Non-resective surgery and radiosurgery for treatment of drug-resistant epilepsy

Epilepsy Research

Volumn 99, Issue 3, 2012, Pages 193-201

  Romanelli, Pantaleo ^a   Striano, Pasquale ^b   Barbarisi, Manlio ^c   Coppola, Giangennaro ^d   Anschel, David J ^e  

^a Centro Diagnostico Italiano   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF SALERNO   (Italy)

^e St Charles Hospital ^*  (United States)

Author keywords

Deep brain stimulation; Epilepsy; Multiple subpial transections; Neuromodulation; Stereotactic radiosurgery; Vagal nerve stimulation

Indexed keywords

BRAIN DEPTH STIMULATION; CLINICAL EFFECTIVENESS; EPILEPSY; HUMAN; IMPLANTABLE NEUROSTIMULATOR; MULTIPLE SUBPIAL TRANSECTION; NEUROMODULATION; NEUROSURGERY; NONHUMAN; OUTCOME ASSESSMENT; PATIENT SAFETY; PRIORITY JOURNAL; REVIEW; STEREOTACTIC RADIOSURGERY; SURGICAL TECHNIQUE; TREATMENT INDICATION; VAGUS NERVE STIMULATION;

ANIMALS; ANTICONVULSANTS; DEEP BRAIN STIMULATION; EPILEPSY; HUMANS; RADIOSURGERY; TREATMENT OUTCOME;

EID: 84860440331     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.12.016     Document Type: Review

References (111)

