Phenotypic & molecular characterization of AmpC β-lactamases among Escherichia coli, Klebsiella spp. & Enterobacter spp. from five Indian Medical Centers

Indian Journal of Medical Research

Volumn 135, Issue 3, 2012, Pages 359-364

  Manoharan, Anand ^a   Sugumar, Madhan ^a   Kumar, Anil ^b   Jose, Hepzibah ^a   Mathai, Dilip ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

^b AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Amp C genotypes; AmpC lactamases; Cefoxitin resistance; ESBL; Multidrug resistance

Indexed keywords

AMIKACIN; BETA LACTAMASE AMPC; BORONIC ACID DERIVATIVE; CEFOXITIN; ERTAPENEM; EXTENDED SPECTRUM BETA LACTAMASE; IMIPENEM; LEVOFLOXACIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DISK DIFFUSION; ENTEROBACTER; ENZYME ANALYSIS; EPSILOMETER TEST; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; GENOTYPE; INDIA; KLEBSIELLA; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PHENOTYPE; PLASMID; PROSPECTIVE STUDY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTER; ESCHERICHIA COLI; GENOTYPE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; KLEBSIELLA; MICROBIAL SENSITIVITY TESTS;

EID: 84860381162     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Philippon A, Arlet G, Jacoby GA. Plasmid determined AmpC type β-lactamases. Antimicrob Agents Chemother 2002; 46: 1-11.
2. Swaminathan B, Barrett T, Hunter SB, Tauxe R, PulseNet. The molecular subtyping network for foodborne disease surveillance in the United States. Emerg Infect Dis 2001; 7: 382-9.
3. Hanson ND. AmpC β-lactamases: what do we need to know for the future? J Antimicrob Chemother 2003; 52: 2-4.
4. Pérez-Pérez FJ, Hanson ND. Detection of plasmid mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 2002; 40: 2153-62.
5. Papanicolaou GA, Medeiros AA, Jacoby GA. Novel plasmid mediated β-lactamases (MIR-1) conferring resistance to oxyimino and α methoxy β-lactams in clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother 1990; 34: 2200-9.
6. Por Beatriz Mirelis A, Alba Rivera A, Elisenda Miró B, Raúl J, Mesa A, Ferran Navarro A, Pere Coll P. A simple phenotypic method for differentiation between acquired and chromosomal AmpC β-lactamases in Escherichia coli. Enferm Infect Microbiol Clin 2006; 24: 370-2.
7. Jacoby GA. AmpC β-lactamases. Clin Microbiol Rev 2009; 22: 161-82.
8. Alvarez M, Tran JH, Chow N, Jacoby GA. Epidemiology of conjugative plasmid mediated AmpC β-lactamases in the United States. Antimicrob Agents Chemother 2004; 48: 533-7.
9. Mulvey MR, Bryce E, Boyd DA, Ofner-Agostini M, Land AM. Molecular characterization of cefoxitin resistant Escherichia coli from Canadian hospitals. Antimicrob Agents Chemother 2005; 49: 358-65.
10. Moland ES, Hanson ND, Black JA, Hossain A, Song W, Thomson KS. Prevalence of newer β-lactamases in gram negative clinical isolates collected in the United States from 2001 to 2002. J Clin Microbiol 2006; 44: 3318-24.
11. Tan TY, Ng SY, Teo L, Koh Y, Teok CH. Detection of plasmid mediated AmpC in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. J Clin Pathol 2008; 61: 642-4.
12. Subha A, Renuka Devi V, Ananthan S. AmpC β-lactamases producing multidrug resistant strains of Klebsiella spp. & Escherichia coli isolated from children under five in Chennai. India. Indian J Med Res 2003; 117: 13-8.
13. Ratna AK, Menon I, Kapur I, Kulkarni R. Occurrence & detection of Amp C β-lactamases at a referral hospital in Karnataka. Indian J Med Res 2003; 118: 29-32.
14. th informational supplement, CLSI document M100-S19. Wayne, PA: CLSI; 2009, 29(3).
15. Thomson KS. Controversies about extended-spectrum and AmpC β-lactamases. Emerg Infect Dis 2001; 7: 333-6.
16. Barlow M, Hall BG. Experimental prediction of the evolution of cefepime resistance from the CMY-2 AmpC β-lactamase. Genetics 2003; 164: 23-9.
17. Manchanda V, Singh NP, Shamweel A, Eideh HK, Thukral SS. Molecular epidemiology of clinical isolates of AmpC producing Klebsiella pneumoniae. Indian J Med Microbiol 2006; 24: 177-81.
18. Taneja N, Rao P, Arora J, Dogra A. Occurrence of ESBL and Amp-C beta-lactamases and susceptibility to newer antimicrobial agents in complicated UTI. Indian J Med Res 2008; 127: 85-8.
19. Pitout JD, Le PG, Moore KL, Church DL, Gregson DB. Detection of AmpC beta-lactamases in Escherichia coli, Klebsiella spp, Salmonella spp and Proteus mirabilis in a regional clinical microbiology laboratory. Clin Microbiol Infect 2010; 16: 165-70.
20. Morosini MI, Ayala JA, Baquero F, Martinez JL, Blazquez J. Biological cost of AmpC production for Salmonella enterica serotype typhimurium. Antimicrob Agents Chemother 2000; 44: 3137-43.
21. Canton R, Perez-Vazquez M, Oliver A, Sanchez Del Saz B, Gutierrez MO, Martinez Ferrer M, et al. Evaluation of the Wider system, a new computer-assisted image-processing device for bacterial identification and susceptibility testing. J Clin Microbiol 2000; 38: 1339-46.
22. Tzouvelekis LS, Vatopoulos AC, Katsanis G, Tzelepi E. Rare case of failure by an automated system to detect extended-spectrum beta-lactamase in a cephalosporin resistant Klebsiella pneumoniae isolate. J Clin Microbiol 1999; 37: 2388.
23. Sanders CC, Peyret M, Moland ES, Cavalieri SJ, Shubert C, Thomson KS, et al. Potential impact of the VITEK 2 system and the Advanced Expert System on the clinical laboratory of a university-based hospital. J Clin Microbiol 2001; 39: 2379-85.