The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever

Medical Hypotheses

Volumn 78, Issue 6, 2012, Pages 717-720

  Alpayci, Mahmut ^a   Bozan, Nazim ^b   Erdem, Seyfettin ^c   Gunes, Muslum ^d   Erden, Metin ^e  

^a BITLIS STATE HOSPITAL   (Turkey)

^b YUZUNCU YIL UNIVERSITY   (Turkey)

^c Bismil State Hospital   (Turkey)

^d Kiziltepe State Hospital   (Turkey)

^e Van Devlet Hastanesi   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; CRYOPYRIN; CYTOCHROME C OXIDASE; INTERLEUKIN 1; INTERLEUKIN 1BETA; MYELIN;

ARTICLE; BLOOD BRAIN BARRIER; BODY TEMPERATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEMYELINATION; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; FAMILIAL MEDITERRANEAN FEVER; HUMAN; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; MEDICAL HISTORY; MITOCHONDRION; MULTIPLE SCLEROSIS; NERVE CONDUCTION; NERVE FIBER DEGENERATION; NERVE INJURY; PATHOGENESIS; REGULATORY MECHANISM; REMYELINIZATION; T LYMPHOCYTE; VASCULITIS; WHITE MATTER;

BLOOD-BRAIN BARRIER; BODY TEMPERATURE; COLCHICINE; CYTOSKELETAL PROTEINS; FAMILIAL MEDITERRANEAN FEVER; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-1BETA; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; MULTIPLE SCLEROSIS; MUTATION; MYELIN SHEATH;

EID: 84860364485     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.02.017     Document Type: Article

References (43)

