Determination of vandetanib in human plasma and cerebrospinal fluid by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS)

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 25, 2011, Pages 2561-2566

  Bai, Feng ^a   Johnson, Jennifer ^a   Wang, Fan ^a   Yang, Lei ^a   Broniscer, Alberto ^a,b   Stewart, Clinton F ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Human plasma and cerebrospinal fluid (CSF); Liquid chromatography electrospray ionization tandem mass spectrometry (LC ESI MS MS); Liquid liquid extraction (LLE); Lower limit of quantitation (LLOQ); Vandetanib (ZD6474)

Indexed keywords

CEREBRO SPINAL FLUIDS; LC-ESI-MS/MS; LIQUID-LIQUID EXTRACTION; LOWER LIMIT OF QUANTITATIONS; VANDETANIB (ZD6474);

AMMONIUM COMPOUNDS; BODY FLUIDS; BRAIN; ELECTROSPRAY IONIZATION; ETHERS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); PLASMAS; SOLVENT EXTRACTION;

LIQUIDS;

AMMONIUM FORMATE; AMMONIUM HYDROXIDE; CARBON 13; TERT BUTYL METHYL ETHER; VANDETANIB;

ACCURACY; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENVIRONMENTAL TEMPERATURE; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MONITORING; PH; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STANDARD; VALIDATION STUDY;

ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CHEMICAL FRACTIONATION; CHILD; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; PIPERIDINES; QUINAZOLINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84860407945     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.07.012     Document Type: Article

References (7)

1. Ciardiello F., Caputo R., Damiano V., Troiani T., Vitagliano D., Carlomagno F., Veneziani B.M., Fontanini G., Bianco A.R., Tortora G. Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res. 2003, 9:1546.
2. Wedge S.R., Ogilvie D.J., Dukes M., Kendrew J., Chester R., Jackson J.A., Boffey S.J., Valentine P.J., Curwen J.O., Musgrove H.L., Graham G.A., Hughes G.D., Thomas A.P., Stokes E.S., Curry B., Richmond G.H., Wadsworth P.F., Bigley A.L., Hennequin L.F. Cancer Res. 2002, 62:4645.
3. Holden S.N., Eckhardt S.G., Basser R., de Boer R., Rischin D., Green M., Rosenthal M.A., Wheeler C., Barge A., Hurwitz H.I. Ann. Oncol. 2005, 16:1391.
4. Zirrolli J.A., Bradshaw E.L., Long M.E., Gustafson D.L. J. Pharm. Biomed. Anal. 2005, 39:705.
5. Kim M.S.J.H., Lee J.-A., Pyo D., Yoon H.-R., Lee H.J., Lee K.R. Chromatographia 2004, 60:335.
6. Viswanathan C.T., Bansal S., Booth B., DeStefano A.J., Rose M.J., Sailstad J., Shah V.P., Skelly J.P., Swann P.G., Weiner R. Pharm. Res. 2007, 24:1962.
7. Rocci M.L., Devanarayan V., Haughey D.B., Jardieu P. AAPS J 2007, 9:E336.