Dedifferentiated peripheral chondrosarcoma: A clinicopathologic, immunohistochemical, and molecular analysis of four cases

Virchows Archiv

Volumn 460, Issue 3, 2012, Pages 335-342

  Franchi, Alessandro ^a   Baroni, Gianna ^a   Sardi, Iacopo ^b   Giunti, Laura ^b   Capanna, Rodolfo ^c   Campanacci, Domenico ^c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

Cell cycle regulators; Dedifferentiated chondrosarcoma; Immunohistochemistry; p53 gene; PDGF receptors; Peripheral

Indexed keywords

CYCLIN D1; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN MDM2; PROTEIN P16; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ADULT; ARTICLE; BONE TUMOR; CARTILAGE; CASE REPORT; CELL CYCLE REGULATION; CHONDROSARCOMA; CLINICAL FEATURE; CONTROLLED STUDY; DEDIFFERENTIATED CHONDROSARCOMA; EXON; EXOSTOSIS; FEMALE; GENE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OSTEOCHONDROMA; OSTEOLYSIS; PELVIS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOLOGY; SOFT TISSUE; TISSUE DIFFERENTIATION; TP53 GENE; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; GENETICS; METABOLISM; MIDDLE AGED; MULTIPLE CANCER; PATHOLOGY;

ADULT; BONE NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; CHONDROSARCOMA; FEMALE; GENES, CDC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; OSTEOCHONDROMA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860338071     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-012-1206-2     Document Type: Article

References (21)

1. Bertoni F, Present D, Bacchini P, Picci P, Pignatti G, Gherlinzoni F, Campanacci M (1989) Dedifferentiated peripheral chondrosarcomas. A report of seven cases. Cancer 63:2054-2059 (Pubitemid 19118911)
2. Staals EL, Bacchini P, Mercuri M, Bertoni F (2007) Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. J Bone Joint Surg Am 89:987-993 (Pubitemid 46724588)
3. Frassica FJ, Unni KK, Beabout JW, Sim FH (1986) Dedifferentiated chondrosarcoma. A report of the clinicopathological features and treatment of seventy-eight cases. J Bone Joint Surg Am 68:1197-1205
4. Coombs NJ, Gough AC, Primrose JN (1999) Optimisation of DNA and RNA extraction from archival formalin-fixed tissue. Nucleic Acids Res 27:e12
5. Rozeman LB, de Bruijn IH, Bacchini P, Staals EL, Bertoni F, Bovée JV, Hogendoorn PC (2009) Dedifferentiated peripheral chondrosarcomas: regulation of EXT-downstream molecules and differentiation-related genes. Mod Pathol 22:1489-1498
6. Bovée JVMG, Cleton-Jansen AM, Wuyts W, Caethoven G, Taminiau AH, Bakker E, Van HulW, Cornelisse CJ, Hogendoorn PC (1999) EXT mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. Am J Hum Genet 65:689-698 (Pubitemid 30468713)
7. de Andrea CE, Reijnders CM, Kroon HM, de Jong D, Hogendoorn PC, Szuhai K, Bovée JV (2012) Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT. Oncogene. doi:10.1038/onc.2011.311
8. Wadayama B, Toguchida J, Yamaguchi T, Sasaki MS, Yamamuro T (1993) p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas. Br J Cancer 68:1134-1139 (Pubitemid 23356665)
9. Simms WW, Ordonez NG, Johnston D, Ayala AG, Czerniak B (1995) p53 expression in dedifferentiated chondrosarcoma. Cancer 76:223-227
10. Terek RM, Healey JH, Garin-Chesa P, Mak S, Huvos A, Albino AP (1998) p53 mutations in chondrosarcoma. Diagn Mol Pathol 7:51-56 (Pubitemid 28285811)
11. Bovée JV, Cleton-Jansen AM, Rosenberg C, Taminiau AH, Cornelisse CJ, Hogendoorn PC (1999) Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis. J Pathol 189:454-462
12. Grote HJ, Schneider-Stock R, Neumann W, Roessner A (2000) Mutation of p53 with loss of heterozygosity in the osteosarcomatous component of a dedifferentiated chondrosarcoma. Virchows Arch 436:494-497 (Pubitemid 30312166)
13. Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM, Marechal V, Chen J, Brennan MF, Levine AJ (1994) Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 54:794-799 (Pubitemid 24068339)
14. Mousses S, McAuley L, Bell RS, Kandel R, Andrulis IL (1996) Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas. Mod Pathol 9:1-6 (Pubitemid 26061121)
15. Yoo J, Lee HK, Kang CS, Park WS, Lee JY, Shim SI (1997) p53 gene mutations and p53 protein expression in human soft tissue sarcomas. Arch Pathol Lab Med 121:395-399 (Pubitemid 27184994)
16. Taubert H, Würl P, Bache M, Meye A, Berger D, Holzhausen HJ, Hinze R, Schmidt H, Rath FW (1998) The p53 gene in soft tissue sarcomas: prognostic value of DNA sequencing versus immunohistochemistry. Anticancer Res 18:183-187 (Pubitemid 28174704)
17. Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245
18. Yamaguchi T, Toguchida J, Wadayama B, Kanoe H, Nakayama T, Ishizaki K, Ikenaga M, Kotoura Y, Sasaki MS (1996) Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas. Anticancer Res 16:2009-2015 (Pubitemid 26270717)
19. Röpke M, Boltze C, Neumann HW, Roessner A, Schneider-Stock R (2003) Genetic and epigenetic alterations in tumor progression in a dedifferentiated chondrosarcoma. Pathol Res Pract 199:437-444 (Pubitemid 36974832)
20. Sulzbacher I, Birner P, Trieb K, Mühlbauer M, Lang S, Chott A (2001) Platelet-derived growth factor-alpha receptor expression supports the growth of conventional chondrosarcoma and is associated with adverse outcome. Am J Surg Pathol 25:1520-1527 (Pubitemid 33096967)
21. Lagonigro MS, Tamborini E, Negri T, Staurengo S, Dagrada GP, Miselli F, Gabanti E, Greco A, Casali PG, Carbone A, Pierotti MA, Pilotti S (2006) PDGFRalpha, PDGFRbeta and KIT expression/ activation in conventional chondrosarcoma. J Pathol 208:615-623