1. Anderson C.T., Davis K., Baltuch G. An update on brain stimulation for epilepsy. Curr. Neurol. Neurosci. Rep. 2009, 9:327-332.
2. Andrade D.M., Zumsteg D., Hamani C., Hodaie M., Sarkissian S., Lozano A.M., Wennberg R.A. Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy. Neurology 2006, 66:1571-1573.
3. Arita K., Kurisu K., Iida K., Hanaya R., Akimitsu T., Hibino S., et al. Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report. J. Neurosurg. 1998, 89:645-648.
4. Asadi-Pooya A.A., Sharan A., Nei M., Sperling M.R. Corpus callosotomy. Epilepsy Behav. 2008, 13:271-278.
5. Asadi-Pooya A.A., Sharan A., Nei M., Sperling M.R. Corpus callosotomy. Epilepsy Behav. 2008, 13:271-278.
6. Baaj A.A., Benbadis S.R., Tatum W.O., Vale F.L. Trends in the use of vagus nerve stimulation for epilepsy: analysis of a nationwide database. Neurosurg. Focus 2008, 25(3):E10.
7. Bailey P., Bremer F. A sensory cortical representation of the vagus nerve with a note on the effects of low blood pressure on the cortical electrogram. J. Neurophysiol. 1938, 1:405-412.
8. Bauman J.A., Feoli E., Romanelli P., Doyle W.K., Devinsky O., Weiner H.L. Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy. Neurosurgery 2005, 56:318-334.
9. Benabid A.L., Koudsie A., Benazzouz A., Vercueil L., Fraix V., Chabardes S., Lebas J.F., Pollak P. Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy. J. Neurol. 2001, 248(Suppl. 3):III37-III47.
10. Benifla M., Rutka J., Logan W., Donner E. Vagus nerve stimulation for refractory epilepsy in children: indications and experience at The Hospital for Sick Children. Childs Nerv. Syst. 2006, 22:1018-1026.
11. Ben-Menachem E., Hamberger A., Hedner T., Hammond E.J., Uthman B.M., Slater J., Treig T., Stefan H., Ramsay R.E., Wernicke J.F., Wilder B.J. Effects of vagus nerve stimulation on amino acids and other metabolites in the CSF of patients with partial seizures. Epilepsy Res. 1995, 20:221-227.
12. Ben-Menachem E., Hellstrom K., Waldton C., Augustinsson L.E. Evaluation of refractory epilepsy treated with vagus nerve stimulation for up to 5 years. Neurology 1999, 52:1265-1267.
13. Blount J.P., Langburt W., Otsubo H., Chitoku S., Ochi A., Weiss S., Snead O.C., Rutka J.T. Multiple subpial transections in the treatment of pediatric epilepsy. J. Neurosurg. 2004, 100:118-124.
14. Bohning D.E., Lomarev M.P., Denslow S., Nahas Z., Shastri A., George M. Feasibility of vagus nerve stimulation-synchronized blood oxygenation leveldependent functional MRI. Invest. Radiol. 2001, 36:470-549.
15. Boon P., Vonck K., De Herdt V., Van Dycke A., Goethals M., Goossens L., Van Zandijcke M., De Smedt T., Dewaele I., Achten R., Wadman W., Dewaele F., Caemaert J., Van Roost D. Deep brain stimulation in patients with refractory temporal lobe epilepsy. Epilepsia 2007, 48(8):1551-1560.
16. Cascino G.D. Surgical treatment for epilepsy. Epilepsy Res. 2004, 60:179-186.
17. Chabardes S., Kahane P., Minotti L., Koudsie A., Hirsch E., Benabid A.L. Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus. Epileptic Disord. 2002, 4(Suppl. 3):S83-S93.
18. Chang E.F., Quigg M., Oh M.C., Dillon W.P., Ward M.M., Laxer K.D., Broshek D.K., Barbaro N.M. Epilepsy Radiosurgery Study Group. Predictors of efficacy after SRS for medial temporal lobe epilepsy. Neurology 2010, 74:165-172.
19. Chervin R.D., Pierce P.A., Connors B.W. Periodicity and directionality in the propagation of epileptiform discharges across neocortex. J. Neurophysiol. 1988, 60:1695-1713.
20. Chkhenkeli S.A., Chkhenkeli I.S. Effects of therapeutic stimulation of nucleus caudatus on epileptic electrical activity of brain in patients with intractable epilepsy. Stereotact. Funct. Neurosurg. 1997, 69:221-224.
21. Cooper I.S., Amin I., Riklan M., Waltz J.M., Poon T.P. Chronic cerebellar stimulation in epilepsy. Clinical and anatomical studies. Arch. Neurol. 1976, 33:559-570.
