Pregnancy outcomes following use of escitalopram: A prospective comparative cohort study

Journal of Clinical Pharmacology

Volumn 52, Issue 5, 2012, Pages 766-770

  Klieger Grossmann, Chagit ^a   Weitzner, Brenda ^a   Panchaud, Alice ^b   Pistelli, Alessandra ^c   Einarson, Thomas ^d   Koren, Gideon ^a   Einarson, Adrienne ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b Swiss Teratogen Information Service   (Switzerland)

^c Florence Teratogen Information Service   (Italy)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Clinical pharmacology; clinical research; drug information; epidemiology; psychopharmacology

Indexed keywords

AMFEBUTAMONE; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; ESCITALOPRAM; MIRTAZAPINE; NEFAZODONE; PARACETAMOL; TRAZODONE; VENLAFAXINE;

ADULT; ADVERSE OUTCOME; ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; CONGENITAL MALFORMATION; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; LIVE BIRTH; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PREGNANCY OUTCOME; PREMATURITY; PROSPECTIVE STUDY; SIDE EFFECT; SPONTANEOUS ABORTION; STILLBIRTH; THERAPEUTIC ABORTION;

ABNORMALITIES, DRUG-INDUCED; ABORTION, SPONTANEOUS; ABORTION, THERAPEUTIC; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BIRTH WEIGHT; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CITALOPRAM; FEMALE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; ITALY; LIVE BIRTH; MATERNAL EXPOSURE; ONTARIO; PATIENT ADMISSION; PREGNANCY; PREGNANCY OUTCOME; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEROTONIN UPTAKE INHIBITORS; STILLBIRTH; SWITZERLAND;

EID: 84860287683     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270011405524     Document Type: Article

References (19)

1. Grigoriadis S, Robinson GE. Gender issues in depression. Ann Clin Psychiatry. 2007 ; 19: 247-255 (Pubitemid 350208795)
2. Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR. Prevalence of depression during pregnancy: systematic review. Obstet Gynecol. 2004 ; 103: 698-709 (Pubitemid 40459031)
3. Borrero S, Moore CG, Qin L, et al. Unintended pregnancy influences racial disparity in tubal sterilization rates. J Gen Intern Med. 2010 ; 25: 122-128
4. Alwan S, Reefhuis J, Rasmussen SA, Friedman JM. Patterns of antidepressant medication use among pregnant women in a United States population. J Clin Pharmacol. 2011 ; 51 (2). 264-270
5. World Health Organization. Data and statistics. www.who.int/research/en. Accessed September 16, 2010.
6. Cipralex/Lexapro [product monograph]. Copenhagen: H Lundbeck A/S; 2009. http://www.cipralex.com/uni0/login/default.aspx?ReturnUrl=%2fstreamfile. aspx%3ffilename%3dmonograph-2009.pdf%26path%3dpdf%2fmonograph&filename= monograph-2009.pdf&path=pdf/monograph. Accessed October 8, 2010.
7. Sivojelezova A, Shuhaiber S, Sarkissian L, Einarson A, Koren G. Citalopram use in pregnancy: prospective comparative evaluation of pregnancy and fetal outcome. Am J Obstet Gynecol. 2005 ; 193: 2004-2009 (Pubitemid 41737626)
8. Reis M, Källén B. Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data. Psychol Med. 2010 ; 40: 1723-1733
9. Pedersen LH, Henriksen TB, Vestergaard M, Olsen J, Bech BH. Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study. BMJ. 2009 ; 339: b3569
10. Report on new patented drugs-Cipralex. http://www.pmprb-cepmb.gc.ca/ english/view.asp?x=479. Accessed October 16, 2010.
11. Einarson A, Choi J, Einarson TR, Koren G. Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry. 2009 ; 54: 242-246
12. Einarson A, Choi J, Einarson TR, Koren G. Adverse effects of antidepressant use in pregnancy: an evaluation of fetal growth and preterm birth. Depress Anxiety. 2010 ; 7: 35-38
13. Lund N, Pedersen LH, Henriksen TB. Selective serotonin reuptake inhibitor exposure in utero and pregnancy outcomes. Arch Pediatr Adolesc Med. 2009 ; 163: 949-954
14. Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C. Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry. 2006 ; 63: 898-906 (Pubitemid 44188483)
15. Källén B. Neonate characteristics after maternal use of antidepressants in late pregnancy. Arch Pediatr Adolesc Med. 2004 ; 158: 312-316 (Pubitemid 38451555)
16. Einarson A, Choi J, Einarson TR, Koren G. Rates of spontaneous and therapeutic abortions following use of antidepressants in pregnancy: results from a large prospective database. J Obstet Gynaecol Can. 2009 ; 31: 452-456
17. Nakhai-Pour HR, Broy P, Bérard A. Use of antidepressants during pregnancy and the risk of spontaneous abortion. Can Med Assoc J. 2010 ; 182: 1031-1037
18. Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004 ; 49: 726-735 (Pubitemid 40100521)
19. Einarson A, Selby P, Koren G. Abrupt discontinuation of psychotropic drugs during pregnancy: fear of teratogenic risk and impact of counselling. J Psychiatry Neurosci. 2001 ; 26: 44-48 (Pubitemid 32185179)