Maternal age and prevalence of isolated congenital heart defects in an urban area of the United States

American Journal of Medical Genetics, Part A

Volumn 155, Issue 9, 2011, Pages 2137-2145

  Miller, Assia ^a,b   Riehle Colarusso, Tiffany ^a   Siffel, Csaba ^a,c   Frías, Jaime L ^a,d   Correa, Adolfo ^a  

^a NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^b RTI INTERNATIONAL   (United States)

^c Advanced Air Traffic Management Solutions   (United States)

^d McKing Consulting Corporation   (United States)

Author keywords

Congenital heart defects; Epidemiology of congenital heart defects; Maternal age

Indexed keywords

ADOLESCENT; ADULT; AORTA COARCTATION; ARTICLE; COHORT ANALYSIS; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; FEMALE; GREAT VESSELS TRANSPOSITION; HEART ATRIUM SEPTUM DEFECT; HEART VENTRICLE SEPTUM DEFECT; HUMAN; INFANT; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; PHENOTYPE; PREMATURE LABOR; PREVALENCE; PRIORITY JOURNAL; RACE; RISK FACTOR; UNITED STATES; URBAN AREA;

ADULT; AGE FACTORS; COHORT STUDIES; FEMALE; HEALTH RECORDS, PERSONAL; HEART DEFECTS, CONGENITAL; HUMANS; INFANT; MALE; MATERNAL AGE; PREGNANCY; PREVALENCE; REGISTRIES; RISK FACTORS; UNITED STATES; URBAN HEALTH; VITAL STATISTICS;

EID: 84860391973     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.34130     Document Type: Article

References (52)

