The cancer marker neutrophil gelatinase-associated lipocalin is highly expressed in human endometrial hyperplasia

Molecular Biology Reports

Volumn 39, Issue 2, 2012, Pages 1029-1036

  Liao, Chi Jr ^a   Huang, Yen Hua ^b   Au, Heng Kien ^c   Wang, Le Ming ^c   Chu, Sin Tak ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adenomyosis; Endometrial hyperplasia; Lipocalin 2

Indexed keywords

BETA CATENIN; CYCLOOXYGENASE 2; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UVOMORULIN; VIMENTIN; ACUTE PHASE PROTEIN; CADHERIN; CTNNB1 PROTEIN, HUMAN; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN; PRIMER DNA; TUMOR MARKER;

ADENOMYOSIS; ARTICLE; BETA CATENIN GENE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; E CADHERIN GENE; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENE LOCATION; GENETIC CORRELATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL; TUMOR GENE; UTERUS BIOPSY; VIMENTIN GENE; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ENDOMETRIOSIS; GENETICS; METABOLISM;

ACUTE-PHASE PROTEINS; ANALYSIS OF VARIANCE; BETA CATENIN; BLOTTING, WESTERN; CADHERINS; CYCLOOXYGENASE 2; DNA PRIMERS; ENDOMETRIAL HYPERPLASIA; ENDOMETRIOSIS; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOCALINS; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; VIMENTIN;

EID: 84860329766     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-0828-9     Document Type: Article

References (33)