22. Davis R., Emmonds S.E. Cerebellar stimulation for seizure control: 17-year study. Stereotact. Funct. Neurosurg. 1992, 58:200-208.
23. De Ribaupierre S., Delalande O. Hemispherotomy and other disconnective techniques. Neurosurg. Focus 2008, 25:E14.
24. Devinsky O., Romanelli P., Orbach D., Pacia S., Doyle W. Surgical treatment of multifocal epilepsy involving eloquent cortex. Epilepsia 2003, 44:718-723.
25. Dinner D.S., Neme S., Nair D., Montgomery E.B., Baker K.B., Rezai A., Luders H.O. EEG and evoked potential recording from the subthalamic nucleus for deep brain stimulation of intractable epilepsy. Clin. Neurophysiol. 2002, 113(9):1391-1402.
26. Ellis T.L., Stevens A. Deep brain stimulation for medically refractory epilepsy. Neurosurg. Focus 2008, 25(3):E11.
27. Fountas K.N., Smith J.R., Murro A.M., Politsky J., Park Y.D., Jenkins P.D. Implantation of a closed-loop stimulation in the management of medically refractory focal epilepsy: a technical note. Stereotact. Funct. Neurosurg. 2005, 83:153-158.
28. Fountas K.N., Kapsalaki E., Hadjigeorgiou G. Cerebellar stimulation in the management of medically intractable epilepsy: a systematic and critical review. Neurosurg. Focus 2010, 29(2):E8.
29. Friehs G.M., Park M.C., Goldman M.A., Zerris V.A., Norén G., Sampath P. Stereotactic radiosurgery for functional disorders. Neurosurg. Focus 2007, 23:E3.
30. Frost M., Gates J., Helmers S.L., Wheless J.W., Levisohn P., Tardo C., Conry J.A. Vagus nerve stimulation in children with refractory seizures associated with Lennox-Gastaut syndrome. Epilepsia 2001, 42:1148-1152.
31. Gale K. Role of the substantia nigra in GABA-mediated anticonvulsant actions. Adv. Neurol. 1986, 44:343-364.
32. Go C., Snead O.C. Pharmacologically intractable epilepsy in children: diagnosis and preoperative evaluation. Neurosurg. Focus 2008, 25(3):E2.
33. Hodaie M., Wennberg R.A., Dostrovsky J.O., Lozano A.M. Chronic anterior thalamus stimulation for intractable epilepsy. Epilepsia 2002, 43:603-608.
34. Hubel D.H., Wiesel T.N. Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J. Physiol. 1962, 160:106-154.
35. Hufnagel A., Zentner J., Fernandez G., Wolf H.K., Schramm J., Elger C.E. Multiple subpial transection for control of epileptic seizures: effectiveness and safety. Epilepsia 1997, 38:678-688.
36. Iadarola M.J., Gale K. Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. Science 1982, 218:1237-1240.
37. Irwin K., Birch V., Lees J., Polkey C., Alarcon G., Binnie C., Smedley M., Baird G., Robinson R.O. Multiple subpial transection in Landau-Kleffner syndrome. Dev. Med. Child Neurol. 2001, 43:248-252.
38. Kerrigan J.F., Litt B., Fisher R.S., Cranstoun S., French J.A., Blum D.E., Dichter M., Shetter A., Baltuch G., Jaggi J., Krone S., Brodie M., Rise M., Graves N. Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy. Epilepsia 2004, 45:346-354.
39. Kossoff E.H., Ritzl E.K., Politsky J.M., Murro A.M., Smith J.R., Duckrow R.B., Spencer D.D., Bergey G.K. Effect of an external responsive neurostimulator on seizures and electrographic discharges during subdural electrode monitoring. Epilepsia 2004, 45:1560-1567.
40. Kurita H., Suzuki I., Shin M., Kawai K., Tago M., Momose T., Kirino T. Successful radiosurgical treatment of lesional epilepsy of mesial temporal origin. Minim. Invasive Neurosurg. 2001, 44:43-46.
41. Kuzniecky R., Devinsky O. Surgery insight: surgical management of epilepsy. Nat. Clin. Pract. Neurol. 2007, 3:673-681.
42. Lee K.J., Jang K.S., Shon Y.M. Chronic deep brain stimulation of subthalamic and anterior thalamic nuclei for controlling refractory partial epilepsy. Acta Neurochir. Suppl. (Wien) 2006, 99:87-91.
43. Litt B. Evaluating devices for treating epilepsy. Epilepsia 2003, 44(Suppl. 7):30-37.
