A potent 2′-O-methylated RNA-based microRNA inhibitor with unique secondary structures

Nucleic Acids Research

Volumn 40, Issue 8, 2012, Pages

  Haraguchi, Takeshi ^a   Nakano, Haruo ^b   Tagawa, Takanobu ^a   Ohki, Tokimitsu ^c   Ueno, Yoshihito ^d   Yoshida, Tetsuo ^b   Iba, Hideo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c Faculty of Engineering   (Japan)

^d GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; LENTIVIRUS VECTOR; MICRORNA; MICRORNA 106; MICRORNA 16; MICRORNA 200; MICRORNA 21; RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HYBRIDIZATION; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA BINDING; RNA METHYLATION; RNA SEQUENCE; RNA SYNTHESIS; WESTERN BLOTTING; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC TRANSFECTION; METABOLISM; NUCLEIC ACID HYBRIDIZATION; TUMOR CELL LINE;

LENTIVIRUS; MAMMALIA;

BINDING SITES; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MICRORNAS; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; RNA; TRANSFECTION;

EID: 84860370660     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkr1317     Document Type: Article

References (28)

1. Ambros, V. (2004) The functions of animal microRNAs. Nature, 431, 350-355.
2. Bartel, D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 281-297.
3. He, L. and Hannon, G.J. (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet., 5, 522-531.
4. Lin, S.L., Chang, D.C., Chang-Lin, S., Lin, C.H., Wu, D.T., Chen, D.T. and Ying, S.Y. (2008) Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA, 14, 2115-2124.
5. Li, Q.J., Chau, J., Ebert, P.J., Sylvester, G., Min, H., Liu, G., Braich, R., Manoharan, M., Soutschek, J., Skare, P. et al. (2007) miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell, 129, 147-161.
6. Lu, J., Getz, G., Miska, E.A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B.L., Mak, R.H., Ferrando, A.A. et al. (2005) MicroRNA expression profiles classify human cancers. Nature, 435, 834-838.
7. Lecellier, C.H., Dunoyer, P., Arar, K., Lehmann-Che, J., Eyquem, S., Himber, C., Saib, A. and Voinnet, O. (2005) A cellular microRNA mediates antiviral defense in human cells. Science, 308, 557-560.
8. Shimono, Y., Zabala, M., Cho, R.W., Lobo, N., Dalerba, P., Qian, D., Diehn, M., Liu, H., Panula, S.P., Chiao, E. et al. (2009) Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell, 138, 592-603.
9. Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M. and Sarnow, P. (2005) Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science, 309, 1577-1581.
10. Hutvagner, G., Simard, M.J., Mello, C.C. and Zamore, P.D. (2004) Sequence-specific inhibition of small RNA function. PLoS Biol., 2, E98.
11. Meister, G., Landthaler, M., Dorsett, Y. and Tuschl, T. (2004) Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing. RNA, 10, 544-550.
12. Orom, U.A., Kauppinen, S. and Lund, A.H. (2006) LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene, 372, 137-141.
13. Davis, S., Lollo, B., Freier, S. and Esau, C. (2006) Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res., 34, 2294-2304.
14. Krutzfeldt, J., Rajewsky, N., Braich, R., Rajeev, K.G., Tuschl, T., Manoharan, M. and Stoffel, M. (2005) Silencing of microRNAs in vivo with 'antagomirs'. Nature, 438, 685-689.
15. Vermeulen, A., Robertson, B., Dalby, A.B., Marshall, W.S., Karpilow, J., Leake, D., Khvorova, A. and Baskerville, S. (2007) Double-stranded regions are essential design components of potent inhibitors of RISC function. RNA, 13, 723-730.
16. Scherr, M., Venturini, L., Battmer, K., Schaller-Schoenitz, M., Schaefer, D., Dallmann, I., Ganser, A. and Eder, M. (2007) Lentivirus-mediated antagomir expression for specific inhibition of miRNA function. Nucleic Acids Res., 35, e149.
17. Sayed, D., Rane, S., Lypowy, J., He, M., Chen, I.Y., Vashistha, H., Yan, L., Malhotra, A., Vatner, D. and Abdellatif, M. (2008) MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol. Biol. Cell., 19, 3272-3282.
18. Ebert, M.S., Neilson, J.R. and Sharp, P.A. (2007) MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods, 4, 721-726.
19. Haraguchi, T., Ozaki, Y. and Iba, H. (2009) Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res., 37, e43.
20. Sakurai, K., Furukawa, C., Haraguchi, T., Inada, K., Shiogama, K., Tagawa, T., Fujita, S., Ueno, Y., Ogata, A., Ito, M. et al. (2011) MicroRNAs miR-199a-5p and-3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res., 71, 1680-1689.
21. Hikichi, M., Kidokoro, M., Haraguchi, T., Iba, H., Shida, H., Tahara, H. and Nakamura, T. (2011) MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy. Mol. Ther, 19, 1107-1115.
22. Lu, Z., Li, Y., Takwi, A., Li, B., Zhang, J., Conklin, D.J., Young, K.H. and Martin, R. (2011) miR-301a as an NF-kB activator in pancreatic cancer cells. EMBO J., 30, 57-67.
23. Gagan, J., Dey, B.K., Layer, R., Yan, Z. and Dutta, A. (2011) MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation. J. Biol. Chem., 286, 19431-19438.
24. Elbashir, S.M., Lendeckel, W. and Tuschl, T. (2001) RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev., 15, 188-200.
25. Sato, K., Hamada, M., Asai, K. and Mituyama, T. (2009) CENTROIDFOLD: a web server for RNA secondary structure prediction. Nucleic Acids Res., 37, W277-W280.
26. Brennecke, J., Stark, A., Russell, R.B. and Cohen, S.M. (2005) Principles of microRNA-target recognition. PLoS Biol., 3, e85.
27. Zeng, Y. and Cullen, B.R. (2004) Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res., 32, 4776-4785.
28. Park, S.M., Gaur, A.B., Lengyel, E. and Peter, M.E. (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev., 22, 894-907.