Optimization of the simultaneous determination of imatinib and its major metabolite, CGP74588, in human plasma by a rapid HPLC method using D-optimal experimental design

Talanta

Volumn 85, Issue 5, 2011, Pages 2320-2329

  Golabchifar, Ali Akbar ^a   Rouini, Mohammad Reza ^a   Shafaghi, Bijan ^b   Rezaee, Saeed ^c   Foroumadi, Alireza ^a   Khoshayand, Mohammad Reza ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

HPLC; Imatinib; Multiple criteria optimization; N desmethyl Imatinib

Indexed keywords

AMINO ACIDS; METABOLITES; PLASMA (HUMAN);

ACCURACY AND PRECISION; CHROMATOGRAPHIC CONDITIONS; HPLC; IMATINIB; MULTIPLE CRITERIA OPTIMIZATION; N-DESMETHYL IMATINIB; SIMULTANEOUS DETERMINATIONS; TYROSINE KINASE INHIBITOR;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84860421871     PISSN: 00399140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.talanta.2011.07.093     Document Type: Article

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