Hormone Supplementation during aging: How much and when?

Rejuvenation Research

Volumn 15, Issue 2, 2012, Pages 128-131

  Sorwell, K G ^a   Garten, J ^a   Renner, L ^a   Weiss, A ^a   Garyfallou, V T ^a   Kohama, S G ^a   Neuringer, M ^a   Urbanski, H F ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRASTERONE; PRASTERONE SULFATE; STEROID; TESTOSTERONE;

ADRENAL GLAND; AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CIRCADIAN RHYTHM; CLIMACTERIUM; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; HORMONAL THERAPY; MACACA MULATTA; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; SPATIAL MEMORY; STEROIDOGENESIS; WORKING MEMORY;

AGING; ANDROGENS; ANIMALS; COGNITION; COGNITION DISORDERS; DEHYDROEPIANDROSTERONE; HORMONES; MACACA MULATTA; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; STEROIDS; TESTOSTERONE;

ANIMALIA; MACACA; MACACA MULATTA; PRIMATES;

EID: 84860309959     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2011.1251     Document Type: Article

References (19)

1. Davis SR, Shah SM, McKenzie DP, Kilkarni J, Davison SL, Bell RJ. Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol Metab 2008;93:801-808.
2. Sanders JL, Cappola AR, Arnold AM, Boudreau RM, Chaves PH, Robbins J, Cushman M, Newman AB. Concurrent change in dehydroepiandrosterone sulfate and functional performance in the oldest-old: Results from the Cardiovascular Health Study All Stars study. J Gerontol A Biol Sci Med Sci 2010; 65:976-981.
3. Flood JF, Roberts E. Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res 1988;448:178-181.
4. Markowski M, Ungeheuer M, Bitran D, Locurto C. Memoryenhancing effects of DHEAS in aged mice on a win-shift water escape task. Physiol Behav 2001;72:521-525.
5. Grimley-Evans J, Malouf R, Huppert F, van Niekerk J.K. 2006. Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people. Cochrane Database Syst Rev 2006;18:CD006221.
6. Sorwell KG, Urbanski HF. Dehydroepiandrosterone and age-related cognitive decline. Age (Dordr) 2010;32:61-67.
7. Sorwell KG, Kohama SG, Urbanski HF. Perimenopausal regulation of steroidogenesis in the nonhuman primate. Neurobiol Aging 2011;(in press) doi:1016/j.neurobiolaging .2011.05.004.
8. Downs JL, Urbanski HF. Neuroendocrine changes in the aging reproductive axis of female rhesus macaques (Macacaca mulatta). Biol Reprod 2006;75:539-546.
9. Downs JL, Mattison JA, IngramDK,Urbanski HF. Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol Aging 2008;29:1412-1422.
10. Urbanski HF. Role of circadian neuroendocrine rhythms in the control of behavior and physiology. Neuroendocrinology 2011;93:211-222.
11. Urbanski HF, Sorwell K. Age-related changes in neuroendocrine rhythmic function in the rhesus macaque. Age (Dodr), 2012; (Special Issue: Primate Models of Aging. (in press).
12. Urbanski HF. Circadian variation in the physiology and behavior of humans and nonhuman primates. In: Raber J (ed.). Animal Models of Behavioral Analysis. Neuromethods 50. Springer, New York, 2011, pp. 217-235.
13. Amory JK, Bremner WJ. Oral testosterone in oil plus dutasteride in men: A pharmacokinetic study. J Clin Endocrinol Metab 2005;90:2610-2317.
14. Schlatt S, Pohl CR, Ehmcke J, Ramaswamy S. Age-related changes in diurnal rhythms and levels of gonadotropins, testosterone, and inhibin B in male rhesus monkeys (Macaca mulatta). Biol Reprod 2008;79:93-99.
15. Pluchino N, Genazzani AD, Barnardi F, Casarosa E, Pieri M, Palumbo M, Picciarelli G, Gabbinini M, Luisi M, Genazzani AR. Tibolone, transdermal estradiol or oral estrogen-progestin therapies: Effects on circulating allopregnanonlone, cortisol and dehydroepiandrosterone levels. Gynecol Endocrinol 2005;20:144-149.
16. Crawford S, Santoro N, Laughlin GA, Sowers MF, McConnell D, Sutton Turrell K, Weiss G, Vuga M, Randolph J, Lasley B. Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition. J Clin Endocrinol Metab 2009;94:2945-2951.
17. Rapp PR, Morrison JH, Roberts JA. Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. J Neurosci 2003;23:5708-5714.
18. Spritzer MD, Galea LA. Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats. Dev Neurobiol 2007;67:1321-1333.
19. Frye CA, Edinger KL, Lephart ED, Walf AA. 3alpha-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats. Front Age Neurosci 2010;2:15.