44. Litt B., Echauz J. Prediction of epileptic seizures. Lancet Neurol. 2002, 1:22-30.
45. Luders H., Bustamante L.A., Zablow L., Goldensohn E.S. The independence of closely spaced discrete experimental spike foci. Neurology 1981, 31:846-851.
46. Maehara T., Shimizu H. Surgical outcome of corpus callosotomy in patients with drop attacks. Epilepsia 2001, 42:67-71.
47. Mapstone T.B. Vagus nerve stimulation: current concepts. Neurosurg. Focus 2008, 25(3):E9.
48. McGregor A., Wheless J., Baumgartner J., Bettis D. Right sided vagus nerve stimulation as a treatment for refractory epilepsy in humans. Epilepsia 2005, 46:91-96.
49. Mirski M.A., Ferrendelli J.A. Anterior thalamic mediation of generalized pentylenetetrazol seizures. Brain Res. 1986, 399:212-223.
50. Molyneux P.D., Barker R.A., Thom M., van Paesschen W., Harkness W.F., Duncan J.S. Successful treatment of intractable epilepsia partialis continua with multiple subpial transections. J. Neurol. Neurosurg. Psychiatry 1998, 65:137-138.
51. Morell F., Whisler W.W., Smith M.C. Multiple subpial transaction in Rasmussen's encephalitis. Chronic Encephalitis and Epilepsy: Rasmussen's Syndrome 1991, 219-234. Butterworth-Heinemann, Boston. F. Andermann (Ed.).
52. Morrell F.H., Hanbery J.W. A new surgical technique for the treatment of focal cortical epilepsy. Electroencephalogr. Clin. Neurophysiol. 1969, 26:120.
53. Morrell F., Whisler W.W., Bleck T.P. Multiple subpial transection: a new approach to the surgical treatment of focal epilepsy. J. Neurosurg. 1989, 70:231-239.
54. Morrell F., Whisler W.W., Smith M.C., Hoeppner T.J., de Toledo-Morrell L., Pierre-Louis S.J., Kanner A.M., Buelow J.M., Ristanovic R., Bergen D., et al. Landau-Kleffner syndrome. Treatment with subpial intracortical transection. Brain 1995, 118:1529-1546.
55. Morrell F., Kanner A.M., de Toledo-Morrell L., Hoeppner T., Whisler W.W. Multiple subpial transection. Adv. Neurol. 1999, 81:259-270.
56. Mountcastle V.B. Modality and topographic properties of single neurons of cat's somatic sensory cortex. J. Neurophysiol. 1957, 20:408-434.
57. Mountcastle V.B. The columnar organization of the neocortex. Brain 1997, 120:701-722.
58. Mulligan L.P., Spencer D.D., Spencer S.S. Multiple subpial transections: the Yale experience. Epilepsia 2001, 42:226-229.
59. Murphy J.V., Torkelson R., Dowler I., Simon S., Hudson S. Vagus nerve stimulation in refractory epilepsy: the first 100 patients receiving vagus nerve stimulation at a pediatric epilepsy center. Arch. Pediatr. Adolesc. Med. 2003, 157:560-564.
60. Noachtar S., Borggraefe I. Epilepsy surgery: a critical review. Epilepsy Behav. 2009, 15(1):66-72.
61. Oikawa H., Sasaki M., Tamakawa Y., Kamei A. The circuit of Papez in mesial temporal sclerosis: MRI. Neuroradiology 2001, 43:205-210.
62. Orbach D., Romanelli P., Devinsky O., Doyle W. Late seizure recurrence after multiple subpial transections. Epilepsia 2001, 42:1316-1319.
63. Osorio I., Frei M.G., Sunderam S., Giftakis J., Bhavaraju N.C., Schaffner S.F., Wilkinson S.B. Automated seizure abatement in humans using electrical stimulation. Ann. Neurol. 2005, 57:258-268.
64. Osorio I., Overman J., Giftakis J., Wilkinson S.B. High frequency thalamic stimulation for inoperable mesial temporal epilepsy. Epilepsia 2007, 48:1561-1571.
65. Parain D., Penniello M.J., Berquen P., Delangre T., Billard C., Murphy J.V. Vagus nerve stimulation in tuberous sclerosis complex patients. Pediatr. Neurol. 2001, 25:213-216.
66. Penfield W., Jasper H. Epilepsy and the Functional Anatomy of the Human Brain 1954, Little Brown and Co, Boston, US.
67. Penry J.K., Dean J.C. Prevention of intractable partial seizures by intermittent vagus stimulation in humans: preliminary results. Epilepsia 1990, 31(Suppl. 2):S40-S43.
68. Quigg M., Barbaro N.M. Stereotactic radiosurgery for treatment of epilepsy. Arch. Neurol. 2008, 65:177-183.
