Mutation of the F-protein cleavage site of avian paramyxovirus type 7 results in furin cleavage, fusion promotion, and increased replication in vitro but not increased replication, tissue tropism, or virulence in chickens

Journal of Virology

Volumn 86, Issue 7, 2012, Pages 3828-3838

  Xiao, Sa ^a   Khattar, Sunil K ^a   Subbiah, Madhuri ^a   Collins, Peter L ^b   Samal, Siba K ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

F PROTEIN; FURIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; AVULAVIRUS; AVULAVIRUS 7; CONTROLLED STUDY; ENZYME KINETICS; IN VITRO STUDY; MICROSCOPY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN FUNCTION; SEROTYPE; SYNCYTIUM; UNTRANSLATED REGION; VIRAL TROPISM; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; VIRUS VIRULENCE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CHICKENS; FURIN; MOLECULAR SEQUENCE DATA; MUTATION; ORGAN SPECIFICITY; PARAMYXOVIRIDAE; PARAMYXOVIRIDAE INFECTIONS; POULTRY DISEASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; VIRAL FUSION PROTEINS; VIRULENCE; VIRUS REPLICATION;

APPLE MOSAIC VIRUS; AVES; CERCOPITHECINE HERPESVIRUS 1; GALLUS GALLUS; NEWCASTLE DISEASE VIRUS; PARAMYXOVIRIDAE;

EID: 84860438124     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06765-11     Document Type: Article

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