Synthesis and biological evaluation of a new class of glycoconjugated disulfides that exhibit potential anticancer properties

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 10, 2012, Pages 3186-3195

  Bonaccorsi, Paola ^a   Marino Merlo, Francesca ^a   Barattucci, Anna ^a   Battaglia, Gianluca ^a   Papaianni, Emanuela ^a   Papalia, Teresa ^a   Aversa, Maria C ^a   Mastino, Antonio ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Apoptosis; Cytotoxicity; Sulfenic acids; Thioglycoconjugates; Unsymmetrical disulfides

Indexed keywords

1,3 DI [[(2,3,4,6 TETRA O ACETYL BETA GALACTOPYRANOSYL)DITHIO]METHYL]BENZENE; 1,3 DI [[(2,3,4,6 TETRA O ACETYL BETA GLUCOPYRANOSYL)DITHIO]METHYL]BENZENE; 1,3 DI [[(BETA GALACTOPYRANOSYL)DITHIO]METHYL]BENZENE; 1,3,5 TRI [[(BETA GLUCOPYRANOSYL)DITHIO]METHYL] 2,4,6 TRIMETHYLBENZENE; 1,4 DI [[(2,3,4,6 TETRA O ACETYL BETA GALACTOPYRANOSYL)DITHIO]METHYL]BENZENE; 1,4 DI [[(2,3,4,6 TETRA O ACETYL BETA GLUCOPYRANOSYL)DITHIO]METHYL]BENZENE; 1,4 DI [[(BETA GLUCOPYRANOSYL)DITHIO]METHYL]BENZENE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CARBOHYDRATE; CARBOHYDRATE BINDING PROTEIN; DISULFIDE; GALACTOSE; GLYCOCONJUGATE; PROTEIN BCL 2; SULFENIC ACID DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARBOHYDRATE METABOLISM; CELL DEATH; CELL STRAIN U937; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISULFIDE BOND; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENANTIOMER; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOHYDRATE SEQUENCE; CELL LINE, TUMOR; CELL SURVIVAL; DISULFIDES; GLYCOCONJUGATES; HUMANS; LEUKOCYTES, MONONUCLEAR; MOLECULAR STRUCTURE; U937 CELLS;

EID: 84860453944     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.070     Document Type: Article

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