69. Rahimi S.Y., Park Y.D., Witcher M.R., Lee K.H., Marrufo M., Lee M.R. Corpus callosotomy for treatment of pediatric epilepsy in the modern era. Pediatr. Neurosurg. 2007, 43:202-208.
70. Regis J., Kerkerian-Legoff L., Rey M., et al. First biochemical evidence of differential functional effects following gamma knife surgery. Stereotact. Funct. Neurosurg. 1996, 66:29-38.
71. Regis J., Bartolomei F., de Toff ol B., et al. Gamma Knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 2000, 47:1943-1952.
72. Regis J., Bartolomei F., Hayashi M., Chauvel P. Gamma knife surgery, a neuromodulation therapy in epilepsy surgery. Acta Neurochir. Suppl. 2002, 84:37-47.
73. Regis J., Rey M., Bartolomei F., et al. Gamma knife surgery in mesial temporal lobe epilepsy: a prospective multicenter study. Epilepsia 2004, 45:504-515.
74. Regis J., Hayashi M., Eupierre L.P., et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Acta Neurochir. Suppl. 2004, 91:33-50.
75. Régis J., Scavarda D., Tamura M., Villeneuve N., Bartolomei F., Brue T., et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Semin. Pediatr. Neurol. 2007, 14:73-79.
76. Romanelli P., Anschel D.J. Radiosurgery for epilepsy. Lancet Neurol. 2006, 5:613-620.
77. Romanelli P., Muacevic A., Striano S. Radiosurgery for hypothalamic hamartomas. Neurosurg. Focus 2008, 24(5):E9.
78. Rosenfeld J.V. The evolution of treatment for hypothalamic hamartoma: a personal odyssey. Neurosurg. Focus 2011, 30:E1.
79. Rosenfeld J.V., Feiz-Erfan I. Hypothalamic hamartoma treatment: surgical resection with the transcallosal approach. Semin. Pediatr. Neurol. 2007, 14:88-98.
80. Saillet S., Langlois M., Feddersen B., Minotti L., Vercueil L., Chabardès S., David O., Depaulis A., Deransart C., Kahane P. Manipulating the epileptic brain using stimulation: a review of experimental and clinical studies. Epileptic Disord. 2009, 11:100-112.
81. Sawhney I.M., Robertson I.J., Polkey C.E., Binnie C.D., Elwes R.D. Multiple subpial transection: a review of 21 cases. J. Neurol. Neurosurg. Psychiatry 1995, 58:344-349.
82. Schramm J. Temporal lobe epilepsy surgery and the quest for optimal extent of resection: a review. Epilepsia 2008, 49(8):1296-1307.
83. Schramm J., Aliashkevich A.F., Grunwald T. Multiple subpial transections: outcome and complications in 20 patients who did not undergo resection. J. Neurosurg. 2002, 97:39-47.
84. Schrottner O., Unger F., Eder H.G., Feichtinger M., Pendl G. Gamma-Knife radiosurgery of mesiotemporal tumour epilepsy observations and long-term results. Acta Neurochir. Suppl. 2002, 84:49-55.
85. Schulze-Bonhage A., Homberg V., Trippel M., et al. Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas. Neurology 2004, 62:644-647.
86. Selch M.T., Gorgulho A., Mattozo C., Solberg T.D., Cabatan-Awang C., DeSalles A.A. Linear accelerator stereotactic radiosurgery for the treatment of gelastic seizures due to hypothalamic hamartoma. Minim. Invasive Neurosurg. 2005, 48:310-314.
87. Shimizu H., Maehara T. Neuronal disconnection for the surgical treatment of pediatric epilepsy. Epilepsia 2000, 41(Suppl. 9):28-30.
88. Shon Y.M., Lee K.J., Kim H.J., Chung Y.A., Ahn K.J., Kim Y.I., Yang D.W., Kim B.S. Effect of chronic deep brain stimulation of the subthalamic nucleus for frontal lobe epilepsy: subtraction SPECT analysis. Stereotact. Funct. Neurosurg. 2005, 83(2-3):84-90.
89. Spencer S.S., Schramm J., Wyler A., O'Connor M., Orbach D., Krauss G., Sperling M., Devinsky O., Elger C., Lesser R., Mulligan L., Westerveld M. Multiple subpial transection for intractable partial epilepsy: an international meta-analysis. Epilepsia 2002, 43:141-145.
90. Srikijvilaikul T., Najm I., Foldvary-Schaefer N., Lineweaver T., Suh J.H., Bingaman W.E. Failure of gamma knife radiosurgery for mesial temporal lobe epilepsy: report of five cases. Neurosurgery 2004, 54:1395-1404.
