Suppression of regrowth of normal skin flora under chlorhexidine gluconate dressings applied to chlorhexidine gluconate-prepped skin

American Journal of Infection Control

Volumn 40, Issue 4, 2012, Pages 344-348

  Bashir, Muhammad H ^a   Olson, Linda K M ^b   Walters, Shelley Ann ^b  

^a A Division of Microbac   (United States)

^b 3M COMPANY   (United States)

Author keywords

Antimicrobial; Catheter; Catheter related bloodstream infections; CHG; Chlorhexidine; CRBSI; Dressing

Indexed keywords

2 PROPANOL; CHLORHEXIDINE GLUCONATE; POLYURETHAN;

ADULT; AEROBIC BACTERIUM; ANTISEPSIS; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; CATHETER INFECTION; COLONY FORMING UNIT; CONTROLLED STUDY; DISEASE CONTROL; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NONHUMAN; NORMAL HUMAN; RANDOM SAMPLE; SKIN FLORA; STUDENT T TEST; WOUND DRESSING;

2-PROPANOL; ADULT; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIA, AEROBIC; BANDAGES; CHLORHEXIDINE; COLONY COUNT, MICROBIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; SKIN; TIME FACTORS;

EID: 84860384977     PISSN: 01966553     EISSN: 15273296     Source Type: Journal    
DOI: 10.1016/j.ajic.2011.03.030     Document Type: Article

References (23)

1. L. Lorente, C. Henry, M.M. Martin, A. Jimenez, and M.L. Mora Central venous catheter-related infection in a prospective and observational study of 2,595 catheters Crit Care 9 2005 R631 R635
2. Centers for Disease Control and Prevention Guidelines for the prevention of intravascular catheter-related infections MMWR 51 RR-10 2002 2,14
3. C.E. Chenoweth, and S. Saint Vascular catheter-related infections M.V. Williams, Comprehensive hospital medicine: an evidence-based approach 2007 Saunders Elsevier Philadelphia 317
4. D.G. Maki, D.A. Goldman, and F.S. Rhame Infection control in intravenous therapy Ann Intern Med 79 1973 876 887
5. D.G. Maki Infections associated with intravascular lines M. Swartz, J. Remmington, Current topics in clinical infectious disease 1982 McGraw-Hill International Book Co New York 309 363
6. H.S. Bjornson, R.N. Colley, R.H. Bower, V.P. Duty, J.T. Schwartz-Fulton, and J.E. Fischer Association between microorganism growth at the catheter insertion site and colonization of the catheter in patients receiving total parenteral nutrition Surgery 92 1982 720 727
7. R.M. Klevens, J.R. Edwards, C.L. Richards, T.C. Horan, R.P. Gaynes, and D.A. Pollock Estimating health care-associated infections and deaths in US hospitals, 2002 Public Health Rep 122 2007 160 166
8. Estimates of healthcare-associated infections. Centers for Disease Control and Prevention Web site. Updated June 15, 2009. Available from: http://www.cdc.gov/ncidod/dhqp/hai.html. Accessed February 17, 2010.
9. Scott RD II. The direct medical costs of healthcare-associated infections in US hospitals and the benefits of prevention. Division of Healthcare Quality Promotion; National Center for Preparedness, Detection, and Control of Infectious Diseases; Coordinating Center for Infectious Diseases; Centers for Disease Control and Prevention; 2009.
10. D.C. Burton, J.R. Edwards, T.C. Horan, J.A. Jernigan, and S.K. Fridkin Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997-2007 JAMA 301 2009 727 736
11. Siempos II, P. Kopterides, I. Tsangaris, I. Dimopoulou, and A.E. Armaganidis Impact of catheter-related bloodstream infections on the mortality of critically ill patients: a meta-analysis Crit Care Med 37 2009 2283 2289
12. D.G. Maki, M. Ringer, and C.J. Alvarado Prospective randomized trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters Lancet 338 1991 339 343
13. D.G. Maki Sepsis arising from extrinsic contamination of the infusion and measures for control I. Phillips, Microbiological hazards of infusion therapy 1977 MTP Press, Ltd Lancaster [England] 99 141
14. P. Williamson, and A. Kligman A new method for the quantitative investigation of cutaneous bacteria J Invest Dermatol 45 1965 498 503
15. US Food and Drug Administration Topical antimicrobial drug products for over-the-counter human use; tentative final monograph for health-care antiseptic drug products Federal Register 59 1994 31402 31452
16. A. Dmitrienko, G. Molenberghs, C. Chuang-Stein, and W. Offen Analysis of clinical trials using SAS: A practical guide 2005 SAS Institute Inc Cary, NC p. 76-83
17. J.-F. Timsit, S. Schwebel, L. Bouadma, A. Geffroy, M. Garrouste-Orgeas, and S. Pease Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial JAMA 301 2009 1231 1241
18. P. Pronovost, D. Needham, S. Berenholtz, D. Sinopoli, H. Chu, and S. Cosgrove An intervention to decrease catheter-related bloodstream infections in the ICU N Engl J Med 355 2006 2725 2732
19. W.R. Jarvis The United States approach to strategies in the battle against healthcare-associated infections, 2006: transitioning from benchmarking to zero tolerance and clinician accountability J Hosp Infect 65 2007 3 9
20. K.M. Ho, and E. Litton Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis J Antimicrob Chemother 58 2006 281 287
21. E.N. Perencevich, and D. Pittet Preventing catheter-related bloodstream infections: thinking outside the checklist JAMA 301 2009 1285 1287
22. Maki DG, Stahl JB, Jacobson CJ, Pyrek J. A novel integrated chlorhexidine-impregnated transparent dressing for prevention of vascular catheter-related bloodstream infection: a prospective comparative study in healthy volunteers. Poster presented at the 18th Annual Scientific Meeting of the Society for Healthcare Epidemiology of America; April 2008, Orlando, FL.
23. Schwab D, Huikko K, Asmus R, Hanggi D, Olson L. Migration of chlorhexidine gluconate under antimicrobial gel pad of IV securement dressing to provide continuous antimicrobial protection. Poster presented at Association of Vascular Access; September 2008, Savannah, GA.