Evolving role of molecular imaging for new understanding: Targeting myofibroblasts to predict remodeling

Annals of the New York Academy of Sciences

Volumn 1254, Issue 1, 2012, Pages 33-41

  de Haas, Hans J ^a,b   van den Borne, Susanne W ^c   Boersma, Hendrikus H ^b   Slart, Riemer H J A ^b   Fuster, Valentin ^a,d   Narula, Jagat ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

Adverse remodeling; Fibrosis; Heart failure; Molecular imaging; Myocardial infarction; Myofibroblast

Indexed keywords

COLLAGEN; GROWTH FACTOR RECEPTOR;

ANGIOGENESIS; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; HEART INFARCTION; HEART INFARCTION SIZE; HEART VENTRICLE REMODELING; MOLECULAR IMAGING; MYOFIBROBLAST; NONHUMAN; PREDICTION; UPREGULATION;

EID: 84860484017     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06476.x     Document Type: Article

References (32)

1. Bujak, M. & N.G. Frangogiannis 2007. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc. Res. 74: 184-195.
2. Blankesteijn, W.M., E. Creemers, E. Lutgens, et al 2001. Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice. Acta Physiol. Scand. 173: 75-82.
3. Desmoulière, A., A. Geinoz, F. Gabbiani, et al 1993. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell. Biol. 122: 103-111.
4. Miettinen, P.J., R. Ebner, A.R. Lopez, et al 1994. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell. Biol. 127: 2021-2036.
5. Sun, Y., M.F. Kiani, A.E. Postlethwaite, et al 2002. Infarct scar as living tissue. Basic Res. Cardiol. 97: 343-347.
6. Cleutjens, J.P., W.M. Blankesteijn, M.J. Daemen, et al 1999. The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions. Cardiovasc. Res. 44: 232-241.
7. Smith-Mungo, L.I. & H.M. Kagan 1998. Lysyl oxidase: properties, regulation and multiple functions in biology. Matrix. Biol. 16: 387-398.
8. Sun, Y. 2000. Infarct scar: a dynamic tissue. Cardiovasc. Res. 46: 250-256.
9. van den Borne, S.W.M., J. Diez, W.M. Blankesteijn, et al 2010. Myocardial remodeling after infarction: the role of myofibroblasts. Nat. Rev. Cardiol. 7: 30-37.
10. Rosenkranz, S., M. Flesch, K. Amann, et al 2002. Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1). Am. J. Physiol. Heart. Circ. Physiol. 283: H1253-H1262.
11. Eyden, B. 2005. The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 1-normal and reactive cells. J. Submicrosc. Cytol. Pathol. 37: 109-204.
12. Hinz, B., S.H. Phan, V.J. Thannickal, et al 2007. The myofibroblast: one function, multiple origins. Am. J. Path. 170: 1807-1816.
13. Blankesteijn, W.M., Y.P. Essers-Janssen, M.J. Verluyten, et al 1997. A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. Nat. Med. 3: 541-544.
14. Wynn, T.A. 2008. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214: 199-210.
15. Hinz, B. 2006. Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission. Eur. J. Cell Biol. 85: 175-181.
16. Hong, H.H., M.I. Uzel, C. Duan, et al 1999. Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva. Lab. Invest. 79: 1655-1667.
17. Weber, K.T. 1997. Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation. Circulation 96: 4065-4082.
18. Harada, K., T. Sugaya, K. Murakami, et al 1999. Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction. Circulation 100: 2093-2099.
19. Pfeffer, M.A., K. Swedberg, C.B. Granger, et al 2003. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 362: 759-766.
20. Pitt, B., P.A. Poole-Wilson, R. Segal, et al 2000. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial-the Losartan Heart Failure Survival Study ELITE II. Lancet. 355: 1582-1587.
21. Cohn, J.N. & G. Tognoni 2001. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N. Engl. J. Med. 345: 1667-1675.
22. The CONSENSUS Trial Study Group. 1987. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N. Engl. J. Med. 316: 1429-1435.
23. The SOLVD Investigators. 1991. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N. Engl. J. Med. 325: 293-302.
24. Verjans, J.W.H., D. Lovhaug, N. Narula, et al 2008. Noninvasive imaging of angiotensin receptors after myocardial infarction. JACC Cardiovasc. Imaging 1: 354-362.
25. Dilsizian, V., W.C. Eckelman, M.L. Loredo, et al 2007. Evidence for tissue angiotensin-converting enzyme in explanted hearts of ischemic cardiomyopathy using targeted radiotracer technique. J. Nucl. Med. 48: 182-187.
26. Dilsizian, V., T.K. Zynda, A. Petrov, et al 2012. Molecular imaging of human angiotensin converting enzyme-1 expression in transgenic rats with hybrid micro SPECT/CT. JACC. Cardiovasc. Imaging. In Press.
27. Asano, Y., H. Ihn, K. Yamane, et al 2005. Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. J. Immunol. 175: 7708-7718.
28. van den Borne, S.W.M., S. Isobe, J.W. Verjans, et al 2008. Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction. J. Am. Coll. Cardiol. 52: 2017-2028.
29. van den Borne, S.W.M., S. Isobe, H.R. Zandbergen, et al 2009. Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling. JACC. Cardiovasc. Imaging 2: 187-198.
30. Verjans, J., S. Wolters, W. Laufer, et al 2010. Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging. J. Nucl. Cardiol. 17: 1065-1072.
31. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico. 1994. GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 343: 1115-1122.
32. Narula, J. & V. Dilsizian 2008. From better understood pathogenesis to superior molecular imaging, and back. JACC. Cardiovasc. Imaging 1: 406-409.