Automated multi-slice extracellular and patch-clamp experiments using the WinLTP data acquisition system with automated perfusion control

Journal of Neuroscience Methods

Volumn 207, Issue 2, 2012, Pages 148-160

  Anderson, William W ^a,b   Fitzjohn, Stephen M ^a,b,d   Collingridge, Graham L ^a,b,c  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b WinLTP Ltd   (United Kingdom)

^c Seoul National University   (South Korea)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

Automated perfusion; Brain slices; Drug discovery; Long term potentiation (LTP); Multi slice; Protocol scripting

Indexed keywords

ARTICLE; AUTOMATION; BRAIN PERFUSION; BRAIN SLICE; COMPUTER PROGRAM; INFORMATION PROCESSING; PATCH CLAMP; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; STIMULATION;

ANIMALS; AUTOMATION, LABORATORY; EXTRACELLULAR FLUID; LONG-TERM POTENTIATION; NEURONAL PLASTICITY; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; PERFUSION; STATISTICS AS TOPIC; SYNAPSES;

EID: 84860382388     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2012.04.008     Document Type: Article

References (5)

1. Anderson W.W., Collingridge G.L. The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events. J. Neurosci. Methods 2001, 108:71-83.
2. Anderson W.W., Collingridge G.L. Capabilities of the WinLTP data acquisition program extending beyond basic LTP experimental functions. J. Neurosci. Methods 2007, 162:346-356.
3. Dunlop J., Bowlby M., Peri R., Vasilyev D. High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nat. Rev. Drug Discov. 2008, 7:358-368.
4. Kroker K.S., Rosenbrock H., Rast G. A multi-slice recording system for stable late phase hippocampal long-term potentiation experiments. J. Neurosci. Methods 2011, 194:394-401.
5. Stopps M., Allen N., Barrett R., Choudhury H.I., Jarolimek W., Johnson M., et al. Design and application of a novel brain slice system that permits independent electrophysiological recordings from multiple slices. J. Neurosci. Methods 2004, 132:137-148.