A simple thermal pain model for the evaluation of analgesic activity in healthy subjects

Journal of Anaesthesiology Clinical Pharmacology

Volumn 28, Issue 2, 2012, Pages 214-220

  Khambam, Sunil Kumar Reddy ^a   Naidu, M U R ^a   Rani, P Usha ^a   Kumar Rao, T Ramesh ^a  

^a NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Analgesia; experimental; heat pain; pharmacodynamics; tramadol

Indexed keywords

PLACEBO; TRAMADOL;

ADULT; ANALGESIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL MODEL; FEMALE; FOOD; FOOD DRUG INTERACTION; FUNCTION TEST; HUMAN; HUMAN EXPERIMENT; MALE; NOCICEPTION; NORMAL HUMAN; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; PAIN THRESHOLD TIME; QUANTITATIVE SENSORY TESTING; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; REPRODUCIBILITY; SEDATION; SENSITIVITY ANALYSIS; SIDE EFFECT; STATE TRAIT ANXIETY INVENTORY; THERMAL PAIN; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDITY;

EID: 84860453754     PISSN: 09709185     EISSN: 22312730     Source Type: Journal    
DOI: 10.4103/0970-9185.94887     Document Type: Article

References (21)

1. Konig HH, Bernert S, Angermeyer MC. Health Status of the German Population: Results of a Representative Survey Using the euroqol questionnaire. Gesundheitswesen 2005;67:173-82. (Pubitemid 40523398)
2. Drewes AM, Gregersen H, Arendt-Nielsen L. Experimental pain in gastroenterology: A reappraisal of human studies. Scand J Gastroenterol 2003;38:1115-30. (Pubitemid 37518595)
3. Posner J, Telekes A, Crowley D, Phillipson R, Peck AW. Effects of an opiate on cold-induced pain and the CNS in healthy volunteers. Pain 1985;23:73-82. (Pubitemid 15236654)
4. Brennum J, Dahl JB, Moiniche S, Arendt-Nielsen L. Quantitative sensory examination of epidural anaesthesia and analgesia in man: Effects of pre-and post-traumatic morphine on hyperalgesia. Pain 1994;59:261-71. (Pubitemid 24348911)
5. Pedersen JL, Kehlet H. Secondary hyperalgesia to heat stimuli after burn injury in man. Pain 1998;76:377-84. (Pubitemid 28342747)
6. Yarnitsky D, Sprecher E, Zaslansky R, Hemli JA. Multiple session experimental pain measurement. Pain 1996;67:327-33. (Pubitemid 26375348)
7. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307-10. (Pubitemid 16134762)
8. Staahl C, Drewes AM. Experimental human pain models: A review of standardized methods for preclinical testing of analgesics. Basic Clin Pharmacol Toxicol 2004;95:97-111. (Pubitemid 39331302)
9. Staahl C, Reddy H, Andersen SD, Arendt-Nielsen L, Drewes AM. Multi-model and tissue-differentiated experimental pain assessment: Reproducibility of a new concept for assessment of analgesics. Basic Clin Pharmacol Toxicol 2006;98:201-11.
10. Youden WJ, Steiner EH, editors. Statistical manual of the official Association of Analytical Chemists. PO Box 540; Benjamin Franklin Station: Washington DC; 1975.
11. Stacher G, Steinringer H, Schneider S, Mittelbach G, Winklehner S, Gaupmann G. Experimental pain induced by electrical and thermal stimulation of the skin in healthy man: Sensitivity to 75 and 150 mg diclofenac sodium in comparison with 60 mg codeine and placebo. Br J Clin Pharmac 1986;21:35-43. (Pubitemid 17170750)
12. Jensen J, McIntosh AR, Crawley AP, Mikulis DJ, Remington G, Kapur S. Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron 2003;40:1251-7. (Pubitemid 38032799)
13. Seymour B, O'Doherty JP, Koltzenburg M, Wiech K, Frackowiak R, Friston K, et al. Opponent appetitive-aversive neural processes underlie predictive learning of pain relief. Nat Neurosci 2005;8:1234-40. (Pubitemid 43348143)
14. Menon M, Jensen J, Vitcu I, Graff-Guerrero A, Crawley A, Smith MA, et al. Temporal difference modeling of the bloodoxygen level dependent response during aversive conditioning in humans: Effects of dopaminergic modulation. Biol Psychiatry 2007;62:765-72. (Pubitemid 47381433)
15. Garcia R, Benet M, Arnau C, Cobo E. Efficiency of the cross-over design: An empirical estimation. Stat Med 2004;23:3773-80. (Pubitemid 40074076)
16. Gijsbers K, Nicholson F. Experimental pain thresholds influenced by sex of experimenter. Percept Mot Skills 2005;101:803-7. (Pubitemid 43569063)
17. Thurauf N, Fleischer WK, Liefhold J, Schmid O, Kobal G. Dose dependent time course of the analgesic effect of a sustained-release preparation of tramadol on experimental phasic and tonic pain. Br J Clin Pharmacol 1996;41:115-23. (Pubitemid 26060740)
18. Absi M, Rokke PD. Can anxiety help us tolerate pain? Pain 1991;46:43-51.
19. James JE, Hardardottir D. Influence of focus and trait anxiety on tolerance of acute pain. Br J Health Psychol 2002;7:149-62. (Pubitemid 34555863)
20. Rhudy JL, Meagher MW. Fear and anxiety: Divergent effects on human pain thresholds. Pain 2000;84:65-75.
21. Tang J, Gibson SJ. A psychophysical evaluation of the relationship between trait anxiety, pain perception, and induced state anxiety. J Pain 2005;6:612-9.