91. Stacey W.C., Litt B. Technology insight: neuroengineering and epilepsy-designing devices for seizure control. Nat. Clin. Pract. Neurol. 2008, 4(4):190-201.
92. Stefan H., Hummel C., Grabenbauer G.G., Müller R.G., Robeck S., Hofmann W., Buchfelder M. Successful treatment of focal epilepsy by fractionated stereotactic radiotherapy. Eur. Neurol. 1998, 39:248-250.
93. Stevens J.R., Vernon H.M., Erwin F., Pacheco P., Suematsu K. Deep temporal stimulation in man, long latency, long lasting psychological changes. Arch. Neurol. 1969, 21:157-169.
94. Sucholeiki R., Alsaadi T.M., Morris G.L., Ulmer J.L., Biswal B., Mueller W.M. fMRI in patients implanted with a vagus nerve stimulator. Seizure 2002, 11:157-162.
95. Sun F.T., Morell M.J., Wharen R.E. Responsive cortical stimulation for the treatment of epilepsy. Neurotherapeutics 2008, 5:68-74.
96. Tabbal S.D., Revilla F.J., Mink J.W., Schneider-Gibson P., Wernle A.R., de Erausquin G.A., Perlmutter J.S., Rich K.M., Dowling J.L. Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's disease. Neurosurgery 2007, 61(3 Suppl):119-127.
97. Tanriverdi T., Olivier A., Poulin N., Andermann F., Dubeau F. Long-term seizure outcome after corpus callosotomy: a retrospective analysis of 95 patients. J. Neurosurg. 2009, 110:332-342.
98. Telfeian A.E., Connors B.W. Layer-specific pathways for the horizontal propagation of epileptiform discharges in neocortex. Epilepsia 1998, 39:700-708.
99. Theodore W.H. Brain stimulation for epilepsy. Nat. Clin. Pract. Neurol. 2005, 1(2):64-65.
100. Theodore W.H., Fisher R.S. Brain stimulation for epilepsy. Lancet Neurol. 2004, 3(2):111-118.
101. Upton A.R., Cooper I.S., Springman M., Amin I. Suppression of seizures and psychosis of limbic system origin by chronic stimulation of anterior nucleus of the thalamus. Int. J. Neurol. 1985, 19-20:223-230.
102. Uthman B.M., Reichl A.M., Dean J.C., Eisenschenk S., Gilmore R., Reid S., Roper S.N., Wilder B.J. Effectiveness of vagus nerve stimulation in epilepsy patients: a 12-year observation. Neurology 2004, 63:1124-1126.
103. Van Roost D., Boon P., Vonck K., Caemaert J. Neurosurgical aspects of temporal deep brain stimulation for epilepsy. Acta Neurochir. 2007, 97:333-336.
104. Velasco F., Velasco M., Ogarrio C., Fanghanel G. Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia 1987, 28:421-430.
105. Velasco F., Velasco M., Jimenez F., Velasco A.L., Marquez I. Stimulation of the central median thalamic nucleus for epilepsy. Stereotact. Funct. Neurosurg. 2001, 77:228-232.
106. Velasco A.L., Velasco F., Jiménez F., Velasco M., Castro G., Carrillo-Ruiz J.D., et al. Neuromodulation of the centromedian thalamic nuclei in the treatment of generalized seizures and the improvement of the quality of life in patients with Lennox-Gastaut syndrome. Epilepsia 2006, 47:1203-1212.
107. Vesper J., Steinhoff B., Rona S., Wille C., Bilic S., Nikkhah G., Ostertag C. Chronic high-frequency deep brain stimulation of the STN/SNr for progressive myoclonic epilepsy. Epilepsia 2007, 48(10):1984-1989.
108. Vonck K., Boon P., Goossens L., Dedeurwaerdere S., Claeys P., Gossiaux F., Van Hese P., De Smedt T., Raedt R., Achten E., Deblaere K., Thieleman A., Vandemaele P., Thiery E., Vingerhoets G., Miatton M., Caemaert J., Van Roost D., Baert E., Michielsen G., Dewaele F., Van Laere K., Thadani V., Robertson D., Williamson P. Neurostimulation for refractory epilepsy. Acta Neurol. Belg. 2003, 103(4):213-217.
109. Wait S.D., Abla A.A., Killory B.D., Nakaji P., Rekate H.L. Surgical approaches to hypothalamic hamartomas. Neurosurg. Focus 2011, 30:E2.
110. Zabara J. Time course of seizure control to brief repetitive stimuli. Epilepsia 1985, 26:518.
111. Zabara J. Controlling seizures by changing GABA receptor sensitivity. Epilepsia 1987, 28:604.