TS: The autonomous Notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem 2009; 106:682-92.
42. deMoraes E, Dar N, deMoura Gallo C, Hainaut P: Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis. Inter J Cancer 2007; 121:929-37. (Pubitemid 47101627)
43. Wang D, Mann J, DuBois R: WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. Cell Cycle 2004; 3:1512-5. (Pubitemid 40521402)
44. Espinosa L, Ingles-Esteve J, Robert-Moreno A, Bigas A: IκBα and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFκB pathways. Mol Biol Cell 2003; 14:491-502. (Pubitemid 36237011)
45. Sander GR, Powell BC: Expression of Notch receptors and ligands in the adult gut. J Histochem Cytochem 2004; 52:509-16. (Pubitemid 38420385)
46. Katoh M, Katoh M: Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. Int J Mol Med 2006; 17:681-5.
47. Sekine A, Akiyama Y, Yanagihara K, Yuasa Y: Hath1 up-regulates gastric mucin gene expression in gastric cells. Biochem Biophys Res Commun 2006; 344:1166-71.
48. Leong KG, Niessen K, Kulic I, et al.: Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 2007; 204:2935-48. (Pubitemid 350179562)