1. Alverson CJ, Strickland MJ, Gilboa SM, Correa A. 2011. Maternal smoking and congenital heart defects in the Baltimore-Washington infant study. Pediatrics 127: 647-653.
2. Amorim LFP, Pires CAB, Lana AMA, Campos AS, Aguiar RALP, Tibúrcio JD, Siqueira AL, Mota CCC, Aguiar MJB. 2008. Presentation of congenital heart disease diagnosed at birth: Analysis of 29, 770 newborn infants. J Pediat (Rio J) 84: 83-90.
3. Baird PA, Sadovnick AD, Yee IM. 1991. Maternal age and birth defects: A population study. Lancet 337: 527-530.
4. Botto LD, Correa A, Erickson JD. 2001. Racial and temporal variations in the prevalence of heart defects. Pediatrics 107: E32.
5. Cameron AC, Trivedi PK. 1998. Regression analysis of count data. Cambridge, UK: Cambridge University Press.
6. Caton AR, Bell EM, Druschel CM, Werler MM, Lin AE, Browne ML, McNutt LA, Romitti PA, Mitchell AA, Olney RS, Correa A. 2009. Antihypertensive medication use during pregnancy and the risk of cardiovascular malformations. Hypertension 54: 63-70.
7. Cedergren MI, Selbing AJ, Källén BAJ. 2002. Risk factors for cardiovascular malformation-A study based on prospectively collected data. Scand J Work Environ Health 28: 12-17.
8. Correa A, Cragan JD, Kucik JE, Alverson CJ, Gilboa SM, Balakrishnan R, Strickland MJ, Duke CW, O'Leary LA, Riehle-Colarusso T, Siffel C, Gambrell D, Thompson D, Atkinson M, Chitra J. 2007. Reporting birth defects surveillance data 1968-2003. Birth Defects Res A Clin Mol Teratol 79: 65-186.
9. Correa A, Gilboa SM, Besser LM, Botto LD, Moore CA, Hobbs CA, Cleves MA, Riehle-Colarusso TJ, Waller DK, Reece EA. 2008. Diabetes mellitus and birth defects. Am J Obstet Gynecol 199: 237-239.
10. Correa-Villasenor A, McCarter R, Downing J, Ferencz C. 1991. White-black differences in cardiovascular malformations in infancy and socioeconomic factors. The Baltimore-Washington Infant Study Group. Am J Epidemiol 134: 393-402.
11. Correa-Villaseñor A, Ferencz C, Neill CA, Wilson PD, Boughman JA. 1994. Ebstein's malformation of the tricuspid valve: Genetic and environmental factors. The Baltimore-Washington Infant Study Group. Teratology 50: 137-147.
12. Croen LA, Shaw GM. 1995. Young maternal age and congenital malformations: A population-based study. Am J Public Health 85: 710-713.
13. Dastgiri S, Stone DH, Le-Ha C, Gilmour WH. 2002. Prevalence and secular trend of congenital anomalies in Glasgow, UK. Arch Dis Child 86: 257-263.
14. Ferencz C, Loffredo C, Correa-Villaseñor A, Wilson PD. 1997. Genetic And Environmental Risk Factors of Major Cardiovascular Malformations. The Baltimore-Washington Infant Study, 1981-1989. Armonk, NY: Futura Publishing Company.
15. Forrester MB, Merz RD. 2008. Precurrence risk of birth defects in Hawaii. Congenit Anom (Kyoto) 48: 40-44.
16. Francannet C, Lancaster PA, Pradat P, Cocchi G, Stoll C. 1993. The epidemiology of three serious cardiac defects. A joint study between five centres. Eur J Epidemiol 9: 607-616.
17. Garg A, Connolly C, Hollier L. Maternal age malformations in singleton births. Female Patient. 2008. Accessed January 29, 2010, from
18. Gilboa SM, Correa A, Botto LD, Rasmussen SA, Waller DK, Hobbs CA, Cleves MA, Riehle-Colarusso TJ. 2010. Association between prepregnancy body mass index and congenital heart defects. Am J Obstet Gynecol 202: 51.e1-51.e10.
19. Hamilton B, Ventura S. 2006. Fertility and abortion rates in the United States, 1960-2002. Int J Androl 29: 34-45.
20. Hollier LM, Leveno KJ, Kelly MA, McIntire DD, Cunningham FG. 2000. Maternal age and malformations in singleton births. Obstet Gynecol 96: 701-706.
21. Jarrell JF, Gocmen A, Akyol D, Brant R. 2002. Hexachlorobenzene exposure and the proportion of male births in Turkey 1935-1990. Reprod Toxicol 16: 65-70.
22. Jenkins K, Correa A, Feinstein J, Botto L, Britt A, Daniels S, Elixson M, Warnes C, Webb C. 2007. Noninherited risk factors and congenital cardiovascular defects: Current knowledge: A scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: Endorsed by the American Academy of Pediatrics. Circulation 115: 2995-3014.
23. Karmaus W, Huang S, Cameron L. 2002. Parental concentration of dichlorodiphenyl dichloroethene and polychlorinated biphenyls in Michigan fish eaters and sex ratio in offspring. J Occup Environ Med 44: 8-13.
24. Lary JM, Paulozzi LJ. 2001. Sex differences in the prevalence of human birth defects: A population-based study. Teratology 64: 237-251.
25. Lee K, Khoshnood B, Chen L, Wall SN, Cromie WJ, Mittendorf RL. 2001. Infant mortality from congenital malformations in the United States, 1970-1997. Obstet Gynecol 98: 620-627.
26. Loane M, Dolk H, Morris JK. 2009. Maternal age-specific risk of non-chromosomal anomalies. BJOG 116: 1111-1119.
