Inflammasomes and intestinal tumorigenesis

Drug Discovery Today: Disease Mechanisms

Volumn 8, Issue 3-4, 2011, Pages

  Zaki, Md Hasan ^a   Lamkanfi, Mohamed ^b,c   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b GHENT UNIVERSITY   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR;

CARCINOGENESIS; CELL MATURATION; CELL PROLIFERATION; COLITIS; COLON CARCINOGENESIS; COLORECTAL CANCER; ENTERITIS; ENZYME ACTIVATION; EPITHELIUM; HOMEOSTASIS; INTESTINE CANCER; MEMBRANE PERMEABILITY; ONCOGENE; REVIEW; SIGNAL TRANSDUCTION;

EID: 84860339104     PISSN: None     EISSN: 17406765     Source Type: Journal    
DOI: 10.1016/j.ddmec.2011.11.003     Document Type: Review

References (49)

1. Choi, P.M. and Zelig, M.P. (1994) Similarity of colorectal cancer in Crohn's disease and ulcerative colitis: implications for carcinogenesis and prevention. Gut 35, 950-954
2. Eaden, J.A. et al. (2001) The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48, 526-535 (Pubitemid 32234798)
3. Dinarello, C.A. (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519-550
4. Kanneganti, T.D. et al. (2006) Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 281, 36560-36568
5. Martinon, F. et al. (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proILbeta. Mol. Cell 10, 417-426 (Pubitemid 35007355)
6. Kanneganti, T.D. et al. (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27, 549-559
7. Lamkanfi, M. and Dixit, V.M. (2009) Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev. 227, 95-105
8. Boyden, E.D. and Dietrich, W.F. (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat. Genet. 38, 240-244 (Pubitemid 43177241)
9. Suzuki, T. et al. (2007) Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog. 3, e111
10. Miao, E.A. et al. (2010) Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc. Natl. Acad. Sci. U. S. A. 107, 3076-3080
11. Mariathasan, S. et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228-232 (Pubitemid 43372102)
12. Martinon, F. et al. (2009) The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265
13. Fernandes-Alnemri, T. et al. (2010) The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 11, 385-393
14. Rathinam, V.A. et al. (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11, 395-402
15. Elinav, E. et al. (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145, 745-757
16. Chen, G.Y. et al. (2011) A functional role for nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186, 7187-7194
17. Masters, S.L. et al. (2011) The inflammasome in atherosclerosis and type 2 diabetes. Sci. Transl. Med. 3, 81ps17
18. Shaw, P.J. et al. (2011) Inflammasomes and autoimmunity. Trends Mol. Med. 17, 57-64
19. Vandanmagsar, B. et al. (2011) The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188
20. Bauer, C. et al. (2007) The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression. Dig. Dis. Sci. 52, 1642-1652 (Pubitemid 46870573)
21. Sivakumar, P.V. et al. (2002) Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 50, 812-820 (Pubitemid 34539043)
22. Siegmund, B. (2002) Interleukin-1beta converting enzyme (caspase-1) in intestinal inflammation. Biochem. Pharmacol. 64, 1-8 (Pubitemid 34775170)
23. Siegmund, B. et al. (2001) Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1264-R1273
24. Allen, I.C. et al. (2010) The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J. Exp. Med. 207, 1045-1056
25. Dupaul-Chicoine, J. et al. (2010) Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367-378
26. Hirota, S.A. et al. (2010) NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm. Bowel Dis. 17, 1359-1372
27. Zaki, M.H. et al. (2010) The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32, 379-391
28. Villani, A.C. et al. (2009) Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat. Genet. 41, 71-76
29. Li, J. et al. (2004) Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum. Mol. Genet. 13, 1715-1725 (Pubitemid 39173441)
30. Tamura, K. et al. (2002) IL18 polymorphism is associated with an increased risk of Crohn's disease. J. Gastroenterol. 37 (Suppl. 14), 111-116 (Pubitemid 35385941)
31. Takagi, H. et al. (2003) Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice. Scand. J. Gastroenterol. 38, 837-844 (Pubitemid 37011577)
32. Zaki, M.H. et al. (2010) IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J. Immunol. 185, 4912-4920
33. Bauer, C. et al. (2010) Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 59, 1192-1199
34. Hu, B. et al. (2010) Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc. Natl. Acad. Sci. U. S. A. 107, 21635-21640
35. Normand, S. et al. (2011) Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad. Sci. U. S. A. 108, 9601-9606
36. Radtke, F. and Clevers, H. (2005) Self-renewal and cancer of the gut: two sides of a coin. Science 307, 1904-1909 (Pubitemid 40404692)
37. Reuter, B.K. and Pizarro, T.T. (2004) Commentary: the role of the IL-18 system and other members of the IL-1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe? Eur. J. Immunol. 34, 2347-2355 (Pubitemid 39302792)
38. Grivennikov, S.I. et al. (2010) Immunity, inflammation, and cancer. Cell 140, 883-899
39. Zaki, M.H. et al. (2011) The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol. 32, 171-179
40. Salcedo, R. et al. (2010) MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625-1636
41. Garlanda, C. et al. (2004) Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc. Natl. Acad. Sci. U. S. A. 101, 3522-3526 (Pubitemid 38338228)
42. Micallef, M.J. et al. (1997) Interleukin 18 induces the sequential activation of natural killer cells and cytotoxic T lymphocytes to protect syngeneic mice from transplantation with Meth A sarcoma. Cancer Res. 57, 4557-4563 (Pubitemid 27441061)
43. Micallef, M.J. et al. (1997) In vivo antitumor effects of murine interferongamma- inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites. Cancer Immunol. Immunother. 43, 361-367 (Pubitemid 27102222)
44. Osaki, T. et al. (1999) Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18). Gene Ther. 6, 808-815 (Pubitemid 29243654)
45. Hegardt, P. et al. (2001) Nitric oxide synthase inhibitor and IL-18 enhance the anti-tumor immune response of rats carrying an intrahepatic colon carcinoma. Cancer Immunol. Immunother. 50, 491-501 (Pubitemid 33079346)
46. Dighe, A.S. et al. (1994) Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN gamma receptors. Immunity 1, 447-456
47. Shankaran, V. et al. (2001) IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410, 1107-1111 (Pubitemid 32391043)
48. Nava, P. et al. (2010) Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32, 392-402
49. Darnell, J.E., Jr et al. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (Pubitemid 24217131)