1. Flower DR (1996) The lipocalin protein family: structure and function. Biochem J 318:1-14 (Pubitemid 26283618)
2. Liu Q, Nilsen-Hamilton M (1995) Identification of a new acute phase protein. J Biol Chem 270:22565-22570
3. Liu Q, Ryon J, Nilsen-Hamilton M (1997) Uterocalin: a mouse acute phase protein expressed in the uterus around birth. Mol Reprod Dev 46:507-514 (Pubitemid 27149086)
4. Moniaux N, Chakraborty S, Yalniz M, Gonzalez J, Shostrom VK, Standop J, Lele SM, Ouellette M, Pour PM, Sasson AR, Brand RE, Hollingsworth MA, Jain M, Batra SK (2008) Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia. Br J Cancer 98: 1540-1547 (Pubitemid 351652327)
5. Bauer M, Eickhoff JC, Gould MN, Mundhenke C, Maass N, Friedl A (2008) Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat 108:389-397 (Pubitemid 351431077)
6. Lim R, Ahmed N, Borregaard N, Riley C, Wafai R, Thompson EW, Quinn MA, Rice GE (2007) Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epi-thelial-mesenchymal transition. Int J Cancer 120:2426-2434 (Pubitemid 46642130)
7. Yang J, Moses MA (2009) Lipocalin 2: a multifaceted modulator of human cancer. Cell Cycle 8:1-6
8. 2 toxicity. Arch Med Res 39:560-566 (Pubitemid 352033610)
9. Huang HL, Chu ST, Chen YH (1999) Ovarian steroids regulate 24p3 expression in mouse uterus during the natural estrous cycle and the preimplantaion period. J Endocrinol 162:11-19 (Pubitemid 29336350)
10. Lin HH, Li WW, Lee YC, Chu ST (2007) Apoptosis induced by uterine 24p3 protein in endometrial carcinoma cell line. Toxicology 234:203-215 (Pubitemid 46635956)
11. Salamonsen LA, Lathbury L (2000) Endometrial leukocytes and menstruation. Hum Reprod Update 6:16-27 (Pubitemid 30099339)
12. Kayisli UA, Mahutte NG, Arici A (2002) Uterine chemokines in reproductive physiology and pathology. AJRI Am J Reprod Immunol Microbiol 47:213-221 (Pubitemid 34441004)
13. Masafumi K, Takako O, Michio U (2004) The relationship between endometrial carcinoma and coexistent adenomyosis uteri, endo-metriosis external and myoma uteri. Can Diet Prevent 28:94-98
14. Boruban MC, Altundag K, Kilic GS, Blankstein J (2008) From endometrial hyperplasia to endometrial cancer: insight into the biology and possible medical preventive measure. Eur J Can Prev 17:133-138 (Pubitemid 351301624)
15. Cakmakoglu BA, Attar R, Kahraman OT, Dalan AB, Iyibozkurt AC, Karateke A, Attar E (2010) Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk. Mol Biol Rep 38(5):3481-3486
16. Fujiwaki R, Lida K, Kanasaki H, Ozaki T, Hata K, Miyazaki K (2002) Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. Hum Pathol 33:213-219 (Pubitemid 34298737)
17. Orejuela FJ, Ramondetta LM, Smith J, Brown J, Lemos LB, Li Y, Hollier LM (2005) Estrogen and progesterone receptors and cyclooxygenase-2 expression in endometrial hyperplasia, and normal endometrium. Gynecol Oncol 97:483-488 (Pubitemid 40614893)
18. Fosslein E (2001) Molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. Ann Clin Lab Sci 31:325-348
19. Bakhle YS (2001) COX-2 and cancer: a new approach to an old problem. Brit J Pharmacol 134:1137-1150 (Pubitemid 33097242)
20. Geert B, Frans VR (2001) The E-cadherin/b-catenin complex an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res 3:289-293
21. Yang J, Bielenberg DR, Rodig SJ, Doiron R, Clifton MC, Kung AL, Strong RK, Zurakowski D, Moses MA (2009) Lipocalin 2 promotes breast cancer progression. Proc Natl Acad Sci USA 106:3913-3918
22. Cowling VH, Cole MD (2007) E-cadherin repression contributes to c-myc-induced epithelial cell transformation. Oncogene 26:35 82-3586
23. Chen L, Chen W, Zhao L, Yu HZ, Li X (2009) Immunoscreening of urinary bladder cancer cDNA library and identification of potential tumor antigen. World J Urol 27:107-112
24. Iannetti A, Pacifico F, Acquaviva R, Lavorgna A, Crescenzi E, Vascotto C, Tell G, Salzano AM, Scaloni A, Vuttariello E, Chiappetta G, Formisano S, Leonardi A (2008) The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells. Proc Natl Acad Sci USA 105:14058-14063
25. Arlinghaus R, Leng X (2008) Requirement of lipocalin 2 for chronic myeloid leukemia. Leuk Lymphoma 49:600-603 (Pubitemid 351517195)
26. Leng X, Lin H, Ding T, Wang Y, Wu Y, Klumpp S, Sun T, Zhou Y, Monaco P, Belmont J, Aderem A, Akira S, Strong R, Arlinghaus R (2008) Lipocalin 2 is required for BCR-ABL-induced tumorigene-sis. Oncogene 27:6110-6119
27. Hu L, Hittelman W, Lu T, Ji P, Arlinghaus R, Shmulerich I, Hamilton BR, Zhang W (2009) NGAL decrease E-cadherin-mediated cell-cell adhesion and increase cell mobility and invasion through Rac1 in colon carcinoma cells. Lab Invest 17:1-18
28. Munday JS, Brennan MM, Kiupel M (2006) Altered expression of b-catenin, E-cadherin, COX-2, and p53 protein by ovine intestinal adenocarcinoma cells. Vet Pathol 43:613-621 (Pubitemid 44379937)
29. Jeong J-W, Lee HS, Frano HL, Broaddus RR, Taketo MM, Tsai SY, Lydon JP, DeMayo FJ (2009) b-catenin mediates glandular formation and dysregulation of b-catenin induces hyperplasia formation in the murine uterus. Oncogene 28:31-40
30. Ashihara K, Saito T, Mizumoto H, Nishimura M, Tanaka R, Kudo R (2002) Mutation of b-catenin gene in endometrial cancer but not in associated hyperplasia. Med Electron Microsc 35:9-15 (Pubitemid 34601463)
31. Giles C, Thompson EW (1996) The epithelial to mesenchymal transition and metastatic progression in carcinoma. Breast J 2:83-96 (Pubitemid 126734144)
32. Tong Z, Kunnumakkara AB, Wang H, Matsuo Y et al (2008) NGAL: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res 68:100-108
33. Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM (2004) Cyclooxygenases in cancer: progression and perspective. Cancer Lett 215:1-20