27. Louik C, Lin AE, Werler MM, Hernández-Díaz S, Mitchell AA. 2007. First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects. N Engl J Med 356: 2675-2683.
28. Malik S, Cleves MA, Zhao W, Correa A, Hobbs CA. 2007. Association between congenital heart defects and small for gestational age. Pediatrics 119: e976-e982.
29. Malik S, Cleves MA, Honein MA, Romitti PA, Botto LD, Yang S, Hobbs CA. 2008. Maternal smoking and congenital heart defects. Pediatrics 121: 810-816.
30. McBride KL, Marengo L, Canfield M, Langlois P, Fixler D, Belmont JW. 2005. Epidemiology of noncomplex left ventricular outflow tract obstruction malformations (aortic valve stenosis, coarctation of the aorta, hypoplastic left heart syndrome) in Texas, 1999-2001. Birth Defects Res A Clin Mol Teratol 73: 555-561.
31. Mili F, Edmonds LD, Khoury MJ, McClearn AB. 1991. Prevalence of birth defects among low-birth-weight infants. A population study. Am J Dis Child 145: 1313-1318.
32. O'Malley CD, Shaw GM, Wasserman CR, Lammer EJ. 1996. Epidemiologic characteristics of conotruncal heart defects in California, 1987-1988. Teratology 53: 374-377.
33. Pradat P. 1992. Epidemiology of major congenital heart defects in Sweden, 1981-1986. J Epidemiol Community Health 46: 211-215.
34. Pradat P, Francannet C, Harris JA, Robert E. 2003. The epidemiology of cardiovascular defects, part I: A study based on data from three large registries of congenital malformations. Pediatr Cardiol 24: 195-221.
35. Rasmussen SA, Moore CA, Paulozzi LJ, Rhodenhiser EP. 2001. Risk for birth defects among premature infants: A population-based study. J Pediatr 138: 668-673.
36. Rasmussen SA, Olney RS, Holmes LB, Lin AE, Keppler-Noreuil KM, Moore CA. 2003. Guidelines for case classification for the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol 67: 193-201.
37. Reefhuis J, Honein MA. 2004. Maternal age and non-chromosomal birth defects, Atlanta-1968-2000: Teenager or thirty-something, who is at risk? Birth Defects Res A Clin Mol Teratol 70: 572-579.
38. Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA, Rasmussen SA. 2009. Assisted reproductive technology and major structural birth defects in the United States. Hum Reprod 24: 360-366.
39. Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A. 2008. Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005. J Pediatr 153: 807-813.
40. Riehle-Colarusso T, Strickland MJ, Reller MD, Mahle WT, Botto LD, Siffel C, Atkinson M, Correa A. 2007. Improving the quality of surveillance data on congenital heart defects in the metropolitan Atlanta congenital defects program. Birth Defects Res A Clin Mol Teratol 79: 743-753.
41. Rosenthal GL. 1996. Patterns of prenatal growth among infants with cardiovascular malformations: Possible fetal hemodynamic effects. Am J Epidemiol 143: 505-513.
42. Rosenthal GL, Wilson PD, Permutt T, Boughman JA, Ferencz C. 1991. Birth weight and cardiovascular malformations: A population-based study. The Baltimore-Washington Infant Study. Am J Epidemiol 133: 1273-1281.
43. Rothman KJ, Fyler DC. 1976. Sex, birth order, and maternal age characteristics of infants with congenital heart defects. Am J Epidemiol 104: 527-534.
44. Rothman KJ, Greenland S, Lash TL. editors. 2008. Modern epidemiology. 3rd edition, Philadelphia: Lippincott-Williams Wilkins.
45. Samanek M. 1994. Boy:girl ratio in children born with different forms of cardiac malformation: A population-based study. Pediatr Cardiol 15: 53-57.
46. Tanner K, Sabrine N, Wren C. 2005. Cardiovascular malformations among preterm infants. Pediatrics 116: e833-e838.
47. Weisskopf M, Anderson H, Hanrahan L. 2003. Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: A retrospective cohort study. Environ Health 2: 2.
48. Wilson PD, Correa-Villaseñor A, Loffredo CA, Ferencz C. 1993. Temporal trends in prevalence of cardiovascular malformations in Maryland and the District of Columbia, 1981-1988. The Baltimore-Washington Infant Study Group. Epidemiology 4: 259-265.
49. Wren C, Richmond S, Donaldson L. 2000. Temporal variability in birth prevalence of cardiovascular malformations. Heart 83: 414-419.
50. Wren C, Birrell G, Hawthorne G. 2003. Cardiovascular malformations in infants of diabetic mothers. Heart 89: 1217-1220.
51. Yang Q, Khoury MJ, Mannino D. 1997. Trends and patterns of mortality associated with birth defects and genetic diseases in the United States, 1979-1992: An analysis of multiple-cause mortality data. Genet Epidemiol 14: 493-505.
52. Yauck J, Malloy M, Blair K, Simpson P, McCarver DG. 2004. Proximity of residence to trichloroethylene-emitting sites and increased risk of offspring congenital heart defects among older women. Birth Defects Res A Clin Mol Teratol 70: 808-814.