1. Hoffjan S., Akkad D.A. The genetics of multiple sclerosis: an update 2010. Mol Cell Probes 2010, 24(5):237-243.
2. Pierrot-Deseilligny C., Souberbielle J.C. Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis?. Brain 2010, 133(Pt 7):1869-1888.
3. Sawcer S., Hellenthal G., Pirinen M., et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476(7359):214-219. 10.1038/nature10251.
4. Sha Y., Markovic-Plese S. A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases. Self Nonself 2011, 2(1):35-42.
5. Carpintero R., Burger D. IFNβ and glatiramer acetate trigger different signaling pathways to regulate the IL-1 system in multiple sclerosis. Commun Integr Biol 2011, 4(1):112-114.
6. Argaw A.T., Zhang Y., Snyder B.J., et al. IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol 2006, 177(8):5574-5584.
7. Campbell G.R., Mahad D.J. Mitochondria as crucial players in demyelinated axons: lessons from neuropathology and experimental demyelination. Autoimmune Dis 2011, 10.4061/2011/262847.
8. Su K.G., Banker G., Bourdette D., Forte M. Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis. Curr Neurol Neurosci Rep 2009, 9(5):411-417.
9. Campbell G.R., Mahad D.J. Mitochondrial changes associated with demyelination: consequences for axonal integrity. Mitochondrion 2011, 10.1016/j.mito.2011.03.007.
10. Mahad D.J., Ziabreva I., Campbell G., Lax N., White K., Hanson P.S., et al. Mitochondrial changes within axons in multiple sclerosis. Brain 2009, 132(5):1161-1174.
11. Kuhlmann T., Lingfeld G., Bitsch A., Schuchardt J., Brück W. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 2002, 125(Pt 10):2202-2212.
12. Kornek B., Storch M.K., Weissert R., et al. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 2000, 157(1):267-276.
13. Lindsay KW, Bone I. Multiple sclerosis. In: Lindsay KW, Bone I, editors. Neurology and neurosurgery illustrated. Churchill Livingstone; 2008. p. 515-24.
14. Pringle C.E., McEwan L.M., Ebers G.C. Laryngeal Uhthoff's phenomenon: a case report. Mult Scler 1995, 1(3):163-164.
15. Cianfrone G., Turchetta R., Mazzei F., Bartolo M., Parisi L. Temperature-dependent auditory neuropathy: is it an acoustic Uhthoff-like phenomenon? A case report. Ann Otol Rhinol Laryngol 2006, 115(7):518-527.
16. Humm A.M., Beer S., Kool J., Magistris M.R., Kesselring J., Rösler K.M. Quantification of Uhthoff's phenomenon in multiple sclerosis: a magnetic stimulation study. Clin Neurophysiol 2004, 115(11):2493-2501.
17. Stutzer P., Kesselring J. Wilhelm Uhthoff: a phenomenon 1853 to 1927. Int MS J 2008, 15(3):90-93.
18. Meinzer U., Quartier P., Alexandra J.F., Hentgen V., Retornaz F., Koné-Paut I. Interleukin-1 targeting drugs in familial Mediterranean fever: a case series and a review of the literature. Semin Arthritis Rheum 2011, 41(2):265-271.
19. Hoffman H.M., Wanderer A.A. Inflammasome and IL-1beta-mediated disorders. Curr Allergy Asthma Rep 2010, 10(4):229-235.
20. Roldan R., Ruiz A.M., Miranda M.D., Collantes E. Anakinra: new therapeutic approach in children with familial Mediterranean fever to clchicine. Joint Bone Spine 2008, 75(4):504-505.
21. Chae JJ, Wood G, Masters SL, et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production. Proc Natl Acad Sci USA 2006;103(26):9982-7.
22. Masters S.L., Simon A., Aksentijevich I., Kastner D.L. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol 2009, 27:621-668.
23. Chae J.J., Cho Y.H., Lee G.S., et al. Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1beta activation and severe autoinflammation in mice. Immunity 2011, 34:755-768.
24. Savic S., Dickie L.J., Battellino M., Mc Dermott M.F. Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases. Curr Opin Rheumatol 2012, 24(1):103-112.
25. Onen F. Familial Mediterranean fever. Rheumatol Int 2006, 26:489-496.
26. Livneh A., Langevitz P., Zemer D., et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997, 40:1879-1885.
27. Yahalom G., Kivity S., Lidar M., et al. Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world's largest FMF cohorts. Eur J Neurol 2011, 10.1111/j.1468-1331.2011.03356.x.
28. Akman-Demir G., Gul A., Gurol E., et al. Inflammatory/demyelinating central nervous system involvement in familial Mediterranean fever (FMF): coincidence or association?. J Neurol 2006, 253:928-934.
29. Topçuoĝlu M.A., Karabudak R. Familial Mediterranean fever and multiple sclerosis. J Neurol 1997, 244:510-514.
30. Yücesan C., Canyiĝit A., Türkçapar N. The coexistence of familial Mediterranean fever with multiple sclerosis. Eur J Neurol 2004, 11:715-717.
31. Guinet A., Grateau G., Nifle C., Rozier A., Pico F. Multiple sclerosis and familial Mediterranean fever: a case report. Rev Neurol (Paris) 2008, 164(11):943-947.
32. Unal A., Emre U., Dursun A., Aydemir S. The co-incidence of multiple sclerosis in a patient with familial Mediterranean fever. Neurol India 2009, 57(5):672-673.
33. Ugurlu S., Bolayir E., Candan F., Gumus C. Familial mediterranean fever and multiple sclerosis-a case report. Acta Reumatol Port 2009, 34(1):117-119.
34. Sayin R., Alpayci M., Soyoral Y.U. A case with multiple sclerosis and familial Mediterranean fever. Genet Couns 2011, 22(3):309-312.
35. Unal A., Dursun A., Emre U., Tascilar N.F., Ankarali H. Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: is it a susceptibility gene?. J Neurol Sci 2010, 294(1-2):38-42.
36. Olgun A., Akman S., Kurt I., Tuzun A., Kutluay T. MEFV mutations in familial Mediterranean fever: association of M694V homozygosity with arthritis. Rheumatol Int 2005, 25:255-259.
37. Shinar Y., Livneh A., Villa Y., et al. Common mutations in the familial Mediterranean fever gene associate with rapid progression to disability in non-Ashkenazi Jewish multiple sclerosis patients. Genes Immun 2003, 4(3):197-203.
38. Martino G., Adorini L., Rieckmann P., et al. Inflammation in multiple sclerosis: the good, the bad, and the complex. Lancet Neurol 2002, 1(8):499-509.
39. Yüksel S., Ayvazyan L., Gasparyan A.Y. Familial Mediterranean fever as an emerging clinical model of atherogenesis associated with low grade inflammation. Open Cardiovasc Med J 2010, 4:51-56.
40. Aksu K., Keser G. Coexistence of vasculitides with familial Mediterranean fever. Rheumatol Int 2011, 10.1007/s00296-011-1840-z.
41. Kraft G.H., Brown T. Comprehensive management of multiple sclerosis. Physical medicine and rehabilitation, principles and practice 2005, 1753-1770. Lippincott Williams and Wilkins, Philadelphia. J.A. DeLisa (Ed.).
42. Pearce J.M.S. Early observations on optic neuritis and Uhthoff's sign. Eur Neurol 2010, 63(4):243-247.
43. Guthrie T.C., Nelson D.A. Influence of temperature changes on multiple sclerosis: critical review of mechanisms and research potential. J Neurol Sci 1995, 129(1):1-8.